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A Palm-Sized, Smartphone-Coupled, and Cost-Effective Biosensing Device for Fluid-Based Alcohol Detection

Journal of The Electrochemical Society 2025年第6期172卷 067509-067509页

作者： Chanyamon Chaiyachati Kodchakorn Khemtonglang Waranya Yosburi Chanin Sanarmat Tinnakorn Kumsaen Kanyarat Holasut Oranat Chuchuen Department of Chemical Engineering Faculty of Engineering Khon Kaen University Khon Kaen 40002 Thailand Biomedical Engineering Program Faculty of Engineering Khon Kaen University Khon Kaen 40002 Thailand

This work presents a palm-sized, cost-effective biosensing device that integrates an enzymatic paper biosensor with an Internet of Things (IoT)-enabled smartphone alert system for fluid-based alcohol detection. The device consists of a paper-based sensing platform, a potentiostat-free data acquisition system using commercially available electronic modules, and an IoT-based wireless alert that notifies the user via smartphone when their blood alcohol concentration (BAC) exceeds the legal limit. The biosensor utilizes alcohol oxidase (AOx) as the catalytic enzyme, immobilized on filter paper and stabilized by bovine serum albumin (BSA). Both electrodes are fabricated from widely accessible materials: aluminum tape as the cathode and graphene–nail polish ink as the anode. Housed in a compact, 3D-printed enclosure (3 × 5 × 5 cm³), the device achieved high electron transfer efficiency with an internal resistance of 10 kΩ. It exhibited a strong linear correlation (R² = 0.9798) across a range of 14.02–88.45 mg dl⁻¹ (sweat-calculated BAC) and 20.70–119.14 mg dl⁻¹ (saliva-calculated BAC), with detection limits of 7.82 mg dl⁻¹ (sweat) and 12.51 mg dl⁻¹ (saliva). The device demonstrates sensitivity across BAC levels from the mild impairment threshold to above the legal limit, with high alcohol specificity. It provides a portable, cost-effective solution for fluid-based alcohol monitoring in low-resource settings.

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Study of the Spike (S) glycoprotein from the SARSCoV-2 as a possible source of translocating peptides of biomedical interest

Study of the Spike (S) glycoprotein from the SARSCoV-2 as a ...

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2020 AIChE Annual Meeting

作者： Henao, Maria C. Ocasión, Camila Yepes, Arnovis Burgos, Juan C. Reyes, Luis H. Cruz, Juan C. Department of Chemical and Food Engineering Universidad de los Andes Bogotá Colombia Physical Sciences Program Universidad de Cartagena Cartagena Colombia Chemical Engineering Program Universidad de Cartagena Cartagena Colombia Department of Biomedical Engineering Universidad de los Andes Bogotá Colombia

ISBN: (纸本)9780816911141

Membranes are natural selective barriers necessary for the correct function of human cells as they control the entry of diverse molecules into the intracellular space. Although small and polar molecules such as amino acids and ions cancome across the membrane through channels, larger macromolecules such as proteins and nucleic acids generally failto do so. This represents a significant obstacle for efficient intracellular drug delivery, which is essential to increase the bioavailability of pharmacological agents for the treatment of numerous diseases. Commonly, diverse methods havebeen studied to mediate the uptake of large molecules, including mechanical and electrical transfection techniques,but also viral carrier systems. Some of these methods have been successfully tested in vitro but exhibit biosafety and cytotoxicity issues. Inconsequence, there is an increasing interest in the development of novel delivery methods with low cytotoxicity butalso high transduction efficiency. An attractive alternative is the cell-penetrating peptides (CPPs), which can beobtained from different origins including signal peptides, viral proteins, or antimicrobial peptides. CPPs are generallyshort peptides with lengths between 5-30 amino acids, positively charged or amphipathic, and rich in arginine andlysine. Due to their ability to intermingle with the phospholipids of membrane bilayers, some CPPs are able toundergo translocation, and consequently can be considered as promising candidates for the delivery of biologically active molecules to cells. The novel coronavirus SARS-CoV-2 has attracted significant attention over the past few months as it is responsible forthe current global sanitary emergency where more than 1.3 M cases have been confirmed and over 70,000 peoplehave died. The Spike (S) glycoprotein has been thought to be responsible as the major determinant of the viraltropism towards human cells. This protein has a 180 kDa molecular weight and is displayed at the viral su

