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The journal of liquid biopsy 2025年 7卷 100290页

作者： Huei-Ying Li Chun-Chuan Chang Yu-Hsuan Yang Chi-Yuan Yao Jason Chia-Hsun Hsieh Shao-Hsuan Chang Medical Microbiota Center of the First Core Laboratory National Taiwan University Taipei Taiwan. Professional Master's Program of Biotechnology Management National Taiwan University Taipei Taiwan. Graduate Institute of Medical Genomics and Proteomics National Taiwan University Taipei Taiwan. Department of Laboratory Medicine National Taiwan University Hospital Taipei Taiwan. Division of Oncology Department of Internal Medicine Linkou Chang Gung Memorial Hospital Taoyuan Taiwan. College of Medicine Chang Gung University Taoyuan Taiwan. Department of Biomedical Engineering Chang Gung University Taoyuan Taiwan.

Objective:Liquid biopsy is a promising, non-invasive diagnostic tool for cancer, offering rapid and cost-effective genomic analysis. It provides a less invasive alternative to traditional tissue biopsies, with potential benefits in monitoring disease progression and detecting minimal residual disease (MRD). However, its clinical integration faces challenges, including utility assessment and workflow adaptation. This study evaluates the value of liquid biopsy in Taiwan from a clinical physician's perspective. Methods:A survey was conducted with 16 physicians specializing in thoracic medicine and hematologic oncology. Participants responded to a 5-point Likert scale to evaluate the timing of liquid biopsy adoption, willingness to incorporate it into clinical practice, and agreement on its role in managing specific clinical conditions. Results:Forty percent of physicians preferred liquid biopsy when tissue samples were unavailable. The inclusion of liquid biopsy under National Health Insurance (NHI) was a key factor in its adoption. Hematologic oncologists showed a stronger preference for liquid biopsy, particularly for MRD testing, compared to their counterparts in thoracic medicine (hematologic oncology vs. thoracic medicine: 4.2 ± 0.83 vs. 3.1 ± 0.60; p value = 0.01). Younger physicians valued turnaround time, while senior physicians prioritized test brand, with a focus on report speed. Conclusion:Physicians are generally less inclined to replace tissue biopsies with liquid biopsy, but hematologic oncologists show more flexibility. Test brand plays a role in physician decision-making, and the inclusion of liquid biopsy under NHI coverage is vital for its broader adoption in Taiwan.

关键词： Cancer diagnosis Clinical adoption Liquid biopsy Minimal residual disease (MRD) National health insurance

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Facile synthesis of copper cobalt sulfide and nickel hydroxide tube-like composites as battery-type active material of energy storage devices

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Journal of Energy Storage 2023年 65卷

作者： Kuo, Tsung-Rong Fitriannisa, Istikhori Chung, Ren-Jei Lin, Kuan-Hsien Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Bimetallic sulfide has attracted much attentions as efficient electroactive materials of battery supercapacitor hybrid (BSH), because of numerous redox states, high conductivity and good energy efficiency. Developing composites having excellent chemical and electrochemical properties is necessary to enhance the energy storage features of bimetallic sulfides. In this study, CuCo2S4 and Ni(OH)2 composites (CuCo2S4@Ni(OH)2) are designed on Ni foam via the facial hydrothermal process and chemical bath deposition as the electroactive material of BSH at first time. Effects of Ni(OH)2 amounts on CuCo2S4 on electrochemical and physical properties of CuCo2S4@Ni(OH)2 are investigated. The physical mixed CuCo2S4 and Ni(OH)2 composite is also fabricated to verify synergistic effects of CuCo2S4@Ni(OH)2. A higher specific capacitance (CF) of 1583.9 F/g along with the capacity of 220.0 mAh/g are got for optimal CuCo2S4@Ni(OH)2 electrode, respectively comparing to 831.7 and 1063.3 F/g of CuCoS4 and Ni(OH)2 electrodes. A BSH is fabricated by the CuCo2S4@Ni(OH)2 electrode and the activated carbon electrode. The potential window of 1.6 V and maximum energy density of 32.1 Wh/kg at 1.1 kW/kg are achieved. The CF retention of 78% and Coulombic efficiency higher than 97% in 8000 charge/discharge cycles are also obtained for this BSH. © 2023

