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Electrochemical detection of antimalarial drug (Amodiaquine) using Dy-MOF@MWCNTs composites to prevent erythrocytic stages of plasmodium species in human bodies

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Microchemical Journal 2024年 202卷

作者： Peter, X. Thatheyus Kuo, Chih-Yu Malar, P. Govindasamy, Mani Rajaji, Umamaheswari Yusuf, Kareem Thinfilm Photovoltaics Laboratory Department of Physics and Nanotechnology SRM Institute of Science and Technology Tamil Nadu Kattankulathur 603203 India Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Herein, we report on fabrication of dysprosium-based metal–organic framework (Dy-MOF)@multiwalled carbon nanotubes (MWCNT) composites modified with glassy carbon electrode (Dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. Dy-MOF@MWCNT composites was prepared by sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, Dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (ADD) by electrochemical techniques such as CV and DPV. The as-prepared Dy@MWCNT composite material showed the oxidation peak current of ADD to be ∼ 60 % higher than other unmodified GC electrodes and showed a low charge transfer resistance (R_ct) of 24 Ω. The Dy@MWCNT provided a broad linear range of 0.4 to 20 µM with a limit of detection of 0.377 μM and sensitivity of 1.817 μA.μM⁻¹ for the detection of ADD. According to the pH study, the amount of electrons and protons involved in the electrochemical processes of ADD was calculated and a plausible mechanism for ADD electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the ADD drug in human urine samples. Hence, the results shows that the Dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of ADD. © 2024 Elsevier B.V.

关键词： Amodiaquine Antimalarial drug Carbon nanomaterials Electrochemical sensor Metal organic framework

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Optical coherence tomography angiography reveals retinal microvascular changes in patients with multiple sclerosis without optic neuritis

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ACTA OPHTHALMOLOGICA 2022年第S275期100卷

作者： Popa-Cherecheanu, Alina Bostan, Mihai Chua, Jacqueline Sim, Yin Ci Tan, Bingyao Bujor, Inna Garhofer, Gerhard Schmetterer, Leopold Ophthalmology Carol Davila University of Medicine and Pharmacy Ophthalmology Emergency University Hospital Singapore Eye Research Institute Singapore National Eye Centre Singapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical School National University of Singapore SERI-NTU Advanced Ocular Engineering (STANCE) Singapore School of Chemical and Biological Engineering Nanyang Technological University Singapore Department of Clinical Pharmacology Medical University Vienna Center for Medical Physics and Biomedical Engineering Medical University Vienna Institute of Molecular and Clinical Ophthalmology Basel Switzerland

Purpose: Retinal imaging has attracted much interest as a non-invasive low-budget biomarker for neurological diseases such as multiple sclerosis (MS). Optical coherence tomography angiography (OCTA) is a functional extension of OCT and allows for the non-invasive visualization of the retinal and choroidal microvasculature. We investigated retinal microvasculature changes in patients with relapsing–remitting MS (RRMS) without history of optic neuritis (ON) and compared them to a healthy control group. Methods: The study was performed in a prospective, case–control design, including 58 participants ( n = 100 eyes) with RRMS without ON and 78 age- and sex-matched control participants ( n = 136 eyes). OCTA images of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) were obtained using a commercial OCTA system (Zeiss Cirrus HD-5000 Spectral-Domain OCT with AngioPlex OCTA, Carl Zeiss Meditec, Dublin, CA). Perfusion density (PD) and foveal avascular zone (FAZ) features (area and circularity) in both the SCP and DCP, as well as flow deficit in the CC were used as outcome variables. Results: MS patients showed significantly increased PD in SCP ( p = 0.003) and decreased PD in DCP ( p < 0.001) as compared to controls when data were corrected for confounders. A significant difference was also noted when large vessels (LV) in the SCP were removed from the PD calculation ( p = 0.004). Deep FAZ was significantly larger ( p = 0.005) and less circular ( p < 0.001) in the eyes of MS patients compared to healthy controls. Neither LV, PD or FAZ features in the SCP, nor flow deficits in the CC showed any statistically significant differences between the MS patients and the controls ( p > 0.186). Conclusions: Our study shows that MS patients have microvascular changes in the macular parafoveal retina even without ON. They show increased PD in SCP and decreased PD in DCP. To which degree retinal biomarkers in MS are associated with the progress

