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Different Particle Sizes of Momordica Charantia Leaf Powder Modify the Rheological and Textural Properties of Corn Starch-Based 3d Food Printing Ink

SSRN

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SSRN 2023年

作者： Fan, Meiqi Choi, Young-Jin Wedamulla, Nishala Erandi Oh, Mirae Bae, Sung Mun Yang, Daeun Kang, Hyo Tang, Yujiao Moon, Sang-Ho Kim, Eun-Kyung Division of Food Bioscience College of Biomedical and Health Sciences Konkuk University Chungju27478 Korea Republic of Department of Food Science and Nutrition College of Health Science Dong-A University Busan49315 Korea Republic of Department of Health Sciences The Graduate School of Dong-A University Busan49315 Korea Republic of Department of Food Science and Technology Faculty of Animal Science and Export Agriculture Uva Wellassa University Badulla90000 Sri Lanka Grassland and Forages Division National Institute of Animal Science Rural Development Administration Cheonan31000 Korea Republic of Gyeongnam Agricultural Research and Extension Services Jinju52733 Korea Republic of BK-21 Four Graduate Program Department of Chemical Engineering Dong-A University Busan49315 Korea Republic of School of Bio-Science and Food Engineering Changchun University of Science and Technology Changchun130600 China Center for Food and Bio Innovation Dong-A University Busan49315 Korea Republic of Nutritional Education Major Graduate School of Education Dong-A University Busan49315 Korea Republic of Nutrinomics Lab. Co. Ltd. Busan49315 Korea Republic of

The study determined the effect of incorporating Momordica charantia leaf powder (MCLP) into corn-starch 3D food-printing ink as a functional ingredient. The effects of the particle size (75, 131, and 200 μm) and quantity of MCLP on 3D printing performance, structural, textural, and rheological properties of corn starch gel were evaluated with different concentrations (5, 10, and 15% (w/w)) of corn starch. The viscoelastic properties of food inks were determined considering their behavior during extrusion and self-recovery after printing. Scanning electron microscope was used to characterize the microstructure. Based on the results, a high starch content (15%) with 5% MCLP was more favorable for 3D food printing. In addition, 3D printing performance, textural and rheological properties of formulated ink was mainly governed by the particle size of MCLP. The food ink with a 5% mass fraction of 200 μm MCLP had the highest printing precision and the best masticatory properties. © 2023, The Authors. All rights reserved.

关键词： Particle size

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Correction: Biomass derived nitrogen functionalized carbon nanodots for nanomolar determination of levofloxacin in pharmaceutical and water samples

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Mikrochimica acta 2023年第7期190卷 269页

作者： Velusamy Arul Natarajan Sampathkumar Sindhuja Kotteeswaran Ponnusamy Arul Ahmed Muteb Aljuwayid Mohamed A Habila Mani Govindasamy Department of Chemistry Sri Eshwar College of Engineering (Autonomous) Coimbatore 641 202 Tamil Nadu India. kvarulchem6@***. Department of Chemistry Korea University 145 Anam-Ro Seongbuk-Gu Seoul South Korea. kvarulchem6@***. Department of Chemistry SSM College of Arts and Science Dindigul 624002 Tamil Nadu India. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Department of Chemical Engineering and Biotechnology Institute of Biochemical and Biomedical Engineering National Taipei University of Technology Taipei 106 Taiwan ROC. vpsarul@***. Department of Chemistry College of Science King Saud University P. O. Box 2455 Riyadh 11451 Saudi Arabia. International PhD Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Research Center for Intelligence Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. govindasamy420700@***. Department of Research and Innovation Saveetha School of Engineering SIMATS 602105 Chennai India. govindasamy420700@***.

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Bioelectrical Interfaces Beyond Cellular Excitability: Cancer, Aging, and Gene Expression Reprogramming

arXiv

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arXiv 2025年

作者： Cadinu, Paolo Burgess, Matthew Jones, Catarina Franco Luciani, Titouan Iarossi, Marzia Schröter, Manuel Nakatsuka, Nako Djamgoz, Mustafa B.A. Gonçalves, Gil Sanjuán-Alberte, Paola Mendes, Paula M. Rawson, Frankie J. Nair, Malavika Levin, Michael Moreddu, Rosalia Program in Cellular and Molecular Medicine Boston Children’s Hospital BostonMA02115 United States Department of Microbiology Blavatnik Institute Harvard Medical School BostonMA02115 United States Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford United Kingdom Department of Bioengineering Institute for Bioengineering and Biosciences Instituto Superior Técnico University of Lisbon Lisbon Portugal Associate Laboratory i4HB Institute for Health and Bioeconomy Instituto Superior Técnico Universidade de Lisboa Lisbon Portugal Department of Neuroscience Institut Pasteur Paris75015 France Department of Biomedical Engineering Technion Israel Institute of Technology Haifa Israel ETH Zurich Department of Biosystems Science and Engineering Basel Switzerland Laboratory of Chemical Nanotechnology Neuro-X Institute EPFL Genève1202 Switzerland Department of Life Sciences Imperial College London United Kingdom Department of Mechanical Engineering University of Aveiro Aveiro3810-193 Portugal Guimarães4800-058 Portugal School of Chemical Engineering University of Birmingham Birmingham United Kingdom Bioelectronics Laboratory Division of Regenerative Medicine and Cellular Therapies School of Pharmacy Biodiscovery Institute University of Nottingham Nottingham United Kingdom Allen Discovery Centre Tufts University Tufts University MedfordMA United States Wyss Institute for Bioinspired Engineering Harvard University BostonMA United States School of Electronics and Computer Science University of Southampton Southampton United Kingdom Institute for Life Sciences University of Southampton Southampton United Kingdom

