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Fabrication of versatile poly(xylitol sebacate)-co-poly(ethylene glycol) hydrogels through multifunctional crosslinkers and dynamic bonds for wound healing

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Acta Biomaterialia 2023年 170卷 344-359页

作者： Yeh, Ying-Yu Lin, Yi-Yun Wang, Ting-Teng Yeh, Yu-Jia Chiu, Ting-Hsiang Wang, Reuben Bai, Meng-Yi Yeh, Yi-Cheun Institute of Polymer Science and Engineering National Taiwan University Taipei Taiwan Institute of Biomedical Engineering National Taiwan University Taipei Taiwan Biomedical Engineering Program Graduate Institute of Applied Science and Technology National Taiwan University of Science and Technology Taipei Taiwan Institute of Food Safety and Health National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Adjunct Appointment to the Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan Program National Taiwan University Taipei Taiwan GIP-TRIAD Master's Degree in Agro-Biomedical Science National Taiwan University Taipei Taiwan

Poly(polyol sebacate) (PPS) polymer family has been recognized as promising biomaterials for biomedical applications with their characteristics of easy production, elasticity, biodegradation, and cytocompatibility. Poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-PEG) has been developed to fabricate PPS-based hydrogels;however, current PXS-co-PEG hydrogels presented limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. Here, we fabricate a new type of PXS-co-PEG hydrogels through the use of multifunctional crosslinkers as well as dynamic bonds. In our design, polyethyleneimine-polydopamine (PEI-PDA) macromers are utilized to crosslink aldehyde-functionalized PXS-co-PEG (APP) through imine bonds and hydrogen bonds. PEI-PDA/APP hydrogels present multiple functional properties (e.g., fluorescent, elastomeric, biodegradable, self-healing, bioadhesive, antioxidant, and antibacterial behaviors). These properties of PEI-PDA/APP hydrogels can be fine-tuned by changing the PDA grafting degrees in the PEI-PDA crosslinkers. Most importantly, PEI-PDA/APP hydrogels are considered promising wound dressings to promote tissue remodeling and prevent bacterial infection in vivo. Taken together, PEI-PDA/APP hydrogels have been demonstrated as versatile biomaterials to provide multiple tailorable properties and desirable functions to expand the utility of PPS-based hydrogels for advanced biomedical applications. Statement of significance: Various strategies have been developed to fabricate poly(polyol sebacate) (PPS)-based hydrogels. However, current PPS-based hydrogels present limited properties and functions due to the limitations of the crosslinkers and crosslinking chemistry used in the hydrogel formation. This work describes that co-engineering crosslinkers and interfacial crosslinking is a promising approach to synthesizing a new type of poly(xylitol sebacate)-co-poly(ethylene glycol) (PXS-co-

关键词： Polyols

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Improving Control Theory Education Through Face-to-Face Implementation of a Mobile Robotics Methodology 16

Improving Control Theory Education Through Face-to-Face Impl...

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16th Brazilian Symposium on Robotics and 15th Workshop on Robotics in Education, SBR-WRE 2024

作者： Pastrana, M.A. Cuéllar Sánchez, William Humberto Mendoza-Peñaloza, Jose Santana, M.S. Muñoz, Daniel M. Department of Mechanical Engineering Mechatronics Graduate Program University of Brasilia DF Brasilia Brazil Faculty of Gama Electronics Engineering Undergraduate Program University of Brasilia DF Brasilia Brazil University of Federal District UDF DF Brasilia Brazil

ISBN: (纸本)9798350391084

Advances in information and communication technologies have significantly transformed engineering education. Virtual laboratories are increasingly adopted to enhance student interaction with control system simulations. The improved visualization and interaction capabilities of modern computers offer a more organic way to teach theoretical foundations. This paper describes the implementation of a methodology for teaching control theory that until now was entirely online in a face-to-face environment at the University of the Federal District in Brasilia, Brazil. This methodology utilizes virtual laboratories with CoppeliaSim, MATLAB, and the EVA mobile robot to teach control theory focused on single-input, single-output (SISO) systems for mobile robot tracking and obstacle avoidance applications. The results of the face-to-face implementation are compared to those of the fully online methodology, revealing that in-person teaching significantly enhances the quality of instruction. ©2024 IEEE.

