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Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

Advanced Healthcare Materials 2023年第28期12卷 e2301504页

作者： Liu, Chia-Hung Liu, Ming-Che Jheng, Pei-Ru Yu, Jiashing Fan, Yu-Jui Liang, Jia-Wei Hsiao, Yu-Cheng Chiang, Chih-Wei Bolouki, Nima Lee, Jyh-Wei Hsieh, Jang-Hsing Mansel, Bradley W Chen, Yan-Ting Nguyen, Hieu Trung Chuang, Er-Yuan Department of Urology School of Medicine College of Medicine Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center of Urology and Kidney Taipei Medical University 250 Wu-Hsing Street Taipei11031 Taiwan Department of Urology Shuang Ho Hospital Taipei Medical University 291 Zhongzheng Road Zhonghe District New Taipei City23561 Taiwan Clinical Research Center Taipei Medical University Hospital Taipei11031 Taiwan School of Dental Technology College of Oral Medicine Taipei Medical University Taipei11031 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering Graduate Institute of Biomedical Optomechatronics School of Biomedical Engineering Research Center of Biomedical Device Innovation Entrepreneurship Education Center College of Interdisciplinary Studies Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering College of Engineering National Taiwan University Taipei106 Taiwan Department of Orthopedics Taipei Medical University Taipei11031 Taiwan Department of Orthopedics Taipei Medical University Hospital Taipei11031 Taiwan Department of Physical Electronics Faculty of Science Masaryk University Brno60177 Czech Republic Department of Materials Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei City24301 Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Cell Physiology and Molecular Image Research Center Taipei Medical University Wan Fang Hospital Taipei11696 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei11031 Taiwan

Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by ≈80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment. © 2023 Wiley-VCH GmbH.

关键词： Diseases

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Novel fibrin-fibronectin matrix accelerates mice skin wound healing

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Bioactive Materials 2020年第4期5卷 949-962页

作者： Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo Nursing School University of CampinasCampinasSPBrazil Laboratory of Cell Signaling University of CampinasCampinasSPBrazil Department of Chemical and Biomolecular Engineering University of NebraskaLincolnNEUSA Biomedical Engineering Program University of NebraskaLincolnNEUSA School of Biological Science University of NebraskaLincolnNEUSA Department of Surgery University of Nebraska Medical Center and the VA Nebraska-Western Iowa Health Care SystemUSA Mary and Dick Holland Regenerative Medicine Program University of Nebraska Medical CenterOmahaNEUSA Fred&Pamela Buffett Cancer Center University of Nebraska Medical CenterOmahaNEUSA

Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound *** 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN *** dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human *** in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN *** toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced *** study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing.

关键词： Fibrin Fibronectin Nanoclusters Wound healing

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Highly efficient capture of E. coli using amidoximated polyacrylonitrile nanofiber membrane immobilized with reactive green 19 dye/polyhexamethylene biguanide: Antibacterial and cytotoxicity studies

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Separation and Purification Technology 2024年 338卷

作者： Quang-Vinh Le Bing-Lan Liu Penjit Srinophakun Jeng-Ywan Shih Chi-Yun Wang Chen‑Yaw Chiu Shen-Long Tsai Kuei-Hsiang Chen Yu-Kaung Chang Department of Chemical Engineering National Taiwan University of Science and Technology Taipei City 10607 Taiwan Department of Applied Chemistry Chaoyang University of Technology Taichung 413310 Taiwan Department of Chemical Engineering Kasetsart University 50 Ngamwongwan Road Chatuchak Bangkok 10900 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243303 Taiwan International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Bone and Joint Research Centre Chang Gung Memorial Hospital Taoyuan City 333423 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University Zhongli Dist. Taoyuan City 320315 Taiwan

