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2021 International Conference on biomedical engineering, ICoBE 2021

作者： Roslan, M.R.M. Nasir, N.F.M. Mohammad, N.F. Meng, C.E. Mohamed, M.S. Abdullah, M.N. Biomedical Engineering Programme Faculty of Electronic Engineering Technology Universiti Malaysia Perlis Kampus Pauh Putra Arau Perlis 02600 Malaysia Universiti Malaysia Perlis Kampus Pauh Putra Arau Perlis 02600 Malaysia Selangor Serdang 43400 Malaysia Selangor Serdang 43400 Malaysia Natural Intention Sdn. Bhd. Simpang Perak 34700 Malaysia

Hydroxyapatite (HA) powders were prepared via chemical solution through aqueous solution of calcium hydroxide and phosphoric acid. The calcium precursor was extracted from the calcium carbonate of Corbiculacea shells while the phosphate precursor originated from the commercially available phosphoric acid. The final product of HA powders is then manipulated through the sintering process at 500°C while the other sample was used as it is. XRD result shows significant changes in its crystallinity, crystallite size and lattice parameters after the sintering process. By sintering the HA, the crystallite size and crystallinity were increases as much as 6.25% and 5.31% respectively. SEM on the other hand showed different morphology for both sintering and non-sintering HA powders. For the sintering HA, the grains size is higher which is 5.00µm compared to non-sintering HA which is 3.91µm due to the agglomeration. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Sintering

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Metrological control of electrolytic sensors for measuring angular deviations: Application in monitoring displacements of engineering structures 10

Metrological control of electrolytic sensors for measuring a...

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10th Brazilian Congress on Metrology, Metrologia 2019

作者： Leaño, E.G. Filho, P. Rocha Hernández, J.D. Frota, M.N. Civil Engineering Depart. Pontifical Catholic University of Rio de Janeiro RJ22451-900 Brazil Postgraduate Programme in Metrology Metrology for Quality and Innovation Pontifical Catholic University of Rio de Janeiro Rio de Janeiro22451-900 Brazil Research Group GIFOURIER. Faculty of Mechanical Electronic and Biomedical Engineering. Mechanical Engineering Program University Antonio Nariño Puerto Colombia Colombia

The work evaluates the metrological reliability of electrolytic sensors (electrolevels) used to determine angular deviations of elements of engineering structures. The motivation for the work resulted from its strategic application to control the stability of civil engineering structures, notably with application in geotechnics (e.g.: different types of dams of interest in engineering). The methodology used is based on the metrological consistency associated with the quality control process of a set of electrolevels submitted, simultaneously, to a careful calibration process, with traceability ensured to a standard angular deviation pattern. Mounted on a rigid bar, but pivoted at one of its ends to allow angular displacements, the output of each electrolevel is compared with the previously calibrated standard, for different controlled conditions of angular deviation imposed on the bar articulated to a center of rotation. The result of the analysis of typical calibration data for nine electrolevels allowed to show that the expression of the uncertainties associated with the calibration measurements performed constitutes an essential foundation to ensure the metrological reliability of the electrolevels, having allowed to validate a method of discard of electrolevels not meeting the allowable tolerance for a specific engineering application. Among the conclusions of the work, it was possible to qualify the statistical treatment of the levels of uncertainty as a sufficiently robust strategy to validate the electrolevels as a reliable instrument for angular displacement measurements, with a level of confidence appropriate to its application in civil engineering. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Uncertainty analysis

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Development and characterization of a dual-fiber Raman probe for accurate and rapid endometrial carcinoma detection

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biomedical Optics Express 2025年第7期16卷 2914-2922页

作者： Xun Chen Zhaoqin Yang Yi Wang Luping Zhang Limin Feng Jing Chen Shijie Zhu Rongxin Fu Shangran Xie Zhiwei Huang Shuhua Yue Key Laboratory of Biomechanics and Mechanobiology (Beihang University) Ministry of Education Key Laboratory of Innovation and Transformation of Advanced Medical Devices Ministry of Industry and Information Technology National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering) School of Biological Science and Medical Engineering School of Engineering Medicine Beihang University Beijing 100191 China Department of Obstetrics & Gynecology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Su Zhou Surgi-Master High Tech Co. Ltd. Suzhou 215626 China School of Medical Technology Zhengzhou Research Institute Engineering Research Center of Integrated Acousto-opto-electronic Microsystems (Ministry of Education of China) Chongqing Institute of Microelectronics and Microsystems Beijing Institute of Technology Beijing 100081 China School of Optics and Photonics Beijing Institute of Technology Beijing 100081 China Optical Bioimaging Laboratory Department of Biomedical Engineering Faculty of Engineering National University of Singapore 117576 Singapore National University of Singapore (Suzhou) Research Institute Suzhou Jiangsu 215123 China NUS Graduate School for Integrative Sciences and Engineering Programme (ISEP) National University of Singapore 119077 Singapore

