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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (vol 603, pg 131, 2022)

NATURE 2024年第8020期631卷 E7-E7页

作者： Brown, Anna-Leigh Wilkins, Oscar G. Keuss, Matthew J. Hill, Sarah E. Zanovello, Matteo Lee, Weaverly Colleen Bampton, Alexander Lee, Flora C. Y. Masino, Laura Qi, Yue A. Bryce-Smith, Sam Gatt, Ariana Hallegger, Martina Fagegaltier, Delphine Phatnani, Hemali Phatnani, Hemali Newcombe, Jia Gustavsson, Emil K. Seddighi, Sahba Reyes, Joel F. Coon, Steven L. Ramos, Daniel Schiavo, Giampietro Fisher, Elizabeth M. C. Raj, Towfique Secrier, Maria Lashley, Tammaryn Ule, Jernej Buratti, Emanuele Humphrey, Jack Ward, Michael E. Fratta, Pietro UCL Queen Square Motor Neuron Disease Centre Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology UCL London UK The Francis Crick Institute London UK UK Dementia Research Institute University College London London UK Department of Molecular Biology and Nanobiotechnology National Institute of Chemistry Ljubljana Slovenia National Institute of Neurological Disorders and Stroke NIH Bethesda MD USA Medical Scientist Training Program Johns Hopkins University School of Medicine Baltimore MD USA Center for Alzheimer’s and Related Dementias National Institutes of Health Bethesda MD USA Queen Square Brain Bank UCL Queen Square Institute of Neurology University College London London UK Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University College London London UK Great Ormond Street Institute of Child Health Genetics and Genomic Medicine University College London London UK Center for Genomics of Neurodegenerative Disease New York Genome Center (NYGC) New York NY USA NeuroResource Department of Neuroinflammation UCL Queen Square Institute of Neurology London UK Molecular Genomics Core Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH Bethesda MD USA Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York NY USA Department of Pathology Fishberg Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA Estelle and Daniel Maggin Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics Evolution and Environment UCL Genetics Institute University College London London UK Mole

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Inside Back Cover: Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches (Angew. Chem. Int. Ed. 52/2021)

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Angewandte Chemie International Edition 2021年第52期60卷

作者： Yanrong He Dr. Shu Zhang Dr. Hari Krishna Bisoyi Jinghui Qiao Hong Chen JingJing Gao Prof. Jinbao Guo Prof. Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Education College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Institute of Advanced Materials School of Chemistry and Chemical Engineering Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast University Nanjing 211189 China Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent Ohio 44242 USA

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A broadband thermal emission spectrum of the ultra-hot Jupiter WASP-18b

