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Electrochemical detection of antimalarial drug (Amodiaquine) using Dy-MOF@MWCNTs composites to prevent erythrocytic stages of plasmodium species in human bodies

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Microchemical Journal 2024年 202卷

作者： Peter, X. Thatheyus Kuo, Chih-Yu Malar, P. Govindasamy, Mani Rajaji, Umamaheswari Yusuf, Kareem Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur 603203 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Herein, we report on fabrication of dysprosium-based metal–organic framework (Dy-MOF)@multiwalled carbon nanotubes (MWCNT) composites modified with glassy carbon electrode (Dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. Dy-MOF@MWCNT composites was prepared by sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, Dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (ADD) by electrochemical techniques such as CV and DPV. The as-prepared Dy@MWCNT composite material showed the oxidation peak current of ADD to be ∼ 60 % higher than other unmodified GC electrodes and showed a low charge transfer resistance (R_ct) of 24 Ω. The Dy@MWCNT provided a broad linear range of 0.4 to 20 µM with a limit of detection of 0.377 μM and sensitivity of 1.817 μA.μM⁻¹ for the detection of ADD. According to the pH study, the amount of electrons and protons involved in the electrochemical processes of ADD was calculated and a plausible mechanism for ADD electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the ADD drug in human urine samples. Hence, the results shows that the Dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of ADD. © 2024 Elsevier B.V.

关键词： Amodiaquine Antimalarial drug Carbon nanomaterials Electrochemical sensor Metal organic framework

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Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

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Cell Reports 2023年第11期42卷 113358页

作者： Chathuranga, W.A. Gayan Nikapitiya, Chamilani Kim, Jae-Hoon Chathuranga, Kiramage Weerawardhana, Asela Dodantenna, Niranjan Kim, Doo-Jin Poo, Haryoung Jung, Jae U. Lee, Chul-Ho Lee, Jong-Soo College of Veterinary Medicine Chungnam National University Daejeon 34314 South Korea Livestock Products Analysis Division Division of Animal Health Daejeon Metropolitan City Institute of Health and Environment Daejeon 34146 South Korea Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141 South Korea Department of Biomedical Science and Engineering Konkuk Institute of Technology Konkuk University Seoul 05029 South Korea Department of Cancer Biology Infection Biology Program and Global Center for Pathogen Research and Human Health Lerner Research Institute Cleveland Clinic Cleveland OH United States Laboratory Animal Resource Center Korea Research Institute of Bioscience and Biotechnology (KRRIB) Daejeon 34141 South Korea

Stress granules (SGs) constitute a signaling hub that plays a critical role in type I interferon responses. Here, we report that growth arrest and DNA damage-inducible beta (Gadd45β) act as a positive regulator of SG-mediated interferon signaling by targeting G3BP upon RNA virus infection. Gadd45β deficiency markedly impairs SG formation and SG-mediated activation of interferon signaling in vitro. Gadd45β knockout mice are highly susceptible to RNA virus infection, and their ability to produce interferon and cytokines is severely impaired. Specifically, Gadd45β interacts with the RNA-binding domain of G3BP, leading to conformational expansion of G3BP1 via dissolution of its autoinhibitory electrostatic intramolecular interaction. The acidic loop 1- and RNA-binding properties of Gadd45β markedly increase the conformational expansion and RNA-binding affinity of the G3BP1-Gadd45β complex, thereby promoting assembly of SGs. These findings suggest a role for Gadd45β as a component and critical regulator of G3BP1-mediated SG formation, which facilitates RLR-mediated interferon signaling. © 2023 The Authors

关键词： CP: Immunology G3BP Gadd45β RLR signaling RNA virus stress granule

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In vitro biocompatibility of polycaprolactone/hydroxyapatite nanocomposite membranes modified by oleic acid for bone regeneration

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Colloids and Surfaces A: Physicochemical and engineering Aspects 2024年 688卷

