检索结果-内蒙古大学图书馆

arXiv 2023年

作者： Haindl, Richard Bellemo, Valentina Rajendran, Praveenbalaji Tan, Bingyao Liu, Mengyang Zhou, Qifa Leitgeb, Rainer A. Drexler, Wolfgang Schmetterer, Leopold Pramanik, Manojit School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University 62 Nanyang Drive Singapore Singapore Centre for Medical Physics and Biomedical Engineering Medical University of Vienna Währinger Gürtel 18-20/4L Vienna Austria Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Program Nanyang Technological University Singapore Singapore Department of Radiation Oncology Stanford University StanfordCA94305 United States University of Southern California Department of Biomedical Engineering Los AngelesCA90033 United States Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical School National University of Singapore Singapore Department of Clinical Pharmacology Medical University Vienna Vienna Austria Institute of Molecular and Clinical Ophthalmology Basel Switzerland Department of Electrical and Computer Engineering Iowa State University AmesIA50011 United States

Non-invasive imaging plays a crucial role in diagnosing and studying eye diseases. However, existing photoacoustic ophthalmoscopy (PAOM) techniques in mice have limitations due to handling restrictions, suboptimal optical properties, limited availability of light sources and permissible light fluence at the retina. This study introduces an innovative approach that utilizes Rose Bengal, a contrast agent, to enhance PAOM contrast. This enables visualization of deeper structures like the choroidal microvasculature and sclera in the mouse eye using visible light. The integration of near-infrared-II optical coherence tomography (NIR-II OCT) provides additional tissue contrast and insights into potential NIR-II PAOM capabilities. To optimize imaging, we developed a cost-effective 3D printable mouse eye phantom and a fully 3D printable tip/tilt mouse platform. This solution elevates PAOM to a user-friendly technology, which can be used to address pressing research questions concerning several ocular diseases such as myopia, glaucoma and/or age-related macular degeneration in the future. © 2023, CC BY.

关键词： Optical tomography

来源：评论

学校读者我要写书评

暂无评论

Empowering biomedical Discovery with AI Agents

arXiv

引用

arXiv 2024年

作者： Gao, Shanghua Fang, Ada Huang, Yepeng Giunchiglia, Valentina Noori, Ayush Schwarz, Jonathan Richard Ektefaie, Yasha Kondic, Jovana Zitnik, Marinka Department of Biomedical Informatics Harvard Medical School BostonMA United States Department of Chemistry and Chemical Biology Harvard University CambridgeMA United States Program in Biological and Biomedical Sciences Harvard Medical School BostonMA United States Department of Brain Sciences Imperial College London London United Kingdom Harvard College CambridgeMA United States Program in Biomedical Informatics Harvard Medical School BostonMA United States Department of Electrical Engineering and Computer Science MIT CambridgeMA United States Kempner Institute for the Study of Natural and Artificial Intelligence Harvard University MA United States Broad Institute of MIT and Harvard CambridgeMA United States Harvard Data Science Initiative CambridgeMA United States

We envision "AI scientists" as systems capable of skeptical learning and reasoning that empower biomedical research through collaborative agents that integrate AI models and biomedical tools with experimental platforms. Rather than taking humans out of the discovery process, biomedical AI agents combine human creativity and expertise with AI’s ability to analyze large datasets, navigate hypothesis spaces, and execute repetitive tasks. AI agents are poised to be proficient in various tasks, planning discovery workflows and performing self-assessment to identify and mitigate gaps in their knowledge. These agents use large language models and generative models to feature structured memory for continual learning and use machine learning tools to incorporate scientific knowledge, biological principles, and theories. AI agents can impact areas ranging from virtual cell simulation, programmable control of phenotypes, and the design of cellular circuits to developing new therapies. © 2024, CC BY.