arXiv

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arXiv 2023年

作者： Coulombe, Louis-Philippe Benneke, Björn Challener, Ryan Piette, Anjali A.A. Wiser, Lindsey S. Mansfield, Megan MacDonald, Ryan J. Beltz, Hayley Feinstein, Adina D. Radica, Michael Savel, Arjun B. Dos Santos, Leonardo A. Bean, Jacob L. Parmentier, Vivien Wong, Ian Rauscher, Emily Komacek, Thaddeus D. Kempton, Eliza M.-R. Tan, Xianyu Hammond, Mark Lewis, Neil T. Line, Michael R. Lee, Elspeth K.H. Shivkumar, Hinna Crossfield, Ian J.M. Nixon, Matthew C. Rackham, Benjamin V. Wakeford, Hannah R. Welbanks, Luis Zhang, Xi Batalha, Natalie M. Berta-Thompson, Zachory K. Changeat, Quentin Désert, Jean-Michel Espinoza, Néstor Goyal, Jayesh M. Harrington, Joseph Knutson, Heather A. Kreidberg, Laura López-Morales, Mercedes Shporer, Avi Sing, David K. Stevenson, Kevin B. Aggarwal, Keshav Ahrer, Eva-Maria Alam, Munazza K. Bell, Taylor J. Blecic, Jasmina Caceres, Claudio Carter, Aarynn L. Casewell, Sarah L. Crouzet, Nicolas Cubillos, Patricio E. Decin, Leen Fortney, Jonathan J. Gibson, Neale P. Heng, Kevin Henning, Thomas Iro, Nicolas Kendrew, Sarah Lagage, Pierre-Olivier Leconte, Jérémy Lendl, Monika Lothringer, Joshua D. Mancini, Luigi Mikal-Evans, Thomas Molaverdikhani, Karan Nikolov, Nikolay K. Ohno, Kazumasa Palle, Enric Piaulet, Caroline Redfield, Seth Roy, Pierre-Alexis Tsai, Shang-Min Venot, Olivia Wheatley, Peter J. Department of Physics Trottier Institute for Research on Exoplanets Université de Montréal MontréalQC Canada Department of Astronomy University of Michigan Ann ArborMI United States Earth and Planets Laboratory Carnegie Institution for Science WashingtonDC United States School of Earth and Space Exploration Arizona State University TempeAZ United States Steward Observatory University of Arizona TucsonAZ United States NHFP Sagan Fellow United States Department of Astronomy Carl Sagan Institute Cornell University NY United States Department of Astronomy and Astrophysics University of Chicago ChicagoIL United States NSF Graduate Research Fellow United States Department of Astronomy University of Maryland College ParkMD United States Center for Computational Astrophysics Flatiron Institute New YorkNY United States Space Telescope Science Institute BaltimoreMD United States Université Côte d’Azur Observatoire de la Côte d’Azur CNRS Laboratoire Lagrange France NASA Goddard Space Flight Center GreenbeltMD United States NASA Postdoctoral Program Fellow United States Tsung-Dao Lee Institute Shanghai Jiao Tong University Shanghai China School of Physics and Astronomy Shanghai Jiao Tong University Shanghai China Atmospheric Oceanic and Planetary Physics Department of Physics University of Oxford Oxford United Kingdom Department of Mathematics and Statistics Faculty of Environment Science and Economy University of Exeter Exeter United Kingdom Center for Space and Habitability University of Bern Bern Switzerland Anton Pannekoek Institute for Astronomy University of Amsterdam Amsterdam Netherlands Department of Physics & Astronomy University of Kansas LawrenceKS United States Department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology CambridgeMA United States Kavli Institute for Astrophysics and Space Research Massachusetts Institute of Technology CambridgeMA United States 51 Pegasi b Fellow France School of

Close-in giant exoplanets with temperatures greater than 2,000 K ("ultra-hot Jupiters") have been the subject of extensive efforts to determine their atmospheric properties using thermal emission measurements from the Hubble and Spitzer Space Telescopes1;2;3. However, previous studies have yielded inconsistent results because the small sizes of the spectral features and the limited information content of the data resulted in high sensitivity to the varying assumptions made in the treatment of instrument systematics and the atmospheric retrieval analysis3;4;5;6;7;8;9;10;11;12. Here we present a dayside thermal emission spectrum of the ultrahot Jupiter WASP-18b obtained with the NIRISS13 instrument on JWST. The data span 0.85 to 2.85 µm in wavelength at an average resolving power of 400 and exhibit minimal systematics. The spectrum shows three water emission features (at >6σ confidence) and evidence for optical opacity, possibly due to H−, TiO, and VO (combined significance of 3.8σ). Models that fit the data require a thermal inversion, molecular dissociation as predicted by chemical equilibrium, a solar heavy element abundance ("metallicity", M/H = 1.03+1.11−0.51 × solar), and a carbon-to-oxygen (C/O) ratio less than unity. The data also yield a dayside brightness temperature map, which shows a peak in temperature near the sub-stellar point that decreases steeply and symmetrically with longitude toward the terminators. © 2023, CC BY.

关键词： Molecular oxygen

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Innenrücktitelbild: Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches (Angew. Chem. 52/2021)

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Angewandte Chemie 2021年第52期133卷

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Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches

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Angewandte Chemie 2021年第52期133卷

Two light-driven chiral fluorescent molecular switches, ( R , S , R )-switch 1 and ( R , S , R )-switch 2 , are prepared by means of hydrogen-bonded (H-bonded) assembly of a photoresponsive ( S ) chiral fluorescent molecule, respectively with a cyano substitution at different positions as an H-bond acceptor and an opposite ( R ) chiral molecule as an H-bond donor. The resulting two switches exhibit tunable and reversible Z / E photoisomerization irradiated with 450 nm blue and 365 nm UV light. When doped into an achiral liquid crystal, both switches are found to be able to form a CPL tunable luminescent helical superstructure. In contrast to the tunable CPL characteristics of the system incorporating switch 2 , exposure of the system incorporating switch 1 to 365 nm and 450 nm radiation can lead to controllable different photostationary CPL behavior, including switching-off and polarization inversion. In addition, optical information coding is demonstrated using the system containing switch 1 .