作者： Lin, Ruei-Hong Hung, Huey-Shan Tang, Cheng-Ming Tsou, Hsi-Kai Chen, Po-Hsiang Yueh, Chun-Yu Wang, Hui-Min David Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung40227 Taiwan Translational Medicine Research China Medical University Hospital Taichung404327 Taiwan Graduate Institute of Biomedical Science China Medical University Taichung404333 Taiwan Institute of Oral Sciences Chung Shan Medical University Taichung40201 Taiwan Department of Dentistry Chung Shan Medical University Hospital Taichung40201 Taiwan Functional Neurosurgery Division Neurological Institute Taichung Veterans General Hospital Taichung40293 Taiwan Department of Rehabilitation Jen-Teh Junior College of Medicine Nursing and Management Miaoli County35664 Taiwan College of Health National Taichung University of Science and Technology Taichung403027 Taiwan School of Medicine China Medical University Taichung404333 Taiwan Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung80708 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung40402 Taiwan

The bone defect is common in the orthopedic clinic, possibly due to trauma, tumor, or congenital diseases. Also, some patients with alveolar bone defects in the dental clinic result from the different proliferation speeds between soft and hard tissue. Biomaterials made of polymers and bioceramics have been developed to deal with these problems but mixing them directly can result in a low-mechanical strength complex. To solve this, we used oleic acid (C18) as a surfactant to improve the dispersity of hydroxyapatite (HA) in the polycaprolactone (PCL) matrix, and then immerse the material in a simulated biomineralization process. The results showed that the low crystallinity PCL formed an evenly distributed mineralized layer that had phosphate ions signal and a hydroxyapatite peak. The biocompatibility of the material was assessed using MC3T3 cells, and found that the PCL-HA membrane and PCL-C18-HA membranes had significant cell filopodia and lamellipodia. Additionally, the polycaprolactone/oleic acid/hydroxyapatite (PCL-C18-HA) membrane had the highest cell viability among all groups. The addition of C18 also decreased the platelets activation degree but had a significant difference in the reactive oxygen species (ROS) amount compared to the control, which requires further investigation. Overall, this study successfully fabricated a safe and promising polycaprolactone/hydroxyapatite/oleic acid nanocomposite membrane as a potential solution for bone biomaterials. © 2024 Elsevier B.V.

关键词： Hydroxyapatite

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PO-438 Hyperthermia as neoadjuvant treatment for pancreatic tumours in murine models

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ESMO Open 2018年 3卷 A403-A403页

作者： Krzykawska-Serda, M. Ware, M.J. Lapin, N. Agha, M. Ho, J. Law, J. Newton, J. Nguyen, L. Curley, S. Corr, S. Faculty of Biochemistry- Biophysics and Biotechnology- Jagiellonian University Biophysics Krakow Poland Baylor Collage of Medicine Surgery Houston USA Baylor College of Medicine Interdepartmental program in Translational Biology and Molecular Medicine Houston USA Swansea University School of Medicine Swansea UK University of Houston Biomedical Engineering Houston USA Rice University Mechanical Engineering and Materials Science Houston USA

ABSTRACTIntroductionPancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer. The hallmarks of this malignancy, such as it’s deprived vasculature, dense tumour stroma and hypoxic tumour microenvironment are some of the reasons for very poor chemotherapy and radiotherapy treatment efficacy. In these regards, a new combinatory treatment regimen was proposed: 1 non-invasive radiofrequency (RF) hyperthermia treatment to increase tumour perfusion, enhance cancer cell death and immune system stimulus; 2 chemotherapy regiment with Gemzar and Abraxane. Material and methodsOrthotropic and subcutaneous models of PDAC were induce by injection of PANC-1, AsPc-1 and Pan_O2 cancer cells into Balb/c nude or C57BL/6J mice. Tumour growth was monitored via ultrasound VEVO2100. Tumour perfusion after hyperthermia was monitored via intravital confocal microscopy and ultrasound microbubble contrast imaging. The tumour active vasculature was investigated using Doppler imaging. The chemotherapy with Gemzar and Abraxane was administered in combination with RF hyperthermia. A portable-RF system was used to produce local hyperthermia in the tumour tissue. The device is powered by 200 W and emits 13.56 MHz electric fields. The entire treatment scheme was repeated a total of 6 times at 72 hour time intervals (Q3D × 6 protocol) resulting in 16 days of treatment. The variety of histochemistry staining was performed post mortem to show the influence of treatment on the tumour vasculature and the degree of perfusion and necrosis. Results and discussionsWe showed that RF hyperthermia treatment as a neoadjuvant therapy can be promising for PDAC treatment. However, the effect is still unpredictable and depends on pre-existing tumour physiology before therapy. We established the most effective RF hyperthermia procedure to increase drug perfusion into tumour tissue (41°C for 20–30 min). We studied a variety of chemotherapy dosages to adjust clinical protocols into mouse mode