关键词： Coronavirus

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An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A

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Journal of Thrombosis and Haemostasis 2025年第6期23卷 1800-1809页

作者： Rana, Jyoti VanDyke, Derek Muñoz-Melero, Maite Fabilane, Charina S. Thirumurugan, Senthilkumar Arisa, Sreevani Zhou, Baohua Spangler, Jamie B. Biswas, Moanaro Herman B Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis United States Department of Chemical and Biomolecular Engineering Johns Hopkins University Baltimore MD United States Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD United States Program in Molecular Biophysics Johns Hopkins University Baltimore MD United States Department of Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD United States Bloomberg∼Kimmel Institute for Cancer Immunotherapy Johns Hopkins University Baltimore MD United States Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD United States Department of Oncology Johns Hopkins University School of Medicine Baltimore MD United States Department of Ophthalmology Johns Hopkins University School of Medicine Baltimore MD United States Department of Molecular Microbiology and Immunology Johns Hopkins University Bloomberg School of Public Health Baltimore MD United States

Background: The development of inhibitory antibodies (inhibitors) is a serious complication in the treatment of hemophilia A with clotting factor (F)VIII replacement therapy. Inhibitor formation critically depends on T cell help and modulation by regulatory T cells (Tregs). Objectives: In this study, we evaluated the F5111 immunocytokine (IC), a single-chain fusion between the human interleukin (IL)-2 cytokine and an IL-2 antibody that biases cytokine activity toward cells with high IL-2 receptor (IL-2R)α expression, leading to extended IL-2 half-life and selective expansion of Tregs. Methods: A transient F5111 IC administration regimen was applied to a hemophilia A murine model of FVIII replacement therapy. Inhibitory antibody development to FVIII was monitored longitudinally by Bethesda assay and ELISA. Results: F5111 IC failed to stimulate cell types that predominantly express the dimeric IL2Rβγ receptor complex such as effector T and natural killer cells. Potent and highly transient Treg expansion was associated with suppression of effector T cells and in vivo conversion into Tregs. When tested in the hemophilia A mouse model, F5111 IC completely prevented the formation of inhibitors against FVIII for up to 4 months, long after Treg numbers returned to baseline levels. Conclusion: These results demonstrate that F5111 IC induces a superior and prolonged tolerogenic response compared with an unbiased control IC. Overall, this study presents a novel and effective strategy for preventing inhibitory antibodies that hinder the effectiveness of FVIII replacement therapy in hemophilia A. © 2025 The Author(s)

关键词： hemophilia IL-2 immunocytokine inhibitors Treg

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Piezoelectric and triboelectric nanogenerators: Promising technologies for self-powered implantable biomedical devices

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Nano Energy 2024年 119卷

作者： Khan, Arshad Joshi, Ravindra Sharma, Manish Kumar Ganguly, Anindita Parashar, Parag Wang, Ting-Wei Lee, Sangmin Kao, Fu-Cheng Lin, Zong-Hong Department of Biomedical Engineering National Taiwan University Taipei10167 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan School of Mechanical Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Orthopaedic Surgery Chang Gung Memorial Hospital Taoyuan33305 Taiwan College of Medicine Chang Gung University Taoyuan33302 Taiwan Department of Chemical Engineering National Taiwan University Taipei10167 Taiwan

