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Wire arc additive manufacturing of commercially pure titanium bio-medical alloy

Materials Today: Proceedings 2023年 90卷 6-10页

作者： Deshmukh P.S. Katiyar A. Sahu A. Sathiaraj D. Palani I.A. Sonawane A. Department of Mechanical Engineering Indian Institute of Technology Indore 453552 India Department of Mechanical Engineering Indian Institute of Technology Bombay 400076 India Department of Biosciences and Biomedical Engineering Indian Institute of Technology Indore 453552 India

Metal additive manufacturing deploys metallic powder or wire as a feedstock to fabricate metallic parts by direct fusion in a layer-by-layer manner. Wire feedstock-based additive manufacturing provides certain advantages such as a higher rate of deposition, high density, and lower material wastage with less capital required. This study reports the Wire Arc Additive Manufacturing (WAAM) of Commercially Pure Titanium (CP Ti) and its microstructure, mechanical properties, and biocompatibility. A single-track deposition is performed to know the optimum parameters for wall structure deposition. The heat treatment is carried out to achieve desired phase transformation followed by Laser Shock Peening (LSP) as post-processing. The as-built samples showed dominant α-phase + β-phase while the content of β-phase increased after heat treatment at 900 °C. the thickness of LSP affected layer is observed to be 43.4476 µm along the cross-section. The hardness reduced after heat treatment and increased after LSP post processing. LSPed zone exhibited higher average hardness of ∼ 225 HV while that of the 30 min and 90 min heat treated samples is ∼ 180 HV0.1 and ∼ 160 HV0.1, respectively. A better antibacterial test is performed to study the inhibition zone on samples. The LSPed sample surface in the biocompatibility test. The LSPed samples showed better antibacterial effect. © 2023

关键词： Biocompatibility biomedical alloy Laser shock peening Microstructure Wire arc additive manufacturing

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Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility

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BIOCELL 2023年第7期47卷 1651-1659页

作者： JAMES LROSENBERG WILLIAM WOOLLEY IHSAN ELNUNU JULIA KAMML DAVID SKAMMER CLAIRE ACEVEDO Department of Mechanical Engineering University of UtahSalt Lake City84112USA Institute for Building Materials ETH ZurichZurichSwitzerland Department of Biomedical Engineering University of UtahSalt Lake City84112USA

Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen,leading to the accumulation of advanced glycation end-products(AGEs)cross-links in collagenous *** recently,AGEs content has been related to loss of bone quality,independent of bone mass,and increased fracture risk with aging and *** of bone quality is mostly attributed to changes in material properties,structural organization,or cellular *** all these factors play a role in bone fragility disease,some common recurring patterns can be found between diabetic and age-related bone *** main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE *** study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales,collagen deformation mechanisms at the nanoscale,and resistance to bone fracture at the macroscale.

关键词： Bone fragility Advanced glycation end-products Collagen Diabetes Aging

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Assessing the stiffness of intact bone marrow with non-contact optical coherence elastography 12

Assessing the stiffness of intact bone marrow with non-conta...

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Optical Elastography and Tissue Biomechanics XII 2025

作者： Singh, Amandeep Singh, Manmohan Aglyamov, Salavat R. Mayerich, David Larin, Kirill V. Department of Biomedical Engineering University of Houston TX77204 United States Department of Mechanical and Aerospace Engineering University of Houston TX77204 United States Department of Electrical and Computer Engineering University of Houston TX77204 United States

ISBN: (纸本)9781510683907

Bone marrow plays an important role in regulating immunity for homeostasis and controlling stromal cell trafficking. Bone marrow cells are sustained by the framework of connective tissues that preserve the mechanical and functional integrity of the tissue. Optical coherence elastography (OCE) is a potential method to measure the biomechanical properties of bone marrow with high spatio-temporal resolution. In this work, we demonstrate the quantification of wave speed at different locations along the diaphysis of mice femur samples using non-contact air-coupled ultrasound OCE (ACUS-OCE). The preliminary results from the current approach show that the ACUS-OCE can characterize the mechanical stiffness of intact bone marrow and can be used for minimally invasive and ex vivo clinical applications. © 2025 SPIE.