关键词： Adversarial machine learning

来源：评论

学校读者我要写书评

暂无评论

A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo

引用

Journal of the Taiwan Institute of chemical Engineers 2024年 160卷

作者： Cheng, Tien-Hsin Lin, Ruei-Hong Cheng, Yu-Shen Shih, Pin-Keng Show, Pau Loke Chen, Hsiao-Yi Nakmee, Pattarawadee Sumthong Chang, Jui-Jen Huang, Dong-Ming Wang, Hui-Min David Department of Chemical and Materials Engineering National Yunlin University of Science and Technology Yunlin Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Xingda Rd. South Dist. Taichung402 China Department of Neurological Institute Taichung Veterans General Hospital Taichung China Doctoral Program in Tissue Engineering and Regenerative Medicine National Chung Hsing University Taichung China Department of Surgery China Medical University Hospital Taichung Taiwan School of Medicine China Medical University Taichung Taiwan Department of Chemical Engineering Khalifa University Abu Dhabi United Arab Emirates Faculty of Science at Sriracha Kasetsart University Sriracha Campus 199 Moo 6 Sukhumvit Rd. Chonburi Sriracha20230 Thailand Department of Medical Research China Medical University Hospital China Medical University Taichung China Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Miaoli County China Regenerative Medicine and Cell Therapy Research Center Graduate Institute of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology China Medical University Taichung China

Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption. © 2024 Taiwan Institute of chemical Engineers

关键词： chemical stability

来源：评论

学校读者我要写书评

暂无评论

Ranking Magnetic Colloid Performance for Magnetic Particle Imaging and Magnetic Particle Hyperthermia

引用

Advanced Functional Materials 2025年第2期35卷 2412321页

作者： Carlton, Hayden Salimi, Marzieh Arepally, Nageshwar Bentolila, Gabriela Sharma, Anirudh Bibic, Adnan Newgren, Matt Goodwill, Patrick Attaluri, Anilchandra Korangath, Preethi Bulte, Jeff W.M. Ivkov, Robert Department of Radiation Oncology and Molecular Radiation Sciences the Johns Hopkins University School of Medicine BaltimoreMD21231 United States Russell H. Morgan Department of Radiology and Radiological Science Division of MR Research the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Cellular Imaging Section and Vascular Biology Program Institute for Cell Engineering the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Mechanical Engineering School of Science Engineering and Technology The Pennsylvania State University – Harrisburg HarrisburgPA17057 United States F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Inc. BaltimoreMD21205 United States Magnetic Insight Inc. AlamedaCA94502 United States Department of Biomedical Engineering the Johns Hopkins University School of Medicine BaltimoreMD21205 United States Department of Chemical & Biomolecular Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States Department of Oncology Sydney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine BaltimoreMD21287 United States Department of Mechanical Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University BaltimoreMD21218 United States

Magnetic particle imaging (MPI) is an emerging modality that can address longstanding technological challenges encountered with magnetic particle hyperthermia (MPH) cancer therapy. MPI is a tracer technology compatible with MPH for which magnetic nanoparticles (MNPs) provide signal for MPI and heat for MPH. Identifying whether a specific MNP formulation is suitable for both modalities is essential for clinical implementation. Current models predict that functional requirements of each modality impose conflicting demands on nanoparticle magnetic properties. This objective here is to develop a measurement and ranking scheme based on end-use performance to streamline evaluation of candidate MNP formulations. The measured MPI point-spread function (PSF) and specific loss power (SLP) is combined to generate a single numerical value for comparison on a relative ranking scale, or figure of merit (FoM). 12 aqueous iron-containing formulations are evaluated, including FDA-approved (parenteral) iron-containing colloids. MNPs with high (Synomag-D70: 123.4), medium (Synomag-D50: 63.2), and low (NanoXact: 0.147) FoM values are selected for in vivo validation of the selection scheme in subcutaneous 4T1 tumors. Results demonstrate that the proposed ranking accurately assessed the relative performance of MNPs for MPI and MPH. Data demonstrated that image quality and tumor temperature rise increased with FoM ranking, validating predictions. It isshown that the MPI signal correlated with MNP concentration in tissue. Computational heat transfer models anchored on tumor MPI data harmonized with experimental results to within an average of 2 °C when MNP content estimated from MPI data is included. Computational studies emphasized the importance of post-injection MNP quantitation and MPI spatial resolution. © 2024 The Author(s). Advanced Functional Materials published by Wiley-VCH GmbH.

