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2008 AIChE Annual Meeting, AIChE 100

作者： Lippincott, Hugh Borgaonkar, Poonam Sharma, Sachin Chen, Ming Bhowmick, Sankha Schmidt, Daniel F. Biomedical Engineering and Biotechnology University of Massachusetts Lowell 1 University Avenue Lowell MA 01854 United States Plastics Engineering University of Massachusetts Lowell 1 University Avenue Lowell MA 01854 United States Mechanical Engineering / Biomedical Engineering and Biotechnology Program University of Massachusetts Dartmouth 285 Old Westport Road Dartmouth MA 02747 United States

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The consumption of 12 Eggs per week for 1 year does not alter fasting serum markers of cardiovascular disease in older adults with early macular degeneration

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Journal of Nutrition and Intermediary Metabolism 2019年 15卷 35-41页

作者： Aljohi, Hassan Dopler-Nelson, Mindy Cifuentes, Manuel Wilson, Thomas A. Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA United States Department of Public Health Regis College Weston MA United States Department of Biomedical and Nutritional Sciences University of Massachusetts Lowell Lowell MA United States

Some studies suggest that eating more than one egg daily may increase risk of death from cardiovascular disease. The objective of this study was to determine the effects of consuming eggs on various serum markers associated with cardiovascular disease (CVD). Forty-five independently living adults diagnosed with early macular degeneration, but healthy otherwise were recruited into the study. Subjects were placed into the Intervention (n = 27) or Control group (n = 18) based on whether or not they would consume eggs. The Intervention group consumed 12 eggs per week while the Control group refrained from consuming any whole egg products for 1 year. Serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, apolipoprotein (apo) A-1 and apo B, lipoprotein (Lp)_a and high-sensitive C reactive protein (hsCRP) were measured at baseline, 6, and 12 months. Serum low-density lipoprotein cholesterol (LDL-C) concentration was calculated via the Friedewald equation. Serum TC, TG, HDL-C, LDL-C, apo A-1, apo B, Lp_a and hsCRP concentrations did not change at any time in both the Intervention and Control groups compared to baseline nor were there any differences between the two treatment. Serum glucose concentrations did increase significantly in the Intervention group at 6 months compared to baseline (23%, P < 0.05) but decreased back to baseline concentrations at 12 months. This study suggests that the consumption of 12 eggs per week for 1 year does not significantly alter fasting serum lipids, lipoprotein cholesterol, or other biomarkers of CVD in older adults diagnosed with early macular degeneration. © 2018 The Authors

关键词： Apolipoprotein A-1 Apolipoprotein B C-reactive protein (CRP) Cardiovascular disease (CVD) HDL cholesterol LDL cholesterol

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Towards a Systematics for Protein Subcellular Location: Quantitative Description of Protein Localization Patterns and Automated Analysis of Fluorescence Microscope Images 8

Towards a Systematics for Protein Subcellular Location: Quan...

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8th International Conference on Intelligent Systems for Molecular Biology, ISMB 2000

作者： Murphy, Robert F. Boland, Michael V. Velliste, Meel Department of Biological Sciences Biomedical Engineering Program Center for Light Microscope Imaging and Biotechnology Carnegie Mellon University 4400 Fifth Avenue PittsburghPA15213 United States

ISBN: (纸本)1577351150

Determination of the functions of all expressed proteins represents one of the major upcoming challenges in computational molecular biology. Since subcellular location plays a crucial role in protein function, the availability of systems that can predict location from sequence or high-throughput systems that determine location experimentally will be essential to the full characterization of expressed proteins. The development of prediction systems is currently hindered by an absence of training data that adequately captures the complexity of protein localization patterns. What is needed is a systematics for the subcellular locations of proteins. This paper describes an approach to the quantitative description of protein localization patterns using numerical features and the use of these features to develop classifiers that can recognize all major subcellular structures in fluorescence microscope images. Such classifiers provide a valuable tool for experiments aimed at determining the subcellular distributions of all expressed proteins. The features also have application in automated interpretation of imaging experiments, such as the selection of representative images or the rigorous statistical comparison of protein distributions under different experimental conditions. A key conclusion is that, at least in certain cases, these automated approaches are better able to distinguish similar protein localization patterns than human observers. Copyright © 2000, AAAI (***). All rights reserved.