关键词： Bone

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Enhanced light-driven photoelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

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International Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising photocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube photoelectrodes. In this work, it is firstly to fabricate TiO2 nanotube photoelectrodes on acid-etched Ti foils by anodization (MNT) for photoelectrochemical catalyzing water splitting. Different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting photoelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT photoelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the photocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as photocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

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Unveiling the size effect of nitrogen-doped carbon-supported copper-based catalysts on nitrate-to-ammonia electroreduction

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Nano Research 2024年第4期17卷 2438-2443页

作者： Ran Li Taotao Gao Wenxi Qiu Minghao Xie Zhaoyu Jin Panpan Li College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at AustinAustinTexas 78712USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ***,it remains a challenge to regulate the size effect of electrocatalysts to optimize the catalytic activity and ammonia ***,the Cu-based catalysts were tailored at the atomic level to exhibit a size gradient ranging from single-atom catalysts(SACs,0.15–0.35 nm)to single-cluster catalysts(SCCs,1.0–2.8 nm)and nanoparticles(NPs,20–30 nm),with the aim of studying the size effect for the NO_(3)^(-)-to-NH_(3) reduction ***,the Cu SCCs exhibit enhanced metal–substrate and metal–metal interactions by taking advantageous features of Cu SACs and Cu ***,Cu SCCs achieve exceptional electrocatalytic performance for the NitRR with a maximum Faradaic efficiency of ca.96%NH_(3)and the largest yield rate of ca.1.99 mg·h^(-1)·cm^(-2) at-0.5 V *** hydrogen electrode(RHE).The theoretical calculation further reveals the size effect and coordination environment on the high catalytic activity and selectivity for the *** work provides a promising various size-controlled design strategy for aerogel-based catalysts effectively applied in various electrocatalytic reactions.

关键词： nitrate electroreduction ammonia electrosynthesis size effect single-cluster catalyst

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Exploring the Connection between Brain Strain and Cognitive Changes: A Protocol Study

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Journal of engineering and Science in Medical Diagnostics and Therapy 2025年第4期8卷 041105页

作者： Menghani, Ritika Raj Bardall, Clayton Tanaka, Martin L. Kraft, Reuben H. Department of Mechanical Engineering The Pennsylvania State University University ParkPA16802 United States College of Engineering and Technology Western Carolina University CullowheeNC28723 United States Department of Mechanical Engineering The Pennsylvania State University PA16802 United States Department of Biomedical Engineering The Pennsylvania State University PA16802 United States Institute of Computational and Data Sciences The Pennsylvania State University University ParkPA United States

Given the rise of head injury in the youth, much focus has been directed toward predicting brain injury using simulation tools such as finite element analysis. Various brain strain measures are proposed as indicators of concussion. However, the clinical connection between brain strain and cognitive changes has not been fully established. In this study, we develop a framework to compare strains and other metrics obtained from finite element brain simulations with sideline cognitive testing results. We conducted a preliminary study for ten college football players. The players were equipped with custom fit mouthguards and were monitored for one season. A total of 2185 impacts were collected, and eight cognitive tests were conducted that were triggered when acceleration measurement exceed a threshold of 30Gs. Axonal injury metrics were examined while considering cognitive scores. This study represents a protocol investigation with preliminary findings, as it explores the correlation between brain strain metrics and cognitive deficits in a sample of ten football players over one season. Copyright © 2025 by ASME.

关键词： Acceleration measurement

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Design and Feasibility Test of In-House Indirect Perfusion Bioreactor for 3-D Cell Culture 15

Design and Feasibility Test of In-House Indirect Perfusion B...

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15th biomedical engineering International Conference, BMEiCON 2023

作者： Suwannaphan, T. Tharasanit, T. Wongpakham, T. Pimpin, A. Chessadangkul, K. King Mongkut's University of Technology North Bangkok Department of Mechanical Engineering Technology Bangkok Thailand Faculty of Veterinary Science Chulalongkorn University Department of Obstetrics Gynaecology and Reproduction Bangkok Thailand Chulalongkorn University Faculty of Engineering Department of Mechanical Engineering Bangkok Thailand Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand

ISBN: (纸本)9798350345247

Selection of bioreactor system depends on many factors such as type of products, process of culture, and product density. No standard for development methodology is available nowadays. This work demonstrated the development of multi mini-chamber indirect perfusion bioreactor to support 3-D cell culture. The systems consisted of scaffolds, cell/scaffold retainers, culture tanks with a single peristaltic pump. Flow simulation was conducted to investigate the effects of flow rate and inlets/outlets' position on the distribution of shear stresses on the cell/scaffold cassettes installed inside the bioreactor. The prototype with 4 culture tanks connected in series was tested for long period operation. Lastly, preliminary experiments to culture and differentiate pig muscle stem cells were conducted. The results showed that muscle cells were successfully differentiated both on glass slides and aloe vera scaffolds inside the developed bioreactor. © 2023 IEEE.

