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Erratum to: A survey of best practices for RNA-seq data analysis

Genome biology 2016年第1期17卷 181页

作者： Ana Conesa Pedro Madrigal Sonia Tarazona David Gomez-Cabrero Alejandra Cervera Andrew McPherson Michal Wojciech Szcześniak Daniel J Gaffney Laura L Elo Xuegong Zhang Ali Mortazavi Institute for Food and Agricultural Sciences Department of Microbiology and Cell Science University of Florida Gainesville FL 32603 USA. aconesa@ufl.edu. Centro de Investigación Príncipe Felipe Genomics of Gene Expression Laboratory 46012 Valencia Spain. aconesa@ufl.edu. Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. pm12@sanger.ac.uk. Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute Anne McLaren Laboratory for Regenerative Medicine Department of Surgery University of Cambridge Cambridge CB2 0SZ UK. pm12@sanger.ac.uk. Centro de Investigación Príncipe Felipe Genomics of Gene Expression Laboratory 46012 Valencia Spain. Department of Applied Statistics Operations Research and Quality Universidad Politécnica de Valencia 46020 Valencia Spain. Unit of Computational Medicine Department of Medicine Karolinska Institutet Karolinska University Hospital 171 77 Stockholm Sweden. Center for Molecular Medicine Karolinska Institutet 17177 Stockholm Sweden. Unit of Clinical Epidemiology Department of Medicine Karolinska University Hospital L8 17176 Stockholm Sweden. Science for Life Laboratory 17121 Solna Sweden. Systems Biology Laboratory Institute of Biomedicine and Genome-Scale Biology Research Program University of Helsinki 00014 Helsinki Finland. School of Computing Science Simon Fraser University Burnaby V5A 1S6BC Canada. Department of Bioinformatics Institute of Molecular Biology and Biotechnology Adam Mickiewicz University in Poznań 61-614 Poznań Poland. Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. Turku Centre for Biotechnology University of Turku and Åbo Akademi University FI-20520 Turku Finland. Key Lab of Bioinformatics/Bioinformatics Division TNLIST and Department of Automation Tsinghua University Beijing 100084 China. School of Life Sciences Tsinghua University Beijing 100084 China. Department of Developmental and Cell Biolo

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Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants

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Antiviral research 2024年 227卷 105920页

作者： Uyen Nguyen Phuong Le Yu-Jen Chang Chih-Hao Lu Yeh Chen Wen-Chi Su Shao-Ting Chao Lia A Baltina Svetlana F Petrova Sin-Rong Li Mien-Chie Hung Michael M C Lai Lidia A Baltina Cheng-Wen Lin Graduate Institute of Biological Science and Technology China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan. The Ph.D. Program of Biotechnology and Biomedical Industry China Medical University Taichung Taiwan Institute of Bioinformatics and Systems Biology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan. Department of Food Science and Biotechnology National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Department of Laboratory Medicine China Medical University Hospital Taichung 404327 Taiwan. Research Center for Cancer Biology China Medical University Taichung 404327 Taiwan Center for Molecular Medicine China Medical University Hospital Taichung 404327 Taiwan. Institute of Molecular Biology Academia Sinica Taipei 115201 Taiwan. Ufa Institute of Chemistry Ufa Federal Research Center of the Russian Academy of Sciences Russia. Electronic address: baltina@anrb.ru. Department of Medical Laboratory Science and Biotechnology China Medical University Taichung Taiwan Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.