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Synthesis, properties, and applications of graphene oxide/reduced graphene oxide and their nanocomposites

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Nano Materials Science 2019年第1期1卷 31-47页

作者： Andrew T. Smith Anna Marie LaChance Songshan Zeng Bin Liu Luyi Sun Polymer Program Institute of Materials Science University of Connecticut Storrs Connecticut 06269 United States Department of Chemical and Biomolecular Engineering University of Connecticut Storrs Connecticut 06269 United States of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Department of Biomedical Engineering University of Connecticut Storrs Connecticut 06269 United States

Thanks to their remarkable mechanical, electrical, thermal, and barrier properties, graphene-based nanocomposites have been a hot area of research in the past decade. Because of their simple top-down synthesis, graphene oxide (GO) and reduced graphene oxide (rGO) have opened new possibilities for gas barrier, membrane separation, and stimuli-response characteristics in nanocomposites. Herein, we review the synthesis techniques most commonly used to produce these graphene derivatives, discuss how synthesis affects their key material properties, and highlight some examples of nanocomposites with unique and impressive properties. We specifically highlight their performances in separation applications, stimuli-responsive materials, anti-corrosion coatings, and energy storage. Finally, we discuss the outlook and remaining challenges in the field of practical industrial-scale production and use of graphene-derivative-based polymer nanocomposites.

关键词： Graphene oxide Reduced graphene oxide Graphene quantum dots polymer Nanocomposites Synthesis Properties of graphene and graphene oxide Applications

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CoAl2O4 nanoparticles modified carbon nanofibers as high-efficiency bifunctional electrocatalyst: An efficient electrochemical aqueous asymmetric supercapacitors and non-enzymatic electrochemical sensors

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Journal of Alloys and Compounds 2023年 931卷 1页

作者： Chinnapaiyan, Sathishkumar Das, Himadri Tanaya Chen, Shen-Ming Govindasamy, Mani Alshgari, Razan A. Fan, Chi-Hsuan Huang, Chi-Hsien Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan Centre for Advanced Materials and Applications Utkal University Vani vihar Odisha Bhubaneswar751004 India Department of Materials Engineering Ming Chi University of Technology New Taipei City243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan Chemistry Department College of Science King Saud University Riyadh11451 Saudi Arabia Korea University of Technology and Education Chungcheongnam-do Cheonan-si31253 Korea Republic of Division of Rheumatology Allergy and Immunology Chang Gung Memorial Hospital Taoyuan33378 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The thriving energy demand of the gradually increasing population and modernized life style requires development in energy storage devices for usage in commercial electronic devices. In this particular work, we have explored electrochemical performances of bimetallic oxide CoAl2O4 and tuned its performance by decorating it on the carbon nanofibers. The CoAl2O4/CNFs are synthesized by deep eutectic solvents based hydrothermal method. The synthesized CoAl2O4 nanoparticle was found electrochemically active and the incorporation of CNFs end up boosting, its electrochemical performances as battery-type electrode. The obtained nanocomposites were characterized by various techniques. The electrochemically active CoAl2O4/CNFs exhibited 2.2-fold higher charge storage capacity than CoAl2O4. The CoAl2O4/CNFs exhibited specific capacity as high as 132 C/g at a constant applied current density of 1 A/g in 1 M KOH. The asymmetric device fabricated with CoAl2O4/CNFs electrodes exhibited excellent energy density of 20 Wh/kg at power density of 3000 W/kg. The CoAl2O4/CNFs electrode long-term stability has been minutely observed;the high Coulombic efficiency of 90% and high rate of capacity retention 95 %. In this work, an enzyme-free electrochemical sensor based on CoAl2O4/CNFs composite was developed for the detection of luteolin (LUT). Further modification of CoAl2O4/CNFs composite can improve the high surface area and catalytic capability of the composites. Under the optimal detection conditions, the prepared sensor has good linearity in the detection of LUT within range 30 nM − 73.5 μM with a limit of detection (LOD) of 0.0124 μM (12.4 nM). The stability and selectivity of the sensor is high, and can be used to detect LUT in various real samples. © 2022 Elsevier B.V.

