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Mitochondrial Activation via Calcium Peroxide/Carrageenan/Soybean Lecithin-Derived Polypyrrole Phototherapeutic Microparticles

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Colloids and Surfaces B: Biointerfaces 2025年

作者： Sih-Chi Chuang Shih-An Yu Pei-Chia Hung Andrew E.-Y. Chuang Jia-Wei Liang Chia-Lu Sun Lekshmi Rethi Hsu-Wei Fang Hieu Trung Nguyen Yao-Tung Tsai Pei-Wei Weng Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 10608 Taiwan Taipei Medical University Derived Company-Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan WELLCARE Health Care Supply Co. Ltd. Taipei Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh city Ho Chi Minh City 700000 Viet Nam Department of Orthopaedic Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist. Taipei City 11490 Taiwan Division of Traumatology Department of Surgery Tri-Service General Hospital National Defense Medical Center No. 325 Sec. 2 Chenggong Rd. Neihu Dist Taipei City 11490 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan； Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City 11031 Taiwan

Mitochondria, often referred to as the "powerhouses" of eukaryotic cells, play a critical role in maintaining cellular homeostasis and supporting essential life functions, particularly in cell survival and apoptosis. This study introduces a composite formulation—combining carrageenan (Car), calcium peroxide (CaO 2 ), and microparticles, derived from soybean oil lecithin, enhanced with photothermally active polypyrrole (PPy)—to create Car-Lec-PPy MP, aimed at promoting mitochondrial activation in cells. The investigation focuses on intercellular mitochondrial transfer and activation as a therapeutic strategy. The formulation seeks to stimulate mitochondrial biogenesis and enhance cellular resilience through targeted mitochondrial activation, leveraging the synergistic effects of near-infrared (NIR) therapy. In the in vivo experiment, phototherapeutic Car-Lec-PPy MP was administered to rodent muscle tissue. The results showed increased expression of heat-shock proteins and reduced oxidative stress in the treated muscle. Preliminary findings suggest that this approach not only boosts mitochondrial activity but also improves cell proliferation and survival, presenting significant potential for applications in regenerative medicine and cellular therapy.

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A high throughput approach to examine biological oxidative damage elicited by multiple classes of engineered nanomaterials

A high throughput approach to examine biological oxidative d...

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The 6 th International Conference on Nanotoxicology (第六届国际纳米毒理学会议)

作者： Shu-Feng Hsieh Dhimiter Bello Daniel Schmidt Anoop K Pal Aaron Stella Eugene J.Rogers Department of Work Environment Biotechnology Program University of Massachusetts Lowell MA 01854 Center for High-rate Nanomanufacturing Biotechnology Program University of Massachusetts Lowell MA 01854 Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell MA 01854 Department of Clinical Laboratory and Nutritional Sciences Biotechnology Program University of Massachusetts Lowell MA 01854 Department of Plastics Engineering Biotechnology Program University of Massachusetts Lowell MA 01854 Center for High-rate Nanomanufacturing Biotechnology Program University of Massachusetts Lowell MA 01854 Department of Clinical Laboratory and Nutritional Sciences Biotechnology Program University of Massachusetts Lowell MA 01854 Center for High-rate Nanomanufacturing Biotechnology Program University of Massachusetts Lowell MA 01854 Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell MA 01854 Center for High-rate Nanomanufacturing Biotechnology Program University of Massachusetts Lowell MA 01854 Center for High-rate Nanomanufacturing Biotechnology Program University of Massachusetts Lowell MA 01854

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Physico-chemical analysis of herbally prepared silver nanoparticles and its potential as a drug bioenhancer

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OpenNano 2017年 2卷 19-27页

作者： Mukkavalli, Sirisha Chalivendra, Vijay Singh, Bal Ram Biomedical Engineering and Biotechnology Program University of Massachusetts Dartmouth Dartmouth 02747 MA United States Department of Mechanical Engineering University of Massachusetts Dartmouth Dartmouth 02747 MA United States School of Indic Studies and Botulinum Research Center Institute of Advanced Sciences 86-410B Faunce Corner Mall Road Dartmouth 02747 MA United States