关键词： Flow simulation

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Strengthening behavior of AlCoCrFeNi(TiN)_(x) high-entropy alloy coatings fabricated by plasma spraying and laser remelting

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Journal of Materials Science & Technology 2022年第26期121卷 163-173页

作者： Bingqian Jin Nannan Zhang Shuo Yin Department of Material Science and Engineering Shenyang University of TechnologyShenyang 110870China Department of Mechanical Manufacturing and Biomedical EngineeringTrinity College DublinThe University of DublinParsons BuildingDublin 2Ireland

High-entropy alloy(HEA)coatings are of great importance in the fabrication of wear resistance *** coatings containing ceramic particles as reinforcement phase usually have better wear *** this study,AlCoCrFe Ni(TiN)_(x)(x:molar ratio;x=0,0.2,0.4,0.6,0.8,1.0)HEA coatings were fabricated on Q235 steel by plasma spray first and then subjected to laser *** experimental results confirm that plasma spray together with post laser remelting could result in the in-situ formation of TiN-Al_(2)O_(3) ceramic particles and cuboidal B2 phase in the AlCoCrFeNi(TiN)_(x) HEA *** in-situ TiN-Al_(2)O_(3) and nano-cuboidal B2 precipitation phase strengthened the coatings and improved their wearresistance *** to the dispersion of hard phase and nano-particles resulting from second heating,the microhardness of the Al Co Cr Fe Ni(Ti N)coatings significantly increased from 493 to 851 HV after laser *** the same reasons,the wear-resistance performance was also significantly promoted after laser remelting.

关键词： High-entropy alloy Coatings Ceramics Laser remelting Microstructure Wear resistance

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An anisotropic lattice Boltzmann-phase field model for dendrite growth and movement in rapid solidification of binary alloys

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npj Computational Materials 2024年第1期10卷 2591-2606页

作者： Shilin Mao Yuting Cao Wei Chen Dongke Sun Key Laboratory of Structure and Thermal Protection of High Speed Aircraft Ministry of EducationSchool of Mechanical EngineeringSoutheast UniversityNanjing 211189China Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 211189China Department of Mechanical Engineering University of Michigan2350 Hayward St.G.G.Brown BuildingAnn ArborMI 48109USA Power Beam Processing Lab AVIC Manufacturing Technology InstituteBeijing 100024China

A model coupling the lattice Boltzmann and the phase field methods with anisotropic effects is proposed,which is used to numerically describe the growth and movement of dendrites in rapid solidification of *** model is quantitatively validated by the simulation of the continuous growth and the drafting-kissing-tumbling phenomenon of two falling particles.

关键词： solidification alloys anisotropic

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Characterization of deformation transition in the rolled LZ91 magnesium alloy under tensile loading

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Journal of Magnesium and Alloys 2024年第8期12卷 3173-3179页

作者： Yutaka Yoshida Jun-ichi Shibano Jyunpei Hagikura Ryuhei Misutani Yuto Monden Faculty of Engineering Kitami Institute of TechnologyKoen-choKitamiHokkaido 090-8507Japan Department of Mechanical Engineering Kitami Institute of TechnologyKoenchoKitamiHokkaido 090-8507Japan School of Regional Innovation and Social Design Engineering Intelligent Machines and Biomechanics Course Program Kitami Institute of TechnologyKoen-choKitamiHokkaido 090-8507Japan

In this study,the mechanical behavior of crystal group of hexagonal close-packed(hcp;αphase)and body-centered cubic(bcc;βphase)during tensile loading was investigated to elucidate the mechanism from elastic to plastic deformation transition of the rolled LZ91 Mg alloy using transmission-X-ray diffraction(transmission-XRD)measurement,transmission electron microscopy(TEM),scanning transmission electron microscopy(STEM),energy dispersive X-ray spectroscopy(EDS).The approximate proof stress of the LZ91 Mg alloy sample was found that the lattice strain retained the expanded state from 0.6%nominal strain,and the transmission-XRD measurement characterized the crystalline behavior during the transition by the integrated intensity of crystal group hcp(100).The lattice strain of bcc(110)decreased from the 0.6%nominal strain due to dislocation activity,which occurred nearβ/βgrain *** addition,we performed the analyses of electron energy loss spectroscopy(EELS)modes,the Li-K peak disappeared from the segregated Li regions of 10–60 nm nearβ/βgrain boundary at the nominal strain of 0.8%.Understanding this mechanical behavior during the elastic to plastic deformation transition by transmission-XRD is crucial for the development of Mg-Li alloys.

关键词： Magnesium-lithium alloy Plastic deformation X-ray diffraction Scanning/transmission electron microscopy Electron energy loss spectroscopy

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