Spiking Neural Networks (SNNs) are inspired by the sparse and event-driven nature of biological neural processing, and offer the potential for ultra-low-power artificial intelligence. However, realizing their efficien...
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As power grids modernize to include wide area monitoring and advanced metering infrastructures, the applications for data-driven methods based on artificial intelligence (AI) for situational awareness, reliability, an...
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Background: Previous efforts to translate vagus nerve stimulation (VNS) therapies from preclinical studies to human clinical applications (e.g., for stroke, heart failure, and inflammatory diseases) did not account fo...
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Background: Previous efforts to translate vagus nerve stimulation (VNS) therapies from preclinical studies to human clinical applications (e.g., for stroke, heart failure, and inflammatory diseases) did not account for individual- or species-specific differences in nerve responses when selecting stimulation parameters. Lack of explicit consideration for producing equivalent nerve responses could contribute to clinical outcomes not replicating promising results from preclinical animal studies. Methods: We used models of VNS built with ASCENT (Musselman, PLoS Comput Biol 17:e1009285, 2021) to quantify nerve responses across species and simulate translation of VNS therapies via either recycling or linear scaling of stimulation parameters. For humans (n = 9) and pigs (n = 12), we used previously validated computational models with the standard clinical helical cuff electrode on individual-specific nerve morphologies (Musselman, J Neural Eng 20:acda64, 2023b). We also modeled rat VNS (n = 9) with the Micro-Leads Neuro bipolar cuff. We calculated thresholds for fiber activation (A-, B-, and C-fibers) with biphasic rectangular pulses (0.13, 0.25, 0.5 ms). We defined "K" as the ratio of activation thresholds between a pair of individuals. We used a mixed model ANOVA on the natural logarithm of K to test for differences in inter-species Ks across fiber types and pulse widths. Lastly, using the same nerve morphologies and application-specific device design (cuff and waveform), we developed models to predict nerve responses in chronic human and rat VNS studies for treatment of stroke, inflammation, and heart failure. Results: Depending on the individual and species, the activation amplitude required to produce a given nerve response varied widely. Thus, applying the same VNS parameters across individuals within a species produced a large range of nerve responses. Further, applying the same or linearly scaled stimulation amplitudes across species also produced highly variable r
Many details of cyber attacks occurred to Industrial Control Systems (ICS) such as power grids remain as a secret. To reveal those secrets and benefit a broad research community, we propose an original cyber-physical ...
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Background: Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are impo...
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Background: Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are important for detecting and relaying sensory information from the periphery to the central nervous system to modulate feeding behavior, metabolism, and inflammation. Confounding variables complicate the process of isolating the role of the vagal afferents in mediating these physiological processes. Therefore, we developed a microfluidic model of the sensory branch of the gut-brain axis. We show that this microfluidic model successfully compartmentalizes the cell body and neurite terminals of the neurons, thereby simulates the anatomical layout of these neurons to more accurately study physiologically-relevant processes. Methods: We implemented a primary rat vagal afferent neuron culture into a microfluidic platform consisting of two concentric chambers interconnected with radial microchannels. The microfluidic platform separated cell bodies from neurite terminals of vagal afferent neurons. We then introduced physiologically-relevant gastrointestinal effector molecules at the nerve terminals and assessed their retrograde transport along the neurite or capacity to elicit an electrophysiological response using live cell calcium imaging. Results: The angle of microchannel outlets dictated the probability of neurites growing into a chamber versus tracking along chamber walls. When the neurite terminals were exposed to fluorescently-labeled cholera toxin subunit B, the proteins were taken up and retrogradely transported along the neurites over the course of 24 h. Additionally, mechanical perturbation (e.g., rinsing) of the neurite terminals significantly increased intracellular calcium concentration in the distal soma. Finally, membrane-displayed receptor for capsaicin was expressed and trafficked along newly projected neurites, as revealed by confocal microscopy
The diagnosis and prevention of lumpy skin disease, a viral ailment affecting cattle and buffalo, present significant financial implications for the livestock industry. Traditional methods for identifying lumpy skin d...
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The diagnosis and prevention of lumpy skin disease, a viral ailment affecting cattle and buffalo, present significant financial implications for the livestock industry. Traditional methods for identifying lumpy skin disease rely on manual visual inspection by veterinarians, which can be labor-intensive, subjective, and prone to errors. To address these challenges, this study proposes a novel deep convolutional neural network (DCNN) model for the automatic recognition and grading of lumpy skin disease from bovine images. The primary contributions of this research include the development of a DCNN architecture specifically tailored for this task, comprising five convolutional layers, five max pooling layers, two fully connected layers with ReLU activation, and a final fully connected layer with softmax activation. The model’s detection accuracy is further enhanced by applying image cropping and patching techniques, which divide each input image into 12 patches to improve local feature extraction. The proposed model was trained and tested using a publicly available dataset from Kaggle. Comparative analysis was conducted against several state-of-the-art models, including InceptionV3, ResNet50, MobileNetV3, VGG19, and Xception. The DCNN model demonstrated superior performance, achieving the highest validation accuracy of 0.96875, outperforming the compared models in terms of accuracy, precision, recall, and F1 score. Additionally, the study explores the potential of transitioning from binary to multiclass classification, which would allow for the assessment of the severity of lumpy skin disease. This future direction aims to provide more nuanced and actionable information for veterinary diagnostics. The significance of this research lies in its potential to offer an objective, efficient, and scalable solution for early disease detection and prevention in livestock, thereby presenting considerable economic benefits for farmers and the livestock industry as a whole. The me
Bone marrow plays an important role in regulating immunity for homeostasis and controlling stromal cell trafficking. Bone marrow cells are sustained by the framework of connective tissues that preserve the mechanical ...
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This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe in...
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This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe internal model approach and the adaptive control technique, a distributed adaptive internal model isconstructed for each agent. Then, based on this internal model, a fully distributed ETC strategy composed ofa distributed event-triggered adaptive output feedback control law and a distributed dynamic event-triggeringmechanism is proposed, in which each agent updates its control input at its own triggering time instants. It isshown that under the proposed ETC strategy, the robust cooperative output regulation problem can be solvedwithout requiring either the global information associated with the communication topology or the bounds ofthe uncertain or unknown parameters in each agent and the exosystem. A numerical example is provided toillustrate the effectiveness of the proposed control strategy.
We report a compact modeling framework based on the Grove-Frohman (GF) model and artificial neural networks (ANNs) for emerging gate-all-around (GAA) MOSFETs. The framework consists of two ANNs;the first ANN construct...
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Breast cancer is a global health problem. Mexican statistics show that 28.2% of new cancer cases in women come from the breast, so efforts must be made to control the burden of the disease. Early detection is an essen...
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