In order to exhibit its potential benefits, a drug must cross the epithelial barrier of the intestinal mucosa for transportation into systemic circulation. Several approaches have been proposed to overcome these barriers, including enhancing drug potency through the use of bioenhancers. The concurrent application of bio-enhancers with pharmaceuticals is not a new development, but has been used for thousands of years. The traditional medical system used in India (Ayurveda) has utilized formulations including metal powders (bhasma) to treat a large number of health issues. However, without the support of modern science, these methodologies are largely ignored throughout the western world. Recent studies have begun to examine not only structure and compositional studies but also studies targeted at understanding the mode of action of these materials. Preliminary studies carried out below indicate the potential of these powders to act as non-reactive bio-enhancer for drug delivery. © 2017 The Authors

关键词： Bhasma Bioenhancer Drug Nanoparticles Silver

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Low intensity mechanical signals promote proliferation in a cell-specific manner:Tailoring a non-drug strategy to enhance biomanufacturing yields

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Mechanobiology in Medicine 2024年第4期2卷 59-68页

作者： M.Ete Chan Christopher Ashdown Lia Strait Sishir Pasumarthy Abdullah Hassan Steven Crimarco Chanpreet Singh Vihitaben S.Patel Gabriel Pagnotti Omor Khan Gunes Uzer Clinton T.Rubin Department of Biomedical Engineering College of Engineering and Applied SciencesRenaissance School of MedicineStony Brook UniversityStony BrookNY11794-5280USA Medical Scientist Training Program Renaissance School of MedicineStony Brook UniversityStony BrookNY11794USA Department of Endocrine Neoplasia and Hormonal Disorders MD Anderson Cancer CenterHoustonTX77030USA Department of Mechanical and Biomedical Engineering College of EngineeringBoise State UniversityBoiseID83725-205USA Center for Biotechnology New York State Center for Advanced Technology in Medical BiotechnologyStony Brook UniversityStony BrookNY11794-5281USA

Biomanufacturing relies on living cells to produce biotechnology-based therapeutics,tissue engineering constructs,vaccines,and a vast range of agricultural and industrial *** the escalating demand for these bio-based products,any process that could improve yields and shorten outcome timelines by accelerating cell proliferation would have a significant impact across the *** these goals are primarily achieved using biological or chemical strategies,harnessing cell mechanosensitivity represents a promising–albeit less studied–physical pathway to promote bioprocessing endpoints,yet identifying which mechanical parameters influence cell activities has remained *** tested the hypothesis that mechanical signals,delivered non-invasively using low-intensity vibration(LIV;<1 g,10–500 Hz),will enhance cell expansion,and determined that any unique signal configuration was not equally influential across a range of cell *** frequency,intensity,duration,refractory period,and daily doses of LIV increased proliferation in Chinese Hamster Ovary(CHO)-adherent cells(t79%in 96 hr)using a particular set of LIV parameters(0.2 g,500 Hz,3-30 min/d,2 hr refractory period),yet this same mechanical input suppressed proliferation in CHO-suspension cells(-13%).Another set of LIV parameters(30 Hz,0.7 g,2-60 min/d,2 hr refractory period)however,were able to increase the proliferation of CHO-suspension cells by 210%and T-cells by 20.3%.Importantly,we also reported that T-cell response to LIV was in-part dependent upon AKT phosphorylation,as inhibiting AKT phosphorylation reduced the proliferative effect of LIV by over 60%,suggesting that suspension cells utilize mechanism(s)similar to adherent cells to sense specific LIV *** image velocimetry combined with finite element modeling showed high transmissibility of these signals across fluids(>90%),and LIV effectively scaled up to T75 ***,when LIV is tailored to the target cell populati

关键词： Biomanufacturing Cell proliferation Mechanical stimulation Biomechanics Adherent cells Suspension cells Stem cells Vibration

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Functional Peptide-Loaded Gelatin Nanoparticles as Eyedrops for Cornea Neovascularization Treatment

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International Journal of Nanomedicine 2023年 18卷 1413-1431页

作者： Chu, Ya-Chun Fang, Hsu-Wei Wu, Yu-Yi Tang, Yu-Jun Hsieh, Erh-Hsuan She, Yizhou Chang, Che-Yi Lin, I-Chan Chen, Yin-Ju Liu, Guei-Sheung Tseng, Ching-Li Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei City Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Department of Ophthalmology Wan Fang Hospital Taipei Medical University Taipei City Taiwan Department of Ophthalmology School of Medicine College of Medicine Taipei Medical University Taipei City Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei City Taiwan Center for Precision Medicine and Translational Cancer Research Taipei Medical University Hospital Taipei City Taiwan Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital East Melbourne VIC Australia Ophthalmology Department of Surgery University of Melbourne East Melbourne VIC Australia Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei City Taiwan