COVID-19 pandemic is predominantly caused by SARS-CoV-2, with its main protease, Mpro, playing a pivotal role in viral replication and serving as a potential target for inhibiting different variants. In this study, potent Mpro inhibitors were identified from glycyrrhizic acid (GL) derivatives with amino acid methyl/ethyl esters. Out of the 17 derivatives semisynthesized, Compounds 2, 6, 9, and 15, with methionine methyl esters, D-tyrosine methyl esters, glutamic acid methyl esters, and methionines in the carbohydrate moiety, respectively, significantly inhibited wild-type SARS-CoV-2 Mpro-mediated proteolysis, with IC50 values ranging from 0.06 μM to 0.84 μM. They also demonstrated efficacy in inhibiting trans-cleavage by mutant Mpro variants (Mpro_P132H, Mpro_E166V, Mpro_P168A, Mpro_Q189I), with IC50 values ranging from 0.05 to 0.92 μM, surpassing nirmatrelvir (IC50: 1.17-152.9 μM). Molecular modeling revealed stronger interactions with Valine166 in the structural complex of Mpro_E166V with the compounds compared to nirmatrelvir. Moreover, these compounds efficiently inhibited the post-entry viral processes of wild-type SARS-CoV-2 single-round infectious particles (SRIPs), mitigating viral cytopathic effects and reducing replicon-driven GFP reporter signals, as well as in vitro infectivity of wild-type, Mpro_E166V, and Mpro_Q189I SRIPs, with EC50 values ranging from 0.02 to 0.53 μM. However, nirmatrelvir showed a significant decrease in inhibiting the replication of mutant SARS-CoV-2 SRIPs carrying Mpro_E166V (EC50: >20 μM) and Mpro_Q189I (EC50: 13.2 μM) compared to wild-type SRIPs (EC50: 0.06 μM). Overall, this study identifies four GL derivatives as promising lead compounds for developing treatments against various SARS-CoV-2 strains, including Omicron, and nirmatrelvir-resistant variants.

关键词： Glycyrrhizic acid derivative Inhibitor Mpro Nirmatrelvir-resistant variant Omicron SARS-CoV-2

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Author Correction: Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease

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Nature communications 2023年第1期14卷 4370页

作者： Matteo D'Antonio Jennifer P Nguyen Timothy D Arthur Hiroko Matsui Agnieszka D'Antonio-Chronowska Kelly A Frazer Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. madantonio@ucsd.edu. Division of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. madantonio@ucsd.edu. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. madantonio@ucsd.edu. Division of Biomedical Informatics University of California San Diego La Jolla CA 92093 USA. Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA 92093 USA. Biomedical Sciences Graduate Program University of California San Diego La Jolla CA 92093 USA. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. Department of Pediatrics University of California San Diego La Jolla CA 92093 USA. kafrazer@health.ucsd.edu. Institute of Genomic Medicine University of California San Diego 9500 Gilman Dr La Jolla CA 92093 USA. kafrazer@health.ucsd.edu.

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The evolutionary history of 2,658 cancers (vol 578, pg 122, 2020)

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NATURE 2023年第7948期614卷 E42-E42页

作者： Gerstung, Moritz Jolly, Clemency Leshchiner, Ignaty Dentro, Stefan C. Gonzalez, Santiago Rosebrock, Daniel Mitchell, Thomas J. Rubanova, Yulia Anur, Pavana Yu, Kaixian Tarabichi, Maxime Deshwar, Amit Wintersinger, Jeff Kleinheinz, Kortine Vazquez-Garcia, Ignacio Haase, Kerstin Jerman, Lara Sengupta, Subhajit Macintyre, Geoff Malikic, Salem Donmez, Nilgun Livitz, Dimitri G. Cmero, Marek Demeulemeester, Jonas Schumacher, Steven Fan, Yu Yao, Xiaotong Lee, Juhee Schlesner, Matthias Boutros, Paul C. Bowtell, David D. Zhu, Hongtu Getz, Gad Imielinski, Marcin Beroukhim, Rameen Sahinalp, S. Cenk Ji, Yuan Peifer, Martin Markowetz, Florian Mustonen, Ville Yuan, Ke Wang, Wenyi Morris, Quaid D. Spellman, Paul T. Wedge, David C. Van Loo, Peter European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Wellcome Sanger Institute Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany University of Ljubljana Ljubljana Slovenia The Francis Crick Institute London UK Big Data Institute University of Oxford Oxford UK Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Big Data Institute Li Ka Shing Centre University of Oxford Oxford UK University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Department of Applied Mathematics and Theoretical Physics Centre for Mathematical Sciences University of Cambridge Cambridge UK Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA Department of Statistics Columbia University New York NY USA Department of Haematology University of Cambridge Cambridge UK University of Leuven Leuven Belgium Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Charlestown MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Dana-Farber Cancer Institute Boston MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Oxford NIHR Biomedical Research Centre Oxford UK Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK University of Toronto Toronto Ontario Canada Vector Institute Toronto Ontario Canada Vector Institute Toronto ON Canada Department of Computer Science University of Toronto Toronto ON Canada Ontario Institute for Cancer Research Toronto Ontario Canada University of California Los Angeles

