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In-vitro analysis of neo-sinus flow dynamics after transcatheter aortic valve replacement using particle image velocimetry technique

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Journal of Biorheology 2023年第2期37卷 162-169页

作者： Xu, Xuetong Hattori, Kaoru Ai, Ryusuke Iwasaki, Kiyotaka Department of Integrative Bioscience and Biomedical Engineering Graduate School and Advanced Science of Engineering Waseda University Tokyo1628480 Japan Waseda Research Institute for Science and Engineering Waseda University Tokyo1698555 Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University Tokyo1628480 Japan Cooperative Major in Advanced Biomedical Sciences Joint Graduate School of Tokyo Women’s Medical University and Waseda University Waseda University Tokyo1628480 Japan

Particle imaging velocimetry (PIV) is an effective methodology for investigating flow in the neo-sinus after transcatheter aortic valve replacement. However, understanding fluid dynamics in the lower part of the neo-sinus has been challenging due to limited optical access. In this study, we developed a novel PIV technique to extensively visualize the neo-sinus and to assess the potential risk of transcatheter heart valve (THV) leaflet thrombosis with the intra-annular valve. This technique involved shooting in the sinus and neo-sinus via the ventral wall of the aortic silicone model to visualize a larger region of the neo-sinus, including the lower portions (overlooking-view shooting). In the neo-sinus, stagnated flow was observed throughout the entire region in middle and late diastole. By contrast, in the native sinus, low-velocity vortical flow that inflows into the coronary artery was developed exclusively in the upper region. The present results suggest that the lower portion of the native sinus, as well as the neo-sinus, may be at high risk for leaflet thrombosis. The novel PIV technique holds promise for revealing influences of fluid dynamics on THV leaflet thrombosis with various stent flame designs. © 2023, Japanese Society of Biorheology. All rights reserved.

关键词： Velocity measurement

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Soft,full Wheatstone bridge 3D pressure sensors for cardiovascular monitoring

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npj Flexible Electronics 2024年第1期8卷 910-917页

作者： Yoonseok Park Haiwen Luan Kyeongha Kwon Ted S.Chung Seyong Oh Jae-Young Yoo Gooyoon Chung Junha Kim Suhyeon Kim Sung Soo Kwak Junhwan Choi Hoang-Phuong Phan Seonggwang Yoo Hyoyoung Jeong Jaeho Shin Sang Min Won Hong-Joon Yoon Yei Hwan Jung John A.Rogers Department of Advanced Materials Engineering for Information and Electronics Integrated Education Institute for Frontier Science&Technology(BK21 Four)Kyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea Department of Mechanical and Aerospace Engineering University of California San DiegoLa JollaCA 92093USA School of Electrical Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Mechanical Engineering Columbia UniversityNew YorkNYUSA Division of Electrical Engineering Hanyang University ERICAAnsan 15588Republic of Korea Department of Semiconductor Convergence Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Biomedical Research Division Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Chemical Engineering Dankook UniversityYonginGyeonggi-do 16890Republic of Korea School of Mechanical and Manufacturing Engineering Tyree Institute of Health EngineeringUniversity of New South WalesSydneyNSW 2052Australia Querrey Simpson Institute for Bioelectronics Northwestern University EvanstonEvanstonIL 60208USA Department of Electrical and Computer Engineering University of California DavisDavisCA 95616USA Department of Electrical and Computer Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Electronic Engineering Gachon UniversitySeongnamsiGyeonggi-do 13120Republic of Korea Department of Electronic Engineering Hanyang UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Biomedical EngineeringNeurological SurgeryChemistryMechanical EngineeringElectrical Engineering and Computer Science Simpson Querrey Institute and Feinberg Medical SchoolCenter for Bio-Integrated ElectronicsNorthwestern University EvanstonEvanstonIL 60208USA

Variations in parameters associated with the ambient environment can introduce noise in soft,body-worn *** example,many piezoresistive pressure sensors exhibit a high degree of sensitivity to fluctuations in temperature,thereby requiring active compensation *** research presented here addresses this challenge with a multilayered 3D microsystem design that integrates four piezoresistive sensors in a full-Wheatstone bridge *** optimized layout of the sensors relative to the neutral mechanical plane leads to both an insensitivity to temperature and an increased sensitivity to pressure,relative to previously reported devices that rely on similar operating *** this 3D pressure sensor into a soft,flexible electronics platform yields a system capable of real-time,wireless measurements from the surface of the *** above the radial and carotid arteries yields high-quality waveforms associated with pulsatile blood flow,with quantitative correlations to blood *** results establish the materials and engineering aspects of a technology with broad potential in remote health monitoring.