关键词： Electrochemical sensors

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Mechanistic insights of evaporation-induced actuation in supramolecular crystals (Sept, 10.1038/s41563-020-0799-0, 2020)

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NATURE MATERIALS 2021年第3期20卷 434-434页

作者： Piotrowska, Roxana Hesketh, Travis Wang, Haozhen Martin, Alan R. G. Bowering, Deborah Zhang, Chunqiu Hu, Chunhua T. McPhee, Scott A. Wang, Tong Park, Yaewon Singla, Pulkit McGlone, Thomas Florence, Alastair Tuttle, Tell Ulijn, Rein V. Chen, Xi Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York New York NY USA PhD Program in Chemistry The Graduate Center of the City University of New York New York NY USA Department of Pure and Applied Chemistry University of Strathclyde Glasgow UK PhD Program in Physics The Graduate Center of the City University of New York New York NY USA EPSRC Continuous Manufacturing and Crystallisation Future Research Hub c/o Strathclyde Institute of Pharmacy and Biomedical Sciences Technology Innovation Centre University of Strathclyde Glasgow UK Department of Chemistry New York University New York NY USA Department of Chemistry and Biochemistry Hunter College City University of New York New York NY USA Department of Chemical Engineering The City College of New York New York NY USA

A Correction to this paper has been published: https://***/10.1038/s41563-021-00950-3.

关键词： Condensed-matter physics Materials science Soft materials

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#23. Elucidating the role of bone marrow stiffness in estrogen signaling in metastatic breast cancer to the bone

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Journal of Bone Oncology 2024年 45卷 100561-100561页

作者： Logan Northcutt Marjan Rafat Julie Rhoades Program in Cancer Biology Vanderbilt University Nashville TN USA Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville TN USA Department of Biomedical Engineering Vanderbilt University Nashville TN USA Department of Radiation Oncology Vanderbilt University Nashville TN USA Department of Clinical Pharmacology USA

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Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation

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Angewandte Chemie 2023年第41期135卷

作者： Sung-Won Hwang Chung-Man Lim Prof. Cong Truc Huynh Hossein Moghimianavval Prof. Nicholas A. Kotov Prof. Eben Alsberg Prof. Allen P. Liu Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 USA Department of Materials Science and Engineering University of Michigan Ann Arbor MI 48109 USA Department of Biomedical Engineering University of Illinois Chicago Chicago IL 60612 USA Department of Mechanical Engineering University of Michigan Ann Arbor MI 48109 USA Departments of Biomedical Engineering Macromolecular Science and Engineering Biointerfaces Institute University of Michigan Ann Arbor MI 48109 USA Departments of Orthopedic Surgery Pharmacology and Regenerative Medicine and Mechanical and Industrial Engineering University of Illinois Chicago Chicago IL 60612 USA Departments of Biomedical Engineering Biophysics Cellular and Molecular Biology Program Applied Physics Program University of Michigan Ann Arbor MI 48109 USA

Stimuli-responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano-responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable strategy that confers mechano-responsive behavior on hydrogels. Our approach involves embedding hybrid vesicles, composed of phospholipids and amphiphilic block copolymers, within the hydrogel matrix to act as signal transducers. Under mechanical stress, these vesicles undergo deformation and rupture, releasing encapsulated compounds that can control the hydrogel network. To demonstrate this concept, we embedded vesicles containing ethylene glycol tetraacetic acid (EGTA), a calcium chelator, into a calcium-crosslinked alginate hydrogel. When compressed, the released EGTA sequesters calcium ions and degrades the hydrogel. This study provides a novel method for engineering mechano-responsive hydrogels that may be useful in various biomedical applications.