Background: Corneal neovascularization (NV) is a process of abnormal vessel growth into the transparent cornea from the limbus and can disturb the light passing through the cornea, resulting in vision loss or even blindness. The use of nanomedicine as an effective therapeutic formulation in ophthalmology has led to higher drug bioavailability and a slow drug release rate. In this research, we designed and explored the feasibility of a new nanomedicine, gp91 ds-tat (gp91) peptide-encapsulated gelatin nanoparticles (GNP-gp91), for inhibiting corneal angiogenesis. Methods: GNP-gp91 were prepared by a two-step desolvation method. The characterization and cytocompatibility of GNP-gp91 were analyzed. The inhibition effect of GNP-gp91 on HUVEC cell migration and tube formation was observed by an inverted microscope. The drug retention test in mouse cornea was observed by in vivo imaging system, fluorescence microscope, and DAPI/TAMRA staining. Finally, the therapeutic efficacy and evaluation of neovascularization-related factors were conducted through the in vivo corneal NV mice model via topical delivery. Results: The prepared GNP-gp91 had a nano-scale diameter (550.6 nm) with positive charge (21.7 mV) slow-release behavior (25%, 240hr). In vitro test revealed that GNP-gp91 enhanced the inhibition of cell migration and tube formation capacity via higher internalization of HUVEC. Topical administration (eyedrops) of the GNP-gp91 significantly prolongs the retention time (46%, 20 min) in the mouse cornea. In chemically burned corneal neovascularization models, corneal vessel area with a significant reduction in GNP-gp91 group (7.89%) was revealed when compared with PBS (33.99%) and gp91 (19.67%) treated groups via every two days dosing. Moreover, GNP-gp91 significantly reduced the concentration of Nox2, VEGF and MMP9 in NV’s cornea. Conclusion: The nanomedicine, GNP-gp91, was successfully synthesized for ophthalmological application. These data suggest that GNP-gp91 contain

关键词： control release corneal neovascularization eye drops gelatin gp91 peptide nanoparticles ocular retention

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Chronic Supplementation with L-Isoleucine Alone or in Combination with Exercise Reduces Hepatic Cholesterol Levels with No Effect on Serum Glucose, Insulin, or Lipids in Rats Fed a High Fructose Diet

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Food and Nutrition Sciences 2023年第5期14卷 480-493页

作者： Michael Dellogono Lyra Clark Cynthia Ferrara Mahdi Garelnabi Thomas A. Wilson Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA USA Department of Health Sciences Merrimack College North Andover MA USA Department of Biomedical and Nutritional Sciences University of Massachusetts Lowell Lowell MA USA

The thought of using branched-chain amino acids (BCAA) in the prevention and treatment of certain disorders is becoming increasingly popular. Individual BCAA use has been associated with improving glucose tolerance and liver disease. Previous studies have cited improvements in glucose metabolism with a single dose of L-isoleucine (ILE). However, it is still unclear whether chronic consumption of ILE has any direct benefit. The objective of this study was to examine the influence of chronic ILE supplementation alone or in combination with exercise on fasting serum glucose, insulin, lipids, and lipoprotein cholesterol levels;glucose tolerance;and hepatic lipids in rats. Male Sprague-Dawley rats (n = 40) were divided into Control (low fructose diet);High Fructose diet (HF);HF plus 1.5% ILE (HF + ILE);HF plus exercise (HF + EX);and HF plus 1.5% ILE and exercise (HF + ILE + EX). The HF diets consisted of 70% kcalories from fructose. After 6 weeks of treatment, no significant differences were observed between groups for changes in fasting serum glucose, insulin, lipids, or lipoprotein cholesterol levels. However, hepatic total cholesterol was significantly lower in the HF + ILE + EX compared to the Control and HF, while, the HF + ILE had significantly lower hepatic free cholesterol compared to the HF. We also found no differences between groups for serum glucose response following an oral glucose tolerance test. In conclusion, our study shows that ILE supplementation in rats does not influence serum glucose and lipid biomarkers but may have an influence on lipid metabolic pathways within the liver.