We report on the development and characterization of a dual-fiber optic Raman probe for enhancing real-time endometrial carcinoma biopsy. The fiber optic probe was designed with two miniaturized coating fibers with an outer diameter (OD) of 3.1 mm. We demonstrate that with the use of the Raman probe associated with the background subtraction algorithms, high-quality tissue Raman spectra covering the fingerprint (FP) (500−1800cm −1 ) can be acquired from different tissue types (e.g., muscle, fat, parathyroid gland, and thyroid gland). Using an anti-reflection coating filter and background subtraction algorithms, our probe has better signal-to-noise (SNR) than a conventional coating probe with a comparable OD. Meanwhile, our probe has less OD and 58% SNR compared with the handheld probe (OD = 10 mm). We developed a Raman fiber probe with a small outer diameter and high SNR (>90 in fat) simultaneously and used the small-size probe for accurate and rapid endometrial carcinoma detection. Specifically, a total of 220 fingerprint Raman spectra was obtained from 22 endometrial carcinoma (EC) patients (benign: 10, malignant: 12) and divided into two batches (110 spectra from 11 patients for each) from different patients for robustness test. The mean area under the receiver operating characteristic curves (AUC) for differentiating benign and malignant EC reached 0.946, with a mean accuracy of 93.1% and a mean time expense of 5 seconds by the ResNet model. Furthermore, the specific Raman features corresponding to biomolecules (e.g., amide I II, lipid, and collagen) were found to contribute to the accurate classification.

关键词： Augmented reality Fiber tapers Multimode fibers Optical filters Raman spectroscopy Single mode fibers

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Retraction Note: The association between prenatal exposure to polycyclic aromatic hydrocarbons and childhood intelligence: a systematic review of observational studies (Environmental Science and Pollution Research, (2023), 30, 8, (19592-19601), 10.1007/s11356-023-25309-w)

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Environmental Science and Pollution Research 2025年第12期32卷 7795-7796页

作者： Ramaiah, Pushpamala Altalbawy, Farag M. A. Margiana, Ria Kumar, N. Bharath Kahar, Fitriani Jalil, Abduladheem Turki Komariah, Aan Failoc-Rojas, Virgilio E. Kadhim, Mustafa M. Sivaraman, R. Iswanto, A. Heri Mustafa, Yasser Fakri Najafi, Moslem Lari Faculty of Nursing Umm Al-Qura University Makkah Saudi Arabia Cairo University Giza12613 Egypt Department of Chemistry University College of Duba Tabuk University Duba71911 Saudi Arabia Department of Anatomy Faculty of Medicine Universitas Indonesia Jakarta Indonesia Master’S Programme Biomedical Sciences Faculty of Medicine Universitas Indonesia Jakarta Indonesia Dr. Soetomo General Academic Hospital Surabaya Indonesia Electrical and Electronics Engineering Department Vignan’S Foundation for Science Technology and Research Guntur India Medical Laboratory Technology Poltekkes Kemenkes Semarang Semarang Indonesia Medical Laboratories Techniques Department Al-Mustaqbal University College Babylon Hilla51001 Iraq Educational Administration Department Faculty of Educational Science Universitas Pendidikan Indonesia Bandung Indonesia Salud Mental Universidad Privada Norbert Wiener Lima Peru Medical Laboratory Techniques Department Al-Farahidi University Baghdad Iraq Department of Mathematics Dwaraka Doss Goverdhan Doss Vaishnav College University of Madras Chennai Arumbakkam India Public Health Department Faculty of Health Science University of Pembangunan Nasional Veteran Jakarta Jakarta Indonesia Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul Mosul41001 Iraq Pharmaceutical Sciences and Cosmetic Products Research Center Kerman University of Medical Sciences Kerman Iran