In this study, we synthesized an amidoximated polyacrylonitrile nanofiber membrane (P-Oxime). Subsequently, we grafted reactive green 19 (RG19) dye onto its surface, resulting in the formation of the P-Oxime-RG19 membrane. Further enhancement was achieved by physically attaching poly(hexamethylene biguanide) hydrochloride (PHMB) to the P-Oxime-RG19 membrane, leading to the formation of the P-Oxime-RG19-PHMB membrane. Extensive characterization of the nanofiber membranes was conducted, focusing on crucial physical and mechanical properties such as functional group content, morphology, and thermostability. The optimization of various modification conditions, including initial dye and PHMB concentrations, duration, temperature, and nitrile group conversion to oxime concentrations, played a pivotal role in achieving superior antibacterial performance in P-Oxime-RG19-PHMB nanofiber membranes. In-depth analyses involved the application of kinetic and equilibrium thermodynamic models to unravel the modification processes of RG19 dye and PHMB in the nanofiber membranes. Under the carefully tuned optimal modification conditions, the P-Oxime-RG19-PHMB nanofiber membrane exhibited remarkable antibacterial efficacy, achieving nearly 100% disinfection of E. coli . In addition to exploring its antimicrobial capabilities, we thoroughly examined the repeatability and biocompatibility of the nanofiber membranes. The results indicated not only the P-Oxime-RG19-PHMB nanofiber membrane was a highly promising antibacterial material but also highlighted its potential for diverse applications, particularly in food and textile fabrication, owing to its exceptional performance and suitability.

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Techno-Economic evaluation of oil palm empty fruit bunch-based encapsulated lignin production process

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AIP Conference Proceedings 2022年第1期2537卷

作者： Muhammad Yusuf Arya Ramadhan Sarah Salsabila Muhammad Arif Darmawan Misri Gozan 1Bioprocess Engineering Program Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Oil Palm Empty Fruit Bunch (EFB) is the main solid waste from the palm oil processing industry. One of the main constituent polymers of Oil Palm EFB is lignin. Currently, lignin is used as wood adhesives. The antioxidant activity of lignin has received much attention recently because of the structure of the polyphenols possessed by lignin. Although previous studies have shown that lignin has antioxidant activity, lignin is easily oxidized while in storage. Therefore, we need materials to maintain lignin stability. This research analyzes the investment feasibility of a lignin production plant encapsulated from oil palm empty fruit bunches (EFB) as raw material. The factory will be built in the Kertajaya area, Banten, Indonesia, with a project life span of 15 years and is targeted to meet a 1% market share. This study compared four pretreatment processes: alkaline with NaOH, acid-alkaline, steam explosion, and alkaline with NH4OH. The production process simulation uses the SuperPro Designer v9.5 to obtain mass, energy, and economic parameter data. Simulations show the production of encapsulated lignin with the alkaline pretreatment using the NaOH method as the best alternative with the profitability parameters in the form of NPV, IRR, and PBP, of USD 6,078,000; 35.23 % and 3.19 years, respectively, at the product selling price of USD 40/kg.

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Non-invasive imaging of extracellular vesicles: Quo vaditis in vivo? (vol 11, e12241, 2022)

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JOURNAL OF EXTRACELLULAR VESICLES 2022年第12期11卷 e12241页

作者： Arifin, D. R. Witwer, K. W. Bulte, J. W. M. Russell H. Morgan Department of Radiology and Radiological Science Division of MR Research the Johns Hopkins University School of Medicine Baltimore Maryland USA Cellular Imaging Section and Vascular Biology Program Institute for Cell Engineering the Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Molecular and Comparative Pathobiology the Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Neurology the Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Oncology the Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Chemical & Biomolecular Engineering the Johns Hopkins University School of Medicine Baltimore Maryland USA Department of Biomedical Engineering the Johns Hopkins University School of Medicine Baltimore Maryland USA