关键词： Isoleucine Branched-Chain Amino Acids Glucose Tolerance Insulin Cholesterol Lipids

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Discovering nanoparticle corona ligands for liver macrophage capture

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Nature Nanotechnology 2025年 1-12页

作者： Bram Bussin Marshall G. G. MacDuff Sara Ahmed Wayne Ngo Jamie L. Y. Wu Zachary P. Lin Benjamin Stordy Zahra Sepahi Jason Moffat Warren C. W. Chan Adrian Granda Farias Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario Canada Institute of Biomedical Engineering University of Toronto Toronto Ontario Canada Terrence Donnelly Centre for Cellular and Biomolecular Research University of Toronto Toronto Ontario Canada Department of Molecular Genetics University of Toronto Toronto Ontario Canada MD/PhD Program University of Toronto Toronto Ontario Canada Gladstone Institutes San Francisco CA USA California Institute for Quantitative Biosciences University of California Berkeley Berkeley CA USA Innovative Genomics Institute University of California Berkeley Berkeley CA USA Program in Genetics and Genome Biology The Hospital for Sick Children Toronto Ontario Canada School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore Singapore

Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. Serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here we use a multi-omics strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors. We discovered six absorbed serum proteins that bind to two liver macrophage receptors. Nanoparticle physicochemical properties can affect the degree of the six serum proteins adsorbing to the surface, the probability of binding to cell receptors and whether the liver removes the nanoparticle from circulation. Identifying the six adsorbed proteins allowed us to engineer decoy nanoparticles that prime the liver to take up fewer therapeutic nanoparticles, enabling more nanoparticles for targeting extrahepatic tissues. Elucidating the molecular interactions governing the nanoparticle journey in vivo will enable us to control nanoparticle delivery to diseased tissues.

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Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes

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Microsystems & Nanoengineering 2020年第1期6卷 494-506页

作者： Ashley A.Chapin Pradeep R.Rajasekaran David N.Quan Liangbing Hu Jens Herberholz William E.Bentley Reza Ghodssi Fischell Department of Bioengineering College ParkMD 20742USA Institute for Systems Research College ParkMD 20740USA Department of Materials Science and Engineering College ParkMD 20740USA Department of Psychology and Neuroscience and Cognitive Science Program College ParkMD 20740USA Institute for Bioscience and Biotechnology Research RockvilleMD 20850USA Robert E.Fischell Institute for Biomedical Devices RockvilleMD 20850USA Department of Electrical and Computer Engineering College ParkMD 20742USA

Gut–brain axis(GBA)communication relies on serotonin(5-HT)signaling between the gut epithelium and the peripheral nervous system,where 5-HT release patterns from the basolateral(i.e.,bottom)side of the epithelium activate nerve *** have been few quantitative studies of this gut-neuron signaling due to a lack of real-time measurement tools that can access the basolateral gut *** vitro platforms allow quantitative studies of cultured gut tissue,but they mainly employ offline and endpoint assays that cannot resolve dynamic molecular-release ***,we present the modification of a microporous cell culture membrane with carbon nanotube-coated gold(Au-CNT)electrodes capable of continuous,label-free,and direct detection of 5-HT at physiological *** characterization of single-walled carbon nanotube(SWCNT)-coated Au electrodes shows increased electroactive surface area,5-HT specificity,sensitivity,and saturation time,which are correlated with the CNT film drop-cast *** microliters of CNT films,with a 10-min saturation time,0.6μA/μM 5-HT sensitivity,and reliable detection within a linear range of 500 nM–10μM 5-HT,can be targeted for high-concentration,high-time-resolution 5-HT *** films(12.5μL)with a 2-h saturation time,4.5μA/μM 5-HT sensitivity,and quantitative detection in the linear range of 100 nM–1μM can target low concentrations with low time *** electrodes achieved continuous detection of dynamic diffusion across the porous membrane,mimicking basolateral 5-HT release from cells,and detection of cell-released 5-HT from separately cultured RIN14B cell ***-integrated cell culture systems such as this can improve in vitro molecular detection mechanisms and aid in quantitative GBA signaling studies.

