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Society of Plastics Engineers Annual Technical Conference 2005, ANTEC 2005

作者： Russell, Stacey Crugnola, Aldo Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Plastics Engineering Department University of Massachusetts Lowell

The study investigated the growth and adhesion of normal human osteoblasts (NHOst) to two different biodegradable systems. These materials included polycaprolactone (PCL) and polycaprolactone/ hydroxyapatite (PCL/HA) composite. We studied the attachment of osteoblasts to twodimensional films of these materials. We specifically looked at the potential of these two biodegradable systems to promote bone tissue growth. The materials were cast into two-dimensional films. They were evaluated for functionality, growth and adhesion at designated intervals using microscopy and bone-specific alkaline phosphatase (BAP) and osteocalcin (OC) immunoassays. The cells on the composite scaffold produced more BAP than the cells alone or on the PCL scaffold. However, the cells on both types of scaffolds showed lower levels of OC than the cells alone.

关键词： Composite materials

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Bioprospecting microalgal strains cultivated using bicarbonate under a pH-regulated regime for enhanced carbon capture and utilization

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Algal Research 2025年 89卷

作者： Latagan, Mary Joy D. Nagarajan, Dillirani Chen, Jih-Heng Huang, Wei-Ming Chen, Chun-Yen Pacquiao, Melvin R. de Luna, Mark Daniel G. Rollon, Analiza P. Chang, Jo-Shu Department of Chemical Engineering National Cheng Kung University Tainan 701 Taiwan Energy Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City 1101 Philippines Institute of Aquatic Science and Technology College of Hydrosphere Science National Kaohsiung University of Science and Technology Kaohsiung City 811532 Taiwan Department of Chemical and Materials Engineering National Kaohsiung University of Science and Technology Kaohsiung 807 Taiwan University Center for Bioscience and Biotechnology National Cheng Kung University Tainan 701 Taiwan Department of Biomedical Engineering National Cheng Kung University Tainan 701 Taiwan Department of Biotechnology and Bioindustry Sciences National Cheng Kung University Tainan 701 Taiwan Environmental Engineering Program National Graduate School of Engineering University of the Philippines Diliman Quezon City 1101 Philippines Department of Chemical Engineering University of the Philippines Diliman Quezon City 1101 Philippines Department of Chemical and Materials Engineering Tunghai University Taichung 407 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Chung-Li Taiwan Department of Life Science National Chung Hsin University Taichung 402202 Taiwan Innovation and Development Center of Sustainable Agriculture National Chung Hsin University Taichung 402202 Taiwan

Microalgae offers significant potential as a sustainable resource for biofuel production. However, an inefficient supply of gaseous CO2 can lead to carbon limitation due to poor mass transfer efficiency, which poses a... 详细信息

Microalgae offers significant potential as a sustainable resource for biofuel production. However, an inefficient supply of gaseous CO₂ can lead to carbon limitation due to poor mass transfer efficiency, which poses a significant challenge in large-scale microalgal cultures. This study investigates pH-stat bicarbonate-based cultivation of various microalgal strains aimed at carbohydrate and lipid production. Four green algal strains were assessed for their capability to utilize bicarbonate ions as their inorganic carbon source for photosynthesis. Among the strains, Chlamydomonas sp. JSC4 attained the highest biomass concentration (1.05 ± 0.05 g/L), biomass productivity (242 mg/L/day), lipid content (42.7 ± 0.85 %), and carbohydrate content (39.16 ± 0.09 %) under conditions of 50 mM KHCO₃, pH 8, and 7 days of cultivation. The biomass productivity attained in this study is higher than those in the reported literature. The predicted biodiesel quality for all strains met the ASTM D6751 and EN 14214 specifications. Increasing the bicarbonate concentration to 100 mM and employing a fed-batch mode elevated the biomass to 1.45 ± 0.32 g/L, carbohydrate accumulation to 58.25 ± 1.28 % DCW, and carbon fixation efficiency to 63.8 ± 3.23 %, which is significantly higher than that of the control cultivated with CO₂ supply (0.30 ± 0.04 %). This study highlights the potential of bicarbonate ion supplementation as an effective strategy for maximal biomass production with high productivity and biomolecule accumulation, aiding in the realization of cost-effective microalgal biofuel production. © 2025 Elsevier B.V.