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Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models

arXiv

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arXiv 2022年

作者： Aubry, Jean-Francois Bates, Oscar Boehm, Christian Pauly, Kim Butts Christensen, Douglas Cueto, Carlos Gélat, Pierre Guasch, Lluis Jaros, Jiri Jing, Yun Jones, Rebecca Li, Ningrui Marty, Patrick Montanaro, Hazael Neufeld, Esra Pichardo, Samuel Pinton, Gianmarco Pulkkinen, Aki Stanziola, Antonio Thielscher, Axel Treeby, Bradley Van't Wout, Elwin Physics for Medicine Paris INSERM U1273 ESPCI Paris PSL University CNRS UMR 8063 France Department of Bioengineering Imperial College London Exhibition Road LondonSW7 2AZ United Kingdom Institute of Geophysics ETH Zürich Sonneggstrasse 5 Zürich8092 Switzerland Department of Radiology Stanford University StanfordCA United States Department of Biomedical Engineering Department of Electrical and Computer Engineering University of Utah United States Department of Surgical Biotechnology Division of Surgery and Interventional Science University College London LondonNW3 2PF United Kingdom Earth Science and Engineering Department Imperial College London London United Kingdom Centre of Excellence IT4Innovations Faculty of Information Technology Brno University of Technology Bozetechova 2 Brno612 00 Czech Republic Graduate Program in Acoustics The Pennsylvania State University University Park PA16802 United States Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill North Carolina State University NC United States Department of Electrical Engineering Stanford University StanfordCA United States Zurich Switzerland Laboratory for Acoustics / Noise control Empa Swiss Federal Laboratories for Materials Science and Technology Dubendorf Switzerland Zurich Switzerland Radiology and Clinical Neurosciences Departments Cumming School of Medicine University of Calgary Canada Department of Applied Physics University of Eastern Finland Kuopio70211 Finland Department of Medical Physics and Biomedical Engineering University College London Gower Street LondonWC1E 6BT United Kingdom Technical University of Denmark Denmark Danish Research Center for Magnetic Resonance Copenhagen University Hospital Hvidovre Denmark Institute for Mathematical and Computational Engineering School of Engineering and Faculty of Mathematics Pontificia Universidad Catolica de Chile Santiago Chile

Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow intercomparison between the different modeling tools and techniques used by the community, an international working group was convened to formulate a set of numerical benchmarks. Here, these benchmarks are presented, along with intercomparison results. Nine different benchmarks of increasing geometric complexity are defined. These include a single-layer planar bone immersed in water, a multi-layer bone, and a whole skull. Two transducer configurations are considered (a focused bowl and a plane piston), giving a total of 18 permutations of the benchmarks. Eleven different modeling tools are used to compute the benchmark results. The models span a wide range of numerical techniques, including the finite-difference time-domain method, angular-spectrum method, pseudospectral method, boundary-element method, and spectral-element method. Good agreement is found between the models, particularly for the position, size, and magnitude of the acoustic focus within the skull. When comparing results for each model with every other model in a cross comparison, the median values for each benchmark for the difference in focal pressure and position are less than 10% and 1 mm, respectively. The benchmark definitions, model results, and intercomparison codes are freely available to facilitate further comparisons. Copyright © 2022, The Authors. All rights reserved.