The Editor-in-Chief and Publisher have retracted this article. An investigation by the Publisher found a number of articles, including this one, which share similar concerns, involving but not limited to, irregularities with respect to authorship and peer review. The Editor-in-Chief therefore no longer has confidence in the results and conclusions presented in this article. Authors Pushpamala Ramaiah, Abduladheem Turki Jalil, R. Sivaraman, A. Heri Iswanto, and Yasser Fakri Mustafa did not respond to correspondence from the Publisher about this retraction. The Publisher has been unable to obtain a current email address for authors Farag M. A. Altalbawy, Ria Margiana, N. Bharath Kumar, Fitriani Kahar, Aan Komariah, Virgilio E. Failoc-Rojas, Mustafa M. Kadhim, and Moslem Lari Najafi. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2025.

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Cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride-induced hypertension and renal dysfunction in rats

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Comparative Clinical Pathology 2024年第1期33卷 33-45页

作者： Oyagbemi, Ademola Adetokunbo Ajibade, Temitayo Olabisi Esan, Oluwaseun Olanrewaju Adetona, Moses Olusola Awoyomi, Omolola Victoria Omobowale, Temidayo Olutayo Ola-Davies, Olufunke Eunice Saba, Adebowale Benard Adedapo, Adeolu Alex Nkadimeng, Sanah Malomile McGaw, Lyndy Joy Kayoka-Kabongo, Prudence Ngalula Yakubu, Momoh Audu Nwulia, Evaristus Oguntibeju, Oluwafemi Omoniyi Department of Veterinary Physiology and Biochemistry Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria Department of Veterinary Medicine Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria Department of Anatomy Faculty of Basic Medical Sciences University of Ibadan Ibadan Nigeria Federal College of Animal Health and Production Technology Moor Plantation Ibadan Nigeria Department of Veterinary Pharmacology and Toxicology Faculty of Veterinary Medicine University of Ibadan Ibadan Nigeria Department of Life and Consumer Sciences College of Agriculture and Environmental Sciences University of South Africa Florida Campus University of South Africa Florida South Africa Phytomedicine Programme Department of Paraclinical Science Faculty of Veterinary Science University of Pretoria Old Soutpan Road Onderstepoort 0110 South Africa Department of Agriculture and Animal Health College of Agriculture and Environmental Sciences University of South Africa Florida South Africa Department of Environmental and Interdisciplinary Sciences College of Science Engineering & Technology COPHS Texas Southern University Houston TX United States Howard University College of Medicine Department of Psychiatry and Behavioral Sciences Howard University Hospital 2041 Georgia Avenue Washington 20060 DC United States Department of Biomedical Sciences Faculty of Health and Wellness Sciences Cape Peninsula University of Technology Bellville 7535 South Africa

Fluoride is an important toxicological and environmental toxicant that is implicated in diverse cardiorenal system dysfunctions via the induction of oxidative stress. The present study aims at evaluating the cardioprotective and renoprotective effects of melatonin and vitamin E on fluoride toxicity on biomarkers of oxidative stress, clinical pathology, and their molecular mechanism of action. Apparently healthy male rats of the Wistar strain (n = 50;160 ± 7.5 g), were randomly distributed into five groups of ten animals per group as follows: Control, sodium fluoride (NaF, 25 mg/kg), NaF and melatonin 20 mg/kg i.p.;NaF and vitamin E 50 mg/kg p/o, NaF plus melatonin and vitamin E administered orally. NaF and melatonin were administered for fifteen consecutive days, whereas vitamin E was administered every 72 h. Blood pressure parameters, oxidative stress biomarkers, electrocardiography, histopathology, and immunohistochemical staining were performed. From this study, NaF intoxication provoked reduction in renal and cardiac systemic antioxidants, alterations of haemodynamic and electrocardiographic parameters, heightened blood urea nitrogen (BUN), creatinine, angiotensin converting enzyme, angiotensin 2 type 1 receptor, kidney injury molecule 1, interleukin 1 beta in the renal tissues, cardiac troponin, and nuclear kappa beta. However, the administration of either melatonin or vitamin E, and its combination mitigated high blood pressure, normalized electrocardiographic changes, abrogated biomarkers of oxidative stress, improved renal function, and attenuated inflammation. The combination of melatonin and vitamin E effectively mitigated cardiovascular and renal toxicities associated with fluoride intoxication through the prevention of cardio-renal dysfunction, oxidative stress, and inflammatory processes. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