关键词： Wheat bridge thereby

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Segmentation Approach for Enhanced DLP Bioprinting 12

Segmentation Approach for Enhanced DLP Bioprinting

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Laser 3D Manufacturing XII 2025

作者： Babayigit, Ceren Tavares-Negrete, Jorge Alfonso Esfandyarpour, Rahim Boyraz, Ozdal Department of Electrical Engineering and Computer Science The University of California IrvineCA92697 United States Department of Biomedical Engineering The University of California IrvineCA92697 United States Department of Mechanical and Aerospace Engineering The University of California IrvineCA92697 United States

ISBN: (纸本)9781510684560

Achieving high-resolution outputs in Digital Light Processing (DLP) bioprinting requires precise control over photocrosslinking, particularly for dense, intricate models with fine gaps. Over-crosslinking is affected by factors such as light scattering, limited depth of focus, and molecular diffusion. Traditionally, these issues are managed by altering the material and light source. This study presents a novel segmentation approach designed to address these challenges by leveraging the inherent diffusion characteristics of the DLP system rather than altering its core components. The generation and diffusion of free radicals increase with light intensity and the density of the illuminated area, which alters the risk of over-crosslinking in these regions. The proposed technique involves segmenting the photomask into discrete regions and employing an on-off activation strategy to enhance control over photopolymerization. By strategically segmenting the mask and alternating the activation of adjacent segments, the technique effectively manages the distribution and concentration of free radicals and allows time for the termination phase of photopolymerization. It creates spatial gaps, helps manage free radical diffusion, prevents unwanted combinations, and filling of small gaps, thus improving resolution. Demonstrated by printing a bronchial model, this approach achieved a 100 µm gap between bronchial branches at a 14.43x compression ratio to anatomical size. The live-dead assay shows sustained cell viability of up to 90% for GelMA and up to 85% for GelMA-PEGDA constructs across seven days. This study shows that the segmentation strategy significantly reduces over-crosslinking, advancing DLP bioprinting for applications requiring precise control over complex features and detailed features. © 2025 SPIE.

关键词： Photopolymerization

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Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

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Bioactive Materials 2024年第6期36卷 580-594页

作者： Liang Fang Zhongting Liu Cuicui Wang Meng Shi Yonghua He Aiwu Lu Xiaofei Li Tiandao Li Donghui Zhu Bo Zhang Jianjun Guan Jie Shen Department of Orthopaedic Surgery School of MedicineWashington UniversitySt.LouisMO63110USA Department of Mechanical Engineering&Materials Sciences School of EngineeringWashington UniversitySt.LouisMO63110USA Department of Developmental Biology Center of Regenerative MedicineWashington UniversitySt.LouisMO63110USA Department of Biomedical Engineering School of MedicineStony Brook UniversityStony BrookNY11794USA

Critical size bone defects represent a significant challenge worldwide,often leading to persistent pain and physical disability that profoundly impact patients’quality of life and mental *** address the intricate and complex repair processes involved in these defects,we performed single-cell RNA sequencing and revealed notable shifts in cellular populations within regenerative ***,we observed a decrease in progenitor lineage cells and endothelial cells,coupled with an increase in fibrotic lineage cells and pro-inflammatory cells within regenerative ***,our analysis of differentially expressed genes and associated signaling pathway at the single-cell level highlighted impaired angiogenesis as a central pathway in critical size bone defects,notably influenced by reduction of Spp1 and Cxcl12 *** deficiency was particularly pronounced in progenitor lineage cells and myeloid lineage cells,underscoring its significance in the regeneration *** response to these findings,we developed an innovative approach to enhance bone regeneration in critical size bone *** fabrication process involves the integration of electrospun PCL fibers with electrosprayed PLGA microspheres carrying Spp1 and *** design allows for the gradual release of Spp1 and Cxcl12 in vitro and in *** evaluate the efficacy of our approach,we locally applied PCL scaffolds loaded with Spp1 and Cxcl12 in a murine model of critical size bone *** results demonstrated restored angiogenesis,accelerated bone regeneration,alleviated pain responses and improved mobility in treated mice.

