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Resveratrol delivery from porous poly(Lactide-co-glycolide) scaffolds promotes an anti-inflammatory environment within visceral adipose tissue 42

Resveratrol delivery from porous poly(Lactide-co-glycolide) ...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Murphy, Kendall Hendley, Michael Isely, Chris Annamalai, Prakasam Gower, Michael Department of Chemical Engineering University of South Carolina United States Biomedical Engineering Program University of South Carolina United States

ISBN: (纸本)9781510883901

Statement of Purpose: Metabolic diseases, such as obesity and type 2 diabetes, are associated with adipose tissue inflammation characterized by accumulation of immune cells and production of inflammatory cytokines. As a therapeutic strategy to combat this disease promoting inflammation, we investigated resveratrol release from porous poly(lactide-co-glycolide) (PLG) scaffolds which upon implant into the adipose tissue will facilitate direct delivery to the target tissue. Resveratrol was chosen because of its metabolic and anti-inflammatory effects on adipocytes and immune cells. This work aimed to demonstrate that resveratrol releasing PLG scaffolds promote a local anti-inflammatory response upon implant in healthy fat and that this response is an effective strategy to protect against pro-inflammatory stimuli, for example, in adipocytes challenged with TNF-α and fat pads of mice fed a high fat diet. © 2019 Omnipress - All rights reserved.

关键词： Resveratrol

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A deep learning system for predicting time to progression of diabetic retinopathy

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NATURE MEDICINE 2024年第2期30卷 358-359页

作者： [Anonymous] Shanghai Belt and Road International Joint Laboratory for Intelligent Prevention and Treatment of Metabolic Disorders Department of Computer Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Department of Endocrinology and Metabolism Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Diabetes Institute Shanghai Clinical Center for Diabetes Shanghai China MOE Key Laboratory of AI School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Huadong Sanatorium Wuxi China Department of Ophthalmology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Hong Kong China Singapore Eye Research Institute Singapore National Eye Centre Singapore Singapore Department of Computer Science and Engineering The Hong Kong University of Science and Technology Hong Kong China Department of Chemical and Biological Engineering The Hong Kong University of Science and Technology Hong Kong China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Ophthalmology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Medical Records and Statistics Office Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab Cluster and Grid Computing Lab School of Computer Science and Tech

We developed and validated a deep learning system (termed DeepDR Plus) in a diverse, multiethnic, multi-country dataset to predict personalized risk and time to progression of diabetic retinopathy. We show that DeepDR Plus can be integrated into the clinical workflow to promote individualized intervention strategies for the management of diabetic retinopathy.

关键词： Diabetes complications Machine learning Predictive markers

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Iron carbonyl polymer microspheres for simultaneously high-speed adsorption and desorption of dye-emulsified micelles with frequency manipulation under an alternating electric field

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chemical engineering Journal 2023年 469卷

作者： Wang, Yu-Xiang Chang, Chi-Jung Lu, Chien-Hsing Chen, Jem-Kun Department of Materials Science and Engineering Taiwan Building Technology Center National Taiwan University of Science and Technology 43 Sec. 4 Keelung Road Taipei10607 Taiwan Department of Chemical Engineering Feng Chia University 100 Wenhwa Road Seatwen Taichung40724 Taiwan Department of Obstetrics and Gynecology Taichung Veterans General Hospital Taichung Taiwan Institute of Biomedical Sciences Ph.D. Program in Translational Medicine and Rong-Hsing Research Center for Translational Medicine National Chung-Hsing University Taichung940227 Taiwan

Developing a versatile methodology for high-speed water purification is critical for environmental and water source protection. Traditional adsorption and desorption were determined based on the concentration gradients. Herein, a versatile methodology is reported based on the simple application of an alternating electric field (AEF) on a system including dye-emulsified micelles (DEM) and adsorbents that simultaneously exhibit high-speed adsorption and desorption of DEM by frequency manipulation. Iron carbonyl polymers are incorporated into polystyrene microspheres (PMs) to generate iron carbonyl polystyrene microspheres (ICPMs) as adsorbents, which can vary the affinity with DEM and dielectric properties simultaneously. Both the DEM and microspheres were polarized under the AEF and generated electric dipole moments that could rapidly assemble the DEM and microspheres. Compared with the adsorption through the concentration gradient, the adsorption rate of DEM was enhanced significantly in the presence of an AEF of 20 V at 150 kHz of frequency because of the effect of particle assembly. At 1000 kHz of frequency, the alternative high-speed change between electrostatic attraction and repulsion hindered the adsorption of the dyes, which could also enhance the desorption rate. The ICPMs could be recycled 10 times within 20 min with frequency manipulation in the presence of AEF. This versatile methodology could provide novel insights into the development of high-speed water purification techniques. © 2023 Elsevier B.V.