关键词： Fluoride Hypertension Melatonin Rat Vitamin E

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A Survey on Cell Nuclei Instance Segmentation and Classification: Leveraging Context and Attention

arXiv

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arXiv 2024年

作者： Nunes, João D. Montezuma, Diana Oliveira, Domingos Pereira, Tania Cardoso, Jaime S. INESC TEC - Institute for Systems and Computer Engineering Technology and Science R. Dr. Roberto Frias Porto4200-465 Portugal University of Porto Faculty of Engineering R. Dr. Roberto Frias Porto4200-465 Portugal IMP Diagnostics Praça do Bom Sucesso Porto4150-146 Portugal R. Dr. António Bernardino de Almeida Porto4200-072 Portugal Doctoral Programme in Medical Sciences School of Medicine and Biomedical Sciences University of Porto ICBAS-UP Porto Portugal FCTUC - Faculty of Science and Technology University of Coimbra Coimbra3004-516 Portugal

Nuclear-derived morphological features and biomarkers provide relevant insights regarding the tumour microenvironment, while also allowing diagnosis and prognosis in specific cancer types. However, manually annotating nuclei from the gigapixel Haematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could alleviate the workload of pathologists and clinical researchers and at the same time facilitate the automatic extraction of clinically interpretable features for artificial intelligence (AI) tools. But due to high intra- and inter-class variability of nuclei morphological and chromatic features, as well as H&E-stains susceptibility to artefacts, state-of-the-art algorithms cannot correctly detect and classify instances with the necessary performance. In this work, we hypothesise context and attention inductive biases in artificial neural networks (ANNs) could increase the performance and generalization of algorithms for cell nuclei instance segmentation and classification. To understand the advantages, use-cases, and limitations of context and attention-based mechanisms in instance segmentation and classification, we start by review works in computer vision and medical imaging. We then conduct a thorough survey on context and attention methods for cell nuclei instance segmentation and classification from H&E-stained microscopy imaging, while providing a comprehensive discussion of the challenges being tackled with context and attention. Besides, we illustrate some limitations of current approaches and present ideas for future research. As a case study, we extend both a general instance segmentation and classification method (Mask-RCNN) and a tailored cell nuclei instance segmentation and classification model (HoVer-Net) with context- and attention-based mechanisms, and do a comparative analysis on a multi-centre colon nuclei identification and

关键词： Classification (of information)

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Analysis of groundwater and surface water quality using modelled water index and multivariate statistics in Kampala and Mbarara Districts, Uganda

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Discover Environment 2024年第1期2卷 1-17页

作者： Sanusi, Idris O. Olutona, Godwin O. Wawata, Ibrahim G. Onohuean, Hope Department of Pharmaceutical Chemistry and Analysis School of Pharmacy Kampala International University Ishaka-Bushenyi Uganda Industrial Chemistry Programme College of Agriculture Engineering and Science Bowen University Iwo Nigeria Department of Pharmaceutics and Pharmaceutical Technology School of Pharmacy Kampala International University Ishaka-Bushenyi Uganda Department of Pure and Applied Chemistry Kebbi State University of Science and Technology Birnin Kebbi Nigeria Institute of Biomedical Research Faculty of Biomedical Science Kampala International University Ishaka-Bushenyi Uganda Biomolecules Metagenomics Endocrine and Tropical Disease Research Group (BMETDREG) Kampala International University Ishaka-Bushenyi Uganda Biopharmaceutics Unit Department of Pharmacology and Toxicology School of Pharmacy Kampala International University Ishaka-Bushenyi Uganda

