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arXiv 2022年

作者： Huayamares, Sebastian G. Lokugamage, Melissa P. Da Silva Sanchez, Alejandro J. Dahlman, James E. Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology Emory School of Medicine AtlantaGA30332 United States Quantitative & Computational Finance Program Georgia Institute of Technology AtlantaGA30332 United States Alloy Therapeutics BostonMA02421 United States Petit Institute for Bioengineering and Biosciences Georgia Institute of Technology AtlantaGA30332 United States Department of Chemical Engineering Georgia Institute of Technology AtlantaGA30332 United States

Biotechnologies are being commercialized at historic rates. In 2020, 74 biotech startups went public through an Initial Public Offering (IPO), and 60 went through the IPO process in the first six months of 2021. However, the traits associated with biotech startups obtaining recent IPOs have not been reported. Here we build a database of biotechs that underwent an IPO in the first half of 2021. By analyzing leadership, technological focus, clinical trials, and financing, we found that advanced degrees among the leadership, clinical trials, and intellectual property are important factors for biotech startups. The data also suggest that large private rounds can decrease time-to-IPO and affect post-IPO stock performance. Notably, these traits were often exhibited by the 138 biotech IPOs in 2018-2019, suggesting 2021 data were not driven by COVID. © 2022, CC BY.

关键词： Investments

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Transformative lactera-polypyrrole@carrageenan microparticles leveraging NIR for skin regeneration and stress relief

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International journal of biological macromolecules 2025年 316卷 144436页

作者： Sih-Chi Chuang Shih-An Yu Pei-Chia Hung Andrew E-Y Chuang Jia-Wei Liang Lekshmi Rethi Chih-Kuang Chen Hsu-Wei Fang Hieu Trung Nguyen Hsien-Tsung Lu Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Doctoral Program of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 10608 Taiwan. Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei 11696 Taiwan. Hsuan Chen Technology CO. LTD. New Taipei City 22055 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan. International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City Taiwan. Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Taoyuan Taiwan. School of Medicine Chang Gung University Taoyuan Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei Taiwan. Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan. Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City 700000 Viet Nam. Department of Orthopedic Taipei Medical University Hospital Taipei City 11031 Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei 11031 Taiwan. Electronic address: lu7788@tmu.edu.tw.

Effective wound healing remains a significant challenge in regenerative medicine, particularly in minimizing inflammation and promoting scarless recovery. This study introduces a bioengineered LAC-PPy@Car MF composite, designed to leverage near-infrared (NIR)-induced photothermal therapy alongside biotherapeutics to accelerate tissue regeneration. The composite integrates the photothermal properties of polypyrrole (PPy) with the anti-inflammatory and regenerative potential of Lactera (LAC) and Carrageenan (Car). Upon NIR activation, the composite generates localized mild-hyperthermia, reducing oxidative stress, enhancing Aryl Hydrocarbon Receptor (AhR) activity, and upregulating heat shock proteins (HSP). These effects synergistically create a bioactive environment conducive to cellular proliferation and tissue repair. Biochemical evaluations demonstrate that LAC-PPy@Car MF effectively reduces oxidative stress, stimulates fibroblast migration, and promotes the proliferation of skin cells. Immunofluorescence staining reveals significant activation of AhR and HSP in treated tissues, correlating with accelerated cellular proliferation and improved skin architecture. The NIR-triggered photothermal effect enhances the therapeutic potential of the composite, ensuring precise and minimally invasive treatment for burn injuries. These findings position phototherapeutic LAC-PPy@Car MF as a promising candidate for advanced wound healing applications. Its dual functionality, combining photothermal therapy with bioactive healing properties, offers a transformative approach to regenerative medicine, paving the way for improved clinical outcomes in wound care.

关键词： Tissue regeneration

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Corrigendum to "Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin" [Acta Biomaterialia Volume 150, Pages 211-220]

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Acta biomaterialia 2024年 179卷 398页

作者： Nicole B Day Rianne Dalhuisen Nichole E Loomis Sarah G Adzema Jai Prakash C Wyatt Shields Department of Chemical and Biological Engineering University of Colorado Boulder Boulder CO 80303 United States. Department of Chemical and Biological Engineering University of Colorado Boulder Boulder CO 80303 United States Department of Advanced Organ Bioengineering and Therapeutics Section: Engineered Therapeutics University of Twente Enschede the Netherlands. Biomedical Engineering Program University of Colorado Boulder Boulder CO 80303 United States. Electronic address: Charles.Shields@colorado.edu.