关键词： Proteins

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Design and in silico validation of a human body on a chip for toxicity assessment of drugs to prevent graft-versus-host disease 18

Design and in silico validation of a human body on a chip fo...

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18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023

作者： Lira Mario, M. Casado Fanny, L. Institute of Omic Sciences and Applied Biotechnology Pontificia Universidad Catolica Del Peru Program of Biomedical Engineering PUCP-UPCH Lima15088 Peru Institute of Omic Sciences Applied Biotechnology Pontificia Universidad Catolica Del Peru Lima15088 Peru

ISBN: (纸本)9798350335460

Toxicity assessment of novel drugs requires the development of models that provide information about the behavior of the cells and the drugs. Current cytotoxicity assays rely on data generated in vitro under static conditions, different from the conditions in the human body, where everything is dynamic and connected. Here we designed a body-on-a-chip and validated its utility to provide in silico information to better design in vitro cytotoxicity assays under dynamic conditions. We focus on cellular and structural features of the integrated main organs affected by systemic toxicity (heart, liver and kidneys), assuming passive mixer conditions for drug-blood interactions using the physicochemical characteristics of a model immuno-modulating drug such as sirolimus or rapamycin. Velocity, pressure and concentration fields were characterized to calculate the values of shear stress, vortex formation and mixing *** Relevance - Chronic diseases are highly prevalent in our society and predicted to become the main burden within the next decade. The most long-term successful treatment for most of them is transplantation of the affected organ. However, the risk of developing graft-versus-host disease is still a limitation for this therapeutic approach despite the availability of drugs to modulate the immune system to tolerate the donor's presence. Therefore, the toxicity assessment of novel immune drugs for organs of interest is a high priority. © 2023 IEEE.

关键词： Shear stress

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Development of a biodegradable nanofiber scaffold by optimization of electrospinning process parameters

Development of a biodegradable nanofiber scaffold by optimiz...

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2005 Summer Bioengineering Conference

作者： Chen, Ming Patra, Prabir Warner, Steve Bhowmick, Sankha Biomedical Engineering and Biotechnology Program University of Massachusetts Dartmouth North Dartmouth MA Textile Science Department University of Massachusetts Dartmouth North Dartmouth MA Mechanical Engineering Department University of Massachusetts Dartmouth North Dartmouth MA

ISBN: (纸本)0974249211

The goal of the current study was to develop a three dimensional scaffold for creating tissue engineered bioactive bandages. In the current study, we chose polycaprolactone (PCL) as the biomaterial and optimized the electro spinning process parameters: concentration, voltage and the distance between capillary and collection screen. Using scanning electron microscopy (SEM), we measured the fiber diameter and also studied the growth of NIH 3T3 fibroblasts into electrospun PCL scaffolds after various days post seeding. Our studies have been able to obtain uniform fibers of a minimal diameter of 650nm which also provides the best environment for cell growth.

关键词： Nanostructured materials

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Responsive hydrogels produced via organic sol-gel chemistry for biomedical applications

Responsive hydrogels produced via organic sol-gel chemistry ...

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作者： Patil, Smruti Clarizia, Liza J. McDonald, Melisenda Reynaud, Emmanuelle Schmidt, Daniel F. Biomedical Engineering and Biotechnology Program University of Massachusetts United States Department of Chemistry University of Massachusetts United States Department of Mechanical Engineering University of Massachusetts United States Department of Plastic Engineering University of Massachusetts United States

ISBN: (纸本)9781617829604

We report the synthesis of novel polyurea networks produced via organic sol-gel chemistry, through the combination of an aliphatic triisocyanate with amine-functional polyether and poly(ethyleneimine) segments. Network formation is rapid and requires no catalyst. The resultant materials exhibit pH responsive swelling and show compatibility with human cells. As such, these materials have potential utility in cell culture as a means of stabilizing pH and delivering nutrients.

关键词： Cell culture

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Expanded Diameter of Coronary Metal Stent: Simulation and Experiment 2

Expanded Diameter of Coronary Metal Stent: Simulation and Ex...