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Corrigendum to "Identification of Differential Tumor Subtypes of T1 Bladder Cancer" [Eur. Urol. 78 (2020) 533-537]

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European urology 2022年第2期81卷 e53页

作者： A Gordon Robertson Clarice S Groeneveld Brian Jordan Xiaoqi Lin Kimberly A McLaughlin Arighno Das Leigh Ann Fall Damiano Fantini Timothy J Taxter Lauren S Mogil Sia Viborg Lindskrog Lars Dyrskjøt David J McConkey Robert S Svatek Aurélien de Reyniès Mauro A A Castro Joshua J Meeks Dxige Research Inc. Courtenay BC Canada. Cartes d'Identité des Tumeurs Program Ligue Nationale Contre le Cancer Paris France Oncologie Moleculaire Institut Curie Equipe Labellisée Ligue Contre le Cancer Paris France. Department of Urology University of Washington Seattle WA USA. Department of Pathology Northwestern University Feinberg School of Medicine Chicago IL USA. Departments of Urology Biochemistry and Molecular Genetics Feinberg School of Medicine Northwestern University Chicago IL USA. Tempus Labs Inc. Chicago IL USA. Center for Translational Data Science University of Chicago Chicago IL USA. Department of Molecular Medicine Aarhus University Hospital Aarhus Denmark. Johns Hopkins Greenberg Bladder Cancer Institute Brady Urological Institute Johns Hopkins University Baltimore MD USA. Experimental Developmental Therapeutics Program UT Health MD Anderson San Antonio TX USA Department of Urology UT Health San Antonio San Antonio TX USA. Cartes d'Identité des Tumeurs Program Ligue Nationale Contre le Cancer Paris France. Bioinformatics and Systems Biology Laboratory Federal University of Paraná Curitiba Brazil. Departments of Urology Biochemistry and Molecular Genetics Feinberg School of Medicine Northwestern University Chicago IL USA Jesse Brown VA Medical Center Chicago IL USA. Electronic address: joshua.meeks@northwestern.edu.

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Correction to: Microbial function and genital inflammation in young South African women at high risk of HIV infection

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Microbiome 2022年第1期10卷 42页

作者： Arghavan Alisoltani Monalisa T Manhanzva Matthys Potgieter Christina Balle Liam Bell Elizabeth Ross Arash Iranzadeh Michelle du Plessis Nina Radzey Zac McDonald Bridget Calder Imane Allali Nicola Mulder Smritee Dabee Shaun Barnabas Hoyam Gamieldien Adam Godzik Jonathan M Blackburn David L Tabb Linda-Gail Bekker Heather B Jaspan Jo-Ann S Passmore Lindi Masson Division of Medical Virology Department of Pathology University of Cape Town Cape Town 7925 South Africa. Division of Biomedical Sciences University of California Riverside School of Medicine Riverside CA 92521 USA. Computational Biology Division Department of Integrative Biomedical Sciences University of Cape Town Cape Town 7925 South Africa. Division of Chemical and Systems Biology Department of Integrative Biomedical Sciences University of Cape Town Cape Town 7925 South Africa. Division of Immunology Department of Pathology University of Cape Town Cape Town 7925 South Africa. Centre for Proteomic and Genomic Research Cape Town 7925 South Africa. Laboratory of Human Pathologies Biology Department of Biology and Genomic Center of Human Pathologies Mohammed V University Rabat Morocco. Institute of Infectious Disease and Molecular Medicine (IDM) University of Cape Town Cape Town 7925 South Africa. Centre for Infectious Diseases Research (CIDRI) in Africa Wellcome Trust Centre University of Cape Town Cape Town 7925 South Africa. Seattle Children's Research Institute University of Washington Seattle WA 98101 USA. Bioinformatics Unit South African Tuberculosis Bioinformatics Initiative Stellenbosch University Stellenbosch 7602 South Africa. DST-NRF Centre of Excellence for Biomedical Tuberculosis Research Stellenbosch University Stellenbosch 7602 South Africa. Desmond Tutu HIV Centre University of Cape Town Cape Town 7925 South Africa. Centre for the AIDS Programme of Research in South Africa Durban 4013 South Africa. National Health Laboratory Service Cape Town 7925 South Africa. Division of Medical Virology Department of Pathology University of Cape Town Cape Town 7925 South Africa. Lindi.Masson@burnet.edu.au. Institute of Infectious Disease and Molecular Medicine (IDM) University of Cape Town Cape Town 7925 South Africa. Lindi.Masson@burnet.edu.au. Centre for the AIDS Programme of Research in South Africa Durban 4013 South Africa. Lindi.Ma

