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检索条件"机构=Bioinformatics and Systems Biology Program"
276 条 记 录,以下是111-120 订阅
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Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants (vol 11, 955, 2020)
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NATURE COMMUNICATIONS 2020年 第1期11卷 955页
作者: Donovan, Margaret K. R. D'Antonio-Chronowska, Agnieszka D'Antonio, Matteo Frazer, Kelly A. University of California San Diego Bioinformatics and Systems Biology Graduate Program La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Biomedical Informatics La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Pediatrics and Rady Children’s Hospital La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Department of Pediatrics and Rady Children’s Hospital La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242) University of California San Diego Institute for Genomic Medicine La Jolla USA (GRID:grid.266100.3) (ISNI:0000 0001 2107 4242)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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CryoEM structure of yeast cytoplasmic exosome complex
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细胞研究(英文版) 2016年 第7期26卷 822-837页
作者: Jun-Jie Liu Chu-Ya Niu Yao Wu Dan Tan Yang Wang Ming-Da Ye Yang Liu Ministry of Education Key Laboratory of Protein Sciences Tsinghua-Peking Joint Center for Life Sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University Beijing 100084 China Joint Graduate Program of Peking-Tsinghua-National Institute of Biological Science Tsinghua University Beijing 100084 China Ministry of Education Key Laboratory of Protein Sciences Tsinghua-Peking Joint Center for Life Sciences Beijing Advanced Innovation Center for Structural Biology School of Life Sciences Tsinghua University Beijing 100084 China National Institute of Biological Sciences Beijing 102206 China Joint Graduate Program of Peking-Tsinghua-National Institute of Biological Science Tsinghua University Beijing 100084 China MOE Key Laboratory of Bioinformatics Tsinghua-Peking Joint Center for Life Sciences Center for Synthetic and Systems Biology School of Life Sciences Tsinghua University Beijing 100084 China
The eukaryotic multi-subunit RNA exosome complex plays crucial roles in 3′-to-5′ RNA processing and decay. Rrp6 and Ski7 are the major cofactors for the nuclear and cytoplasmic exosomes, respec... 详细信息
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Core packing of well-defined x-ray and NMR structures is the same
arXiv
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arXiv 2022年
作者: Grigas, Alex T. Liu, Zhuoyi Regan, Lynne O’Hern, Corey S. Graduate Program in Computational Biology and Bioinformatics Yale University New HavenCT06520 United States Integrated Graduate Program in Physical and Engineering Biology Yale University New HavenCT06520 United States Department of Mechanical Engineering and Materials Science Yale University New HavenCT06520 United States Institute of Quantitative Biology Biochemistry and Biotechnology Centre for Synthetic and Systems Biology School of Biological Sciences University of Edinburgh United Kingdom Department of Physics Yale University New HavenCT06520 United States Department of Applied Physics Yale University New HavenCT06520 United States
Numerous studies have investigated the differences and similarities between protein structures determined by solution NMR spectroscopy and those determined by x-ray crystallography. A fundamental question is whether a... 详细信息
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Integration of Protein Structure and Population-Scale DNA Sequence Data for Disease Gene Discovery and Variant Interpretation
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Biomedical Data Science 1000年 第1期5卷 141-161页
作者: Bian Li Bowen Jin John A. Capra William S. Bush 1Department of Biological Sciences and Center for Structural Biology Vanderbilt University Nashville Tennessee USA 2Graduate Program in Systems Biology and Bioinformatics Department of Nutrition School of Medicine Case Western Reserve University Cleveland Ohio USA 3Bakar Computational Health Sciences Institute and Department of Epidemiology and Biostatistics University of California San Francisco California USA email: tony@*** 4Cleveland Institute for Computational Biology Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA email: wsb36@case.edu
The experimental and computational techniques for capturing information about protein structures and genetic variation within the human genome have advanced dramatically in the past 20 years, generating extensive new ... 详细信息
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Traveling fronts in self-replicating persistent random walks with multiple internal states
arXiv
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arXiv 2020年
作者: Ishihara, Keisuke George, Ashish B. Cornelius, Ryan Korolev, Kirill S. Max Planck Institute for the Physics of Complex Systems Nöthnitzer Strasse 38 Dresden01187 Germany Max Planck Institute of Molecular Cell Biology and Genetics Pfotenhauer Strasse 108 Dresden01307 Germany Department of Physics Boston University BostonMA02215 United States Graduate Program in Bioinformatics Boston University BostonMA02215 United States
Self-activation coupled to a transport mechanism results in traveling waves that describe polymerization reactions, forest fires, tumor growth, and even the spread of epidemics. Diffusion is a simple and commonly used... 详细信息