关键词： Sulfur compounds

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Advanced highly precise simultaneous electrochemical detection of toxic azo dyes with Nanoengineered yttrium Iron oxide decorated functionalized carbon nanofibers

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Food Chemistry 2025年 486卷 144607页

作者： Senthilkumar, Dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani National Taipei University of Technology Taipei City10608 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Taipei10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh11451 Saudi Arabia International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Tamil Nadu Chennai602105 India Department of Chemistry Korea University Seoul Seongbuk-gu Korea Republic of

It is essential to monitor the concentration of synthetic coloring agents in food and beverages due to their potential severe side effects on human health. In this study, yttrium iron oxide (YFO) nanoparticles were synthesized via a hydrothermal method, followed by modification with functionalized carbon nanofibers (f-CNF) through a simple sono-chemical process. The synthesized YFO/f-CNF was thoroughly characterized using various analytical techniques. Concurrent electrochemical detection of sunset yellow (SSY) and tartrazine (TRT) was achieved using a glassy carbon electrode modified with the YFO/f-CNF nanocomposite, enabling highly effective detection of SSY and TRT in food samples. Under optimized conditions, the modified electrode demonstrates a wide linear range (0.05 μM – 466.15 μM) and very low limits of detection (LOD) for SSY (1.5 nM) and TRT (3.2 nM). Additionally, the modified electrode exhibits significantly higher sensitivity (7.23 μAμM1cm−2) for SSY and (3.01 μAμM−1cm−2) for TRT compared to other reported values. This work showcases excellent sensitivity and selectivity, capable of identifying trace amounts of azo dyes in complex food matrices such as fruit juices, soft drinks, and packaged foods. The sensor's performance in real food samples, including both beverages and solid food products, was comparable to traditional high-performance liquid chromatography (HPLC), with a strong correlation in detection limits and accuracy (95.7–99.1 %). Furthermore, the sensor demonstrated exceptional stability and reproducibility in food matrix analysis, providing a reliable and efficient tool for routine monitoring of azo dye contamination in food and beverage industries. © 2025

关键词： Fruit juices

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Design and in silico validation of a human body on a chip for toxicity assessment of drugs to prevent graft-versus-host disease

Design and in silico validation of a human body on a chip fo...

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IEEE Nanotechnology Materials and Devices Conference (NMDC)

作者： M. Lira Mario L. Casado Fanny Program of Biomedical Engineering PUCP-UPCH Institute of Omic Sciences and Applied Biotechnology at Pontificia Universidad Catolica del Peru Lima Peru Institute of Omic Sciences Applied Biotechnology at Pontificia Universidad Catolica del Peru Lima Peru

Toxicity assessment of novel drugs requires the development of models that provide information about the behavior of the cells and the drugs. Current cytotoxicity assays rely on data generated in vitro under static conditions, different from the conditions in the human body, where everything is dynamic and connected. Here we designed a body-on-a-chip and validated its utility to provide in silico information to better design in vitro cytotoxicity assays under dynamic conditions. We focus on cellular and structural features of the integrated main organs affected by systemic toxicity (heart, liver and kidneys), assuming passive mixer conditions for drug-blood interactions using the physicochemical characteristics of a model immuno-modulating drug such as sirolimus or rapamycin. Velocity, pressure and concentration fields were characterized to calculate the values of shear stress, vortex formation and mixing *** Relevance — Chronic diseases are highly prevalent in our society and predicted to become the main burden within the next decade. The most long-term successful treatment for most of them is transplantation of the affected organ. However, the risk of developing graft-versus-host disease is still a limitation for this therapeutic approach despite the availability of drugs to modulate the immune system to tolerate the donor’s presence. Therefore, the toxicity assessment of novel immune drugs for organs of interest is a high priority.