关键词： Polystyrenes

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engineering the Hydrogel Extracellular Matrix Composition for the Salivary Gland Microbubble Tissue Chip

SSRN

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SSRN 2022年

作者： Mereness, Jared A. Benoit, Danielle S.W. Piraino, Lindsay R. Chen, Chiao Yun Moyston, Tracey DeLouise, Lisa A. Ovitt, Catherine E. Department of Biomedical Engineering University of Rochester RochesterNY United States Department of Dermatology University of Rochester RochesterNY United States Department of Biomedical Genetics University of Rochester RochesterNY United States Materials Science Program University of Rochester RochesterNY United States Department of Chemical Engineering University of Rochester RochesterNY United States Center for Musculoskeletal Research University of Rochester RochesterNY United States Knight Campus Bioengineering Department University of Oregon EugeneOR United States

Salivary gland dysfunction resulting in xerostomia occurs in the majority of head and neck cancer patients treated with radiation therapy. Progress in determining the mechanism of radiation damage and methods for prevention has been hampered by the lack of in vitro salivary gland models. We recently developed a salivary gland tissue mimetic (SGm), comprised of salivary gland tissue clusters encapsulated in matrix metalloproteinase (MMP)–degradable poly(ethylene glycol) hydrogels within arrays of ~320 Om diameter spherical cavities molded in PDMS. The SGm provides a functional and physiologically relevant salivary gland model well suited to high-throughput drug screening for radioprotective compounds. However, the utility of the SGm would significantly benefit from improved retention of acinar phenotype and function over longer culture durations. We hypothesize that tuning biochemical cues presented within the PEG hydrogel matrix will improve maintenance of acinar cell phenotype and function by mimicking the natural extracellular matrix microenvironment of the intact gland. Hydrogels formed using slower-degrading MMP-sensitive peptide crosslinkers showed >2-fold increase in sphere number formed at 48 hr, increased expression of acinar cell markers, and more robust response to calcium stimulation by the secretory agonist, carbachol, with reduced SGm tissue cluster disruption and outgrowth during prolonged culture. The incorporation of adhesive peptides containing RGD or IKVAV improved calcium flux response to secretory agonists at 14 days of culture. Tuning the hydrogel matrix improved cell aggregation, and promoted acinar cell phenotype, and stability of the SGm in long-term culture. Furthermore, combining this matrix with optimized media conditions synergistically improved retention of acinar cells in SGm. © 2022, The Authors. All rights reserved.

关键词： Polyethylene glycols

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Prediction of Pelvic Organ Prolapse Postsurgical Outcome Using Biomaterial-Induced Blood Cytokine Levels: Machine Learning Approach

JMIR Perioperative Medicine

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JMIR Perioperative Medicine 2023年第1期6卷 e40402页

作者： Waugh, Mihyun Lim Boltin, Nicholas Wolf, Lauren Goodwin, Jane Parker, Patti Horner, Ronnie Hermes, Matthew Wheeler, Thomas Goodwin, Richard Moss, Melissa Biomedical Engineering Program University of South Carolina Columbia SC United States Biomedical Sciences University of South Carolina School of Medicine-Greenville Greenville SC United States Prisma Health Greenville Greenville SC United States Department of Health Services Research and Administration University of Nebraska Medical Center Omaha NE United States Department of Bioengineering Clemson University Clemson SC United States Spartanburg Regional Healthcare System Spartanburg SC United States Department of Chemical Engineering University of South Carolina Columbia SC United States