Extracellular vesicles (EVs) are lipid-bilayer delimited vesicles released by nearly all cell types that serve as mediators of intercellular signalling. Recent evidence has shown that EVs play a key role in many normal as well as pathological cellular processes. EVs can be exploited as disease biomarkers and also as targeted, cell-free therapeutic delivery and signalling vehicles for use in regenerative medicine and other clinical settings. Despite this potential, much remains unknown about the in vivo biodistribution and pharmacokinetic profiles of EVs after administration into living subjects. The ability to non-invasively image exogeneous EVs, especially in larger animals, will allow a better understanding of their in vivo homing and retention patterns, blood and tissue half-life, and excretion pathways, all of which are needed to advance clinical diagnostic and/or therapeutic applications of EVs. We present the current state-of-the-art methods for labeling EVs with various diagnostic contrast agents and tracers and the respective imaging modalities that can be used for their in vivo visualization: magnetic resonance imaging (MRI), X-ray computed tomography (CT) imaging, magnetic particle imaging (MPI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and optical imaging (fluorescence and bioluminescence imaging). We review here the strengths and weaknesses of each of these EV imaging approaches, with special emphasis on clinical translation.

关键词： bioluminescence CT extracellular vesicle imaging MRI PET SPECT

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Comparison of In Vitro and In Vivo Degradation of Polyurethane Foams with Tunable Degradation Rates

SSRN

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SSRN 2022年

作者： Vakil, Anand Utpal Petryk, Natalie Marie Du, Changling Howes, Bryanna Stinfort, Darnelle Serinelli, Serenella Gitto, Lorenzo Ramezani, Maryam Beaman, Henry T. Monroe, Mary Beth Browning Department of Biomedical and Chemical Engineering Syracuse Biomaterials Institute BioInspired Syracuse Institute for Material and Living Systems Syracuse University SyracuseNY13244 United States Department of Chemistry Lemoyne College SyracuseNY United States Biotechnology Program Syracuse University SyracuseNY13244 United States SUNY Upstate Medical University 8718 750 East Adams Street SyracuseNY13210 United States

Polyurethane foams present a highly tunable biomaterial platform with potential for use in a range of regenerative medicine applications. Achieving a balance between scaffold degradation rates and tissue ingrowth is vital for successful wound healing in tissue engineering, and significant in vivo testing is required to understand these processes. Selection of promising polymer formulations for testing in appropriate models is essential, and vigorous in vitro testing can minimize the number of animals that are required to gather reliable data. However, it is difficult to accurately select in vitro degradation conditions that can effectively mimic in vivo results. To that end, we performed a comprehensive in vitro assessment of the degradation of porous shape memory polyurethane foams with tunable degradation rates using varying concentrations of hydrogen peroxide to identify the medium that closely mimics measured in vivo degradation rates. Material degradation was studied over 12 weeks in vitro in 1, 2, or 3% hydrogen peroxide and in vivo in subcutaneous pockets in Sprague Dawley rats. We found that the in vitro degradation conditions that best predicted in vivo degradation rates varied based on the number of mechanisms by which the polymer degraded and the polymer hydrophilicity. Namely, more hydrophilic materials that degrade by both hydrolysis and oxidation require lower concentrations of hydrogen peroxide (1%) to mimic in vivo rates, while more hydrophobic scaffolds that degrade by oxidation alone require higher concentrations of hydrogen peroxide (3%) to model in vivo degradation. This information can be used to rationally select in vitro degradation conditions that accurately identify in vivo degradation rates prior to characterization in an animal model. © 2022, The Authors. All rights reserved.

关键词： Oxidation

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Novel design of NiS 2 and V 3 Ni(SO 4 ) 4 · 24H 2 O composites with controllable synthetic temperature and duration as an efficient active material for battery supercapacitor hybrids

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Journal of Energy Storage 2025年 130卷

作者： Tsung-Rong Kuo Wei-Lun Huang Chutima Kongvarhodom Muhammad Saukani Sibidou Yougbaré Hung-Ming Chen Lu-Yin Lin Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Precision Medicine and Translational Cancer Research Center Taipei Medical University Hospital Taipei 11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok 10140 Thailand Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin 70124 Indonesia Institut de Recherche en Sciences de la Santé (IRSS-DRCO)/Nanoro 03 B.P 7192 Ouagadougou 03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei 11054 Taiwan

