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检索条件"机构=Biological Physics Structure and Design Program"
12 条 记 录,以下是1-10 订阅
Computational design of serine hydrolases
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Science (New York, N.Y.) 2025年 第6744期388卷 eadu2454页
作者: Lauko, Anna Pellock, Samuel J. Sumida, Kiera H. Anishchenko, Ivan Juergens, David Ahern, Woody Jeung, Jihun Shida, Alexander F. Hunt, Andrew Kalvet, Indrek Norn, Christoffer Humphreys, Ian R. Jamieson, Cooper Krishna, Rohith Kipnis, Yakov Kang, Alex Brackenbrough, Evans Bera, Asim K. Sankaran, Banumathi Houk, K.N. Baker, David Department of Biochemistry University of Washington Seattle WA United States Institute for Protein Design University of Washington Seattle WA United States Graduate Program in Biological Physics Structure and Design University of Washington Seattle WA United States Department of Chemistry University of Washington Seattle WA United States Graduate Program in Molecular Engineering University of Washington Seattle WA United States Paul G. Allen School of Computer Science and Engineering University of Washington Seattle WA United States Medical Scientist Training Program University of Washington Seattle WA United States Howard Hughes Medical Institute University of Washington Seattle WA United States Department of Chemistry and Biochemistry University of California Los Angeles CA United States
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of RFdiffusion with ...
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Correction to: Multistate and functional protein design using RoseTTAFold sequence space diffusion (Nature Biotechnology, (2024), 10.1038/s41587-024-02395-w)
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Nature Biotechnology 2024年
作者: Lisanza, Sidney Lyayuga Gershon, Jacob Merle Tipps, Samuel W. K. Sims, Jeremiah Nelson Arnoldt, Lucas Hendel, Samuel J. Simma, Miriam K. Liu, Ge Yase, Muna Wu, Hongwei Tharp, Claire D. Li, Xinting Kang, Alex Brackenbrough, Evans Bera, Asim K. Gerben, Stacey Wittmann, Bruce J. McShan, Andrew C. Baker, David Department of Biochemistry University of Washington SeattleWA United States Institute for Protein Design University of Washington SeattleWA United States Graduate Program in Biological Physics Structure and Design University of Washington SeattleWA United States Department of Molecular Engineering University of Washington SeattleWA United States Molecular & amp Cellular Biology Medical Scientist Training Program University of Washington SeattleWA United States Faculty of Engineering Sciences Heidelberg University Heidelberg Germany School of Chemistry and Biochemistry Georgia Institute of Technology AtlantaGA United States Office of the Chief Scientific Officer Microsoft RedmondWA United States Howard Hughes Medical Institute University of Washington SeattleWA United States
Correction to: Nature Biotechnologyhttps://***/10.1038/s41587-024-02395-w, published online 25 September 2024. In the version of the article initially published, in the key to Fig. 2f the colors were swapped and have ...
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BPS2025 - Structural and functional characterization of integrin α5-targeting antibodies for anti-angiogenic therapy
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Biophysical Journal 2025年 第3期124卷 12a-12a页
作者: Adam Nguyen Joel B. Heim Gabriele Cordara Matthew C. Chan Hedda Johannesen Cristine Charlesworth Ming Li Caleigh M. Azumaya Benjamin Madden Ute Krengel Alexander Meves Melody G. Campbell Basic Sciences Fred Hutchinson Cancer Center Seattle WA USA Biological Physics Structure and Design Graduate Program University of Washington Seattle WA USA Department of Dermatology Mayo Clinic Rochester MN USA Department of Chemistry University of Oslo Oslo Norway Medical Genome and Proteomics Core Mayo Clinic Rochester MN USA
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An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting
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Npj viruses 2023年 第1期1卷 2页
作者: Edgar A Hodge Ananya Chatterjee Chengbo Chen Gajendra S Naika Mint Laohajaratsang Vidya Mangala Prasad Kelly K Lee Department of Medicinal Chemistry University of Washington Seattle WA 98195 USA. Molecular Biophysics Unit Indian Institute of Science Bangalore Karnataka 560012 India. Biological Physics Structure and Design Graduate Program University of Washington Seattle WA 98195 USA. Center for Infectious Diseases Research Indian Institute of Science Bangalore Karnataka 560012 India.
The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade. Many high-resolution structures of bnAbs, typically with one or two we... 详细信息
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Accurate de novo design of membrane-traversing macrocycles
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四川生理科学杂志 2022年 第8期44卷 1474-1474页
作者: Gaurav Bhardwaj Institute for Protein Design University of Washington Seattle WA 98195 USA Department of Medicinal Chemistry University of Washington Seattle WA 98195 USA Biological Physics Structure and Design program University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Molecular Cell and Biology program University of Washington Seattle WA 98195 USA Institute for Molecular Bioscience Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science The University of Queensland Brisbane QLD 4072 Australia Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences Rensselaer Polytechnic Institute Troy NY 12180 USA Molecular Engineering and Sciences Program University of Washington Seattle WA 98195 USA Departamento de Quίmica Fίsica Universidad de Valencia Avenida Dr. Moliner 50 Burjassot 46100 Valencia Spain Department of Medicine Division of Allergy and Infectious Disease University of Washington Seattle WA USA Department of Chemistry and Biochemistry University of California-Los Angeles Los Angeles CA USA Takeda Pharmaceuticals Inc. Cambridge MA USA Howard Hughes Medical Institute University of Washington Seattle WA 98195 USA
We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral *** designed 1846-12 residue macrocycles with a ... 详细信息
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Publisher Correction: Multistate and functional protein design using RoseTTAFold sequence space diffusion
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Nature biotechnology 2024年 2024 Oct 7页
作者: Sidney Lyayuga Lisanza Jacob Merle Gershon Samuel W K Tipps Jeremiah Nelson Sims Lucas Arnoldt Samuel J Hendel Miriam K Simma Ge Liu Muna Yase Hongwei Wu Claire D Tharp Xinting Li Alex Kang Evans Brackenbrough Asim K Bera Stacey Gerben Bruce J Wittmann Andrew C McShan David Baker Department of Biochemistry University of Washington Seattle WA USA. Institute for Protein Design University of Washington Seattle WA USA. Graduate Program in Biological Physics Structure and Design University of Washington Seattle WA USA. Department of Molecular Engineering University of Washington Seattle WA USA. Molecular & Cellular Biology Medical Scientist Training Program University of Washington Seattle WA USA. Faculty of Engineering Sciences Heidelberg University Heidelberg Germany. School of Chemistry and Biochemistry Georgia Institute of Technology Atlanta GA USA. Office of the Chief Scientific Officer Microsoft Redmond WA USA. Department of Biochemistry University of Washington Seattle WA USA. dabaker@uw.edu. Institute for Protein Design University of Washington Seattle WA USA. dabaker@uw.edu. Howard Hughes Medical Institute University of Washington Seattle WA USA. dabaker@uw.edu.