Background: Pelvic organ prolapse (POP) refers to symptomatic descent of the vaginal wall. To reduce surgical failure rates, surgical correction can be augmented with the insertion of polypropylene mesh. This benefit is offset by the risk of mesh complication, predominantly mesh exposure through the vaginal wall. If mesh placement is under consideration as part of prolapse repair, patient selection and counseling would benefit from the prediction of mesh exposure;yet, no such reliable preoperative method currently exists. Past studies indicate that inflammation and associated cytokine release is correlated with mesh complication. While some degree of mesh-induced cytokine response accompanies implantation, excessive or persistent cytokine responses may elicit inflammation and implant rejection. Objective: Here, we explore the levels of biomaterial-induced blood cytokines from patients who have undergone POP repair surgery to (1) identify correlations among cytokine expression and (2) predict postsurgical mesh exposure through the vaginal wall. Methods: Blood samples from 20 female patients who previously underwent surgical intervention with transvaginal placement of polypropylene mesh to correct POP were collected for the study. These included 10 who experienced postsurgical mesh exposure through the vaginal wall and 10 who did not. Blood samples incubated with inflammatory agent lipopolysaccharide, with sterile polypropylene mesh, or alone were analyzed for plasma levels of 13 proinflammatory and anti-inflammatory cytokines using multiplex assay. Data were analyzed by principal component analysis (PCA) to uncover associations among cytokines and identify cytokine patterns that correlate with postsurgical mesh exposure through the vaginal wall. Supervised machine learning models were created to predict the presence or absence of mesh exposure and probe the number of cytokine measurements required for effective predictions. Results: PCA revealed that proinflammatory

关键词： biomaterial cytokines inflammatory response pelvic organ prolapse polypropylene mesh principal component analysis repair surgery supervised machine learning models surgical outcome prediction

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Breathable Palladium Hydride Hydrogels Mediated 'Head and Tail' Co-Blocking HMGB1-RAGE Axis Strategy for Diabetic Foot Ulcer Treatment

SSRN

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SSRN 2025年

作者： Wang, Weidi Liu, Xueling Xiao, Jiali Zhang, Yunning Hao, Yu Hou, Ruidong You, Qing Song, Yilin Department of Pharmaceutical Sciences School of Pharmacy Shenyang Pharmaceutical University 103 Wenhua Road Shenyang110016 China Department of Pharmacy The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou450008 China School of Food and Healthy Beijing Technology and Business University 11 Fucheng Road Haidian District Beijing100048 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine Faculty of Engineering National University of Singapore Singapore119074 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore117599 Singapore

Diabetes patients suffer from severe chronic consequences known as diabetic foot ulcers (DFUs), for which there are no particular therapy options. The inflammatory and oxidative microenvironments in DFUs stimulate the secretion of high mobility group box-1 (HMGB1), which binds with the receptor of advanced glycation endproducts (RAGE), causing inflammatory cascade reactions and immune microenvironment (IME) disorder, further exacerbating DFU damage. Strategies targeting the HMGB1-RAGE axis to end this vicious loop are still lacking. This study proposes a novel strategy based on "breathable hydrogels" to achieve HMGB1-RAGE axis "head and tail" co-blocking to regulate the IME for DFU treatments. Specifically, with palladium hydride (PdH) nanocubes as the functional structure, a hydrogel dressing was prepared from a double cross-linking network of biocompatible alginate and polyacrylamide and modified with trehalose as the network-repairing agent. Mechanistically, the obtained hydrogels can "inhale" the excess accumulated reactive oxygen species, inhibiting HMGB1 secretion, the "head" of the HMGB1-RAGE axis. Meanwhile, H2 "exhaled" from the hydrogels can suppress the expression of intracellular RAGE, thus blocking the HMGB1-RAGE axis and breaking the vicious cycle. The proposed "head and tail" co-blocking strategy based on "breathable hydrogels" offers a highly efficient, safe, and facile therapeutic protocol for DFUs. © 2025, The Authors. All rights reserved.

关键词： Crosslinking

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A facile yeast-display approach for antibody mask discovery

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Protein engineering, design & selection : PEDS 2025年 38卷 gzaf006页

作者： Nithya M Badarinath Basudeb Mondal Christopher M Yellman Kendreze L Holland Hee Jun Lee Hathaichanok Phuengkham Andrew P Cazier Jaewoo Son Jacob R Smith John R Cox Andrew J Kristof Yusef A Haikal Gabriel A Kwong John Blazeck School of Chemical and Biomolecular Engineering Georgia Institute of Technology Atlanta GA United States. Bioengineering Program Georgia Institute of Technology Atlanta GA United States. Department of Biomedical Engineering Georgia Institute of Technology and Emory University Atlanta GA United States.