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Compositionally Complex Perovskite Oxides for Solar Thermochemical Water Splitting

arXiv

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arXiv 2022年

作者： Zhang, Dawei De Santiago, Héctor A. Xu, Boyuan Liu, Cijie Trindell, Jamie Li, Wei Park, Jiyun Rodriguez, Mark A. Coker, Eric N. Sugar, Josh McDaniel, Anthony Lany, Stephan Ma, Liang Wang, Yi Collins, Gregory Tian, Hanchen Li, Wenyuan Qi, Yue Liu, Xingbo Luo, Jian Program of Materials Science and Engineering University of California San Diego La Jolla CA92093 United States Department of Mechanical and Aerospace Engineering Benjamin M. Statler College of Engineering and Mineral Resources West Virginia University MorgantownWV26506 United States Department of Physics Brown University ProvidenceRI02912 United States Sandia National Laboratories LivermoreCA94551 United States School of Engineering Brown University ProvidenceRI02912 United States Sandia National Laboratories AlbuquerqueNM87185 United States Materials Science Center National Renewable Energy Laboratory GoldenCO80401 United States School of Materials Science and Engineering Hebei University of Engineering Hebei Province Handan056038 China Department of Chemical and Biomedical Engineering Benjamin M. Statler College of Engineering and Mineral Resources West Virginia University MorgantownWV26506 United States Department of NanoEngineering University of California San Diego La Jolla CA92093 United States

Solar thermochemical hydrogen generation (STCH) is a promising approach for eco-friendly H2 production, but conventional STCH redox compounds often suffer from thermodynamic and kinetic limitations with limited tunability. Expanding from the nascent high-entropy ceramics field, this study explores a new class of compositionally complex perovskite oxides (La0.8Sr0.2)(Mn(1-x)/3Fe(1-x)/3CoxAl(1-x)/3)O3 for STCH. In situ X-ray diffraction demonstrates the phase stability during redox cycling and in situ X-ray photoelectron spectroscopy shows preferential redox of Co. The extent of reduction increases, but the intrinsic kinetics decreases, with increased Co content. Consequently, (La0.8Sr0.2)(Mn0.2Fe0.2Co0.4Al0.2)O3-δ achieves an optimal balance between the thermodynamics and kinetics properties. The combination of a moderate enthalpy of reduction, high entropy of reduction, and preferable surface oxygen exchange kinetics enables a maximum H2 yield of 395 ± 11 μmol g-1 in a short 1-hour redox duration. Entropy stabilization expectedly contributes to the structure stability during redox without phase transformation, which enables an exceptional STCH stability for >50 cycles under harsh interrupted conditions. The underlying redox mechanism is further elucidated by the density functional theory based parallel Monte Carlo computation, which represents a new computation paradigm first established here. This study suggests a new class of non-equimolar compositionally complex ceramics for STCH and chemical looping. © 2022, CC BY.

关键词： Entropy

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Bacteria-based bioactive materials for tumor immunotherapy

Precision Medicine and Engineering

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Precision Medicine and engineering 2024年第2期1卷

作者： Yongcan Li Fangfang Cao Lie Ma Lulu Jin MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 PR China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore 117597 Singapore

As one of the most abundant biological populations endowed with unique properties such as specific targeting and genetic engineering vectors, bacteria with immunogenic potential have garnered significant attention for their ability to elicit immune activation against tumors. This approach has achieved substantial breakthroughs as a modality for cancer treatment and is known as bacterial immunotherapy. However, the immunosuppressive tumor microenvironment (TME) can inhibit the immune response induced by bacteria and promote tumor growth and metastasis. To overcome this challenge, recent advancements in bacteria-based bioactive materials, which are biological substances synthesized by bacteria, have not only harnessed the inherent properties of bacteria but also specifically targeted the modulation of the TME, providing a more favorable environment for immune activation and significantly enhancing the efficacy of immunotherapy for cancer treatment. This review introduces the key mechanisms of bacteria-based biomaterials as anticancer agents and reviews the latest research progress, along with their clinical applications in cancer treatment. Finally, the potential and challenges of bacteria-based biomaterials for tumor therapy are explored, aiming to provide insights into the functions of bacteria-based bioactive materials and their role in advancing cancer immunotherapy while offering recommendations for the development of new bacteria-based biomaterials.

