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Diversity in women and their vaginal microbiota

Trends in Microbiology 2025年

作者： Condori-Catachura, Sandra Ahannach, Sarah Ticlla, Monica Kenfack, Josiane Livo, Esemu Anukam, Kingsley C. Pinedo-Cancino, Viviana Collado, Maria Carmen Dominguez-Bello, Maria Gloria Miller, Corrie Vinderola, Gabriel Merten, Sonja Donders, Gilbert G.G. Gehrmann, Thies Lebeer, Sarah Laboratory of Applied Microbiology and Biotechnology Department of Bioscience Engineering University of Antwerp Groenenborgerlaan 171 Antwerp 2020 Belgium U-MaMi Centre of Excellence University of Antwerp Antwerp Belgium Unit Society Gender and Health – Department of Epidemiology and Public Health Swiss Tropical and Public Health Institute Allschwil Switzerland Department of Biochemistry Faculty of Science University of Yaounde I Yaounde Cameroon Centre for Research on Emerging and Reemerging Diseases Institute of Medical Research and Medicinal Plant Studies Yaounde Cameroon The Biotechnology Center University of Yaounde I Yaounde Cameroon Department of Biomedical Sciences Faculty of Health Sciences University of Buea Buea Cameroon Strengthening Health and Applied Research Yaounde Cameroon Department of Medical Microbiology and Public Health Faculty of Medical Laboratory Science Nnamdi Azikiwe University Nigeria Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía (LIPNAA) Centro de Investigaciones de Recursos Naturales de la UNAP (CIRNA) Universidad Nacional de la Amazonía Peruana (UNAP) Iquitos Peru Facultad de Medicina Humana Universidad Nacional de la Amazonía Peruana (UNAP) Iquitos Peru Department of Biotechnology Institute of Agrochemistry and Food Technology – National Research Council (IATA-CSIC) Valencia Paterna Spain Department of Biochemistry and Microbiology Rutgers University New Brunswick NJ United States Department of Anthropology Rutgers University New Brunswick NJ United States Humans and the Microbiome Program Canadian Institute for Advanced Research Toronto ON Canada Department of Obstetrics Gynecology and Women's Health Division of Maternal Fetal Medicine John A. Burns School of Medicine University of Hawaii at Manoa Honolulu 96813 HI United States Instituto de Lactología Industrial (INLAIN CONICET-UNL) Facultad de Ingeniería Química Universidad Nacional del Litoral Santa Fe Argentina Department

Women's health is essential to global societal and economic wellbeing, yet health disparities remain prevalent. The vaginal microbiota plays a critical role in health, with research indicating that reduced levels of core bacteria, such as lactobacilli, are associated with conditions like bacterial vaginosis (BV) and increased infection susceptibility. Lower levels of vaginal lactobacilli are reported more frequently in women of African and Latin American descent compared with women of European and Asian descent. However, geographical and other study inclusion and analysis biases influence current research. This opinion highlights the need for a more comprehensive understanding of a ‘healthy’ vaginal microbiome. It underscores efforts to broaden global research on microbiome diversity in socially relevant contexts, avoiding inappropriate applications of terms such as race and ethnicity. © 2025 The Authors

关键词： capacity building citizen science community outreach health equity internationalization open science and transparency taboo breaking vaginal microbiome women empowerment women's health

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Classification of protein localization patterns obtained via fluorescence light microscopy

Classification of protein localization patterns obtained via...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： M.V. Boland M.K. Markey R.F. Murphy Center for Light Microscope Imaging and Biotechnology and Biomedical Engineering Program Carnegie Mellon University Pittsburgh PA USA Center for Light Microscope Imaging and Department of Biological Sciences Carnegie Mellon University Pittsburgh PA USA

Describes a method of classifying cellular protein localization patterns based on their appearance in fluorescence light microscope images. Images depicting cellular protein localization were obtained using immunofluorescence microscopy. After collection, the images were processed and subject to feature extraction. Zernike moments were calculated for each image and used as inputs to one of two classification schemes: a classification tree or a neural network. Of the two classifiers, the neural network demonstrated better performance, correctly classifying 84% of previously unseen images. This work has application as a novel approach to protein description, as a means of automating microscopes, and as part of a new approach to gene discovery.