Implantable biomedical devices (IBDs) have garnered wide-scale attention in recent years due to their enormous contribution to the biomedical sector. However, an uninterrupted and reliable power source has consistently been the primary barrier for IBDs, which is greatly alleviated by batteries. The widespread application of battery-powered IBDs is hindered by several limitations, including bulkiness, limited capacity and shelf-life, and expenditure associated with surgery-based battery recharge/replacement. To address these challenges, state-of-the-art self-powering technologies have emerged, including implantable piezoelectric nanogenerators (iPENGs) and implantable triboelectric nanogenerators (iTENGs). These technologies enable IBDs to operate autonomously by harnessing the minute mechanical movements of internal organs, such as heartbeat, respiration, blood circulation, muscle contraction/relaxation, and lung vibration. This review focuses on the recent advancements in iTENGs and iPENGs for the development of self-powered IBDs with a wide range of applications, including energy harvesting from biomechanical and ultrasound sources and energy storage using batteries and capacitors. This study also explores the extensive sensing applications of IBDs in various areas including cardiac, gastrointestinal, bladder, and ligament-strain monitoring. Finally, therapeutic applications of IBDs, such as nerve stimulation, bone stimulation, cartilage therapy, tissue regeneration, muscle stimulation, drug delivery, and diabetes management are discussed. © 2023 Elsevier Ltd

关键词： Nanogenerators

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Using Machine Learning to Study the Effects of Genetic Predisposition on Brain Aging in the UK Biobank

Using Machine Learning to Study the Effects of Genetic Predi...

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IEEE International Symposium on biomedical Imaging

作者： Karen Ardila Emily Munro Fernando Vega Aashka Mohite Charlotte Curtis Amanda V. Tyndall M. Ethan MacDonald Department of Electronic and Automation Biomedical Engineering Universidad Autónoma de Manizales Manizales Colombia Department of Biomedical Engineering University of Calgary Calgary Canada Department of Electrical & Software Engineering University of Calgary Calgary Canada Department of Radiology University of Calgary Calgary Canada Hotchkiss Brain Institute University of Calgary Calgary Canada Mitacs Globalink Research Internship Program Canada Department of Chemical Engineering University of Calgary Calgary Canada Department of Mathematics and Computing Mount Royal University Calgary Canada Department of Medical Genetics University of Calgary Calgary Canada

The influence of genetic predisposition on changes in brain morphology during aging remains largely unknown. This study explores the effects of genetic predisposition on three key brain regions: total brain volume (TBV), lateral ventricular volume (LVV), and total hippocampal volume (THV). The brain age gap estimate (BrainAGE) biomarker is used as an input to a genome-wide association study to determine which single nucleotide polymorphisms (SNPs) and genes are associated with accelerated brain aging. Six independent significant SNPs were found to contribute to accelerated morphological changes: TBV had associations on chromosome 17 linked with brain aging, and the total THV had independent significant associations in the APOC1 and TOMM40 gene regions related to neurodegeneration. Lastly, LVV presented a possible novel discovery in the gene NUAK1, known to play a role in cellular senescence. This study provides a framework to uncover complex associations between brain aging physiology and genetics.

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A Label-Free Droplet Sorting Platform Integrating Dielectrophoretic Separation for Estimating Bacterial Antimicrobial Resistance

Biosensors

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Biosensors 2024年第5期14卷 218页

作者： Yan, Jia-De Yang, Chiou-Ying Han, Arum Wu, Ching-Chou Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung City402 Taiwan Institute of Molecular Biology National Chung Hsing University Taichung City402 Taiwan Department of Electrical and Computer Engineering Texas AM University College StationTX77843 United States Department of Biomedical Engineering Texas AM University College StationTX77843 United States Department of Chemical Engineering Texas AM University College StationTX77843 United States Department of Bio-Industrial Mechatronics Engineering National Chung Hsing University Taichung City402 Taiwan Innovation and Development Center of Sustainable Agriculture National Chung Hsing University Taichung City402 Taiwan