关键词： release saturation dynamic

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Analysis of phosphorylation sites on autophagy proteins

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Protein & Cell 2015年第9期6卷 698-701页

作者： Wenzhi Feng Wenhao Zhang Hui Wang Lili Ma Di Miao Zexian Liu Yu Xue Haiteng Deng Li Yu PTN Program College of Life SciencePeking UniversityBeijing100871China Center for Biomedical Analysis Medical SchoolTsinghua UniversityBeijing100084China Key Laboratory of Cardiovascular Remodeling and Function Research Department of CardiologyQilu Hospital of Shandong UniversityJinan250012China Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University–Peking University Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing100084China

Autophagy is a lysosome-based degradation pathway,characterized by formation of a double-membrane vesicle named the *** autophagy,various cargos are engulfed and delivered to lysosomes(or the vacuole in yeast)for *** is an evolutionarily conserved pathway and plays important roles in various physiological and pathological conditions such as develop-ment,immunity,cancer and neuronal degeneration(Jiang and Mizushima,2014;Martin et al.,2014).

关键词：蛋白磷酸化自噬位点分析降解途径溶酶体双层膜液泡进化

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Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis

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Environmental Toxicology 2024年第6期39卷 3356-3366页

作者： Kuo, Min-Yung Dai, Wen-Chyi Chang, Jie-Li Chang, Jo-Shu Lee, Tse-Min Chang, Chia-Che Pediatric Surgery Division Department of Surgery Tungs' Taichung MetroHarbor Hospital Taichung Taiwan Doctoral Program in Biotechnology Industrial Innovation and Management National Chung Hsing University Taichung Taiwan Taichung Municipal Taichung First Senior High School Taichung Taiwan Department of Chemical and Materials Engineering Research Center for Smart Sustainable Circular Economy Tunghai University Taichung Taiwan Department of Life Sciences National Chung Hsing University Taichung Taiwan Department of Marine Biotechnology and Resources National Sun Yat-sen University Kaohsiung Taiwan Graduate Institute of Biomedical Sciences Master Program in Precision Health Doctoral Program in Translational Medicine Rong Hsing Research Center for Translational Medicine The iEGG and Animal Biotechnology Research Center National Chung Hsing University Taichung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Department of Medical Research China Medical University Hospital Taichung Taiwan Traditional Herbal Medicine Research Center Taipei Medical University Hospital Taipei Taiwan

Melanoma is the most lethal skin malignancy. Fucoxanthin is a marine carotenoid with significant anticancer activities. Intriguingly, Fucoxanthin's impact on human melanoma remains elusive. Signal Transducer and Activator of Transcription 3 (STAT3) represents a promising target in cancer therapy due to its persistent activation in various cancers, including melanoma. Herein, we revealed that Fucoxanthin is cytotoxic to human melanoma cell lines A2758 and A375 while showing limited cytotoxicity to normal human melanocytes. Apoptosis is a primary reason for Fucoxanthin's melanoma cytotoxicity, as the pan-caspase inhibitor z-VAD-fmk drastically abrogated Fucoxanthin-elicited clonogenicity blockage. Besides, Fucoxanthin downregulated tyrosine 705-phosphorylated STAT3 (p-STAT3 (Y705)), either inherently present in melanoma cells or inducible by interleukin 6 (IL-6) stimulation. Notably, ectopic expression of STAT3-C, a dominant-active STAT3 mutant, abolished Fucoxanthin-elicited melanoma cell apoptosis and clonogenicity inhibition, supporting the pivotal role of STAT3 blockage in Fucoxanthin's melanoma cytotoxicity. Moreover, Fucoxanthin lowered BCL-xL levels by blocking STAT3 activation, while ectopic BCL-xL expression rescued melanoma cells from Fucoxanthin-induced killing. Lastly, Fucoxanthin was found to diminish the levels of JAK2 with dual phosphorylation at tyrosine residues 1007 and 1008 in melanoma cells, suggesting that Fucoxanthin impairs STAT3 signaling by blocking JAK2 activation. Collectively, we present the first evidence that Fucoxanthin is cytotoxic selectively against human melanoma cells while sparing normal melanocytes. Mechanistically, Fucoxanthin targets the JAK2/STAT3/BCL-xL antiapoptotic axis to provoke melanoma cell death. This discovery implicates the potential application of Fucoxanthin as a chemopreventive or therapeutic strategy for melanoma management. © 2024 Wiley Periodicals LLC.

关键词： Carotenoids

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