关键词： Fluorescence Microscopy Protein engineering USA Councils Pattern recognition Immune system Classification tree analysis Neural networks Handwriting recognition Character recognition

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OPTIMIZATION OF ELECTROSPINNING PROCESS PARAMETERS FOR TISSUE engineering SCAFFOLDS

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Biophysical Reviews and Letters 2006年第2期1卷 153-178页

作者： MING CHEN PRABIR K. PATRA STEVEN B. WARNER SANKHA BHOWMICK Biomedical Engineering and Biotechnology Program All University of Massachusetts — Dartmouth N. Dartmouth MA 02747 USA Department of Textile Sciences All University of Massachusetts — Dartmouth N. Dartmouth MA 02747 USA Department of Mechanical Engineering All University of Massachusetts — Dartmouth N. Dartmouth MA 02747 USA

The goal of the current study was to optimize important process parameters for electrospinning polycaprolactone (PCL) for growing 3T3 fibroblasts. We hypothesized that the smallest obtainable fiber diameter would provide the best cell growth kinetics and we tested this hypothesis for three different process parameters: solution concentration, voltage and collector screen distance. Beaded structures were formed when using low concentration electrospinning solutions (8 wt% to 13 wt%), in which the viscosity ranged from 16.0 c P to 340.0 c P . In this concentration range, cell growth kinetics was impeded when using a high concentration of cells (8–10 × 10 5 ). Higher PCL concentration led to an increase in the average fiber diameter from 400 nm to 1600 nm when PCL solution concentration changed from 15 wt% to 20 wt%. Although, the mean values indicated that cell growth kinetics were higher at the lower end of the concentration (15% as opposed to 20%) and this correlated with lower average fiber diameter, the results in this range were not statistically significant (p > 0.05). The average fiber diameter of scaffolds first decreased and then increased when electrospinning voltage was increased. The cell growth kinetics demonstrated that smaller average diameter PCL fiber scaffolds had higher growth kinetics than larger average diameter scaffolds with the best conditions obtained at 15 KV. By increasing the screen distance, the average fiber diameter decreased but had no significant impact on cell growth kinetics. In summary, the optimal parametric space for 3T3 fibroblast growth for our studies was electrospinning a 15 wt% PCL solution using 15 kV voltage and a 25 cm collector distance.

关键词： Electrospinning polycaprolactone tissue engineering scaffold SEM cell growth kinetics

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In-solution characterization and morphology determination of Carbon nanotubes (CNTs) for in-vitro studies based on Scanning Ion Occlusion Sensing (SIOS) technology

In-solution characterization and morphology determination of...

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The 6 th International Conference on Nanotoxicology (第六届国际纳米毒理学会议)

作者： Anoop K.Pal Iraj Aalaei Yaniv Ganor Philip Demokritou Dhimiter Bello Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell MA 01854 Izon Science Ltd Cambridge MA 02139USA Harvard School of Public Health Department of Environmental Health Boston MA Department of Work Environment

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Effect of PDI on the bacterial behavior of clinically important Gram negatives

Effect of PDI on the bacterial behavior of clinically import...

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Latin America Optics and Photonics Conference, LAOP 2022

作者： Vieira, R.L. Machado, J.S. Corrêa, T.Q. Blanco, K.C. Bagnato, V.S. Biotechnology Graduate Program Federal University of São Carlos SP - Rod. Washington Luiz Monjolinho SP São Carlos13565-905 Brazil São Carlos Institute of Physics University of São Paulo PO Box 369 SP São Carlos13560-970 Brazil Department of Biomedical Engineering Texas A&M University College StationTX77843 United States

Photodynamic inactivation with a subdose of light and curcumin as a photosensitizer causes effects on the bacterial behavior of important pathogenic Gram negatives, which may receive antibiotic resistance genes, becom... 详细信息

ISBN: (纸本)9781957171135

关键词： Photosensitizers

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Novel synthesis of ZIF67 derived cobalt and nickel oxides induced by ammonium tetrafluoroborate as electroactive material of battery supercapacitor hybrids

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Journal of Energy Storage 2023年 68卷