Bioelectrical interfaces represent a significant evolution in the intersection of nanotechnology and biophysics, oRering new strategies for probing and influencing cellular processes. These systems capitalize on the subtle but powerful electric fields within living matter, potentially enabling applications beyond cellular excitability, ranging from targeted cancer therapies to interventions in genetic mechanisms and aging. This perspective article envisions the translation, development and application of next-generation solid-state bioelectrical interfaces and their transformative impact across several critical areas of medical research. © 2025, CC BY.

关键词： Medical nanotechnology

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Coating rheology. A review and recent work

Coating rheology. A review and recent work

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TAPPI Paper Conference and Trade Show, PaperCon 2018

作者： Weeks, Lisa Bousfield, Doug Paper Surface Science Program Department of Chemical and Biomedical Engineering University of Maine OronoME04469 United States

ISBN: (纸本)9781510871892

The evaluation of the rheology of paper coating suspensions and their impact on the blade coating operation has been of interest for over four decades and has been summarized in various publications. However, there is still a need for better understanding between the relationship between coating rheology, operation speed, blade geometry, blade loading and coating operational issues. Past work related to the rheology of suspensions and work to link rheology with operation conditions is reviewed. Recent work that involves a high speed blade coater is presented that maps out the operational window of high solid suspensions. A rheological parameter that explains the results is not clear, but a simple relationship between the solids, maximum solids and maximum speed is found. Copyright © 2018 by the Tappi *** right Reserved.

关键词： Coatings

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A Dual-Modality nanozyme Exploiting ROS-Responsive oxygen Catalysis for Precision NF-κB pathway Suppression in gouty arthritis

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chemical engineering Journal 2025年 516卷

作者： Sathiyamoorthy Padmanaban Sree Samanvitha Kuppa Omkar Sangabathula Amal Babu Adityanarayan Mohapatra Sung Sun Kim Hong Yeol Yang Aravindkumar Sundaram Hyung Keun Kim Jong Keun Seon In-Kyu Park Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP) Chonnam National University Medical School Hwasun 58128 Republic of Korea Department of Orthopaedics Surgery Center for Joint Disease of Chonnam National University Hwasun Hospital 322 Seoyang-ro Hwasun-eup Jeonnam 519-763 Republic of Korea Korea Biomedical Materials and Devices Innovation Research Center of Chonnam National University Hospital 42 Jebong-ro Dong-gu Gwangju 501-757 Republic of Korea Department of Chemical Engineering Indian Institute of Technology Hyderabad Kandi 502284 Telangana India DRCure Inc. Hwasun 58128 Republic of Korea Department of Pathology Chonnam National University Medical School Gwangju 61469 Republic of Korea

Gout is characterized by urate deposition in joints leading to immune cell recruitment and inflammatory cytokine release. This condition poses significant therapeutic challenges due to its association with the activation of the nuclear factor (NF)-κB pathway, which promotes inflammation. Traditional treatment modalities often fall short of effectively targeting gout pathophysiology. To address this gap, nanoparticles present a promising avenue by improving drug bioavailability and reducing toxicity. This study explores the therapeutic potential of hollow cerium oxide (CeO) nanoparticles loaded with alpha-lipoic acid (α-LA) in alleviating NF-κB pathway activation. Synthesized through the solvothermal method, hollow CeO nanoparticles were loaded with α-LA through solvent evaporation. Characterization revealed a hollow spherical morphology, uniform size distribution, and sustained α-LA release in vitro . Treatment with CeO nanoparticles, α-LA, and CeO-loaded α-LA resulted in decreased levels of reactive oxygen species (ROS), hydrogen peroxide (H 2 O 2 ), and nitric oxide (NO), alongside increased antioxidant enzyme activities (superoxide dismutase and catalase). Moreover, the nanoparticle efficacy was evaluated in RAW 264.7 macrophage cells stimulated with monosodium urate (MSU) and in a murine model of MSU-induced joint inflammation. While CeO nanoparticles and α-LA individually exhibited moderate reductions in inflammatory mediator release and NF-κB pathway activity, CeO-loaded α-LA synergistically suppressed MSU-induced NF-κB pathway activation. Notably, CeO-loaded α-LA also ameliorated MSU-induced joint inflammation in mice. These findings explore the therapeutic potential of α-LA-loaded CeO nanoparticles, a novel formulation combining antioxidant and anti-inflammatory nanocarriers, to mitigate MSU-induced NF-κB activation. The hollow spherical nanoparticles enable controlled α-LA release, enhancing bioavailability and targeting dual pathways of oxidative stress an