关键词： Tumor immunotherapy Immune cells Tumor microenvironment Bioactive materials

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POS-600 Investigations on the Impact of Hemodialysis Clinical Practices on Human Plasma Proteins Loss and von Willebrand factor

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Kidney International Reports 2022年第2期7卷 S258-S258页

作者： A. ABDELRASOUL A. Shoker University of Saskatchewan Chemical and Biological Engineering- Division of Biomedical Engineering Saskatoon Canada University of Saskatchewan & St. Paul Hospital Nephrology- College of medicine & Saskatchewan Transplant Program Saskatoon Canada

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Endogenous opioid signaling in the retina modulates sleep/wake activity in mice

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Neurobiology of Sleep and Circadian Rhythms 2022年 13卷 100078页

作者： Berezin, Casey-Tyler Bergum, Nikolas Luchini, Kes A. Curdts, Sierra Korkis, Christian Vigh, Jozsef Cell and Molecular Biology Graduate Program Colorado State University 1005 Campus Delivery Fort Collins 80523 CO United States Department of Biomedical Sciences Colorado State University 1601 Campus Delivery Fort Collins 80523 CO United States Department of Chemical and Biological Engineering Walter Scott Jr. College of Engineering Colorado State University 1376 Campus Delivery Fort Collins 80523 CO United States

Circadian sleep/wake rhythms are synchronized to environmental light/dark cycles in a process known as photoentrainment. We have previously shown that activation of β-endorphin-preferring μ-opioid receptors (MORs) inhibits the light-evoked firing of intrinsically photosensitive retinal ganglion cells (ipRGCs), the sole conduits of photoentrainment. Although we have shown that β-endorphin is expressed in the adult mouse retina, the conditions under which β-endorphin is expressed are unknown. Moreover, it is unclear whether endogenous activation of the MORs expressed by ipRGCs modulates the photoentrainment of sleep/wake cycles. To elucidate this, we first measured the mRNA expression of β-endorphin's precursor, proopiomelanocortin (POMC), at various times of day by quantitative reverse-transcription PCR. POMC mRNA appears to have cyclic expression in the mouse retina. We then studied β-endorphin expression with immunohistochemistry and found that retinal β-endorphin is more highly expressed in the dark/at night. Finally, we used telemetry to measure activity, EEG and EMG in freely moving animals to compare sleep/wake cycles in wild-type and transgenic mice in which only ipRGCs lack functional MORs. Results from these experiments suggest that the MORs expressed by ipRGCs contribute to the induction and maintenance of activity in the dark phase in nocturnal mice, via the promotion of wakefulness and inhibition of slow-wave sleep. Together, these data suggest that endogenous β-endorphin activates MORs expressed by ipRGCs to modulate sleep/wake activity via the photoentrainment pathway. © 2022 The Authors

关键词： Proopiomelanocortin Retina Sleep/wake Telemetry β-endorphin μ-Opioid receptor

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CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation

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Journal of controlled release : official journal of the Controlled Release Society 2025年 384卷 113872页

作者： Sang Eun Kim Soyeon Bak Jung Hee Park Ji Eun Lee Yun Ji Lee Min Seok Park Soyeon Ko Hani Choi Kyung Hee Jung Kun Na Soon-Sun Hong Department of Medicine College of Medicine and Program in Biomedical Science & Engineering Inha University 3-ga Sinheung-dong Jung-gu Incheon 22332 Republic of Korea. Department of Biotechnology The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea Department of BioMedical-Chemical Engineering The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea. Department of BioMedical-Chemical Engineering The Catholic University of Korea 43 Jibong-ro Wonmi-gu Bucheon-si Gyeonggi-do 14662 Republic of Korea. Electronic address: kna6997@catholic.ac.kr. Department of Medicine College of Medicine and Program in Biomedical Science & Engineering Inha University 3-ga Sinheung-dong Jung-gu Incheon 22332 Republic of Korea. Electronic address: hongs@inha.ac.kr.