Nickel–vanadium (Ni V) composites are considered as promising active materials for battery supercapacitor hybrids (BSHs), owing to multiple oxidation states, high theoretical capacitance, and tunable redox activity. Structural optimization and sulfur incorporation are effective strategies to improve conductivity and structural stability. Hydrothermal parameters such as temperature and duration significantly influence the material and electrochemical properties. In this study, novel Ni V composites are synthesized via a hydrothermal process at different temperatures and durations as the active material of BSHs. The Ni V composites primarily consist of NiS 2 and V 3 Ni(SO 4 ) 4 · 24H 2 O. The Ni V composites synthesized using 150 °C and 10 h (Ni-V150@10) shows the largest specific capacitance (C F ) of 1381.3 F/g (621.6 C/g) at 20 mV/s, owing to its favorable twisted layered structure and abundant electroactive NiS 2 . A BSH constructed with Ni-V150@10 and reduced graphene oxide electrodes shows a maximum energy density of 9.6 Wh/kg at the power density of 857 W/kg. The capacitance retention of 96.6% and a Coulombic efficiency of 96.9% are also attained after 10,000 charge/discharge cycles. This study provides a clear approach for designing high-performance active materials with controllable hydrothermal temperature and duration, which can be extended to improve the electrochemical performance of other bimetallic composites in the future.

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Spatiotemporal multi-omics:exploring molecular landscapes in aging and regenerative medicine

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Military Medical Research 2025年第4期12卷 528-566页

作者： Liu-Xi Chu Wen-Jia Wang Xin-Pei Gu Ping Wu Chen Gao Quan Zhang Jia Wu Da-Wei Jiang Jun-Qing Huang Xin-Wang Ying Jia-Men Shen Yi Jiang Li-Hua Luo Jun-Peng Xu Yi-Bo Ying Hao-Man Chen Ao Fang Zun-Yong Feng Shu-Hong An Xiao-Kun Li Zhou-Guang Wang Affiliated Cixi Hospital Wenzhou Medical UniversityNingbo 315300ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina National Key Laboratory of Macromolecular Drug Development and Manufacturing School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina State Key Laboratory of Bioelectronics School of Biological Science&Medical EngineeringSoutheast UniversityNanjing 210096China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China Department of Human Anatomy Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000ShandongChina Integrative Muscle Biology Laboratory Division of Regenerative and Rehabilitative SciencesUniversity of Tennessee Health Science CenterMemphisTN 38163United States Key Laboratory for Laboratory Medicine Ministry of EducationZhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui Hospital of Zhejiang UniversityLishui 323000ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 324025ZhejiangChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program NUS Center for Nanom

Aging and regeneration represent complex biological phenomena that have long captivated the scientific *** fully comprehend these processes,it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal *** omics methodologies,such as genomics and transcriptomics,have been instrumental in identifying critical molecular facets of aging and ***,these methods are somewhat limited,constrained by their spatial resolution and their lack of capacity to dynamically represent tissue *** advent of emerging spatiotemporal multi-omics approaches,encompassing transcriptomics,proteomics,metabolomics,and epigenomics,furnishes comprehensive insights into these intricate molecular *** sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells,tissues,and organs,thereby offering an in-depth understanding of the fundamental mechanisms at *** review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration *** underscores how these methodologies augment our comprehension of molecular dynamics,cellular interactions,and signaling ***,the review delineates the foundational principles underpinning these methods,followed by an evaluation of their recent applications within the *** review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the ***,spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration,thus charting a course toward potential therapeutic innovations.