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Construction of Synthetic Escherichia Coli Producing s-linalool
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Procedia Computer Science 2012年 11卷 88-95页
作者: Ratana Thanasomboon Dujduan Waraho Supapon Cheevadhanarak Asawin Meechai Systems Biology and Bioinformatics research laboratory King Mongkut's University of Technology Thonburi Bangkok 10140 Thailand Biological Engineering Program King Mongkut's University of Technology Thonburi Bangkok10140Thailand Division of Biotechnology School of Bioresources and Technology3 King Mongkut's University of Technology Thonburi Bangkok10140 Thailand Department ofChemical Engineering King Mongkut's University of Technology Thonburi Bangkok10140 Thailand
Floral scents are used in many industries and demand for them increases every year. However, the shortage of extracted fragrance supplies from plants leads to high market costs of floral scents. Production of these fr... 详细信息
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Mutually beneficial confluence of structure-based modeling of protein dynamics and machine learning methods
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Current Opinion in Structural biology 2023年 78卷 102517页
作者: Banerjee, Anupam Saha, Satyaki Tvedt, Nathan C. Yang, Lee-Wei Bahar, Ivet Computational and Systems Biology University of Pittsburgh School of Medicine Pittsburgh 15261 PA United States Computational and Applied Mathematics and Statistics The College of William and Mary Williamsburg 23185 VA United States Institute of Bioinformatics and Structural Biology and PhD Program in Biomedical Artificial Intelligence National Tsing Hua University Hsinchu 300044 Taiwan Physics Division National Center for Theoretical Sciences Taipei 106319 Taiwan
Proteins sample an ensemble of conformers under physiological conditions, having access to a spectrum of modes of motions, also called intrinsic dynamics. These motions ensure the adaptation to various interactions in...
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Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation (vol 18, pg 573, 2017)
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NATURE IMMUNOLOGY 2017年 第6期18卷 573-582页
作者: Yu, Bingfei Zhang, Kai Milner, J. Justin Toma, Clara Chen, Runqiang Scott-Browne, James P. Pereira, Renata M. Crotty, Shane Chang, John T. Pipkin, Matthew E. Wang, Wei Goldrath, Ananda W. Division of Biological Sciences University of California San Diego La Jolla California USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla California USA Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla California USA Department of Immunology and Microbial Science The Scripps Research Institute Jupiter Florida USA Division of Signaling and Gene Expression La Jolla Institute for Allergy and Immunology La Jolla California USA Division of Infectious Diseases Department of Medicine University of California San Diego La Jolla California USA Department of Medicine University of California San Diego La Jolla California USA Department of Chemistry and Biochemistry University of California San Diego La Jolla California USA Department of Cellular and Molecular Medicine University of California San Diego La Jolla California USA.
Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor ... 详细信息
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Computational approaches to understanding protein aggregation in neurodegeneration
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Journal of Molecular Cell biology 2014年 第2期8卷 104-115页
作者: Rachel L. Redler David Shirvanyants Onur Dagliyan Feng Ding Doo Nam Kim Pradeep Kota Elizabeth A. Proctor Srinivas Ramachandran Arpit Tandon Nikolay V. Dokholyan Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Chapel Hill NC USA Program in Cellular and Molecular Biophysics University of North Carolina at Chapel Hill Chapel Hill NC USA Curriculum in Bioinformatics and Computational Biology University of North Carolina at Chapel Hill Chapel Hill NC USA Center for Computational and Systems Biology University of NorthCarolina at Chapel Hill chapel Hill NC USA Department of Physics and Astronomy Ctemson University Ctemson SC USA Cellular Growth Mechanisms Section Laboratory of Cell and Developmental Signaling Frederick National Laboratory for Cancer Research Frederick MD USA Division of Basic Sciences Fred Hutchison Cancer Research Center Seatt{e WA USA
The generation of toxic non-native protein conformers has emerged as a unifying thread among disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Atomic-level detail regardi... 详细信息
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Predicting regional somatic mutation rates using DNA motifs
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PLoS Computational biology 2023年 第10 October期19卷 e1011536-e1011536页
作者: Liu, Cong Wang, Zengmiao Wang, Jun Liu, Chengyu Wang, Mengchi Ngo, Vu Wang, Wei Department of Chemistry and Biochemistry University of California San Diego La Jolla CA United States State Key Laboratory of Remote Sensing Science Center for Global Change and Public Health Faculty of Geographical Science Beijing Normal University Beijing China Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA United States Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA United States
How the locus-specificity of epigenetic modifications is regulated remains an unanswered question. A contributing mechanism is that epigenetic enzymes are recruited to specific loci by DNA binding factors recognizing ... 详细信息
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