Tuning in vivo activity of protein therapeutics can improve their safety. In this vein, it is possible to add a 'mask' moiety to a protein therapeutic such that its ability to bind its target is prevented until the mask has been proteolytically removed, for instance by a tumor-associated protease. As such, new methods to isolate functional masking sequences can aid development of protein therapies. Here, we describe a yeast display-based method to discover peptide sequences that prevent binding of antibody fragments to their antigen target. Our method includes an in situ ability to screen for restoration of binding by scFvs after proteolytic mask removal, and it takes advantage of the antigenic target itself to guide mask discovery. First, we genetically linked a yeast-displayed αPSCA scFv to overlapping 'tiles' of its target. By selecting for reduced antigen binding via flow cytometry, we discovered two peptide masks that we confirmed to be linear epitopes of the αPSCA scFv. We then expanded our method towards developing masks for three-dimensional epitopes by using a co-crystal structure of an αHer2 antibody in complex with its antigen to guide combinatorial mask design. In sum, our efforts show the feasibility of employing yeast-displayed, antigen-based libraries to find antibody masks.

关键词： antibody masks antigen tiling array mimotope discovery yeast display

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Polyvinyl chloride microplastics and drought co-exposure alter rice growth by affecting metabolomics and proteomics

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Science of the Total Environment 2024年 955卷 177002页

作者： Khan, Kiran Yasmin Ali, Barkat Ghani, Hafiz Usman Cui, Xiaoqiang Luo, Xiaohan Ali, Zeshan Ahmed, Waqar Tan, Jinglu Lysenko, Vladimir Guo, Ya Key Laboratory of Advanced Process Control for Light Industry Ministry of Education Jiangnan University Wuxi214122 China Food Science Research Institute National Agricultural Research Centre Islamabad44000 Pakistan Hebei Medical University Shijiazhuang050000 China School of Environmental Science and Engineering/Tianjin Key Lab of Biomass Waste Utilization Tianjin University Tianjin300072 China Ecotoxicology Research Program Institute of Plant and Environmental Protection National Agriculture Research Center Islamabad44000 Pakistan Department of Biomedical Biological & Chemical Engineering University of Missouri ColumbiaMO65211 United States Southern Federal University Academy of Biology and Biotechnology Rostov-on-Don344041 Russia International Joint Research Center for Intelligent Optical Sensing and Applications at Jiangnan University Wuxi214122 China

Microplastics, interacting with drought stress, have become threat to crops by altering soil environment. Currently, the effect of combined microplastic and drought stress on crop growth remain poorly understood. In this work, the mechanism of multi-stress responses was investigated under the exposure of polvinylchloride microplastic (PV) and drought (D) individually and in combination (DPV) on rice varieties Hanyou73 and Q280 through proteomics and metabolomic analysis. All treatments negatively affect chlorophyll content, antioxidant enzyme activities, rice grain composition, metabolome and proteomic profiling of both rice varieties. Full rice grain yield was decreased under all treatments except PV treatment in which it was increased in both rice varieties. DPV treatment shows the lowest grain yield and more adverse effects on metabolome by affecting glycerophospholipid metabolism, tryptophan metabolism and alanine, aspartate and glutamate metabolism. Soluble sugar contents were decreased in H73 but in Q280 increased by 159 % under DPV and 123 % in PV treatment, compared to their control group. The results from metabolomics illustrate that glycerophospholipid metabolism is commonly altered in both rice types under all treatments. PV and drought alone and in combination induce extensive alterations in proteomics of rice leaves especially impacting proteins related to binding, translation and photosynthetic process. The results reveal that PV and DPV treatments highly distort the abundance of metabolites and proteins in both rice types, demonstrating that microplastic toxicity effects on rice plants become more severe when combined with drought stress. © 2024 Elsevier B.V.