关键词： Critical size bone defects Angiogenesis Spp1 Cxcl12 Polycaprolactone scaffold

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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren Dan Wu Zhonghua Ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

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Learning to Adapt Foundation Model DINOv2 for Capsule Endoscopy Diagnosis

Learning to Adapt Foundation Model DINOv2 for Capsule Endosc...

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International Conference on Biomimetic Intelligence and Robotics & Medical Robotics Forum, ICBIR+MRF 2024

作者： Zhang, Bowen Chen, Ying Bai, Long Zhao, Yan Sun, Yuxiang Yuan, Yixuan Zhang, Jianhua Ren, Hongliang Department of Electronic Engineering The Chinese University of Hong Kong Hong Kong Shenzhen Research Institute The Chinese University of Hong Kong Shenzhen China School of Mechanical Engineering University of Science and Technology Beijing Beijing China Department of Mechanical Engineering City University of Hong Kong Hong Kong Department of Biomedical Engineering National University of Singapore Singapore

Foundation models have become prominent in computer vision, achieving notable success in various tasks. However, their effectiveness largely depends on pre-training with extensive datasets. Applying foundation models directly to small datasets of capsule endoscopy images from scratch is challenging. Pre-training on broad, general vision datasets is crucial for successfully fine-tuning our model for specific tasks. In this work, we introduce a simplified approach called Adapt foundation models with a low-rank adaptation (LoRA) technique for easier customization. Our method, inspired by the DINOv2 foundation model, applies low-rank adaptation learning to tailor foundation models for capsule endoscopy diagnosis effectively. Unlike traditional fine-tuning methods, our strategy includes LoRA layers designed to absorb specific surgical domain knowledge. During the training process, we keep the main model (the backbone encoder) fixed and focus on optimizing the LoRA layers and the disease classification component. We tested our method on two publicly available datasets for capsule endoscopy disease classification. The results were impressive, with our model achieving 97.75% accuracy on the Kvasir-Capsule dataset and 98.81% on the Kvasir-v2 dataset. Our solution demonstrates that foundation models can be adeptly adapted for capsule endoscopy diagnosis, highlighting that mere reliance on straightforward fine-tuning or pre-trained models from general computer vision tasks is inadequate for such specific applications. © 2024 The Authors.

关键词： Endoscopy

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Microchannel-based Droplet Generation Using Multiphase Flow: A Review 3

Microchannel-based Droplet Generation Using Multiphase Flow:...

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3rd International Symposium on Advances and Innovation in mechanical engineering, ISAIME 2022

作者： Raynaldo, K. Whulanza, Y. Irwansyah, R. Laboratory of Fluid Mechanics Department of Mechanical Engineering Faculty of Engineering Universitas Indonesia West Java Depok16424 Indonesia Research Center on Biomedical Engineering Universitas Indonesia West Java Depok16424 Indonesia

Microfluidics is a multidisciplinary field that allows for precise control of fluids at a micrometer scale, with the goal of generating encapsulated structures or droplets for specific purposes. However, producing monodispersed droplets remains a challenge, making it necessary for researchers to investigate optimal microchannel geometries and parameters for controlling droplet size. Channel-based geometries, including T-junction, flow-focusing, co-flowing, membrane, and step emulsification, are the most commonly used geometries, each with its own advantages and weaknesses. This literature review aims to highlight assessment methods of microfluidic device performance and physical phenomenon in droplet generation for each channel-based geometry, including recent findings by researchers. Output parameters such as microchannel geometries, flow patterns, and flow regime maps with interpretations can be used to evaluate the optimum input for generating droplets that are suitable for a certain application. With the COVID-19 pandemic affecting the world, there is an opportunity to use microfluidic devices to study SARS-CoV-2 and develop post-pandemic therapeutics. The next challenge in microfluidic device development is producing high-throughput double emulsion droplets with monodispersed size using optimum input parameters to satisfy the drug delivery purpose. © Published under licence by IOP Publishing Ltd.