关键词： MATLAB

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DESIGN, VERIFICATION AND VALIDATION OF A DYNAMIC MODEL FOR AN INTRAMUSCULAR AUTOINJECTOR

DESIGN, VERIFICATION AND VALIDATION OF A DYNAMIC MODEL FOR A...

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2024 Design of Medical Devices Conference, DMD 2024

作者： Magubane, Ntokozo Ngoepe, Malebogo Sivarasu, Sudesh Centre for Research in Computational and Applied Mechanics Department of Mechanical Engineering University of Cape Town Western Cape South Africa Division of Biomedical Engineering Department of Human Biology University of Cape Town Western Cape South Africa

ISBN: (纸本)9780791887752

The development of new injectable molecules for different diseases and reformation of first-generation pharmaceuticals has led to growing interest in making autoinjectors usable for different medications. The major challenge in this quest is the complexity of injecting highly viscous drugs in large volumes. This research aims to develop a dynamic model to describe the influence of drug viscosity and volume on the injection process and evaluate the sensitivity of medication fluid behaviour to variations in component dimensions of the autoinjector fluid delivery system. Using mathematical modelling, the plunger motion is characterised by the spring, fluid resistance and frictional forces between the vial and plunger. It displaces linearly and accelerates until maximum velocity is reached. Slow plunger motion is associated with increasing glide and break-loose force. Wall shear stress captured via Computational Fluid Dynamics (CFD) modelling is directly proportional to the medication viscosity and it increases linearly for Newtonian and shear-thinning medications. Separation flow is observed in the syringe for viscosities between 15 - 80 cP. This represents decreasing flow as pressure increases, increasing the chances of needle deformation and injection pain due to tissue damage. Injecting highly-viscous drugs is possible via considerations of kinematic and rheological properties. © 2024 by ASME.

关键词： Shear thinning

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

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Bioactive Materials 2023年第9期27卷 303-326页

作者： Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong SARPR China Faculty of Science University of WaterlooWaterlooOntarioCanada State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouPR China

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy.

关键词： Microneedles Microfabrication Wound healing Tissue regeneration Drug delivery

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Omnichannel Retail in Small and Medium-Sized Enterprises: Insights from Indonesia

Omnichannel Retail in Small and Medium-Sized Enterprises: In...

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2023 IEEE International Conference on Industrial engineering and engineering Management, IEEM 2023

作者： Febriani, Atik Sopha, Bertha Maya Wibisono, Muhammad Arif Universitas Gadjah Mada Department of Mechanical and Industrial Engineering Yogyakarta Indonesia Institut Teknologi Telkom Purwokerto Industrial Engineering Program Faculty of Industrial Engineering and Design Purwokerto Indonesia

ISBN: (纸本)9798350323153

An omnichannel retail strategy integrates multiple channels, enabling customers to shop across all available online and offline channels at the same time. This strategy is required to overcome different obstacles that develop as a result of changes in the retailer's business environment. This study aims to provide an overview of the extent to which SMEs in Indonesia implement an omnichannel strategy. Omnichannel retail implementation in SMEs has shown positive developments in recent years. They recognize the importance of providing a consistent and unified shopping experience across multiple channels. In this context, the marketplace is essential for SMEs to expand their reach of customers in various locations. However, despite positive developments, there are still some challenges to implementing omnichannel for SMEs in Indonesia. These challenges include dynamic changes in consumer behavior, limited staff capabilities, and the mindset of SME leaders or owners. © 2023 IEEE.

关键词： multichannel omnichannel retail SMEs strategy

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Tribology Performance of Silica Nanoparticles as Lubricant Additives in a Reciprocating Four-Stroke Engine Motorcycle

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International Journal of Automotive Technology 2023年第2期24卷 435-444页

作者： Lue, Yeou-Feng Hsiao, Wei-Liang Chen, Yi-Shun Undergraduate Program of Vehicle and Energy Engineering National Taiwan Normal University Taipei10610 Taiwan Department of Industrial Education National Taiwan Normal University Taipei10610 Taiwan Department of Mechanical Engineering Asia Eastern University of Science and Technology Taipei22061 Taiwan