关键词： Block Copolymers Functional Material Stimuli-Responsive Hydrogel Stress-Induced Degradation Vesicles

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Graphene Acid Quantum Dots: A Highly Active Multifunctional Carbon Nano Material that Intervene in the Trajectory Towards Neurodegeneration

SSRN

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SSRN 2024年

作者： ElMorsy, Sherin M. Gutierrez, Denisse A. Valdez, Salvador Kumar, Jyotish Aguilera, Renato J. Noufal Sanad, Mohamed Sarma, Hemen Chinnam, Sampath Narayan, Mahesh The Environmental Science & Engineering Program The University of Texas at El Paso El PasoTX79968 United States Cellular Characterization and Biorepository Core Facility Border Biomedical Research Center Department of Biological Sciences College of Science The University of Texas at El Paso 500 West University Avenue El PasoTX79968-0519 United States Department of Chemistry and Biochemistry The University of Texas at El Paso 500 West University Avenue El PasoTexas79968 United States Department of Chemical Engineering Hampton University HamptonVA23668 United States Assam Kokrajhar783370 India Department of Chemistry M.S. Ramaiah Institute of Technology Karnataka Bengaluru560054 India Autonoumous Institution Affiliated to Visvesvaraya Technological University Belgaum India

Carbon dots (CDs) are carbon nano materials (CNMs) that find use across several biological applications because of their water solubility, biocompatible nature, eco-friendliness, and ease of synthesis. Additionally, their physiochemical properties can be chemically tuned for further optimization towards specific applications. Here, we investigate the efficacy of C70-derived Graphene Acid Quantum Dots (GAQDs) in mitigating the transformation of soluble, monomeric Hen Egg-White Lysozyme (HEWL) to mature fibrils during its amyloidogenic trajectory. Our findings reveal that GAQDs exhibit dose-dependent inhibition of HEWL fibril formation (up to 70% at 5 mg/mL) without affecting mitochondrial membrane potential or inducing apoptosis at the same density. Furthermore, GAQDs scavenged reactive oxygen species (ROS);achieving a 50% reduction in ROS levels at a mere 100 µg/mL when exposed to a standard free radical generator. GAQDs were not only found to be biocompatible with a human neuroblastoma-derived SHSY-5Y cell line but also rescued the cells from rotenone-induced apoptosis. The GAQD-tolerance of SHSY-5Y cells coupled with their ability to restitute cells from rotenone-dependent apoptosis, when taken in conjunction with the biocompatibility data, indicate that GAQDs possess neuroprotective potential. The data position this class of CNMs as promising candidates for resolving aberrant cellular outputs that associate with the advent and progress of multifactorial neurodegenerative disorders including Parkinson's (PD) and Alzheimer’s diseases (AD) wherein environmental causes are implicated (95% etiology). The data suggest that GAQDs are a multifunctional carbon-based sustainable nano-platform at the intersection of nanotechnology and neuroprotection for advancing green chemistry-derived, sustainable healthcare solutions. © 2024, The Authors. All rights reserved.