关键词： Bone

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Hybrid Solar Cells: Enhanced Light Absorption of Silicon Nanotube Arrays for Organic/Inorganic Hybrid Solar Cells (Adv. Mater. 21/2014)

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Advanced Materials 2014年第21期26卷

作者： Huisu Jeong Hui Song Yusin Pak Il Keun Kwon Kyubong Jo Heon Lee Gun Young Jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju 500‐712 Republic of Korea Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology School of Dentistry Kyung Hee University Seoul 130‐701 Republic of Korea Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology Sogang University Seoul 121‐741 Republic of Korea Department of Materials Science and Engineering Korea University Seoul 136‐701 Republic of Korea

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Analysis of micro-inflammation in human keratinocytes by quantitative measurement of mechanical property changes

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Journal of Dermatological Science 2016年第1期84卷 e136-e136页

作者： Choi, Hyeongwon Shin, Min Kyung Ahn, Hey Jin Son, Youngsook Park, Hun-Kuk Kim, Kyung Sook Department of Genetic Engineering College of Life Science and Graduate School of Biotechnology Kyung Hee University Yongin South Korea Department of Dermatology College of Medicine Kyung Hee University Seoul South Korea Kyung Hee Institute of Regenerative Medicine Seoul South Korea Department of Biomedical Engineering College of Medicine Kyung Hee University Seoul South Korea Program of Medical Engineering College of Medicine Kyung Hee University Seoul South Korea

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Ultrasensitive detection of ornidazole–antibiotic drug residues in water using NiMOFs functionalized MWCNT modified electrode

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Microchemical Journal 2024年 197卷

作者： Vignesh, Kondusamy Senthil Kumar, Annamalai Arumugam Napoleon, Ayyakannu Kuo, Chih-Yu Yusuf, Kareem Govindasamy, Mani Nano and Bioelectrochemistry Research Laboratory Carbon dioxide Research and Green Technology Centre and Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Nitroimidazole-based drugs are widely used as an antibiotic for the treatment of anaerobic bacterial and parasite illnesses. The widespread use of these drugs in animal feed and the consequent environmental pollution have become significant concerns in recent years. Simple, sensitive, and rapid detection of the antibody in various real samples is demanding research interest. Herein, we report a Nickel-metal organic framework functionalized Multiwalled Carbon nanotubes modified glassy carbon electrode (MWCNT@NiMOFs) as an ultrasensitive and rapid voltammetric sensor for the detection of ornidazole (ORDZ) in a neutral pH solution. The MWCNT@NiMOFs were prepared using a microwave-assisted solvothermal technique accompanied by an ultrasonication method. The designed MWCNT@NiMOFs offered a low charge transfer resistance (R_ct) of 141 Ω along with excellent electrocatalytic activity, and high current density at the lowered cathodic peak potential (-0.62 V vs Ag/AgCl) for ORDZ detection. The surface adsorption capacity (Γ_s) in terms of surface excess and heterogeneous charge transfer rate constant (k⁰) of the MWCNT@NiMOFs were calculated to be 3.29 × 10^-9 mol cm⁻² and 5.33 × 10^-3 cm s⁻¹, respectively. Under an optimal working condition, differential pulse voltammetry measurements of ORDZ have shown concentration linearity in a window, 100 nm to 10 µM range with excellent sensitivity, 5.69 × 10^-5A µM⁻¹ cm⁻², and detection limit, 26 nM (3.3/s). The designed MWCNT@NiMOFs offered appreciable reproducibility, and repeatability up to 30 days of storage time. The real-time quantitative evaluation of ORDZ in human urine and tap water specimens was done along with ∼ 100 % recovery values. Since the new approach is simple, selective, and separation-free, it can be extendable to a variety of real-time practical applications. © 2024 Elsevier B.V.