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Publisher Correction: Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

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Nature communications 2021年第1期12卷 4318页

作者： Bahar Behsaz Edna Bode Alexey Gurevich Yan-Ni Shi Florian Grundmann Deepa Acharya Andrés Mauricio Caraballo-Rodríguez Amina Bouslimani Morgan Panitchpakdi Annabell Linck Changhui Guan Julia Oh Pieter C Dorrestein Helge B Bode Pavel A Pevzner Hosein Mohimani Bioinformatics and Systems Biology Program University of California San Diego La Jolla CA USA. Center for Microbiome Innovation University of California at San Diego La Jolla CA USA. Computational Biology Department School of Computer Science Carnegie Mellon University Pittsburgh PA USA. Molecular Biotechnology Department of Biosciences Goethe University Frankfurt Frankfurt am Main Germany. Center for Algorithmic Biotechnology Institute of Translational Biomedicine St. Petersburg State University St Petersburg Russia. Tiny Earth Chemistry Hub University of Wisconsin-Madison Madison WI USA. Collaborative Mass Spectrometry Innovation Center Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San Diego La Jolla CA USA. The Jackson Laboratory of Medical Genomics Farmington CT USA. Molecular Biotechnology Department of Biosciences Goethe University Frankfurt Frankfurt am Main Germany. helge.bode@mpi-marburg.mpg.de. Buchmann Institute for Molecular Life Sciences (BMLS) Goethe University Frankfurt & Senckenberg Research Institute Frankfurt am Main Germany. helge.bode@mpi-marburg.mpg.de. Max-Planck-Institute for Terrestrial Microbiology Department for Natural Products in Organismic Interactions Marburg Germany. helge.bode@mpi-marburg.mpg.de. Department of Computer Science and Engineering University of California San Diego La Jolla CA USA. ppevzner@ucsd.edu. Computational Biology Department School of Computer Science Carnegie Mellon University Pittsburgh PA USA. hoseinm@andrew.cmu.edu.

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Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes

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Genome medicine 2021年第1期13卷 139页

作者： David Z Pan Zong Miao Caroline Comenho Sandhya Rajkumar Amogha Koka Seung Hyuk T Lee Marcus Alvarez Dorota Kaminska Arthur Ko Janet S Sinsheimer Karen L Mohlke Nicholas Mancuso Linda Liliana Muñoz-Hernandez Miguel Herrera-Hernandez Maria Teresa Tusié-Luna Carlos Aguilar-Salinas Kirsi H Pietiläinen Jussi Pihlajamäki Markku Laakso Kristina M Garske Päivi Pajukanta Department of Human Genetics David Geffen School of Medicine at UCLA Los Angeles USA. Bioinformatics Interdepartmental Program UCLA Los Angeles USA. Computational and Systems Biology Interdepartmental Program UCLA Los Angeles USA. Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland. Department of Medicine David Geffen School of Medicine at UCLA Los Angeles USA. Department of Computational Medicine David Geffen School of Medicine at UCLA Los Angeles USA. Department of Genetics University of North Carolina at Chapel Hill Chapel Hill North Carolina USA. Center for Genetic Epidemiology Department of Preventative Medicine Keck School of Medicine University of Southern California Los Angeles USA. Tecnologico de Monterrey Escuela de Medicina y Ciencias de la Salud Ave. Morones Prieto 3000 Monterrey N.L. México 64710. Unidad de Investigación de Enfermedades Metabólicas Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico. Departamento de Endocrinología y Metabolismo del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico. Departamento de Cirugía Instituto Nacional de Ciencias Médicas y Nutrición Mexico City Mexico. Unidad de Biología Molecular y Medicina Genómica Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico. Obesity Research Unit Research Program for Clinical and Molecular Metabolism Faculty of Medicine University of Helsinki Helsinki Finland. Obesity Center Endocrinology Abdominal Center Helsinki University Central Hospital and University of Helsinki Helsinki Finland. Department of Medicine Endocrinology and Clinical Nutrition Kuopio University Hospital Kuopio Finland. Department of Medicine University of Eastern Finland and Kuopio University Hospital Kuopio Finland. Department of Human Genetics David Geffen School of Medicine at UCLA Los Angeles USA. ppajukant