Antimicrobial resistance (AMR) has become a crucial global health issue. Antibiotic-resistant bacteria can survive after antibiotic treatments, lowering drug efficacy and increasing lethal risks. A microfluidic water-in-oil emulsion droplet system can entrap microorganisms and antibiotics within the tiny bioreactor, separate from the surroundings, enabling independent assays that can be performed in a high-throughput manner. This study presents the development of a label-free dielectrophoresis (DEP)-based microfluidic platform to sort droplets that co-encapsulate Escherichia coli (E. coli) and ampicillin (Amp) and droplets that co-encapsulate Amp-resistant (AmpR) E. coli with Amp only based on the conductivity-dependent DEP force (FDEP) without the assistance of optical analyses. The 9.4% low conductivity (LC) Luria–Bertani (LB) broth diluted with 170 mM mannitol can maintain E. coli and AmpR E. coli growth for 3 h and allow Amp to kill almost all E. coli, which can significantly increase the LCLB conductivity by about 100 μS/cm. Therefore, the AmpR E. coli/9.4%LCLB/Amp where no cells are killed and the E. coli/9.4%LCLB/Amp-containing droplets where most of the cells are killed can be sorted based on this conductivity difference at an applied electric field of 2 MHz and 100 Vpp that generates positive FDEP. Moreover, the sorting ratio significantly decreased to about 50% when the population of AmpR E. coli was equal to or higher than 50% in droplets. The conductivity-dependent DEP-based sorting platform exhibits promising potential to probe the ratio of AmpR E. coli in an unknown bacterial sample by using the sorting ratio as an index. © 2024 by the authors.

关键词： Escherichia coli

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Water Activated Catechol Adhesive Allows Dip Coated Antimicrobial Coatings

SSRN

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SSRN 2023年

作者： Ghosh, Animesh Singh, Juhi Lim, Sierin Steele, Terry W.J. 639798 Singapore NTU Institute for Health Technologies Interdisciplinary Graduate Program Nanyang Technological University 61 Nanyang Drive 637335 Singapore School of Chemical and Biomedical Engineering Nanyang Technological University 70 Nanyang Drive Block N1.3 637457 Singapore

Bioadhesives comprising of catechol crosslinkers have displayed broad utility against both soft and hard substrates. However, catechol’s two-part adhesion chemistry requires oxidative chemicals that are detrimental to organic substrates. Herein, a water-activated adhesive with inherent antibacterial properties is prepared by grafting catechol groups onto branched polyethylenimine (PEI-DBA20). The resultant PEI-DBA20 is stable in organic solvents but undergoes curing in the presence of water. The in-built oxidation method relies on the close proximity of catechol/Schiff-base functional groups that form tautomers in the presence of aqueous solvents. The curing mechanism is demonstrated by dip coating hydrated substrates, where the grafted dendrimers subsequently crosslink and form thin films. Coated PET films and polyester textiles exhibit an antimicrobial surface with 4-6 log reduction against model Gram-negative bacteria. © 2023, The Authors. All rights reserved.

关键词： Adhesion

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Snake-scale stimulated robust biomimetic composite triboelectric layer for energy harvesting and smart health monitoring

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Nano Energy 2024年 122卷

作者： Huang, Ming-Zheng Parashar, Parag Chen, An-Rong Shi, Shih-Chen Tseng, Yao-Hsuan Lim, Kee Chin Yeh, Hsuan-Yu Pal, Arnab Kang, Dun-Yen Lin, Zong-Hong Institute of Biomedical Engineering National Tsing Hua University Hsinchu 30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 10617 Taiwan Department of Chemical Engineering National Taiwan University Taipei 10617 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan Department of Mechanical Engineering National Cheng Kung University Tainan 70101 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu 30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu 30013 Taiwan Internet of Senses Research Center National Tsing Hua University Hsinchu 30013 Taiwan

Extreme frictional wear of triboelectric layers severely hinders long-term sustainability of triboelectric nanogenerators (TENGs) for efficient ambient energy harvesting. The state-of-the-art solutions necessitate sophisticated structural designs and complex packaging constraints, impeding the feasibility of TENGs for practical applications. Herein, inspired by the structures and compositions of snake scales, a biomimetic composite (BC) film is fabricated as a wear-resistant triboelectric contact layer. The successful formation of disulfide bond-facilitated cross-linkage of cysteine proteins in the keratin-based BC film promotes excellent mechanical resilience and durability, thereby solving the material abrasion challenges associated with solid-solid triboelectric layers. The BC film, with toothed microstructure, exhibits improved charge transfer, low friction, and consistent long-term stable outputs compared to commercial films. Furthermore, a self-powered BC film-based TENG is integrated into a bicycle for biomechanical energy harvesting, lightening warning signals for safer night ride with stable 300 V electrical output for at least 6 h. Moreover, a smart health monitoring system is further proposed by embedding TENG-based sensors into the bicycle saddle, accurately capturing the rider's pelvic-saddle interactions on varying terrain slopes. By leveraging the unique biomechanical information, machine learning-assisted user identification and terrain slope data classifications are achieved with high accuracies, laying a foundation for futuristic smart healthcare applications. This work provides a strategy to reduce material abrasion by exploiting the unique characteristics of a biomimetic material, facilitating a basis for efficient environmental energy harvesting and smart sensing. © 2024 Elsevier Ltd