关键词： Hyperthermia therapy

来源：评论

学校读者我要写书评

暂无评论

Effect of alginate and chitosan addition in the fabrication of polyvinyl alcohol-based matrix for tissue engineering applications

引用

AIP Conference Proceedings 2024年第1期3215卷

作者： Retno Wahyu Nurhayati Fatimah Azzahra Nuzli Fahdia Mazfufah Siti Fauziyah Rahman Wildan Mubarok Department of Chemical Engineering Faculty of Engineering Universitas Indonesia 16464 Depok Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia 16464 Depok Indonesia Stem Cells & Tissue Engineering Cluster Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Doctoral Program in Biomedical Sciences Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Department of Electrical Engineering Faculty of Engineering Universitas Indonesia 16464 Depok Indonesia Division of Chemical Engineering Department of Materials Engineering Science Graduate School of Engineering Science Osaka University 560-0031 Toyonaka Japan

Recently, there has been a growing interest in artificial skin on hydrogels as a potential alternative for animal testing to evaluate the efficacy and safety of new drugs or cosmetics. Synthetic polymers have been widely used due to their superior physicochemical properties. However, synthetic polymers such as polyvinyl alcohol (PVA) are limited by their poor biocompatibility and cell adhesion. Combining synthetic and natural polymers can improve these properties. Therefore, in this study, we aimed to investigate the effect of alginate and chitosan addition to PVA-based hydrogels on protein adsorption, cell viability and cell attachment. The addition of chitosan decreased protein adsorption, which was caused by the changes in electrostatic charge by PVA-chitosan interaction and changes in surface roughness. Primary human fibroblast cells cultured on PVA, PVA-alginate and PVA-chitosan had >80% viability which indicates the cytocompatibility of the hydrogels. More importantly, alginate and chitosan also improved the cell attachment on the PVA-based hydrogels. Taken together, the addition of both alginate and chitosan has the potential to improve PVA-based hydrogels for artificial skin application.

关键词：

来源：评论

学校读者我要写书评

暂无评论

PM@DCm nanohybrid-mediated pleiotropic antigen presentation for enhanced melanoma immunotherapy

引用

Nano Today 2025年 64卷

作者： Xu, Zhongsheng He, Xiaojing Luo, Ranran Zhang, Chenxi Zhang, Zening Ren, Pengchen Zhang, Jingjing Chen, Xiaoyuan Liu, Yun Department of Radiology Second Affiliated Hospital of Chongqing Medical University Chongqing400010 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore119074 Singapore Clinical Imaging Research Centre centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore117597 Singapore Yong Loo Lin School of Medicine National University of Singapore 11 Biopolis Way Helios Singapore138667 Singapore 61 Biopolis Drive Proteos Singapore138673 Singapore

Melanoma, an aggressive cancer with poor prognosis, benefits only minimally from the current immunotherapies. To address these therapeutic shortcomings, achieving efficient antigen presentation is pivotal for robust tumor-specific T-cell activation and durable antitumor immunity. Here, a multifunctional nanohybrid (denoted as PM@DCm) with activated DC membrane-coated, platinum-embedded, hollow manganese-based nanohybrid is developed, which can effectively proceed antigens presentation. The core of multispiked platinum-manganese oxide (termed as Pt@MnO2) functions dually as a Stimulator of Interferon Genes (STING) agonist and an inducer of immunogenic cell death (ICD) in response to the tumor microenvironment, triggering inflammatory cytokine and actionable tumor antigens release. These events facilitate in-situ DC maturation, improving antigen uptake and presentation to T cells. Simultaneously, the DC-mimetic structure of PM@DCm retains critical costimulatory markers, MHC class I antigen complexes, and chemokine receptors, effectively simulating the functionality of mature DCs. This dual mechanism ensures robust pleiotropic antigen cross-presentation and cytotoxic T-cell priming. As a result, this PM@DCm nanohybrid significantly suppresses tumor growth and metastasis, elicits robust antitumor immunity, and shows strong prophylactic potential. This novel strategy leverages the synergy between mimicking mature DCs and promoting in-stiu DC maturation, delivering pleiotropic antigen presentation for enhanced melanoma immunotherapy. © 2025 Elsevier Ltd

关键词： T-cells

来源：评论

学校读者我要写书评

暂无评论

Terahertz Time-Domain Spectroscopy for Probing DC Conductivity of Single-Layer Graphene

Terahertz Time-Domain Spectroscopy for Probing DC Conductivi...