The demand for domestic, public and industrial use of water increases with population growth. However, activities from humans and natural environment have resulted into decline in water quality. The aim of this study was to evaluate the quality of groundwater and surface water collected from Kampala and Mbarara districts of Uganda using water quality index and multivariate statistics. A total of 10 physicochemical parameters (pH, water temperature, chloride, sulphate, nitrate, electrical conductivity, total dissolved solids, total suspended solids, total solids, and phosphate) were measured monthly to evaluate the quality of water in the study districts. Results showed that sulphate, electrical conductivity and total dissolved solids were observed with significantly high values in surface water than the groundwater for both seasons. Among all the parameters measured, electrical conductivity was observed with the highest value (2129.67 ± 1.41 µS/cm) while nitrate concentration (0.57 ± 0.02 mg/L) was observed with the lowest during the wet season in surface water. In addition, the mean values of nitrate, electrical conductivity, total dissolved solids and sulphate detected in the groundwater and surface water were within the recommended limits, while phosphate and chloride were observed with mean concentrations above the regulatory limits in 50% of the samples. The correlation analysis revealed strong and positive association between electrical conductivity and total dissolved solids in groundwater and surface water for both seasons. Also, the chemical make-up of groundwater and surface water within the study districts revealed that the determination of water quality rests on two major indices (conductivity and anthropogenic-pollutants) based on the factor analysis. The two indices accounted for 0.619% in groundwater and over 0.70% in surface water, indicating more pollution in surface water. Moreover, the water quality index (WQI) values obtained ranged from 14.

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Flavonoid-rich fraction of Monodora tenuifolia Benth seeds improves antioxidant status in male Wistar rats with streptozotocin-induced Diabetes mellitus

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Phytomedicine Plus 2024年第4期4卷 100646-100646页

作者： Nzekwe, Samuel Morakinyo, Adetoun Ntwasa, Monde Lebelo, Sogolo Oguntibeju, Oluwafemi Oyedapo, Oluokun Ayeleso, Ademola Department of Biochemistry Faculty of Science Adeleke University Ede Osun State 232101 Nigeria Department of Life and Consumer Sciences University of South Africa Florida Park Johannesburg 1709 South Africa Phytomedicine and Phytochemistry Group Oxidative Stress Research Centre Department of Biomedical Sciences Faculty of Health and Wellness Sciences Cape Peninsula University of Technology Bellville 7535 South Africa Department of Biochemistry Faculty of Science Obafemi Awolowo University Osun State Ife 220282 Nigeria Biochemistry Programme College of Agriculture Engineering and Science Bowen University Osun State Iwo 232102 Nigeria

Background: Oxidative stress is a disruption in the balance between free radicals and the body's natural defenses. This study investigated the modulatory effect of a flavonoid-rich fraction of Monodora tenuifolia seed (FRFMTS) on oxidative stress and antioxidant enzymes in diabetic Wistar rats. The plant seeds were collected, and identified then, hydro-ethanolic extract was obtained with 80 % (v/v) ethanol and partitioned with solvents to obtain the FRFMTS. Diabetes mellitus was induced with a single dose of 40 mg/kg bwt streptozotocin and the rats were treated according to their grouping;group 1: non-diabetic control, groups 2 and 3: non-diabetic treated with 25 mg/kg FRFMTS and 50 mg/kg FRFMTS, respectively. Group 4: diabetic control group, groups 5 and 6: diabetic groups treated with 25 mg/kg and 50 mg/kg FRFMTS, respectively, while group 7: diabetic treated with 6.67 mg/kg metformin. Antioxidant status, oxidative stress biomarkers and activities of antioxidant enzymes were determined in plasma, heart, and kidney tissues using established procedures. Results: Plasma total antioxidant status (TAS) was increased significantly (p < 0.05) in diabetic rats upon treatment with 25 mg/kg FRFMTS (70.4 %), while 50 mg/kg FRFMTS increased TAS by 70 %. The activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in the plasma, heart, and kidney of diabetic rats significantly decreased (61.3 %, 58.8 % and 31.4 % respectively) while lipid peroxidation (LPO) was elevated when compared with normal control groups. Flavonoid-rich fraction of M. tenuifolia at 25 mg/kg bwt and 50 mg/kg bwt significantly increased the activity GPx enzyme by 32.3 % and 72 % in plasma, while there was no significant differences in both kidney and heart of diabetic rats when compared with diabetic control groups. The treatment of diabetic rats with 25 mg/kg FRFMTS and 50 mg/kg FRFMTS improved SOD activity in the plasma (51.5 % and 69.8 %), heart (32.3 % and 27.6 %) and k

关键词： Antioxidants Diabetes mellitus Hyperglycemia Monodora tenuifolia Oxidative stress

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Iron Magnetic Nanoparticles Coated with Various Pvp Loadings: Evaluation of Magnetic Properties and Morphology