关键词： circularly polarized luminescence handedness inversion hydrogen-bonded chiral fluorescent switch luminescent helical superstructures

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Electronic structure and 4f-electron character in Ce2PdIn8 studied by angle-resolved photoemission spectroscopy

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Physical Review B 2019年第8期99卷 081107(R)-081107(R)页

作者： Q. Yao D. Kaczorowski P. Swatek D. Gnida C. H. P. Wen X. H. Niu R. Peng H. C. Xu P. Dudin S. Kirchner Q. Y. Chen D. W. Shen D. L. Feng State Key Laboratory of Surface Physics Department of Physics and Laboratory of Advanced Materials Fudan University Shanghai 200438 China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT) Chinese Academy of Sciences Shanghai 200050 China Institute of Low Temperature and Structure Research Polish Academy of Sciences P.O. Box 1410 50-950 Wroclaw Poland Centre for Advanced Materials and Smart Structures Polish Academy of Sciences Okolna 2 50-422 Wroclaw Poland Division of Materials Science and Engineering Ames Laboratory Ames Iowa 50011 USA Department of Physics and Astronomy Iowa State University Ames Iowa 50011 USA Diamond Light Source Harwell Science and Innovation Campus Didcot OX11 0DE United Kingdom Zhejiang Institute of Modern Physics Zhejiang University Hangzhou Zhejiang 310027 China Science and Technology on Surface Physics and Chemistry Laboratory Mianyang 621908 China CAS Center for Excellence in Superconducting Electronics (CENSE) Shanghai 200050 China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093 China

The localized-to-itinerant transition of f electrons lies at the heart of heavy-fermion physics, but has only been directly observed in single-layer Ce-based materials. Here, we report a comprehensive study on the electronic structure and nature of the Ce 4f electrons in the heavy-fermion superconductor Ce2PdIn8, a typical n=2 CenMmIn3n+2m compound, using high-resolution and 4d−4f resonant photoemission spectroscopies. The electronic structure of this material has been studied over a wide temperature range, and hybridization between f and conduction electrons can be clearly observed to form a Kondo resonance near the Fermi level at low temperatures. The characteristic temperature of the localized-to-itinerant transition is around 120 K, which is much higher than its coherence temperature Tcoh∼30K.

关键词： Electronic structure Heavy-fermion systems Angle-resolved photoemission spectroscopy

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The repertoire of mutational signatures in human cancer (vol 578, pg 94, 2020)

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NATURE 2023年第7948期614卷 E41-E41页