Lubricants, such as any types of greases and oils, are usually used to reduce the effect of friction. However, they also have multifunctions that increase the overall performance and application life. To clarify how lubricants decrease friction and reduce friction-related issues, this study evaluated the performance of specific fuel consumption and exhaust emissions (such as hydrocarbon, carbon monoxide, and particulate matter) of motorcycle with nanosilica (nano-SiO2) added to the original lubricant. Lubricants with 0.5, 1.5, 2.5, 3.5, and 4.5 wt.% nano-SiO2 were evaluated after testing their basic properties and conducting tribology tests. The lubricant with 3.5 wt.% nano-SiO2 was the best candidate for the four-stroke engine motorcycle experiments. The results of the tribology experiment with nano-SiO2 lubricant showed that the abrasion loss corresponding to the 3.5 wt.% nano-SiO2 lubricant decreased by an average of 42.43 %. Overall, the 3.5 wt.% nano-SiO2 lubricant improved the effect of lubrication. The primary focus of the current study was the development of nano-SiO2 lubricant technology for applications in industry environments. © 2023, The Korean Society of Automotive Engineers.

关键词： Tribology

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Lumbar spine localisation method based on feature fusion

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 931-945页

作者： Yonghong Zhang Ning Hu Zhuofu Li Xuquan Ji Shanshan Liu Youyang Sha Xiongkang Song Jian Zhang Lei Hu Weishi Li Robotics Institute School of Mechanical Engineering and AutomationBeihang UniversityBeijingChina Beijing Zhuzheng Robot Co. LTDBeijingChina Department of Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxvilleTennesseeUSA Department of Orthopaedics Peking University Third HospitalBeijingChina Engineering Research Center of Bone and Joint Precision Medicine Ministry of EducationBeijingChina Beijing Key Laboratory of Spinal Disease Research BeijingChina School of Biological Science and Medical Engineering Beihang UniversityBeijingChina Department of Computer Science University of WarwickCoventryUK

To eliminate unnecessary background information,such as soft tissues in original CT images and the adverse impact of the similarity of adjacent spines on lumbar image segmentation and surgical path planning,a two‐stage approach for localising lumbar segments is ***,based on the multi‐scale feature fusion technology,a non‐linear regression method is used to achieve accurate localisation of the overall spatial region of the lumbar spine,effectively eliminating useless background information,such as soft *** the second stage,we directly realised the precise positioning of each segment in the lumbar spine space region based on the non‐linear regression method,thus effectively eliminating the interference caused by the adjacent *** 3D Intersection over Union(3D_IOU)is used as the main evaluation indicator for the positioning *** an open dataset,3D_IOU values of 0.8339�0.0990 and 0.8559�0.0332 in the first and second stages,respectively is *** addition,the average time required for the proposed method in the two stages is 0.3274 and 0.2105 s ***,the proposed method performs very well in terms of both pre-cision and speed and can effectively improve the accuracy of lumbar image segmentation and the effect of surgical path planning.

关键词： CT image lumbar spatial orientation multi‐scale information fusion

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Application of Response Surface Methodology (RSM) for the optimization of energy generation from Jebba hydro-power plant, Nigeria

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ISH Journal of Hydraulic engineering 2022年第1期28卷 1-9页

作者： Onokwai, A.O. Owamah, H.I. Ibiwoye, M.O. Ayuba, G.C. Olayemi, O.A. Department of Mechanical and Biomedical Engineering Bells University Ogun State Ota Nigeria Department of Civil Engineering Delta State University Oleh Campus Delta State Abraka Nigeria Department of Mechanical Engineering Kwara State University Kwara State Maleta Nigeria Department of Mechanical Maintenance Jebba Hydropower Station Niger State Jebba Nigeria Department of Aeronautical and Astronautics Engineering Kwara State University Kwara State Maleta Nigeria

This research was performed to optimize the performance characteristics of the Nigerian Jebba Hydropower Plant in order to enhance its generation of electricity. Pertinent hydropower data were hourly collected from the plant from 8:00 am to 5:00 pm between 2016 and 2018. The coefficient of determination obtained from the response surface methodology (RSM) showed that discharge, pressure drop, stator temperature and water pressure strongly influenced the generation of estimated power. Also, the contour and surface plots suggested that the discharge (D) 8200.00–8600.00 m3/s and pressure drop (Pd) ranging from 27.50–28.50 m gave the optimal power generation indicating that both factors must be kept high when the hydropower plant is in operation. The instability of power generation was attributed to the reduction in the net available head as turbine inlet decreased. The study, therefore, showed that net power output, speed of the turbine, and efficiency of the hydropower plant could be optimized with increase discharge and gross head. Predicted optimal values for discharge, pressure drop, stator temperature, and water pressure were 8783.3667 m3, 28.59 m, 58.00°C, and 31.00 N/m2 respectively. © 2020 Indian Society for Hydraulics.