关键词： Bicarbonate Biofuel Carbohydrate Chlamydomonas Microalgae pH-stat culture

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Rethinking Pharmaceutical Industry with Quality by Design: Application in Research, Development, Manufacturing, and Quality Assurance

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The AAPS journal 2025年第4期27卷 96页

作者： Joana Galvão Duarte Maria Galvão Duarte Ana Paula Piedade Filipa Mascarenhas-Melo Doctoral Program in Biomedical Sciences School of Medicine & Biomedical Sciences University of Porto (ICBAS-UP) Rua Jorge Viterbo Ferreira 228 4050-513 Porto Portugal. Faculty of Pharmacy University of Coimbra Azinhaga Sta. Comba 3000-548 Coimbra Portugal. University of Coimbra CEMMPRE Department of Mechanical Engineering 3030-788 Coimbra Portugal. Higher School of Health Polytechnic Institute of Guarda Av. Dr. Francisco Sá Carneiro 50 6300-559 Guarda Guarda Portugal. filipamelo@ff.uc.pt. BRIDGES - Biotechnology Research Innovation and Design for Health Products Polytechnic University of Guarda Avenida Dr. Francisco Sá Carneiro N.º 50 6300-559 Guarda Portugal. filipamelo@ff.uc.pt.

Quality by Design (QbD) is a transformative and systematic approach to developing top-tier pharmaceutical products, ushering in a departure from traditional trial-and-error methods toward a more science-based, risk-oriented, and holistic strategy. Central to QbD implementation is the meticulous development of formulations and manufacturing processes, consistently fulfilling predefined quality objectives. The core objective of QbD remains unwavering - to guarantee the steadfast alignment of the final pharmaceutical product with predetermined quality attributes, thereby mitigating batch-to-batch variations and potential recalls. This article succinctly explores the multifaceted application of QbD methodology within the pharmaceutical industry. Emphasizing its pivotal role in research and development, manufacturing, quality control, and quality assurance, the discussion navigates through the strategic deployment of QbD elements and tools. Amidst the evident advantages of QbD, challenges persist in its widespread adoption within the pharmaceutical sector and regulatory frameworks. This article sheds light on the regulatory landscape that currently governs the implementation of QbD in these crucial stages of pharmaceutical processes. For that reason, this review article aims to provide researchers, scientists, and industry professionals with a thorough introduction to QbD so they may adopt this methodical approach to developing and producing high-quality pharmaceutical products, always in compliance with the underlying regulations.

关键词： pharmaceutical manufacturing pharmaceutical quality by design quality assurance quality control research and development

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In vitro evaluation of a composite scaffold made from electrospun nanofibers and a hydrogel for tissue engineering

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Journal of Bionanoscience 2009年第1期3卷 45-57页

作者： Feingold-Leitman, Dana Zussman, Eyal Seliktar, Dror Faculty of Biomedical Engineering Haifa 32000 Israel Inter-Departmental Program for Biotechnology Haifa 32000 Israel Faculty of Mechanical Engineering Technion-Israel Institute of Technology Haifa 32000 Israel

The design of a composite biodegradable scaffold for tissue engineering was the main focus of this investigation. The composite material was made from a highly porous mesh of poly(epsiloncaprolactone) (PCL) nanofibers, fabricated by electrospinning and permeated with a hydrogel biomaterial made from PEGylated fibrinogen. The PCL nanofiber mesh provided the structural reinforcement whereas the PEGylated fibrinogen hydrogel provided a precisely tunable matrix for an improved biocompatible interfacing between the cells and the PCL nanofibers. The architectural and mechanical properties of the PCL nanofiber mesh were examined using scanning electron microscopy (SEM) and uniaxial tensile testing. Smooth muscle cells (SMCs) were encapsulated in the hydrogel phase and cultured in the composite scaffold for up to one week in vitro. The ability of the composite structure to support cell attachment, proliferation and migration, was examined by microscopy with whole constructs and histological sections. The results indicated that the SMCs become highly spindled and proliferate in the composite material. Time-lapse microscopy showed that the SMCs migrated on the stiffer PCL nanofibers of the scaffold and populated the mesh at a higher cell density. In the PCL mesh region, the SMCs expressed a more contractile phenotype as indicated by smooth muscle alpha-actin staining. In contrast, the more compliant hydrogel region contained few smooth muscle alpha-actin positive SMCs. The electrospun PCL nanofibers exhibited significantly higher elastic modulus in comparison to the PEGylated fibrinogen hydrogel, suggesting that mechanics may play a role in the phenotype expression of the SMCs in the nanofiber region of the composite scaffold. In conclusion, we verified that the composite material exhibited suitable biocompatibility for SMC culture and adequate mechanical properties for use as a scaffold material in tissue engineering. Copyright © 2009 American Scientific Publishers All right

关键词： Nanofibers

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Effect of polarity on electrospinning polycaprolactone tissue engineering scaffolds

Effect of polarity on electrospinning polycaprolactone tissu...