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Erratum to: The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species

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Genome biology 2017年第1期18卷 11页

作者： Alexie Papanicolaou Marc F Schetelig Peter Arensburger Peter W Atkinson Joshua B Benoit Kostas Bourtzis Pedro Castañera John P Cavanaugh Hsu Chao Christopher Childers Ingrid Curril Huyen Dinh HarshaVardhan Doddapaneni Amanda Dolan Shannon Dugan Markus Friedrich Giuliano Gasperi Scott Geib Georgios Georgakilas Richard A Gibbs Sarah D Giers Ludvik M Gomulski Miguel González-Guzmán Ana Guillem-Amat Yi Han Artemis G Hatzigeorgiou Pedro Hernández-Crespo Daniel S T Hughes Jeffery W Jones Dimitra Karagkouni Panagiota Koskinioti Sandra L Lee Anna R Malacrida Mosè Manni Kostas Mathiopoulos Angela Meccariello Monica Munoz-Torres Shwetha C Murali Terence D Murphy Donna M Muzny Georg Oberhofer Félix Ortego Maria D Paraskevopoulou Monica Poelchau Jiaxin Qu Martin Reczko Hugh M Robertson Andrew J Rosendale Andrew E Rosselot Giuseppe Saccone Marco Salvemini Grazia Savini Patrick Schreiner Francesca Scolari Paolo Siciliano Sheina B Sim George Tsiamis Enric Ureña Ioannis S Vlachos John H Werren Ernst A Wimmer Kim C Worley Antigone Zacharopoulou Stephen Richards Alfred M Handler Hawkesbury Institute for the Environment Western Sydney University Sydney Australia. Justus-Liebig-University Giessen Institute for Insect Biotechnology 35394 Giessen Germany. Department of Biological Sciences Cal Poly Pomona Pomona CA 91768 USA. Department of Entomology and Center for Disease Vector Research University of California Riverside Riverside CA 92521 USA. Interdepartmental Graduate Program in Genetics Genomics & Bioinformatics University of California Riverside Riverside CA 92521 USA. Department of Biological Sciences University of Cincinnati Cincinnati OH 45221 USA. Insect Pest Control Laboratory Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture Seibersdorf Vienna Austria. Department of Environmental and Natural Resources Management University of Patras Agrinio Greece. Department of Environmental Biology Centro de Investigaciones Biológicas CSIC 28040 Madrid Spain. Human Genome Sequencing Center Department of Human and Molecular Genetics Baylor College of Medicine 77030 Houston TX USA. National Agricultural Library USDA 20705 Beltsville MD USA. Georg-August-Universität Göttingen Johann-Friedrich-Blumenbach-Institut für Zoologie und Anthropologie 37077 Göttingen Germany. Department of Biology University of Rochester 14627 Rochester NY USA. Department of Biological Sciences Wayne State University 48202 Detroit MI USA. Department of Biology and Biotechnology University of Pavia 27100 Pavia Italy. USDA-ARS Pacific Basin Agricultural Research Center 96720 Hilo HI USA. DIANA-Lab Department of Electrical & Computer Engineering University of Thessaly 382 21 Volos Greece and Hellenic Pasteur Institute 11521 Athens Greece. Department of Entomology University of Illinois at Urbana-Champaign 61801 Urbana IL USA. Department of Biological Sciences Oakland University 48309 Rochester MI USA. Department of Biochemistry and Biotechnology University of Thessaly Larissa Greece. Department of Biology Univer

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Author Correction: Generation of accurate, expandable phylogenomic trees with uDance

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Nature biotechnology 2024年第5期42卷 814页

作者： Metin Balaban Yueyu Jiang Qiyun Zhu Daniel McDonald Rob Knight Siavash Mirarab Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. Biodesign Center for Fundamental and Applied Microbiomics Arizona State University Tempe AZ USA. School of Life Sciences Arizona State University Tempe AZ USA. Department of Pediatrics University of California San Diego La Jolla CA USA. Department of Computer Science and Engineering Jacobs School of Engineering University of California San Diego La Jolla CA USA. Department of Bioengineering University of California San Diego La Jolla CA USA. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu. Department of Computer Science and Engineering Jacobs School of Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu.

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