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Glycoproteomics analysis of plasma proteins associated with Opisthorchis viverrini infection-induced cholangiocarcinoma in hamster model

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1142-1147页

作者： Pramote Sriwanitchrak Atchara Paemanee Sittiruk Roytrakul Vithoon Viyanant Kesara Na-Bangchang Graduate Program in Biomedical Sciences Faculty of Allied Health SciencesThammasat University Proteomics Research Laboratory National Center for Genetic Engineering and Biotechnology Graduate Program in Bioclinical Sciences Center of Excellence in Pharmacology and Molecular Biology of Malaria and CholangiocarcinomaChulabhorn International College of Medicine Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma Chulabhorn International College of Medicine Excellence Center in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma Thammasat University

Objective: To apply lectin affinity chromatography and glycoproteomics-based LC-MS/MS to preliminarily investigate the possible potential plasma biomarkers of Opisthorchis viverrini(OV)-associated CCA in OV/dimethylnitrosamine(DMN)-induced CCA hamster model. Methods: Nine Syrian hamsters were divided into 3 groups as follows(n=3 each): normal(healthy control group); OV group; and OV/DMN group(CCA group). Pooled plasma samples collected from animals in each group at the 6th month post-infection with OV metacercarae were subjected to glycoproteomics analysis. Glycoproteins in the pooled sample from each group were initially isolated by concanavilin A(Con A)-based affinity chromatography. The expression of glycoproteins isolated by both enrichment methods were determined using LCMS/MS. Results: Among the 24 Con A-binding glycoproteins isolated, two proteins, N-myc downstream regulated gene 1(NDRG1) and fetuin-B(FETUB) were found up-regulated only in the samples from the OV and control groups, but not in the OV/DMN(CCA) groups. On the other hand, one protein, i.e., NSFL1 cofactor p47 isoform x3(NSFL1C) was found only in the samples from OV/DMN(CCA) and control groups, but not in the OV group. The remaining 21 proteins were upregulated in the samples from all groups. Conclusions: NDRG1, FETUB and NSFL1 C glycoproteins isolated by Con A-based affinity chromatography could be potential biomarkers for CCA. Plasma samples with negative for NDRG1 and FETUB proteins but positive for NSFL1 C are likely to be OV-associated CCA. Nevertheless, this conclusion remains to be confirmed whether this battery test can discriminate OV-associated CCA from other risk factors.

关键词： Cholangiocarcinoma Opisthorchis viverrini Glycoprotein Hamster model ConA binding protein LC-MS/MS

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Heterojunction and co-catalyst engineering of bismuth vanadate by nickel molybdenum oxide and carbon quantum dot decorations for photoelectrochemical water splitting

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International Journal of Hydrogen Energy 2024年 51卷 1099-1108页

作者： Kuo, Tsung-Rong Chiou, Yu-Tai Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Improving the charge diffusion length and water oxidation kinetics of bismuth vanadate (BiVO4) is essential to achieve better photoelectrochemical catalytic ability for water oxidation. Establishing heterojunctions and incorporating co-catalysts with BiVO4 create facile charge transfer paths and generate more water oxidation reactions. In this work, nickel molybdenum oxide (NM) and carbon quantum dot (CQD) are firstly deposited on BiVO4 by hydrothermal and soaking processes to design an efficient co-catalyst/photocatalyst system for water oxidation. The depositing amount of CQD is optimized to balance contributions of CQD and NM as the hole sink and the light-to-electron generator, respectively. The highest photocurrent densities of 2.2 and 3.9 mA/cm2 are achieved for BiVO4/NM/CQD in the electrolyte without and with hole scavenger, respectively. The BiVO4 electrode only shows a photocurrent density of 1.2 mA/cm2 in the electrolyte without hole scavenger. The best photoelectrochemical catalytic ability of BiVO4/NM/CQD is approached by the reduced charge-transfer resistance and charge recombination as well as the enhancement on carrier densities. The excellent long-term stability with the photocurrent retention of 90% under illumination for 24 h is also obtained for BiVO4/NM/CQD. This study opens a blueprint on designing efficient catalysts for water oxidation by incorporating heterojunction and co-catalyst materials simultaneously. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Efficiently catalyzing photo-oxidation of water by surface engineering of bismuth vanadate with nickel molybdenum oxide coverages