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Society of Plastics Engineers Annual Technical Conference: Plastics Encounter at ANTEC 2007

作者： Lippincott, Hugh Crugnola, Aldo M. Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA 01854 Department of Plastics Engineering University of Massachusetts Lowell

ISBN: (纸本)1604232145

Electrospun polycaprolactone (PCL) fabric was affected by the electrospinning voltage polarity. The tensile test breaking strain and breaking stress of negative polarity spun samples was half that of positive polarity samples. The differences were investigated using XRD, DSC, scanning electron microscopy (SEM), and mercury porosimetry. XRD found a peak of a different magnitude, but DSC found no significant differences in crystallinity. The SEM show few differences, but the porosimetry shows a different distribution.

关键词： Scaffolds

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Towards a high-performance epoxy resin free of Bisphenol A (BPA)

Towards a high-performance epoxy resin free of Bisphenol A (...

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71st Annual Technical Conference of the Society of Plastics Engineers 2013, ANTEC 2013

作者： Romano, Robert Patil, Smruti Schmidt, Daniel Department of Plastics Engineering University of Massachusetts Lowell Lowell MA United States Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA United States

ISBN: (纸本)9781632665300

Bisphenol A is a key component of many epoxy resins, but is under pressure especially in food contact applications, necessitating the identification of high performance alternatives. In this work we report on the preparation, properties and performance of one such alternative, the bis(epoxide) of 2, 2, 4, 4-tetramethyl-l, 3-cyclobutanediol. This resin has been crosslinked with a typical amine hardener to produce a stiff, hard thermoset with a high T g. Curing behavior and cured resin properties are improved vs. the bis(epoxide) of cyclohexanedimethanol, a structural isomer of CBDO. Compared to a BPA-based equivalent, resin viscosity and UV cutoff are lower and lap shear adhesion to mild steel is superior, the latter on par with a commercial heavy duty epoxy adhesive. These results indicate promise from this material as a high-performance BPA-free epoxy resin.

关键词： Epoxy resins

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Dextran-integrated polypyrrole-Cu2O composite for improved electrochemical quantification of melatonin in biological samples

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International Journal of Biological Macromolecules 2025年第Pt 2期310卷 143247页

作者： Aiswarya, B. Gopika, M.G. Saraswathyamma, Beena Kuo, Chih-Yu Jeridi, Mouna Alshahrani, Thamraa Govindasamy, Mani International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Polymer Science Central Institute of Petrochemical Engineering and Technology Kochi Eloor Udyogamandal P O Kochi683501 India Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kerala Kollam690525 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei106 Taiwan Biology Department College of Science King Khalid University Abha61413 Saudi Arabia Department of Physics College of Science Princess Nourah bint Abdulrahman University P. O. Box 84428 Riyadh11671 Saudi Arabia Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City24301 Taiwan Department of Research and Innovation Saveetha School of Engineering SIMATS Chennai602105 India

Monitoring the level of melatonin (MEL), a neurohormone that plays a vital role in governing the body's circadian rhythms and sleep cycles, is critical due to its physiological importance and potential adverse side effects during overexposure. This research deals with the design and development of a novel electrochemical sensor by modifying a glassy carbon electrode (GCE) with a composite of poly(vinyl alcohol) (PVA), dextran (Dex), polypyrrole (PPy) and copper oxide particles (Cu2O) forming the PDPC composite. The synthesized composite was analyzed using both structural and morphological characterization methods. Additionally, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were conducted to examine electrochemical behaviour of the composite. Significantly, the dextran inclusion, which is a biocompatible polysaccharide, makes the composite more hydrophilic, film forming, and stable enhancing sensor properties, more importantly, electrochemically. The sensor showed high electrocatalytic activity towards MEL oxidation as studied using CV and DPV. For MEL oxidation, the oxidation peak was found at +0.6 V in phosphate buffer (pH 7.0) with an increase in current with respect to melatonin concentration. The sensor has a detection limit of 5.2 nM with a linear range of 10.0 nM to 850.0 μM, found to be better than most reported sensors. Analysis of real samples, such as human serum and urine, demonstrated the ability to selectively, stably, and reproducibly detect MEL. These data confirm the potential possibilities of using the sensor for clinical and point-of-care testing showing a significant development in polysaccharide-based electrochemical sensors. © 2025 Elsevier B.V.