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Publisher Correction: Modular and tunable biological feedback control using a de novo protein switch
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Nature 2020年 第7798期579卷 E8页
作者: Andrew H Ng Taylor H Nguyen Mariana Gómez-Schiavon Galen Dods Robert A Langan Scott E Boyken Jennifer A Samson Lucas M Waldburger John E Dueber David Baker Hana El-Samad Department of Biochemistry and Biophysics University of California San Francisco San Francisco CA USA. Department of Bioengineering University of California Berkeley Berkeley CA USA. The UC Berkeley-UCSF Graduate Program in Bioengineering UC Berkeley Berkeley CA USA. Cell Design Initiative University of California San Francisco CA USA. Department of Biochemistry University of Washington Seattle WA USA. Institute for Protein Design University of Washington Seattle WA USA. Graduate Program in Biological Physics Structure and Design University of Washington Seattle WA USA. Howard Hughes Medical Institute University of Washington Seattle WA USA. Department of Biochemistry and Biophysics University of California San Francisco San Francisco CA USA. hana.el-samad@ucsf.edu. Cell Design Initiative University of California San Francisco CA USA. hana.el-samad@ucsf.edu. Chan-Zuckerberg Biohub San Francisco CA USA. hana.el-samad@ucsf.edu.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Complementary Approaches to Dissecting Mechanisms of Protein-mediated Membrane Fusion
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Microscopy and Microanalysis 2015年 第S3期21卷 1279-1280页
作者: Long Gui Natalie K. Garcia Miklos Guttman Jamie L. Ebner Kelly K. Lee Department of Medicinal Chemistry University of Washington Seattle WA USA Biological Physics Structure and Design Program University of Washington Seattle WA USA
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Erratum for Gui et al., Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement
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mBio 2016年 第1期7卷 e01928-15页
作者: Long Gui Eric Jurgens Jamie L Ebner Matteo Porotto Anne Moscona Kelly K Lee Department of Medicinal Chemistry University of Washington Seattle Washington USA Biological Physics Structure and Design Graduate Program University of Washington Seattle Washington USA. Department of Pediatrics Weill Medical College of Cornell University New York New York USA. Department of Medicinal Chemistry University of Washington Seattle Washington USA. Department of Pediatrics Weill Medical College of Cornell University New York New York USA kklee@uw.edu Anm2047@med.cornell.edu Map2028@med.cornell.edu. Department of Pediatrics Weill Medical College of Cornell University New York New York USA Department of Microbiology and Immunology Weill Medical College of Cornell University New York New York USA kklee@uw.edu Anm2047@med.cornell.edu Map2028@med.cornell.edu. Department of Medicinal Chemistry University of Washington Seattle Washington USA Biological Physics Structure and Design Graduate Program University of Washington Seattle Washington USA Department of Microbiology University of Washington Seattle Washington USA kklee@uw.edu Anm2047@med.cornell.edu Map2028@med.cornell.edu.
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Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Abstracts
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FLUIDS AND BARRIERS OF THE CNS 2017年 第SUPPL 2期14卷 27-27页
作者: [Anonymous] The Jerzy Kukuczka Academy of Physical Education Katowice Poland The Institute of Animal Physiology and Food Research Polish Academy of Sciences Olsztyn Poland University of Miami Miami FL USA Institute of Pharmaceutical Science King’s College London London United Kingdom Department of Ophthalmology and Molecular and Integrative Physiology The University of Michigan Ann Arbor MI USA Department of Internal Medicine and Cardiology The University of Michigan Ann Arbor MI USA School of Medicine Department of Cellular and Molecular Medicine Koc University Istanbul Turkey Department of Cellular and Molecular Medicine Medical Faculty Koc University Istanbul Turkey Department of Neuroscience School of Medicine Koc University Istanbul Turkey Department of Neuroscience Medical Faculty Koc University Istanbul Turkey Department of Laboratory Animals Science Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey Department of Neuroscience Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey School of Medicine Koc University Istanbul Turkey Department of Forensic Science Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Histology and Embryology School of Medicine Koc University Istanbul Turkey Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Physiology School of Medicine Koc University Istanbul Turkey Theodor Kocher Institute University of Bern Bern Switzerland Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Zurich Center of Integrative Human Physiology University of Zurich Zurich Switzerland Institute for Veterinary Physiology and Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Institute of Veterinary Physiology Univer
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