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2nd International Conference on Bioinformatics, biotechnology and biomedical engineering - Bioinformatics and biomedical engineering, BioMIC 2019

作者： Tontowi, Alva Edy Ramadhani, Ogy Satria Sukiman Dewi, Nurul Aulia Taufiq, Nahar Universitas Gadjah Mada Department of Mechanical and Industrial Engineering Yogyakarta55281 Indonesia Universitas Khairun Department of Mechanical Ternate97719 Indonesia Faculty of Engineering Department of Mechanical and Industrial Engineering Yogyakarta55281 Indonesia Universitas Gadjah Mada Biomedical Engineering Biotechnology Program Study Yogyakarta55281 Indonesia

ISBN: (纸本)9781728147116

Information of expanded-diameter of stent provided by manufacturer is important for cardiologists and required during percutaneous coronary intervention (PCI) procedure. The expanded diameter of the stent is experimentally obtained by inflating a balloon catheter at a certain pressure, from normal to burst pressures. For stent manufacturer view in which stent mass production was taken place, testing of huge number of stent by experiment would be costly and it would be less expensive by simulation. The aims of the present work therefore would investigate the correlation of inflated pressures to expanded diameters which would be done by simulation or numerical and experiment. Numerical work has been performed by software ABAQUS and experiment has been done by using hydraulic inflated device. Stent model was open cell type made of stainless steel 316. The inflated pressures of 0.8, 1.2 and 1.6 MPa were applied to both numerical and experiment works. Results on numerical and experimental show that expanded diameter increases proportionally to the increase of inflated pressures. However, at the inflated pressure of 0.8 MPa, there was significant gap between the outer diameter obtained by numerical and experiment. Numerical result depicted over estimate to that of experiment. The inflated pressure window for having inflated diameter of 4mm to 4.5mm was 0.8 to 1.1 MPa. Although, numerically the stent has been fractured due to the von Mises stress was already over the ultimate stress of the material, in fact there was no evident depicted by SEM image. © 2019 IEEE.

关键词： Stents

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Functionalization of Electrospun Poly (caprolactone) to Achieve Enhanced Cell Attachment

Functionalization of Electrospun Poly (caprolactone) to Achi...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Jassal, Manisha Regis, Shawn M. Bhowmick, Sankha Biomedical Engineering and Biotechnology Program University Of Massachusetts Dartmouth 285 Old Westport Road Dartmouth MA 02747 United States Department of Mechanical Engineering University Of Massachusetts Dartmouth 285 Old Westport Road North Dartmouth MA 02747 United States

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Enhanced light-driven photoelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

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International Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising photocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube photoelectrodes. In this work, it is firstly to fabricate TiO2 nanotube photoelectrodes on acid-etched Ti foils by anodization (MNT) for photoelectrochemical catalyzing water splitting. Different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting photoelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT photoelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the photocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as photocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

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Analysis of Brain Excitability After Transcranial Direct Current Stimulation and Brain-Computer Interface Based on Motor Imagery on a Post-stroke Patient 9th

Analysis of Brain Excitability After Transcranial Direct Cu...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Silva, Leticia Lima, Jéssica Schreider, Sheila Delisle-Rodriguez, Denis Krishnan, Sridhar Bastos-Filho, Teodiano Postgraduate Program in Electrical Engineering Universidade Federal do Espirito Santo Vitoria Brazil Postgraduate Program in Biotechnology Universidade Federal do Espirito Santo Vitoria Brazil Edmond and Lily Safra International Institute of Neurosciences Instituto Santos Dumont Macaiba Brazil Department of Electrical Computer and Biomedical Engineering Toronto Metropolitan University Toronto Canada

ISBN: (纸本)9783031494062

Stroke is a neurological syndrome that may cause severe cognitive and motor impairments for survival. Alternative rehabilitation techniques have been developed to recover lower-limb movements and gait of post-stroke patients, such as Motor Imagery (MI)-based Brain-Computer Interfaces (BCIs), Virtual Reality (VR), and robotic devices. Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique to stimulate the brain and modulate cortical excitability. This study aims to analyze the short-term effects of tDCS compared to sham stimulation before a lower-limb MI-BCI pedaling training (through a robotic monocycle) task in a patient with subacute stroke. We studied a post-stroke patient with 2 months of ischemic stroke and right hemiparesis who was submitted to the following tasks: active pedaling, sham tDCS and MI-BCI, and tDCS and MI-BCI. We evaluated the relative power around the foot area (Cz electrode), and a significant (p-value © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Brain computer interface

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