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International Journal of Hydrogen Energy 2024年 51卷 613-622页

作者： Kuo, Tsung-Rong Huang, Hsiao-Wen Kongvarhodom, Chutima Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Bismuth vanadate with suitable band edges is one of the efficient photocatalysts for water oxidation. Establishing heterojunction can improve electron diffusion lengths and photocatalytic ability of BiVO4. In this work, nickel molybdenum oxide (Ni–Mo–O) and BiVO4 heterojunction is established by the hydrothermal process with different nickel to molybdenum precursor ratios. The Ni–Mo–O/BiVO4 electrode is applied as photoanodes for water oxidation. The growth mechanism of Ni–Mo–O on BiVO4 surface is proposed. The Ni–Mo–O deposition amount is optimized regarding to light absorbance and charger transportation. The largest photocurrent density of 1.72 mA/cm2 at 1.23 VRHE is obtained for the optimal NiMoO4/BiVO4 electrode (NM12) in the electrolyte without hole scavenger, while the pure BiVO4 electrode only shows a photocurrent density of 0.90 mA/cm2. The NM12 electrode even presented an impressive photocurrent density of 5.39 mA/cm2 at 1.23 VRHE in the electrolyte with the hole scavenger, owing to the abundant active sites and higher light absorbance as well as the favorable synergistic effects from its suitable Ni to Mo ratio. The NM12 electrode also shows excellent long-term stability with the photocurrent retention of 83% after illumination for 6500 s. This work opens a blueprint for establishing a novel heterojunction with the adjustable metal ratio and coverage on BiVO4. © 2023 Hydrogen Energy Publications LLC

关键词： Heterojunctions

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Coronary heart diseases prediction based on cardiology clinical features 5

Coronary heart diseases prediction based on cardiology clini...

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5th IEEE International Conference on Big Data Intelligence and Computing, DataCom 2019

作者： Yang, Cheng-Hong Chuang, Li-Yeh Chang, Po-Yin National Kaohsiung University of Science and Technology Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Dept. of Electronic Engineering Kaohsiung Taiwan I-Shou University Dept. of Chemical Engineering Institute of Biotechnology and Chemical Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Dept. of Electronic Engineering Kaohsiung Taiwan

ISBN: (纸本)9781728141176

The development of modern health systems has generated a large amount of medical data. Recent research has shown that data mining technology can discover potential patterns from a vast array of medical data, providing insight into disease and predicting disease. Coronary heart disease (CHD) is one of the most important research topics in the health field. In recent years, research on CHD has been extensively studied;however, the accuracy of CHD prediction needs to be improved. Here, a hybrid prediction method BOSVM combining Bayesian optimization (BO) and support vector machine (SVM) is proposed to predict the CHD. In BOSVM, BO aims to adjust of SVM parameters for enhancing the accuracy of CHD prediction. BOSVM compares performance of CHD prediction with five forecasting algorithms, including classification and regression tree, logistic regression, k-nearest neighbors, AdaBoost, and SVM. The experimental results show that the BOSVM has superior prediction accuracy than other algorithms in CHD prediction, indicating BOSVM can effectively predict CHD. © 2019 IEEE.

关键词： Support vector regression

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Oxygen generating scaffolds regenerate critical size bone defects

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Bioactive Materials 2022年第7期7卷 64-81页

作者： Sanika Suvarnapathaki Xinchen Wu Tengfei Zhang Michelle A.Nguyen Anastasia A.Goulopoulos Bin Wu Gulden Camci-Unal Biomedical Engineering and Biotechnology Program University of Massachusetts LowellOne University AvenueLowellMA01854USA Department of Chemical Engineering University of Massachusetts LowellOne University AvenueLowellMA01854USA Department of Neurosurgery Sanbo Brain HospitalCapital Medicine UniversityBeijing100069China Department of Surgery University of Massachusetts Medical School55 Lake Avenue NorthWorcesterMA01605USA