作者： Alexandrov, Ludmil B. Kim, Jaegil Haradhvala, Nicholas J. Huang, Mi Ni Ng, Alvin Wei Tian Wu, Yang Boot, Arnoud Covington, Kyle R. Gordenin, Dmitry A. Bergstrom, Erik N. Islam, S. M. Ashiqul Lopez-Bigas, Nuria Klimczak, Leszek J. McPherson, John R. Morganella, Sandro Sabarinathan, Radhakrishnan Wheeler, David A. Mustonen, Ville Getz, Gad Rozen, Steven G. Stratton, Michael R. Department of Cellular and Molecular Medicine Department of Bioengineering Moores Cancer Center University of California San Diego CA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Cellular and Molecular Medicine and Department of Bioengineering University of California San Diego La Jolla CA USA UC San Diego Moores Cancer Center San Diego CA USA University of California San Diego San Diego CA USA Broad Institute of MIT and Harvard Cambridge MA USA Center for Cancer Research Massachusetts General Hospital Boston MA USA Massachusetts General Hospital Boston MA USA Department of Pathology Massachusetts General Hospital Boston MA USA Harvard Medical School Boston MA USA Laboratory for Medical Science Mathematics RIKEN Center for Integrative Medical Sciences Yokohama Japan Computational Biology Program Ontario Institute for Cancer Research Toronto ON Canada Programme in Cancer & Stem Cell Biology Duke-NUS Medical School Singapore Singapore Centre for Computational Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore Programme in Cancer and Stem Cell Biology Centre for Computational Biology Duke-NUS Medical School Singapore Singapore SingHealth Duke-NUS Institute of Precision Medicine National Heart Centre Singapore Singapore Singapore Cancer Science Institute of Singapore National University of Singapore Singapore Singapore Institute of Molecular and Cell Biology Singapore Singapore Laboratory of Cancer Epigenome Division of Medical Science National Cancer Centre Singapore Singapore Singapore Duke-NUS Medical School Singapore Singapore Human Genome Sequencing Center Baylor College of Medicine Houston TX USA Dan L. Duncan Cancer Center Baylor College of Medicine Houston TX USA Department of Molecular and Human Genetics Baylor College of Medicine Houston TX USA Genome Integrity and Structural Biology Laboratory National Ins

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Assessing faculty and organizational change in a professional development program with workshops and disciplinary communities of practice 125

Assessing faculty and organizational change in a professiona...

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125th ASEE Annual Conference and Exposition

作者： Krause, Stephen J. Hjelmstad, Keith D. Judson, Eugene Middleton, James A. Culbertson, Robert J. Ankeny, Casey Jane Chen, Ying-Chih Ross, Lydia Mayled, Lindy Hamilton Hjelmstad, Kara L. Arizona State University Materials Science Program Fulton Schools of Engineering United States Department of Civil Engineering School of Sustainable Engineering and the Built Environment Arizona State University United States Mary Lou Fulton Teachers College Arizona State University United States Department of Mechanical and Aerospace Engineering Center for Research on Education in Science Mathematics Engineering and Technology Arizona State University United States Arizona State University Department of Physics United States Northwestern University Department of Instruction in Biomedical Engineering United States Arizona State University Division of Teacher Preparation Mary Lou Fulton Teachers College TempeAZ United States

To achieve more effective teaching and learning in undergraduate engineering education, professional development needs to promote change toward innovation of use of evidence-based instructional strategies (EBIS) in faculty beliefs and practice as well as change in organizational attitudes and norms. To develop an effective program, a strategy for change needs to be utilized and assessed at the individual level and the organizational level. Rogers Diffusion of Innovation (DOI) is an individual change model which consists of five steps of a progression towards any type of adoption of innovation change such as sports, business or teaching. The steps for adoption of change consist of awareness, interest, evaluation, trial, and adoption. Coburn's organizational innovation (COI) change model for organizations consists of four components necessary to support broader change in an educational organization, which include the following. Depth is deep change in faculty beliefs and practice. Sustainability of Innovation refers to flexibility of innovation in differing contexts or disciplines. Spread of Innovation refers to change in beliefs, norms, and principles of individuals across an organization. Shift of Ownership refers to shift in ownership from external facilitators to internal ownership by individuals and their organization. These change theories have been used to develop and assess a large scale NSF IUSE project at a large southwestern university called Just-in-Time-Teaching with Two Way Formative Feedback for Multiple Disciplines (JTFD). The first year of the project has trained 43 faculty in four disciplines using a train-the-trainer model with one semester of 8 biweekly workshops followed by a second semester of 6 disciplinary community of practice (CoP) discussion sessions. Assessment of elements of the two change theories was done with pre-post measurements of participants with surveys, questions and classroom observations. For the DOI model, Awareness of evidenc

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Lattice distortion in the spin-orbital entangled state in RVO3 perovskites

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Physical Review B 2019年第18期100卷 184423-184423页