作者： Kuo, Tsung-Rong Draviana, Hanny Tika Hsu, Chia-Shuo Chung, Ren-Jei Chen, Min-Wen Wang, Su-Ching Lee, Pin-Yan Yougbaré, Sibidou Lin, Lu-Yin Wu, Yung-Fu International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei106 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan BP 218 11 Nanoro Burkina Faso Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Cobalt and nickel oxides with large theoretical capacitance, high redox activity and low-cost features are widely applied as electroactive material of battery supercapacitor hybrids (BSH) to reduce energy consumption and create renewable energy. Synthesizing cobalt and nickel oxides using zeolitic imidazolate framework 67 (ZIF67) can enhance conductivity and electroactivity and maintain surface area and porosity of ZIF67. Structure directing agent (SDA) can control morphology and improve electrochemical performance. It is attractive to apply SDA for controlling morphology of oxidized ZIF67 and achieving excellent energy storage. In this work, ammonium tetrafluoroborate (NH4BF4) is firstly applied as SDA to synthesize ZIF67 derivative, which is then annealed to form leaf-like cobalt and nickel oxides as electroactive material. The optimal oxidized ZIF67 derivative shows a larger specific capacitance (CF) of 828.9 F/g than those of 519.9 and 5.0 F/g respectively for the oxidized ZIF67 and pristine ZIF67 electrodes, due to preferable leaf-like structure and (311) facet for the former case. A BSH with oxidized ZIF67 derivative positive electrode and graphene negative electrode shows maximum energy density of 10.2 Wh/kg at 357 W/kg, and CF retention of 91% and Coulombic efficiency of 97% after 10,000 cycles. The novel SDA of NH4BF4 is expected to design other efficient electroactive materials for effective energy storage. © 2023 Elsevier Ltd

关键词： Nickel oxide

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Photothermal Temperature-Modulated Cancer Metastasis Harnessed Using Proteinase-Triggered Assembly of Near-Infrared II Photoacoustic/Photothermal Nanotheranostics

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ACS Applied Materials and Interfaces 2024年第31期16卷 40611-40627页

作者： Chuang, Yao-Chen Hsia, Yu Chu, Chia-Hui Maharajan, Sivasubramanian Hsu, Fang-Chi Lee, Hsin-Lun Chiou, Jeng Fong Ch’ang, Hui-Ju Liao, Lun-De Lo, Leu-Wei Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli Zhunan35053 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei110301 Taiwan Institute of Biotechnology National Tsing Hua University Hsinchu30013 Taiwan The Ph.D. Program for Translational Medicine College of Medical Science and Technology Taipei Medical University and Academia Sinica Taipei110301 Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei110301 Taiwan National Institute of Cancer Research National Health Research Institutes Miaoli Zhunan35053 Taiwan

Here we demonstrate that cancer metastasis could be modulated by the judicious tuning of physical parameters such as photothermal temperature in nanoparticle-mediated photothermal therapy (PTT). This is supported by theranostic nanosystem design and characterization, in vitro and in vivo analyses, and transcriptome-based gene profiling. In this work, the highly efficient near-infrared II (NIR-II) photoacoustic image (PA)-guided PTT are selectively activated using our developed matrix metalloproteinase (MMP)-triggered in situ assembly of gold nanodandelions (GNDs@gelatin). Unlike other "always-on" NIR PTT agents lacking specific bioactivation and suffering from the intrinsic nonspecific pseudosignals and treatment-related side effects such as metastasis, our GNDs@gelatin possesses important advantages while deployed in cancer PTT that include the following: (1) The theranostic effects could be "turned on" only after specific MMP-2/-9 activity and with acidity in the tumor microenvironment. (2) The quantitative PA diagnosis allows for precise PTT planning for better cancer treatment. (3) GNDs@gelatin could noninvasively quantify MMP activity and efficiently harness NIR-I (808 nm) and NIR-II (1064 nm) energies for tumor ablation. (4) The multibranched nanostructures reabsorb scattered laser photons, thus enhancing the surface plasmons for the pronounced photothermal conversion of aggregated GNDs@gelatin in situ. (5) It is noteworthy that in situ tumor eradication at higher PTT temperature (>55 °C) mediated by GNDs@gelatin could induce subsequent metastasis, which could be otherwise abolished at lower PTT temperatures (50 °C > T > 43 °C). (6) Furthermore, the gene profiling using transcriptome-based microarray including GO and KEGG analyses revealed that 315 differentially expressed genes were identified in higher PTT temperature treated tumors compared with lower PTT temperature ones. These were enriched into some well-known cancer-related pathways, such as cell migrat

关键词： Plasmonics

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A self-powered multifunctional dressing for active infection prevention and accelerated wound healing