关键词： Graphene

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The effect of catalyst concentration in poly lactic acid synthesis from L-lactide using Candida rugosa lipase and DMA (dimethylacetamide) solvent through ring-opening polymerization (ROP)

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AIP Conference Proceedings 2022年第1期2493卷

作者： Cynthia Laurent Santoso Catia Angli Curie Yusuf Arya Ramadhan Muhammad Arif Darmawan Misri Gozan 1Bioprocess Engineering Program Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 Indonesia 2Research Centre for Biomedical Engineer Faculty of Engineering Universitas Indonesia Kampus Baru Depok 16424 Indonesia

Poly Lactic Acid (PLA) is a polymer that can be used as an alternative to fossil-based plastics. PLA is the right solution because of its biodegradability, biocompatibility, mechanical strength, and processability. PLA synthesis process is more often carried out using the Ring-Opening Polymerization (ROP) pathway since it allows to produce a high molecular weight PLA. This study used Candida rugosa lipase as a green catalyst and DMA (Dimethylacetamide) as the solvent in the ROP of L-lactide. The observations were made by varying the catalyst ratio at 2, 5, and 10% w/w. The obtained PLA was characterized using H-NMR (H Nuclear Magnetic Resonance) to estimate the average number molecular weight (Mn) and monomer conversion, and GPC (Gel Permeation Chromatography) was also used to determine the number average and weight average molecular weight (Mn and Mw) of the PLA. It was found that the optimal catalyst ratio when the polymerization was performed at 80℃ for 3 days was 5%w/w.

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Graphene Nanoribbons/Manganese Oxide Nanocomposite Modified Electrode for Detection of Antimicrobial Drug Nitrofurantoin

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Journal of Nanomaterials 2023年第1期2023卷

作者： Nagarajan, Ramila D. Magesh, Vasanth Sundramoorthy, Ashok K. Murugan, Preethika Atchudan, Raji Ganapathy, Dhanraj Arya, Sandeep Mahmoud Karami, Abdulnasser Govindasamy, Mani Department of Chemistry V.V.Vanniaperumal College for Women Tamil Nadu Virudhunagar626001 India Centre for Nano-Biosensors Department of Prosthodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Poonamallee High Road Velappanchavadi Tamil Nadu Chennai600077 India Augsburg University Am Technologiezentrum 8 Augsburg86159 Germany School of Chemical Engineering Yeungnam University Gyeongsan38541 Korea Republic of Department of Physics University of Jammu Jammu and Kashmir Jammu180006 India Department of Chemistry College of Science King Saud University Riyadh11451 Saudi Arabia International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City243303 Taiwan

The design and development of a new kind of cost-effective electrode material with excellent selectivity and stability are still a great challenge in the field of electrochemical sensors. Recently, researchers have paid more attention to the electrochemical reduction of nitro compounds due to their hazardous nature. Nitro compounds play a vital role in various industrial applications. However, the direct discharge of nitro compounds to the environment as industrial wastewater is harmful. In this study, a nanocomposite made of 1D graphene nanoribbons decorated with manganese dioxide (GNR-MnO2) was prepared to fabricate an electrochemical transducer for the determination of nitrofurantoin (NFT) in biofluids. First, 1D GNR was prepared by unzipping of multiwalled carbon nanotubes. Second, the GNR was decorated with MnO2 by the hydrothermal reduction method. As-prepared GNR-MnO2 nanocomposite was comprehensively characterized by field emission scanning electron microscopy with EDX, XRD, UV-visible, electrochemical impedance spectroscopy, and cyclic voltammetry. Moreover, GNR-MnO2-coated glassy carbon electrode (GCE) exhibited good electrocatalytic activity toward NFT. The electroreduction of NFT was found at -0.40 V which was 50 mV lower than bare GCE. GNR-MnO2 nanocomposite modified GCE showed a well-defined linear reduction peak current for NFT from 10 nM to 1,000 μM. The selectivity of the sensor was also analyzed in the presence of other nitro compounds which confirmed that NFT can be selectively detected at -0.4 V. The GNR-MnO2 modified electrode was also able to separate reduction peaks of other nitro compounds. In addition, the detection of NFT was carried out in human urine samples with a good recovery of 99.60%-98.60%. © 2023 Ramila D. Nagarajan et al.

关键词： Scanning electron microscopy

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