关键词： Dextran-based composite Electrochemical sensor Melatonin

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BPS2025 - Cross-scale conundrum: Slow masticatory myosin in jaw muscles that are both fast and strong

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Biophysical Journal 2025年第3期124卷 516a-516a页

作者： Varun V. Dhorajia Nicholas LaFave Brandon Reder Robert Brocklehurst Nicolai Konow Sam Walcott Jeffrey R. Moore Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA USA Department of Biological Sciences University of Massachusetts Lowell Lowell MA USA Department of Mathematical Sciences Worcester Polytechnic Institute Worcester MA USA Department of Bioinformatics and Computational Biology Worcester Polytechnic Institute Worcester MA USA

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Sol-gel derived polycaprolactone / castor oil based copolyurethanes for medical applications

Sol-gel derived polycaprolactone / castor oil based copolyur...

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66th Annual Technical Conference of the Society of Plastics Engineers, Plastics Encounter at ANTEC 2008

作者： Lippincott, Hugh Schmidt, Daniel F. Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA 01854 United States Departmento of Plastics Engineering University of Massachusetts Lowell Lowell MA 01854 United States

ISBN: (纸本)9781605603209

Sol-gel synthesis of two previously unreported families of biomedically relevant copolyurethane thermosets based on castor oil in combination with two different PCL oligomers is reported as a step towards the production of porous, biodegradable shape memory polymers, to yield materials with Tg values near body temperature. Various solvents and catalysts were explored for synthesis while thermal analysis (TGA & DSC), solvent uptake and sol fraction data were used to characterize the products. Semi-crystalline compositions were also identified, expanding the properties achievable in these systems.

关键词： Polycaprolactone

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Targeting metastatic melanoma: Pumpkin seed extracts as potential antineoplastic agents

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Journal of Supercritical Fluids 2025年 223卷

作者： Amarante, Bruno Antônio Saccomori, Eduardo Bilibio, Denise Bender, João Paulo da Silva, Gilnei Bruno Manica, Daiane Bagatini, Margarete Dulce Bruno, Alessandra Nejar Priamo, Wagner Luiz Department of Food Engineering IFRS - Campus Erechim RS Erechim Brazil Center for Experimentation and Analytical Studies IFRS - Campus Sertão RS Sertão Brazil Department of Engineering UFFS SC Chapecó Brazil Multicentric Postgraduate Program in Biochemistry and Molecular Biology UDESC Santa Catarina Lages Brazil Postgraduate Program in Biochemistry UFSC Santa Catarina Florianópolis Brazil Postgraduate Program in Biomedical Sciences UFFS Santa Catarina Chapecó Brazil Department of Biotechnology IFRS – Campus Porto Alegre RS Brazil

In this study, the fatty acid composition and antitumor potential of pumpkin seed extracts, obtained through ultrasound-assisted extraction (UAE) and pressurized ethanol extraction (PEE) against melanoma cells was studied. An experimental design was employed to optimize parameters in both methods and gas chromatography identified the extracts based on fatty acids. SK-MEL-28 and A375 melanoma cells were treated with UAE and PEE extracts and assessed for viability (MTT assay, acridine orange staining), redox profile (NOx, PSH, NPSH), and mitochondrial membrane potential (MMP). The highest extraction yields were 48.99 % for UAE and 30.28 % for PEE. Major fatty acids included methyl linoleate (∼ 47 %) and methyl cis-9 oleate (∼ 25 %). Extracts reduced melanoma cell viability, increased NOx, and decreased MMP, particularly with UAE-derived extracts, highlighting the significance of the extraction method. These effects may be linked to altered redox balance, reduced MMP, and tumor cell death. © 2025 Elsevier B.V.

关键词： Gas chromatography

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