Recent innovations in bone tissue engineering have introduced biomaterials that generate oxygen to substitute *** strategy provides the immediate oxygen required for tissue viability and graft *** we demonstrate a novel oxygen-generating tissue scaffold with predictable oxygen release kinetics and modular material *** hydrogel scaffolds were reinforced with microparticles comprised of emulsified calcium peroxide(CaO_(2))within polycaprolactone(PCL).The alterations of the assembled materials produced constructs within 5±0.81 kPa to 34±0.9 kPa in mechanical *** mass swelling ratios varied between 11%and 25%.Our in vitro and in vivo results revealed consistent tissue viability,metabolic activity,and osteogenic differentiation over two *** optimized in vitro cell culture system remained stable at pH *** in vivo rodent models demonstrated that these scaffolds support a 70 mm^(3) bone volume that was comparable to the native bone and yielded over 90%regeneration in critical size cranial ***,the in vivo bone remodeling and vascularization results were validated by tartrate-resistant acid phosphatase(TRAP)and vascular endothelial growth factor(VEGF)*** promising results of this work are translatable to a repertoire of regenerative medicine applications including advancement and expansion of bone substitutes and disease models.

关键词： Bone Cranial regeneration Critical size defect Oxygen Calcium peroxide

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Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides

Effect of the electrostatic potential on the internalization...

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2011 AIChE Annual Meeting, 11AIChE

作者： Flores, Karen A. Salgado, J. Cristian Zapata-Torres, Gerald Gerdtzen, Ziomara P. Gonzalez, María-Julieta Hermoso, Marcela A. Laboratory of Process Modeling and Distributed Computing Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Millennium Institute for Cell Dynamics and Biotechnology Centre for Systems Biology University of Chile Santiago Chile Department of Inorganic and Analytical Chemistry Faculty of Chemical and Pharmaceutical Sciences University of Chile Santiago Chile Centre for Biochemical Engineering and Biotechnology Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Laboratory of Cell Biology Cell and Molecular Program Faculty of Medicine University of Chile Santiago Chile Laboratory of Innate Immunology Institute of Biomedical Sciences University of Chile Santiago Chile

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Corrigendum to “Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device” [J. Energy Storage 80 (2024) 110316]

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Journal of Energy Storage 2025年 108卷

作者： Chuan-Chih Hsu You Zher Yu Chung-Hsien Wu Pin-Yan Lee Hung-Ming Chen Sadang Husain Chutima Kongvarhodom Yu-Cheng Hsiao Lu-Yin Lin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei 11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin 70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok 10140 Thailand Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei 11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA 94305-5428 USA Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

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Generation of high aspect-ratio pdms microfibers for 3D myelination culture of schwann cells 23

Generation of high aspect-ratio pdms microfibers for 3D myel...

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Lin, Hui-Ying Chiu, Ing-Ming Wang, Horng-Dar Hsu, Chia-Hsien Graduate Program of Biotechnology in Medicine NTHU NHRI Department of Life Sciences National Tsing Hua University Hsinchu Taiwan Institute of Biomedical Engineering and Nanomedicine NHRI Miaoli Taiwan Institute of Cellular and Systems Medicine National Health Research Institutes Miaoli Taiwan

ISBN: (纸本)9781733419000

We report a new approach to generate synthetic axons for in-vitro myelination culture of Schwann cells using high aspect-ratio (HAR) PDMS microfibers. In our approach, a microdevice containing ordered no-crossing suspended PDMS micropillars was first fabricated by using softlithography technique. Next, by applying a mechanical force to the device, the PDMS micropillars can be elongated to become microfibers > 100 um long with small diameters ( © 2019 CBMS-0001.