作者： J.-Q. Yan W. Tian H. B. Cao S. Chi F. Ye A. Llobet A. Puretzky Q. Chen J. Ma Y. Ren J.-G. Cheng J.-S. Zhou M. A. McGuire R. J. McQueeney Materials Science and Technology Division Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Neutron Scattering Division Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA P-23 Neutron Science and Technology Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge Tennessee 37831 USA Department of Physics and Astronomy University of Tennessee Knoxville Tennessee 37996 USA Key Laboratory of Artificial Structures and Quantum Control School of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 People's Republic of China X-ray Science Division Argonne National Laboratory Argonne Illinois 60439 USA Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 People's Republic of China Materials Science and Engineering Program University of Texas at Austin Austin Texas 78712 USA Ames Laboratory and Department of Physics and Astronomy Iowa State University Ames Iowa 50011 USA

We report a thorough study of Y0.7La0.3VO3 single crystals by measuring magnetic properties, specific heat, thermal conductivity, Raman scattering, x-ray and neutron diffraction with the motivation of revealing the lattice response to the spin-orbital entanglement in RVO3. Upon cooling from room temperature, the orbitally disordered paramagnetic state changes around T*∼220 K to a spin-orbital entangled state which is then followed by a transition at TN = 116 K to C-type orbital-ordered (OO) and G-type antiferromagnetic ordered (AF) ground state. In the temperature interval TNstate to a C-OO/G-AF ground state where the long-range OO suppresses the spin-orbital entanglement. Our analysis suggests that the spin-orbital entangled state and G-OO are comparable in energy and compete with each other. Rare-earth site disorder favors the spin-orbital entanglement rather than a cooperative Jahn-Teller distortion. The results also indicate for LaVO3 a C-OO/G-AF state in Tt ≤ T ≤TN and an orbital flipping transition at Tt.

关键词： Exchange interaction Jahn-Teller effect Magnetic phase transitions Orbital order Antiferromagnets Magnetic insulators Neutron diffraction

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The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI

arXiv

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arXiv 2023年

作者： Moawad, Ahmed W. Janas, Anastasia Baid, Ujjwal Ramakrishnan, Divya Saluja, Rachit Ashraf, Nader Jekel, Leon Amiruddin, Raisa Adewole, Maruf Albrecht, Jake Anazodo, Udunna Aneja, Sanjay Anwar, Syed Muhammad Bergquist, Timothy Calabrese, Evan Chiang, Veronica Chung, Verena Conte, Gian Marco Marco Dako, Farouk Eddy, James Ezhov, Ivan Familiar, Ariana Farahani, Keyvan Iglesias, Juan Eugenio Jiang, Zhifan Johanson, Elaine Kazerooni, Anahita Fathi Kofler, Florian Krantchev, Kiril LaBella, Dominic Van Leemput, Koen Li, Hongwei Bran Linguraru, Marius George Link, Katherine E. Liu, Xinyang Maleki, Nazanin Meier, Zeke Menze, Bjoern H. Moy, Harrison Osenberg, Klara Piraud, Marie Reitman, Zachary Shinohara, Russel Takeshi Tahon, Nourel hoda Nada, Ayman Velichko, Yuri S. Wang, Chunhao Wiestler, Benedikt Wiggins, Walter Shafique, Umber Willms, Klara Avesta, Arman Bousabarah, Khaled Chakrabarty, Satrajit Gennaro, Nicolo Holler, Wolfgang Kaur, Manpreet LaMontagne, Pamela Lin, MingDe Lost, Jan Marcus, Daniel S. Maresca, Ryan Merkaj, Sarah Nada, Ayaman Pedersen, Gabriel Cassinelli von Reppert, Marc Sotiras, Aristeidis Teytelboym, Oleg Tillmans, Niklas Westerhoff, Malte Youssef, Ayda Godfrey, Devon Floyd, Scott Rauschecker, Andreas Villanueva-Meyer, Javier Pflüger, Irada Cho, Jaeyoung Bendszus, Martin Brugnara, Gianluca Cramer, Justin Perez-Carillo, Gloria Guzman J. Johnson, Derek R. Kam, Anthony Kwan, Benjamin Yin Ming Lai, Lillian Lall, Neil U. Memon, Fatima Patro, Satya Narayana Petrovic, Bojan So, Tiffany Y. Thompson, Gerard Wu, Lei Schrickel, E. Brooke Bansal, Anu Barkhof, Frederik Besada, Cristina Chu, Sammy Druzgal, Jason Dusoi, Alexandru Farage, Luciano Feltrin, Fabricio Fong, Amy Fung, Steve H. Gray, R. Ian Ikuta, Ichiro Iv, Michael Postma, Alida A. Mahajan, Amit Joyner, David Krumpelman, Chase Letourneau-Guillon, Laurent Lincoln, Christie M. Maros, Mate E. Miller, Elka Morón, Fanny Nimchinsky, Esther A. Ozsarlak, Ozkan Patel, Uresh Rohatgi, Saurabh Saha, Atin Sayah, Anousheh Schwartz, Eric D. Shih, Robert Shiroishi, Mark Trinity health Mid Atlantic Hosiptals DarbyPA United States Department of Radiology and Biomedical Imaging Yale School of Medicine New HavenCT United States Division of Computational Pathology Department of Pathology and Laboratory Medicine School of Medicine Indiana University IndianapolisIN United States Department of Electical and Computer Engineering Cornell University Cornell Tech New YorkNY United States Department of Radiology Weill Cornell Medicine New YorkNY United States ImagineQuant Children’s Hospital of Philadelphia PhiladelphiaPA United States College of Medicine Alfaisal University Riyadh Saudi Arabia DKFZ Division of Translational Neurooncology The WTZ German Cancer Consortium DKTK Partner Site University Hospital Essen Essen Germany Medical Artificial Intelligence Lab Crestview Radiology Lagos Nigeria Sage Bionetworks SeattleWA United States Montreal Neurological Institute McGill University Montreal Canada lab Crestview Radiology Lagos Nigeria Department of Therapeutic Radiology Yale School of Medicine New HavenCT United States Sheikh Zayed Institute for Pediatric Surgical Innovation Children’s National Hospital WashingtonDC United States Department of Radiology Mayo Clinic RochesterMN United States Department of Radiology Duke University Medical Center DurhamNC United States Department of Neurosurgery Yale School of Medicine New HavenCT United States Center for Global Health Perelman School of Medicine University of Pennsylvania PA United States Department of Informatics Technical University Munich Germany Children’s Hospital of Philadelphia University of Pennsylvania PhiladelphiaPA United States Cancer Imaging Program National Cancer Institute National Institutes of Health BethesdaMD United States Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital BostonMA United States Children’s National Hospital WashingtonDC United States PrecisionFDA U.S. Food and Drug Administration S