SSRN

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SSRN 2023年

作者： Shikh Zahari, S.M. Shahrul Nizan Weber, Cameron C. Puspitasari, Poppy Che Sam, Nur Fatin Izzati Muhamad Tajuddin, Nurul Hafizah Mohd Zainon, Nurazilah Elzaneen, Kholoud M.H. Industrial Chemical Technology Programme Faculty of Science and Technology Universiti Sains Islam Malaysia Bandar Baru Nilai Negeri Sembilan Nilai71800 Malaysia Department of Chemical Engineering South Kensington Campus Imperial College London LondonSWZ 2AZ United Kingdom Mechanical Engineering Department Engineering Faculty Malang State University Semarang Street 5 Malang East Java Indonesia School of Chemical Sciences University of Auckland Auckland1010 New Zealand MacDiarmid Institute of Advanced Materials and Nanotechnology Wellington6140 New Zealand Industrial Centre of Innovation in Biomedical SIRIM Industrial Research Lot 34 Jalan Hi-Tech 2/3 Kulim Hi-Tech Park Kulim Kedah 09000 Malaysia

Polyvinylpyrrolidone iron magnetic nanoparticles (PVP-Fe MNPs) have proven to be useful materials for the separation of oil-water mixtures. However, the relationship between the PVP loading and properties of these materials is not currently well understood. In this study, we examine the changes in the magnetic properties and morphology of PVP-Fe MNPs as a result of varying the PVP loading. The samples were synthesised by a co-precipitation technique in a homogeneous solution containing PVP and iron salts. Analysis revealed that the PVP loading had an inverse relationship with the magnetic properties (M s , M r and H c ), which was mainly impacted by the morphology of the resultant PVP-Fe MNPs. Thermogravimetric and CNS analyses were used to characterise the proportion of PVP bound to these materials. These results suggest that the properties of these PVP-Fe MNPs can be tuned by the PVP loading used in their synthesis, allowing these materials to be tailored for the targeted application. © 2023, The Authors. All rights reserved.

关键词： Magnetic properties

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Melt electrowritten Medium Chain Length Polyhydroxyalkanoate Cardiac Patches for Post-MI Cardiac Regeneration

Research Square

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Research Square 2024年

作者： Majid, Qasim A. Pandey, Pragati Bellahcene, Mohamed Grigsby, Christopher L. Stevens, Molly M. Talman, Virpi Stuckey, Daniel J. Harding, Sian E. Roy, Ipsita Földes, Gábor National Heart and Lung Institute Faculty of Medicine Imperial College London LondonW12 0NN United Kingdom Heart and Vascular Center Semmelweis University BudapestH1122 Hungary Drug Research Programme Division of Pharmacology and Pharmacotherapy Faculty of Pharmacy University of Helsinki Finland Department of Materials Science and Engineering Faculty of Engineering University of Sheffield Sheffield United Kingdom Insigneo Institute for in Silico Medicine Pam Liversidge Building University of Sheffield Sir Robert Hadfield Building United Kingdom Department of Medical Biochemistry and Biophysics Karolinska Institute Stockholm171 77 Sweden School of Pharmacy Queens University Belfast 97 Lisburn Road BelfastBT9 7BL United Kingdom Department of Materials Department of Bioengineering Institute of Biomedical Engineering Imperial College London LondonSW7 2AZ United Kingdom Centre for Advanced Biomedical Imaging Division of Medicine University College London LondonWC1E 6DD United Kingdom Research Centre for Integrative Physiology & Pharmacology Institute of Biomedicine University of Turku Turku Finland

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold promise in averting functional decline towards heart failure following myocardial infarction (MI). However, challenges persist in retaining these cells within the myocardium. We developed a novel three-dimensional cardiac patch and evaluated its potential to prevent post-MI functional decline. For the first time, melt electrowritten (MEW), structurally anisotropic scaffolds were derived from high molecular weight, medium chain-length polyhydroxyalkanoates (MCL-PHAs). These scaffolds supported hPSC-CMs, facilitating their rapid structural and functional maturation in vitro. Different cellular combinations were seeded on the scaffolds and layered to create cardiac patches. These were well-accepted in a murine MI model, without capsule formation. Patches containing hPSC-derived cardiac microvascular-like endothelial cells initiated vascular regeneration;although, this did not prevent post-MI functional decline. This novel advancement enabled the production of MCL-PHA-based MEW-cardiac patches that matured hPSC-CMs and promoted vascular regeneration, offering potential for future improvement in cardiac function through enhanced hPSC-CM retention. © 2024, CC BY.

关键词： Chain length

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