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Additive manufacturing for multimodal photoacoustic ophthalmoscopy

Additive manufacturing for multimodal photoacoustic ophthalm...

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Photons Plus Ultrasound: Imaging and Sensing 2023

作者： Haindl, Richard Bellemo, Valentina Rajendran, Praveenbalaji Tan, Bingyao Liu, Mengyang Leitgeb, Rainer Drexler, Wolfgang Schmetterer, Leopold Pramanik, Manojit School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University 62 Nanyang Drive Singapore Singapore Centre for Medical Physics and Biomedical Engineering Medical University of Vienna Währinger Gürtel 18-20/4L Vienna Austria Program Nanyang Technological University Singapore Singapore Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Electrical and Computer Engineering Iowa State University AmesIA United States

ISBN: (纸本)9781510658639

Photoacoustic ophthalmoscopy in rodents is gaining research momentum, due to advancement in transducer shape and technology. Needle transducers emerged as most valuable tool for photoacoustic retinal imaging and have proven to be sensitive enough to resolve retinal vasculature in-vivo. Nevertheless, placement of the eye and screening of the retina remains challenging, since needle transducers must remain static during image acquisition, while the optical field of view is limited. Such restriction mandates movement of the mouse to rotate the eye and therefore the imaging area on the retina. The needle transducer needs to be temporarily detached during this process to avoid damage to the eye or the transducer. Re-attachment involves additional application of ultrasound gel and doesn’t guarantee ideal placement for optimized imaging performance. Additive manufacturing can help to tackle those challenges and allows to design novel rotational rodent holders for imaging. Hence, we present a fully 3D printable rotatable tip/tilt mouse platform with the eye in the center of rotation, combined with a printable needle transducer holder. Such system guarantees optimal placement of the needle transducer during imaging and rotation of the mouse eye, avoiding detachment of the transducer and effortless screening of the retina. The capabilities for retinal screening are demonstrated by a multimodal optical coherence photoacoustic ophthalmoscopy system employing two separated wavelengths, 1310 nm for optical coherence and 570 nm for photoacoustic ophthalmoscopy. © 2023 SPIE.

关键词： Optical tomography

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Statistical analysis of retinal tomographic pseudo images for diagnostic purpose

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Journal of Mathematical Modelling and Algorithms 2010年第3期9卷 257-273页

作者： Bruni, C. de Juan, J. Ferrone, C. Giannini, D. Grzywacz, N.M. Huang, D. Koch, G. Russo, V. Tan, O. D.I.S. Department University La Sapienza 00185 Rome Via Ariosto 25 Italy Department of Biotechnology University of Alicante Alicante Spain Departments of Biomedical and Electrical Engineering Neuroscience Graduate Program Center for Vision Science and Technology University of Southern California Los Angeles United States Department of Ophthalmology and Doheny Eye Institute University of Southern California Los Angeles United States

The majority of visual impairments are related to retinal disorders. Therefore, techniques useful for early detection of retinal anomalies are of great interest for diagnosis and treatment of related pathologies. Optical Coherence Tomography (OCT) is a non-invasive technique that is becoming increasingly important in the analysis of human retina. This technique produces sections of a three dimensional reflectance map, which are pseudo-images of the retinal structure. In these pseudo-images, early pathologies may produce local modifications of reflectance, which visually, appear as blots. Consequently, automatic procedures for detection of such blots may be of help in the diagnosis of many retinal diseases. Due to the complexity of the measurement technique and of the retinal structure, the pseudo-images produced by OCT can be modeled as 2D random signals: the above pathological blots correspond to sudden changes in the distribution of such OCT signals. In this work, we performed a statistical analysis of retinal OCT data. We found that the so-called stretched-exponential distribution, a two-parameter probability density function, provides a model that describes the data in a satisfactory way. In addition, we analyzed spatial-reflectance interdependence by studying the autocorrelation function;this analysis showed a significant correlation between contiguous pixels about 5 μm apart. We then developed a procedure to obtain the maximum-likelihood estimate of distribution parameters along the retinal pseudo-image. With this procedure, we analyzed their spatial dependence both along and across retinal layers. We observed that along suitable thin layers, the two parameters were statistically constant. By exploiting this result, a statistical procedure was developed for automatic detection of parameter variations due to retinal pathological blots. Some first results are reported for detection of diabetic retinopathy. © 2010 Springer Science+Business Media B.V.