关键词： Drought Metabolite Polyvinyl chloride microplastic Protein Rice

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Controlled release of carbamazepine at Therapeutically relevant doses using photocrosslinkable polyanhydrides

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International journal of pharmaceutics 2025年 679卷 125728页

作者： Hamzeh Ghaempanah Kalin I Penev Armin Geraili Jorge G Burneo Kibret Mequanint School of Biomedical Engineering the University of Western Ontario London Ontario Canada. Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada. Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada Department of Pharmaceutical Sciences Leslie Dan Faculty of Pharmacy University of Toronto Toronto Ontario Canada. Epilepsy Program Department of Clinical Neurological Sciences the University of Western Ontario London Ontario Canada. School of Biomedical Engineering the University of Western Ontario London Ontario Canada Department of Chemical and Biochemical Engineering the University of Western Ontario London Ontario Canada. Electronic address: kmequani@uwo.ca.

Epilepsy, one of the most common neurological disorders, is primarily managed with oral antiseizure medications. While effective for many patients, the short half-lives of most anti-epilepsy drugs (AEDs) necessitate frequent dosing, leading to poor adherence and compromised seizure control. Controlled-release drug delivery systems offer a promising solution by maintaining consistent drug levels, reducing dosing frequency, and minimizing side effects. Among these systems, photocrosslinkable polyanhydrides are particularly promising due to their unique surface erosion properties across a wide pH range, making them ideal for oral drug delivery applications. These polymers are synthesized from cost-effective starting materials, have tunable structures, and are biocompatible, biodegradable, and nontoxic. This study explores the potential of photocrosslinkable polyanhydrides synthesized via thiol-ene 'click' chemistry for the controlled release of carbamazepine. Carbamazepine is an antiepileptic drug with poor water solubility and a narrow therapeutic range. Unlike other controlled-release systems, which faced challenges with high drug loading or compromised polymer integrity, here we demonstrate that photocrosslinkable polyanhydrides can achieve carbamazepine loadings of up to 30 wt% while preserving their surface erosion properties. Cylindrical tablets fabricated from these polymers exhibit tailored release profiles, achieving sustained drug release over 5 to 33 h by adjusting the monomer ratios. Additionally, delayed release systems are demonstrated, allowing controlled onset times ranging from 2 to 10 h by varying the monomer composition. This approach provides a practical and efficient system for high-dose controlled-release carbamazepine delivery, offering a versatile and effective platform for enhanced epilepsy treatment.

关键词： Carbamazepine Controlled release tablet Epilepsy Photocrosslinkable polyanhydrides Surface erosion Therapeutic dose drug loading

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Microspheres for 3D bioprinting: a review of fabrication methods and applications

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Frontiers in bioengineering and biotechnology 2025年 13卷 1551199页

作者： Dmitri Karaman Kira Williams Jolene Phelps Fynn La Boucan Gretchen Lewandowski Kerrin O'Grady Bosco Yu Stephanie M Willerth Department of Mechanical Engineering University of Victoria Victoria BC Canada. Division of Medical Sciences University of Victoria Victoria BC Canada. Axolotl Biosciences Victoria BC Canada. Biomedical Engineering Program Department of Mechanical Engineering University of Victoria Victoria BC Canada. Biology Program Department of Science University of Victoria Victoria BC Canada. Department of Biomedical and Chemical Engineering Syracuse University Syracuse NY United States. BioInspired Syracuse Institute for Material and Living Systems Syracuse University Syracuse NY United States. School of Biomedical Engineering Faculty of Applied Science and Faculty of Medicine University of British Columbia Vancouver BC Canada.

Bioprinting incorporates printable biomaterials into 3D printing to create intricate tissues that maintain a defined 3D structure while supporting the survival and function of relevant cell types. A major challenge in 3D bioprinting is tuning material properties to ensure compatibility with different types of cells, while accurately mimicking the physiological microenvironment. Developing novel bioinks tailored to specific applications can help address this challenge by combining various materials and additives to tune the bioink formulation. Microspheres - small spherical particles - can incorporate drugs or growth factors to enable their controlled release, encapsulate cells to provide protection during printing, and provide structural reinforcement to tune mechanical properties and enable complex architectures. The particles range in size from 1 to 1000 μm and can be tuned to meet desired functions by optimizing their mode of production and the materials used for fabrication. This review presents an overview of microsphere production methods and considerations for optimizing the production process. It then summarizes how microspheres have been used to date in bioprinting applications. Finally, the existing challenges associated with the creation and use of microspheres are discussed along with avenues for future research.

关键词： biomaterials bioprinting drug encapsulation electrospray emulsification microfluidics microspheres

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