关键词： Biomechanical energy harvesting Biomimetic Smart healthcare Snake-scales Triboelectric nanogenerator Wear resistance

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Facilitating light utilization and electron transfer of TiO2 nanotube arrays for catalyzing photoelectrochemical water reduction via acid etching and copper doping

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Materials Today Chemistry 2023年 34卷

作者： Hsu, Chuan-Chih Kubendhiran, Subbiramaniyan Lai, Jhih-Hong Saukani, Muhammad Yougbaré, Sibidou Chen, Hung-Ming Hsiao, Yu-Cheng Wu, Yung-Fu Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 03 Ouagadougou Burkina Faso Gingen Technology Co. LTD Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan

Photoelectrochemical catalytic capability mainly relies on light absorption and charge transfer efficiency. TiO2 nanotube array (TNA) having suitable band edges and one-dimensional hollow structure is regarded as one of efficient photoelectrocatalysts toward water reduction. In this study, two strategies are firstly applied to modify TNA as the photocatalyst of water reduction. Ti foils are etched by acid to produce multiple light reflections planes for improving light absorption, and Cu is doped in TNA to enhance charge transfer efficiency. The optimal Cu-doped TNA electrode on the acid-etched Ti foil presents a much smaller overpotential of 91 mV at 10 mA/cm2 compared with that of the undoped TNA (524 mV). A smaller Tafel slope of 134 mV/dec is obtained for the optimal Cu-doped TNA electrode than that of the undoped TNA (167 mV/dec). After measuring the photoelectrochemical performance for 1000 cycles, overpotential and charge-transfer resistance of modified TNA are largely reduced owing to activation. Current retention of 96.7% is achieved after continuously illuminating for 10 h. Highly improved photoelectrochemical catalytic ability of TNA modified by acid etching and Cu doping provides new pages for material modifications on substrate and active material. © 2023 Elsevier Ltd

关键词： Light absorption

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Study on Ag(I) Loaded ZIF-8 and Ag(I) Ion Release in Artificial Seawater

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Materials 2023年第5期16卷 2040页

作者： Tsai, Shang-Tien Tang, Wei-Cheng Wei, Yeu-Kuen Wu, Kevin C.-W. Program of Green Materials and Precision Devices National Taiwan University Taipei10617 Taiwan Material and Chemical Research Laboratories Industrial Technology Research Institute Hsinchu30011 Taiwan Department of Chemical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes 35 Keyan Road Miaoli35053 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Yonsei Frontier Lab Yonsei University 50 Yonsei-ro Seoul03722 Korea Republic of

From a porous structure perspective, the one-stage de novo synthesis method and impregnation method were applied to synthesize Ag(I) ion-containing ZIF-8 samples. With the de novo synthesis method, Ag(I) ions could be located inside micropores or adsorbed on the external surface of the ZIF-8 by selecting AgNO3 in water or Ag2CO3 in ammonia solution as precursors, respectively. The ZIF-8 confining Ag(I) ion exhibited a much lower constant releasing rate than the Ag(I) ion adsorbed on the ZIF-8 surface in artificial seawater. As such, strong diffusion resistance in association with the confinement effect is contributed by ZIF-8’s micropore. On the other hand, the release of Ag(I) ions adsorbed on the external surface was diffusion limited. Therefore, the releasing rate would reach a maximum not increasing with Ag(I) loading in the ZIF-8 sample. © 2023 by the authors.

关键词： Ions

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