引用

Western New York Image Processing Workshop (WNYIPW)

作者： Debamitra Chakraborty Declan Walden Jing Cheng Julia Wallace Kiryl A. Niherysh Andrei V. Felsharuk Donats Erts Ivan Komissarov Roman Sobolewski Materials Science Graduate Program University of Rochester Rochester New York USA Laboratory for Laser Energetics Rochester New York USA Department of Physics and Astronomy University of Rochester Rochester New York USA Department of Biomedical Engineering University of Rochester Rochester New York USA Institute of Chemical Physics University of Latvia Riga Latvia Department of Microtechnology and Nanoscience Chalmers University of Technology Gothenburg Sweden Department of Electrical and Computer Engineering University of Rochester Rochester New York USA

We report preliminary results of extracting electrical parameters like DC conductivity, mobility, and carrier concentration of single-layer graphene using Terahertz time-domain spectroscopy (THz-TDS) in transmission geometry. We utilize a simple Drude model and its extension, the Drude-Smith model, capable of accommodating charge carrier scattering by optical and acoustic phonons to describe the complex conductivity in graphene. We observed that a significant area of the sample scanned followed the Drude-Smith behavior, while at a few locations, the simple Drude behavior prevailed. We identified possible reasons that might contribute to this observation, like defects, the presence of polymer residue on the sample, or the sample strain. This research sheds new light on our understanding of graphene's electrical properties and lays the foundation for future investigations addressing defects and contaminants in graphene samples.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo

引用

Advanced Materials 2023年第13期35卷 e2208966页

作者： Magoling, Bryan John Abel Wu, Anthony Yan-Tang Chen, Yen-Ju Wong, Wendy Wan-Ting Chuo, Steven Ting-Yu Huang, Hsi-Chien Sung, Yun-Chieh Hsieh, Hsin Tzu Huang, Poya Lee, Kang-Zhang Huang, Kuan-Wei Chen, Ruey-Hwa Chen, Yunching Lai, Charles Pin-Kuang Institute of Atomic and Molecular Sciences Academia Sinica Taipei10617 Taiwan Graduate Institute of Biochemical Sciences National Taiwan University Taipei10617 Taiwan Chemical Biology and Molecular Biophysics Program TIGP Academia Sinica Taipei11529 Taiwan Department of Pharmacology College of Medicine National Taiwan University Taipei100233 Taiwan Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Department of Chemical Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of Biological Chemistry Academia Sinica Taipei11529 Taiwan Genome and Systems Biology Degree Program National Taiwan University Taipei10617 Taiwan

Extracellular vesicles (EVs) are released by cells to mediate intercellular communication under pathological and physiological conditions. While small EVs (sEVs;200 nm, microvesicles) are less well explored. Here, bEVs and sEVs are identified as distinct EV populations, and it is determined that bEVs are released in a greater bEV:sEV ratio in the aggressive human triple-negative breast cancer (TNBC) subtype. PalmGRET, bioluminescence-resonance-energy-transfer (BRET)-based EV reporter, reveals dose-dependent EV biodistribution at nonlethal and physiological EV dosages, as compared to lipophilic fluorescent dyes. Remarkably, the bEVs and sEVs exhibit unique biodistribution profiles, yet individually promote in vivo tumor growth in a syngeneic immunocompetent TNBC breast tumor murine model. The bEVs and sEVs share mass-spectrometry-identified tumor-progression-associated EV surface membrane proteins (tpEVSurfMEMs), which include solute carrier family 29 member 1, Cd9, and Cd44. tpEVSurfMEM depletion attenuates EV lung organotropism, alters biodistribution, and reduces protumorigenic potential. This study identifies distinct in vivo property and function of bEVs and sEVs in breast cancer, which suggest the significant role of bEVs in diseases, diagnostic and therapeutic applications. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

关键词： Mass spectrometry

来源：评论

学校读者我要写书评

暂无评论

Boron carbide decorated tungsten disulfide nanosheet composite for determination of chloramphenicol in food and pharmaceutical samples