关键词： Electrocatalytic reduction Multi-walled carbon nanotubes Nickel Metal-organic frameworks Ornidazole drug Ultrasensitive detection

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Corrigendum to “Paclitaxel/sirolimus combination coated drug-eluting stent: In vitro and in vivo drug release studies” [J. Pharm. Biomed. Anal. 54 (2011) 807–811]

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Journal of Pharmaceutical and biomedical Analysis 2012年 59卷 217-217页

作者： Xiaodong Ma Shizu Oyamada Fan Gao Tim Wu Michael P. Robich Hao Wu Xingwei Wang Bryan Buchholz Stephen McCarthy Zhiyong Gu Cesario F. Bianchi Frank W. Sellke Roger Laham Biomedical Engineering and Biotechnology Doctoral Program University of Massachusetts Lowell MA 01854 USA VasoTech Inc. Lowell MA 01854 USA Division of Cardiothoracic Surgery Brown Medical School Providence RI 02903 USA Department of Chemical Engineering University of Massachusetts Lowell MA 01854 USA Department of Cardiology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA

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Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways

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Chemico-Biological Interactions 2023年第1期370卷 110329页

作者： Hsu, Chia-Hung Weng, Pei-Wei Chen, Ming-Yao Yeh, Chi-Tai Setiawan, Syahru Agung Yadav, Vijesh Kumar Wu, Alexander T.H. Tzeng, David T.W. Gong, Jian-Xian Yang, Zhen Tzeng, Yew-Min Department of Emergency Medicine Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Injury Prevention and Control College of Public Health Taipei Medical University Taipei City 11031 Taiwan Department of Emergency Medicine School of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Department of Orthopaedics Shuang Ho Hospital Taipei Medical University New Taipei City 23561 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine Shuang Ho Hospital New Taipei City 23561 Taiwan Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Continuing Education Program of Food Biotechnology Applications College of Science and Engineering National Taitung University Taitung 95092 Taiwan International Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan Ph.D. Program of Translational Medicine College of Medical Science and Technology Taipei Medical University Taipei 11031 Taiwan School of Life Sciences The Chinese University of Hong Kong 999077 Hong Kong Lifebit London EC2A 2AP United Kingdom Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 China State Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education and Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 China Shenzhen Bay Laboratory Shenzhen 518055 China Department of Applied Science National Taitung University Taitung

Until recently, sorafenib has been the only treatment approved by the U.S. Food and Drug Administration for patients with advanced hepatocellular carcinoma (HCC). Some patients, however, exhibit resistance to this treatment and subsequently experience cancer progression, recurrence, or death. Therefore, identifying a new alternative treatment for patients with little or no response to sorafenib treatment is vital. In this study, we explored the therapeutic potential and underlying molecular mechanism of antrocinol ((3aS,4R,6aS,10aR)-4-(hydroxymethyl)-7,7-dimethyldecahydro-1H-naphtho[1,8a-c]furan-1-one) in patients with HCC. The results indicated that antrocinol was more therapeutically effective than antrocin, Stivarga, and sorafenib against HCC cell lines. Antrocinol also substantially suppressed the expression of KRAS-GTP, p-MEK1/2, p-ERK1/2, and p-AKT in the Huh7 cell line. Additionally, antrocinol-induced apoptosis in the Huh7 cell line, inhibited the formation of tumorspheres, and suppressed the expression of cancer stem cell markers CD133, KLF4, CD44, OCT4, SOX2, and c-Myc. Animal studies revealed that antrocinol alone considerably suppressed tumor growth in nonobese diabetic/severe combined immunodeficient mice inoculated with Huh7 tumorspheres. It also synergistically enhanced the anticancer effect of sorafenib, resulting in enhanced suppression of tumor growth (p < 0.001) and tumorsphere formation (p < 0.001). In tumor samples resected from mice treated with antrocinol alone or in combination with sorafenib, immunohistochemical analysis revealed an increase in BAX expression and a decrease in ERK and AKT protein expression. To the best of our knowledge, this is the first report of the anti-HCC activity of antrocinol. With its higher therapeutic efficacy than that of sorafenib, antrocinol is a candidate drug for patients with HCC who demonstrate little or no response to sorafenib treatment. © 2022 Elsevier B.V.

关键词： Antrocinol Cancer stemness Hepatocellular carcinoma KRAS/AKT/ERK axis Sorafenib

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