The translation of AI-generated brain metastases (BM) segmentation into clinical practice relies heavily on diverse, high-quality annotated medical imaging datasets. The BraTS-METS 2023 challenge has gained momentum for testing and benchmarking algorithms using rigorously annotated internationally compiled real-world datasets. This study presents the results of the segmentation challenge and characterizes the challenging cases that impacted the performance of the winning algorithms. Untreated brain metastases on standard anatomic MRI sequences (T1, T2, FLAIR, T1PG) from eight contributed international datasets were annotated in stepwise method: published UNET algorithms, student, neuroradiologist, final approver neuroradiologist. Segmentations were ranked based on lesion-wise Dice and Hausdorff distance (HD95) scores. False positives (FP) and false negatives (FN) were rigorously penalized, receiving a score of 0 for Dice and a fixed penalty of 374 for HD95. The mean scores for the teams were calculated. Eight datasets comprising 1303 studies were annotated, with 402 studies (3076 lesions) released on Synapse as publicly available datasets to challenge competitors. Additionally, 31 studies (139 lesions) were held out for validation, and 59 studies (218 lesions) were used for testing. Segmentation accuracy was measured as rank across subjects, with the winning team achieving a LesionWise mean score of 7.9. The Dice score for the winning team was 0.65 ± 0.25. Common errors among the leading teams included false negatives for small lesions and misregistration of masks in space. The Dice scores and lesion detection rates of all algorithms diminished with decreasing tumor size, particularly for tumors smaller than 100 mm3. In conclusion, algorithms for BM segmentation require further refinement to balance high sensitivity in lesion detection with the minimization of false positives and negatives. The BraTS-METS 2023 challenge successfully curated well-annotated, diverse d

关键词： Image segmentation

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