关键词： Aspect ratio

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12-week treadmill exercise program elicits lower energy availability without changes in serum testosterone in male rats

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Sport Sciences for Health 2018年第3期14卷 537-545页

作者： Clark, Lyra R. Dellogono, Michael J. Chenette, Erin E. Mangano, Kelsey M. Wilson, Thomas A. Biomedical Engineering and Biotechnology Doctoral Program University of Massachusetts Lowell Lowell MA United States Physical Therapy Doctoral Program Department of Physical Therapy University of Massachusetts Lowell Lowell MA United States Department of Biomedical and Nutritional Sciences University of Massachusetts Lowell 3 Solomont Way Suite 4 Lowell 01854-5124 MA United States Institute for Aging Research Hebrew SeniorLife Harvard Medical School Affiliate Boston MA United States

Purpose: The purpose of this study was to investigate whether a treadmill endurance exercise program would reduce serum testosterone and leptin in male rats and assess the impact of increased dietary cholesterol on serum hormones. Methods: Male Sprague-Dawley Rats (n = 20) were randomly assigned to a control group (C) or an exercise training group (EX) that performed treadmill running 40 min/day, 6 days/week for 12 weeks. At study midpoint (week 6), rats were randomized to a high-cholesterol (HC) diet (n = 10) or remain on standard semi-purified (LC) diet (n = 10). Results: Results are presented as median [IQR]. At end of week 6, EX + LC had significantly lower body weight (508 [460–527] vs 570 [516–606] g;p = 0.01), mean daily energy intake (76.3 [74.9–82.2] vs 90.9 [86.9–94.5] kcal;p < 0.01), and serum leptin (0.4 [0.3–0.6] vs 3.3 [2.0–4.0] ng/mL;p < 0.01) in comparison to C + LC. No difference was observed between EX + LC and C + LC in serum testosterone (12.6 [6.9–18.3] vs 11.7 [7.6–18.9] ng/mL). At end of week 12, EX + LC had significantly lower body weight (514 [483–568] g) compared to C + LC (644 [575–680] g;p < 0.01) and C + HC (650 [583–702] g;p < 0.01). Serum Leptin in both EX + LC (0.6 [0.2–0.8] ng/mL) and EX + HC (0.6 [0.3–1.6] ng/mL) was significantly lower than C + LC (3.0 [2.2–4.2] ng/mL;p < 0.01). No significant difference in testosterone was observed between C + LC and C + HC (4.3 [3.3–8.3] vs 6.3 [3.2–9.3] ng/mL, respectively). Conclusions: Despite lower energy availability, exercise-induced changes in sex hormones may not occur in training programs ≤ 12 weeks. Lower voluntary energy intake observed in exercise groups despite greater energy expenditure may indicate that lower energy availability in endurance-trained individuals may be inadvertent. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.

关键词： Cholesterol Endurance training Leptin Running Testosterone

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Systematic designs of single metal compounds synthesized using ammonia fluoride-based complex as structure directing agents for energy storage

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Journal of Colloid and Interface Science 2023年第PartA期652卷 294-304页

作者： Kuo, Tsung-Rong Zher Yu, You Wu, Chung-Hsien Lee, Pin-Yan Kongvarhodom, Chutima Chen, Hung-Ming Husain, Sadang Yougbaré, Sibidou Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso

Tailoring morphology and composition of metal organic frameworks (MOF) can improve energy storage by establishing high surface area, large porosity and multiple redox states. Structure directing agents (SDA) is functional of designing surface properties of electroactive materials. Ammonium fluoride has functional abilities for designing MOF derivatives with excellent energy storage abilities. Systematic design of MOF derivatives using ammonia fluoride-based complex as SDA can essentially create efficient electroactive materials. Metal species can also play significant roles on redox reactions, which are the main energy storage mechanism for battery-type electrodes. In this work, 2-methylimidazole, two novel SDAs of NH4BF4 and NH4HF2, and six metal species of Al, Mn, Co, Ni, Cu and Zn are coupled to synthesize MOF derivatives for energy storage. Metal species-dependent compositions including hydroxides, oxides, and hydroxide nitrates are observed. The nickel-based derivative (Ni-HBF) shows the highest specific capacitance (CF) of 698.0F/g at 20 mV/s, due to multiple redox states and advanced flower-like surface properties. The diffusion and capacitive-control contributions of MOF derivatives are also analyzed. The battery supercapacitor hybrid with Ni-HBF electrode shows a maximum energy density of 27.9 Wh/kg at 325 W/kg. The CF retention of 170.9% and Coulombic efficiency of 93.2% are achieved after 10,000 cycles. © 2023 Elsevier Inc.

关键词： Supercapacitor

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