关键词： Diabetic retinopathy Optical coherence tomography Retinal pseudo-images Statistical analysis

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Expanded Diameter of Coronary Metal Stent: Simulation and Experiment

Expanded Diameter of Coronary Metal Stent: Simulation and Ex...

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International Conference on Bioinformatics, biotechnology, and biomedical engineering - Bioinformatics and biomedical engineering (BioMIC)

作者： Alva Edy Tontowi Ogy Satria Ramadhani Sukiman Nurul Aulia Dewi Nahar Taufiq Department of Mechanical and Industrial Engineering Universitas Gadjah Mada Yogyakarta Indonesia Department of Mechanical Universitas Khairun Ternate Indonesia Department of Mechanical and Industrial Engineering Faculty of Engineering Yogyakarta Indonesia Biomedical Engineering Biotechnology Program Study Universitas Gadjah Mada Yogyakarta Indonesia

The following topics are dealt with: biomedical materials; diseases; finite element analysis; medical image processing; medical disorders; medical signal processing; electroencephalography; cellular biophysics; biolog... 详细信息

ISBN: (数字)9781728147116

ISBN: (纸本)9781728147123

关键词： Stress Numerical models Simulation Hydraulic systems Steel Scanning electron microscopy

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Erratum: African American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups

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BMC Biology 2007年第1期5卷 1-5页

作者： Bert Ely Jamie Lee Wilson Bruce A Jackson Fatimah Jackson Department of Biological Sciences University of South Carolina Columbia South Carolina 29208 USA Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell MA 01854 USA Department of Anthropology University of Maryland College Park MD 20742 USA

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing. © 2023

关键词： Adhesion

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Multiple cells of origin in cholangiocarcinoma underlie biological,epidemiological and clinical heterogeneity

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 94-102页

作者： Vincenzo Cardinale Guido Carpino Lola Reid Eugenio Gaudio Domenico Alvaro Department of MedicoSurgical Sciences and Biotechnologies Polo PontinoSapienza University of Rome00137 RomeItaly Department of Health Sciences University of Rome "Foro Italico"000135 RomeItaly Department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of Rome000137 RomeItaly Department of Cell and Molecular Physiology Biomedical EngineeringProgram in Molecular Biology and BiotechnologyUNC School of MedicineChapel HillNC 27599United States Eleonora Lorillard Spencer-Cenci Foundation 00156 RomeItaly

Recent histological and molecular characterization of cholangiocarcinoma(CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological ***,different stem cell niches have been recently described in the liver and biliarytree,suggesting this as the basis of the heterogeneity of intrahepatic(IH)-and extrahepatic(EH)-CCAs,which are two largely different tumors from both biological and epidemiological points of *** complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver *** recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic,prognostic and,hopefully,therapeutic categories of IH-and EH-CCAs.

关键词： Intrahepatic cholangiocarcinoma Extrahepatic cholangiocarcinoma Cholangiocarcinoma classification Cholangiolocarcinoma Cells of origin Cancer stem cells Peribiliary glands Biliary tree stem/progenitor cells Human hepatic stem cells Risk factors Targeted therapies

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