关键词： Stators

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Novel interpretable Feature set extraction and classification for accurate atrial fibrillation detection from ECGs

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Computers in Biology and Medicine 2024年 179卷 108872-108872页

作者： Sharmin, Ruhi Brindise, Melissa C. Kolliyil, Jibin Joy Meyers, Brett A. Zhang, Jiacheng Vlachos, Pavlos P. Department of Biomedical Engineering Purdue University United States Department of Mechanical Engineering Pennsylvania State University United States Department of Mechanical Engineering Purdue University United States

Objective: We present a novel method for detecting atrial fibrillation (AFib) by analyzing Lead II electrocardiograms (ECGs) using a unique set of features. Methods: For this purpose, we used specific signal processing techniques, such as proper orthogonal decomposition, continuous wavelet transforms, discrete cosine transform, and standard cross-correlation, to extract 48 features from the ECGs. Thus, our approach aims to more effectively capture AFib signatures, such as beat-to-beat variability and fibrillatory waves, than traditional metrics. Moreover, our features were designed to be physiologically interpretable. Subsequently, we incorporated an XGBoost-based ECG classifier to train and evaluate it using the publicly available ‘Training’ dataset of the 2017 PhysioNet Challenge, which includes ‘Normal,’ ‘AFib,’ ‘Other,’ and ‘Noisy’ ECG categories. Results: Our method achieved an accuracy of 96 % and an F1-score of 0.83 for ‘AFib’ detection and 80 % accuracy and 0.85 F1-score for ‘Normal’ ECGs. Finally, we compared our method's performance with the top-classifiers from the 2017 PhysioNet Challenge, namely ENCASE, Random Forest, and Cascaded Binary. As reported by Clifford et al., 2017, these three best performing models scored 0.80, 0.83, 0.82, in terms of F1-score for ‘AFib’ detection, respectively. Conclusion: Despite using significantly fewer features than the competition's state-of-the-art ECG detection algorithms (48 vs. 150–622), our model achieved a comparable F1-score of 0.83 for successful ‘AFib’ detection. Significance: The interpretable features specifically designed for ‘AFib’ detection results in our method's adaptability in clinical settings for real-time arrhythmia detection and is even effective with short ECGs ( © 2024 Elsevier Ltd

关键词： Electrocardiograms

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Design of monitoring and control device for biogas production in a pilot scale anaerobic digester 4

Design of monitoring and control device for biogas productio...

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4th International Symposium on Advances and Innovation in mechanical engineering, ISAIME 2023

作者： Daud, Muhammad Sabarullah Nurjannah, Siti Setiawan, Adi Hasibuan, Arnawan Faisal Yusuf, Edy Electrical Engineering Department Faculty of Engineering Universitas Malikussaleh Jalan Batam Kampus Bukit Indah Lhokseumawe24352 Indonesia Magister Program in Renewable Energy Engineering Faculty of Engineering Universitas Malikusssaleh Jalan Batam Bukit Indah Lhokseumawe24352 Indonesia Mechanical Engineering Department Faculty of Engineering Universitas Malikussaleh Jalan Batam Kampus Bukit Indah Lhokseumawe24352 Indonesia

Monitoring and control in the biogas production process play important role to optimize the processes occurred inside the digester and help to achieve a stable and safe process. Anaerobic digestion is a complex process involving several groups of microorganisms that are sensitive to many operating factors. Therefore, it is important to monitor and detect the process imbalances at an early stage, thus action can be taken in time to prevent the failure. The purpose of this study is to design an appropriate biodigester to produce biogas from culinary food waste and a smart-based design device which can help in monitoring and controlling the process to enhance the biogas yields and control the process of purifying biogas into biomethane. The research method in this study consists of several stages including designing the reactors and instrumentation, fabrication and installation, testing and calibration of the sensors. Performance of biodigester plants was evaluated based on data gained from the sensors. The efficiency of digesters equipped with control and monitoring instruments is better than ordinary manual digesters. Smart-based digesters can increase the rate of gas production more measurably and be recorded systematically and in real time. It can be concluded that a smart biogester equipped with a microcontroller and monitoring with Web Application can save the time and improve biogas production and safety. © 2025 Institute of Physics Publishing. All rights reserved.

关键词： Anaerobic digestion

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