关键词： Spatiotemporal multi-omics Aging and regeneration Cellular interactions Innovative therapeutic strategies

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Ultrasensitive detection of ornidazole–antibiotic drug residues in water using NiMOFs functionalized MWCNT modified electrode

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Microchemical Journal 2024年 197卷

作者： Vignesh, Kondusamy Senthil Kumar, Annamalai Arumugam Napoleon, Ayyakannu Kuo, Chih-Yu Yusuf, Kareem Govindasamy, Mani Nano and Bioelectrochemistry Research Laboratory Carbon dioxide Research and Green Technology Centre and Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India Department of Chemistry School of Advanced Sciences Vellore Institute of Technology Vellore 632 014 India International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Centre for Applied Research Saveetha School of Engineering Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Chennai 602105 India Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan

Nitroimidazole-based drugs are widely used as an antibiotic for the treatment of anaerobic bacterial and parasite illnesses. The widespread use of these drugs in animal feed and the consequent environmental pollution have become significant concerns in recent years. Simple, sensitive, and rapid detection of the antibody in various real samples is demanding research interest. Herein, we report a Nickel-metal organic framework functionalized Multiwalled Carbon nanotubes modified glassy carbon electrode (MWCNT@NiMOFs) as an ultrasensitive and rapid voltammetric sensor for the detection of ornidazole (ORDZ) in a neutral pH solution. The MWCNT@NiMOFs were prepared using a microwave-assisted solvothermal technique accompanied by an ultrasonication method. The designed MWCNT@NiMOFs offered a low charge transfer resistance (R_ct) of 141 Ω along with excellent electrocatalytic activity, and high current density at the lowered cathodic peak potential (-0.62 V vs Ag/AgCl) for ORDZ detection. The surface adsorption capacity (Γ_s) in terms of surface excess and heterogeneous charge transfer rate constant (k⁰) of the MWCNT@NiMOFs were calculated to be 3.29 × 10^-9 mol cm⁻² and 5.33 × 10^-3 cm s⁻¹, respectively. Under an optimal working condition, differential pulse voltammetry measurements of ORDZ have shown concentration linearity in a window, 100 nm to 10 µM range with excellent sensitivity, 5.69 × 10^-5A µM⁻¹ cm⁻², and detection limit, 26 nM (3.3/s). The designed MWCNT@NiMOFs offered appreciable reproducibility, and repeatability up to 30 days of storage time. The real-time quantitative evaluation of ORDZ in human urine and tap water specimens was done along with ∼ 100 % recovery values. Since the new approach is simple, selective, and separation-free, it can be extendable to a variety of real-time practical applications. © 2024 Elsevier B.V.

关键词： Electrocatalytic reduction Multi-walled carbon nanotubes Nickel Metal-organic frameworks Ornidazole drug Ultrasensitive detection

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Coronary heart diseases prediction based on cardiology clinical features 5

Coronary heart diseases prediction based on cardiology clini...

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5th IEEE International Conference on Big Data Intelligence and Computing, DataCom 2019

作者： Yang, Cheng-Hong Chuang, Li-Yeh Chang, Po-Yin National Kaohsiung University of Science and Technology Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Dept. of Electronic Engineering Kaohsiung Taiwan I-Shou University Dept. of Chemical Engineering Institute of Biotechnology and Chemical Engineering Kaohsiung Taiwan National Kaohsiung University of Science and Technology Dept. of Electronic Engineering Kaohsiung Taiwan

ISBN: (纸本)9781728141176

The development of modern health systems has generated a large amount of medical data. Recent research has shown that data mining technology can discover potential patterns from a vast array of medical data, providing insight into disease and predicting disease. Coronary heart disease (CHD) is one of the most important research topics in the health field. In recent years, research on CHD has been extensively studied;however, the accuracy of CHD prediction needs to be improved. Here, a hybrid prediction method BOSVM combining Bayesian optimization (BO) and support vector machine (SVM) is proposed to predict the CHD. In BOSVM, BO aims to adjust of SVM parameters for enhancing the accuracy of CHD prediction. BOSVM compares performance of CHD prediction with five forecasting algorithms, including classification and regression tree, logistic regression, k-nearest neighbors, AdaBoost, and SVM. The experimental results show that the BOSVM has superior prediction accuracy than other algorithms in CHD prediction, indicating BOSVM can effectively predict CHD. © 2019 IEEE.

关键词： Support vector regression

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