引用

Microchemical Journal 2024年 203卷

作者： Senthilkumar, Dhayanithi Kuo, Chih-Yu Aldossari, Samar A. Govindasamy, Mani Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry P. O. Box 2455 College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Making the nanocomposites of metal oxides or metal sulfides with carbon source materials has a huge impact on the electrochemical determination of toxic chemicals. To determine the adverse side effects of the antibiotics, electrochemical sensors have been used as they can peek into the sensitivity of the drug sample. This work has done the sensitive amperometric evaluation of a chloramphenicol antibiotic by modifying the electrode of tungsten disulfide decorated boron carbide. Here, tungsten disulfide (WS₂) nanosheets and boron carbide (B₄C) materials were synthesized by conventional methods which give a good amount of yield. The composite was prepared by the green and cost-effective sonochemical approach with good morphology. The conductivity of the nanocomposite and the response to chloramphenicol were determined by cyclic voltammetry. The sensitivity, limit of detection (LOD), and the linear range were observed by the highly sensitive amperometric technique. From the amperometric analysis, the prepared nanocomposite shows nominal LOD as a 17.4 nM, a broad linear range (0.025–1134.6 µM), and good sensitivity of 1.52 µA µM⁻¹ cm⁻². Practicability of the modified sensor was studied in food and pharmaceutical samples with adequate recovery performances. Moreover, the modified electrode shows good stability, repeatability, reproducibility, and anti-interfering properties against the array of food and biological interferences. © 2024 Elsevier B.V.

关键词： Amperometric technique Antibiotic detection Boron carbide Food quality test Health analysis Tungsten disulfide

来源：评论

学校读者我要写书评

暂无评论

Development of a Bioactive, Piezoelectric PVDF-TrFE Scaffold to Modulate Wound Response in the Peripheral Nervous System

SSRN

引用

SSRN 2024年

作者： Bryan, Andrew E. Krutko, Maksym Rebholz, Sandra Marquez, Lindsey E. Busch, Emma Dong, Kevin Pixley, Sarah K. Cushion, Melanie T. Esfandiari, Leyla Harris, Greg M. Department of Chemical and Environmental Engineering University of Cincinnati CincinnatiOH45221 United States Department of Biomedical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Internal Medicine University of Cincinnati College of Medicine CincinnatiOH45267 United States Medical Research Service Cincinnati Veterans Affairs Medical Center CincinnatiOH45220 United States Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine CincinnatiOH45267 United States Department of Electrical Engineering University of Cincinnati CincinnatiOH45221 United States Department of Environmental & Public Health Sciences University of Cincinnati College of Medicine CincinnatiOH45267 United States Neuroscience Graduate Program University of Cincinnati College of Medicine CincinnatiOH45267 United States

To address current limitations in biomaterials for peripheral nerve repair regarding a lack of physiologically relevant signaling and immune response following implantation, this study evaluated the development and feasibility of a multi-cue biomaterial with physiologically relevant chemical, electrical, and physical signaling. To accomplish this, a bulk-functionalized poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) scaffold was fabricated using blend electrospinning to incorporate decellularized extracellular matrix (dECM) to mediate the foreign body response in vivo and promote enhanced wound healing. Decellularized ECM was secreted and assembled by fibroblast cells and incorporated into the electrospinning solution with concentration values ranging from 0% to 0.4% (m/v). Physical, chemical, and electrical properties of the scaffold were analyzed by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), mechanical tensile testing, and voltage readings for piezoelectricity. Blended scaffolds were evaluated in vitro for analysis of cell-material interactions in the context of peripheral nerve injury (PNI) repair and in vivo for immune response. In vitro work demonstrated increased cell metabolism and elongated, repair-like morphologies in Schwann cells on scaffolds with higher dECM concentrations. Subcutaneous implantation of blended scaffolds in rats at 7 days revealed limited multi-nucleated giant cell formation. Following 28 days in vivo, regenerative characteristics of the proliferative phase of wound healing were present with enhanced nerve growth and vasculature to scaffold. Overall, blend-electrospun scaffolds with native dECM showed promise in mitigating pro-inflammatory responses and promote advanced regenerative behaviors, thereby providing an implantable biomaterial with the necessary physical, chemical, and electrical characteristics desired for c

关键词： Fourier transform infrared spectroscopy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：