Receptor-interacting protein kinase 3 (RIP3)-mediated necroptosis has attracted interest as a potential target for cancer therapy as it boosts tumor immunogenicity. Here, we synthesized a pH-sensitive polymer (CA) by conjugating aminopropyl imidazole (API) to chondroitin sulfate (CHS) for RIP3 gene delivery. CA can target cancer cells due to the specific binding ability of CHS to CD44 which is overexpressed in cancer cells. In addition, the introduction of API conferred pH sensitivity, facilitating efficient endosomal escape and enhancing gene delivery efficiency. Increased levels of high mobility group box-1, EEA1, and Rab5 and high activation of RIP3/mixed-lineage kinase domain-like pseudokinase signaling were observed in the CA-shielded RIP3 complex (CA-PEI/RIP3)-treated groups. Significant tumor selectivity and ablation efficacy of CA-PEI/RIP3 were confirmed in A549 xenografts and LLC1 orthotopic lung cancer mouse models. Furthermore, CA-PEI/RIP3-induced necroptotic cell death could enhance the immune response by increasing phagocytosis of dendritic cells (DCs), resulting in large numbers of CD4+ and CD8+ T cells and mature DCs infiltrating tumor tissues and lymph nodes. Collectively, CA-PEI/RIP3 showed significant potential in cancer gene therapy due to the enhanced transfection efficiency and the tumor-targeting properties of CA, providing a safe and robust strategy to activate the immune response for cancer immunotherapy.

关键词： Cancer gene therapy Gene delivery Necroptosis RIP3 pH-sensitive polymer

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Quantum-Well Bound States in Graphene Heterostructure Interfaces

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Physical Review Letters 2021年第8期127卷 086805-086805页

作者： Zhongwei Dai (代中伟) Zhaoli Gao Sergey S. Pershoguba Nikhil Tiwale Ashwanth Subramanian Qicheng Zhang Calley Eads Samuel A. Tenney Richard M. Osgood Chang-Yong Nam Jiadong Zang A. T. Charlie Johnson Jerzy T. Sadowski Center for Functional Nanomaterials Brookhaven National Laboratory Upton New York 11973 USA Department of Physics and Astronomy University of Pennsylvania Philadelphia Pennsylvania 19104 USA Department of Biomedical Engineering The Chinese University of Hong Kong Hong Kong China Department of Physics and Astronomy and Materials Science Program University of New Hampshire Durham New Hampshire 03824 USA Department of Materials Science and Chemical Engineering Stony Brook University Stony Brook New York 11794 USA Department of Electrical Engineering Columbia University New York New York 10027 USA

We present experimental evidence of electronic and optical interlayer resonances in graphene van der Waals heterostructure interfaces. Using the spectroscopic mode of a low-energy electron microscope (LEEM), we characterized these interlayer resonant states up to 10 eV above the vacuum level. Compared with nontwisted, AB-stacked bilayer graphene (AB BLG), an ≈0.2 Å increase was found in the interlayer spacing of 30° twisted bilayer graphene (30°-tBLG). In addition, we used Raman spectroscopy to probe the inelastic light-matter interactions. A unique type of Fano resonance was found around the D and G modes of the graphene lattice vibrations. This anomalous, robust Fano resonance is a direct result of quantum confinement and the interplay between discrete phonon states and the excitonic continuum.

关键词： Electronic structure Graphene Heterostructures Low-energy electron microscopy Raman spectroscopy

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Product design of memory-boosting jelly drink for young adult

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AIP Conference Proceedings 2022年第1期2537卷

作者： Misri Gozan Brigitta Angelina Cindyara Nayanda Nur Annisa Ruth Silva Amanat Taqwa Woro Bismo 1Bioprocess Engineering Program Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Memory loss can occur in an older adult or even a younger age person. From our preliminary survey with 85 respondents, 91% of respondents ever experienced memory loss symptoms, and 63% have ever consumed memory-boosting products. This study examines a product development of a jelly drink for memory boosting, especially for youth and young adults using Brahmi (Bacopa monnieri), one of the herbal plants that can increase cell neurogenesis in the hippocampus. Initially, the needs of the respondents were classified, benchmarked with available similar products, and then transformed into specifications. The concept generation and selection were carried to fulfill the specification, including regulatory requirements. Three concepts were market-tested in jelly drink, milkshake, and syrup, where 53% prefer jelly drink. The final; formulation ingredients include Bacopa monnieri, Honey, Blueberry extract, Sugar, Agar, Jelly, Water, and Sodium benzoate.

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