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Science Advances 2023年第4期9卷 000-000页

作者： Barman, Snigdha Roy Chan, Shuen-Wen Kao, Fu-Cheng Ho, Hsuan-Yu Khan, Imran Pal, Arnab Huang, Chih-Ching Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan Department of Orthopaedic Surgery Spine Section Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of NanoEngineering and Microsystems National Tsing Hua University Hsinchu30013 Taiwan Department of Bioscience and Biotechnology National Taiwan Ocean University Keelung202301 Taiwan Center of Excellence for the Oceans National Taiwan Ocean University Keelung202301 Taiwan School of Pharmacy College of Pharmacy Kaohsiung Medical University Kaohsiung80708 Taiwan Department of Chemistry National Tsing Hua University Hsinchu30013 Taiwan Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan

Interruption of the wound healing process due to pathogenic infection remains a major health care challenge. The existing methods for wound management require power sources that hinder their utilization outside of clinical settings. Here, a next generation of wearable self-powered wound dressing is developed, which can be activated by diverse stimuli from the patient’s body and provide on-demand treatment for both normal and infected wounds. The highly tunable dressing is composed of thermocatalytic bismuth telluride nanoplates (Bi2Te3 NPs) functionalized onto carbon fiber fabric electrodes and triggered by the surrounding temperature difference to controllably generate hydrogen peroxide to effectively inhibit bacterial growth at the wound site. The integrated electrodes are connected to a wearable triboelectric nanogenerator (TENG) to provide electrical stimulation for accelerated wound closure by enhancing cellular proliferation, migration, and angiogenesis. The reported self-powered dressing holds great potential in facilitating personalized and user-friendly wound care with improved healing outcomes. Copyright © 2023 The Authors, some rights reserved.

关键词： Patient treatment

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Multiple intracellular approaches to determine toxicity of micro and nano-sized titanium dioxide

Multiple intracellular approaches to determine toxicity of m...

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The 6 th International Conference on Nanotoxicology (第六届国际纳米毒理学会议)

作者： Aaron Stella Shu-Feng Hsieh Dhimiter Bello Daniel Schmidt Eugene Rogers Biomedical Engineering and Biotechnology Program Department of Clinical Laboratory and Nutritional Sciences Department of Clinical Laboratory and Nutritional Sciences Department of Work Environment Center for High-rate Nanomanufacturing Center for High-rate Nanomanufacturing Center for High-rate Nanomanufacturing Department of Plastics Engineering University of Massachusetts Lowell MA 01854

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Text and data mining for biomedical discovery 18

Text and data mining for biomedical discovery

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18th Pacific Symposium on Biocomputing, PSB 2013

作者： Gonzalez, Graciela Cohen, Kevin Bretonnel Kann, Maricel G. Greene, Casey S. Leaman, Robert Hahn, Udo Shah, Nigam Ye, Jieping Department of Biomedical Informatics Arizona State University ScottsdaleAZ85259 United States Computational Bioscience Program U. Colorado School of Medicine AuroraCO United States Department of Biological Science University of Maryland Baltimore County BaltimoreMD21250 United States Department of Genetics Geisel School of Medicine at Dartmouth HanoverNH03755 United States National Center for Biotechnology Information BethesdaMD20894 United States Friedricdh Schiller University Jena Language and Information Engineering Lab. Jena Germany Stanford Center for Biomedical Informatics Research StanfordCA94305 United States Computer Science and Engineering Arizona State University TempeAZ85287 United States

ISBN: (纸本)9781627480161

The biggest challenge for text and data mining is to truly impact the biomedical discovery process, enabling scientists to generate novel hypothesis to address the most crucial questions. Among a number of worthy submissions, we have selected six papers that exemplify advances in text and data mining methods that have a demonstrated impact on a wide range of applications. Work presented in this session includes data mining techniques applied to the discovery of 3-way genetic interactions and to the analysis of genetic data in the context of electronic medical records (EMRs), as well as an integrative approach that combines data from genetic (SNP) and transcriptomic (microarray) sources for clinical prediction. Text mining advances include a classification method to determine whether a published article contains pharmacological experiments relevant to drug-drug interactions, a fine-grained text mining approach for detecting the catalytic sites in proteins in the biomedical literature, and a method for automatically extending a taxonomy of health related terms to integrate consumer-friendly synonyms for medical terminologies.

关键词： Data mining

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