关键词： Microfluidics

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Bio-tribological Characteristics of 3D-Printed Ti–Ta–Nb–Mo–Zr High Entropy Alloy in Human Body Emulating Biofluids for Implant Applications

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Journal of Bio- and Tribo-Corrosion 2023年第1期9卷 1-21页

作者： Kumar, Pankaj Patel, Mahesh Jain, Neelesh Kumar Gupta, Sharad Department of Mechanical Engineering Indian Institute of Technology Indore MP Indore453 552 India Department of Metallurgical and Material Science Engineering Indian Institute of Technology Indore MP Indore453 552 India Department of Biosciences and Biomedical Engineering Indian Institute of Technology Indore MP Indore453 552 India

This paper presents findings on corrosion and tribo-corrosion characteristics in human body emulating biofluids of 7.4 pH value at 37 °C, dry fretting wear, and abrasion resistance of equiatomic Ti–Ta–Nb–Mo–Zr high entropy alloy (HEA) developed by μ-plasma-based 3D-printing process. Physiological saline, phosphate buffered saline (PBS) solution, and 1% fetal bovine serum mixed with the PBS solution were used as the human body emulating biofluids to study corrosion and tribo-corrosion characteristics of the developed HEA. Minor abrasive wear and material ploughing in dry fretting wear zone are observed occurring due to the formation of loose wear debris and large-scale material displacement, respectively. The presence of biofluids significantly reduced coefficient of friction, average depth of worn scar, specific wear rate, open-circuit potential values, corrosion potential, and corrosion current density. Ti–Ta–Nb–Mo–Zr HEA showed better corrosion and tribo-corrosion resistance than Ti–22Nb, Ti–22Nb–6Zr, Ti–12Mo–5Ta, and Ti–20Nb–10Zr–5Ta alloys due to the formation of strong passive layers of oxides of its constituents, i.e., TiO2, Ta2O5, Nb2O5, NbO2, and ZrO2. It has higher abrasion resistance at higher applied load without much change in coefficient friction imparting it better resistance to wear and tear. Findings of this study make Ti–Ta–Nb–Mo–Zr HEA as preferable orthopedic implant material than the presently used materials. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

关键词： Titanium dioxide

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Cidade Inteligente: análise da evolução dos indicadores de uma Cidade Universitária da região norte a partir da ISO 37122:2020 15

Cidade Inteligente: análise da evolução dos indicadores d...

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15th IEEE International Conference on Industry Applications, INDUSCON 2023

作者： Santos, Lucas Henrique Brito de Sousa Silva, Kaylane Lobato, Elen Priscila dos Santos, Jhennifer Freitas Manito, Allan R.A. da Silva Fonseca, Wellington de Oliveira e Silva, Marcelo Faculty of Electrical and Biomedical Engineering Federal University of Pará Belém Brazil Electrical Engineering Graduate Program Federal University of Pará Belém Brazil Mechanical Engineering Graduate Program Federal University of Pará Belém Brazil

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Monitoring industrial systems using ESP-NOW protocol with Mesh and Ad Hoc network 15

Monitoring industrial systems using ESP-NOW protocol with Me...

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15th IEEE International Conference on Industry Applications, INDUSCON 2023

作者： Santos, Lucas Henrique Brito da Silva, Eduardo José Monteiro de Oliveira Farias, Aleqssandro Alexandre dos Santos, Jhennifer Freitas Morais, Iago Ranieri Miranda Rodrigues da Silva Fonseca, Wellington de Oliveira e Silva, Marcelo Faculty of Electrical and Biomedical Engineering Federal University of Pará Belém Brazil Electrical Engineering Graduate Program Federal University of Pará Belém Brazil Mechanical Engineering Graduate Program Federal University of Pará Belém Brazil

ISBN: (纸本)9798350314182

Nowadays, industrial processes are creating increasing demands for optimized and efficient sensing systems and require high reliability and a short time interval for information delivery. This paper presents an embedded sensor system that uses the ESP-NOW protocol with a Mesh and Ad Hoc network, in order to provide an auto mesh configuration upon failure at some point in the network. This system was implemented to monitor the variables of an induction motor, after which, before sending the data to the cloud, local processing is performed to reduce the volume of data. Finally, a computer simulation of the WROOM-32 module is performed for a thermal analysis during its operation, where the heating points of the plate are identified and analyzed, in order to validate that the system, even processing a large amount of data, maintains a high reliability during its operation. ©2023 IEEE.

关键词： ad hoc espnow mesh simulation thermal

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