关键词： Alpha lipoic acid Cerium oxide Drug release Gout Inflammation

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Frontispiece: Visible Light-Driven Molecular Switches and Motors: Recent Developments and Applications

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Chemistry – A European Journal 2022年第18期28卷

作者： Dr. Hao Wang Dr. Hari Krishna Bisoyi Xinfang Zhang Dr. Fathy Hassan Prof. Quan Li Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent Ohio 44242 USA Department of Chemistry Faculty of Science Tanta University Tanta El-Gharbia 31527 Egypt Institute of Advanced Materials School of Chemistry and Chemical Engineering and Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast University Nanjing 211189 China

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Front Cover: chemically Tuned Intracellular Gene Delivery by Core-Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption (ChemMedChem 7/2022)

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ChemMedChem 2022年第7期17卷

作者： Dr. Soo Kyung Cho Rebecca T. Lee Prof. Yoon-Hwae Hwang Prof. Young Jik Kwon Crystal Bank PNU Pusan National University 2222 Nano Building Samnangjin-ro Miryang Gyeongsangnam-do 50463 Republic of Korea Department of Biomedical Engineering and Medical Scientist Training Program University of California Irvine B200 Sprague Hall Irvine CA 92697-3958 USA Department of Nano Energy Engineering Pusan National University Pusandaehak-ro 63 beon-gil 2 Jangjeon-dong Geumjung-gu Busan 46241 (Republic of Korea) Departments of Pharmaceutical Science Chemical and Biomolecular Engineering Biomedical Engineering and Molecular Biology and Biochemistry University of California Irvine 132 Sprague Hall Irvine CA 92697-3958 USA

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Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

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Nature biomedical engineering 2025年第2期9卷 285页

作者： Christopher L Yankaskas Keyata N Thompson Colin D Paul Michele I Vitolo Panagiotis Mistriotis Ankit Mahendra Vivek K Bajpai Daniel J Shea Kristen M Manto Andreas C Chai Navin Varadarajan Aikaterini Kontrogianni-Konstantopoulos Stuart S Martin Konstantinos Konstantopoulos Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. Marlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center University of Maryland School of Medicine Baltimore MD USA. Graduate Program in Molecular Medicine University of Maryland School of Medicine Baltimore MD USA. Department of Physiology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering University of Houston Houston TX USA. Department of Chemical and Systems Biology Stanford University Stanford CA USA. Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Baltimore MD USA. Department of Chemical and Biomolecular Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Johns Hopkins Institute for NanoBioTechnology The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Biomedical Engineering The Johns Hopkins University Baltimore MD USA. konstant@jhu.edu. Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD USA. konstant@jhu.edu.

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Soft X-ray Characterization of Sulfur-Poisoned Cation-Exchanged Pt/KL Catalysts for Aromatization of Hexane

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ACS Symposium Series 2019年 1320卷 243-260页

作者： Martinelli, Michela Mehrbod, Mohammad Graham, Uschi M. Hu, Yongfeng Gnanamani, Muthu K. Jacobs, Gary Center for Applied Energy Research University of Kentucky 2540 Research Park Drive LexingtonKY40511 United States Department of Mechanical Engineering University of Texas at San Antonio One UTSA Circle San AntonioTX78249 United States Faraday Energy University of Kentucky 1500 Bull Lea Road LexingtonKY40511 United States Canadian Light Source Inc. 44 Innovation Boulevard SaskatoonSKS7N 2V3 Canada Chemical Engineering Program Department of Biomedical Engineering University of Texas at San Antonio One UTSA Circle San AntonioTX78249 United States

ISBN: (纸本)9780841234598

One percent Pt/KL catalysts containing ion-exchanged cations, for example, calcium (Ca), scandium (Sc), and manganese (Mn), were prepared by chemical vapor deposition. Catalysts were reduced at 500 °C in hydrogen and either cooled and fixed in wax directly, or subjected to H2S poisoning at 20.3 ppm for 2 h prior to cooling and fixing in wax. This prevented oxidation of catalyst samples, allowing for characterization by X-ray absorption near-edge spectroscopy (XANES) at the Soft X-ray Microcharacterization Beamline at the Canadian Light Source, Inc. K-edges of S, K, Ca, Sc, and Mn were examined following normalization of XANES spectra. There are two competing theories for the poisoning mechanism of Pt/KL catalysts. The first involves poisoning of charge-compensating cations located on Pt/KL, which is suggested to prevent the cation from assisting in ring closure of the adsorbed hexatriene intermediate on the Pt surface through an electrostatic interaction. The second mechanism involves direct poisoning of Pt surface by H2S. Once formed, Pt particles are proposed to migrate and agglomerate within KL channels, preventing diffusion of reactants and products to Pt clusters located within L-zeolite channels. XANES did not reveal evidence of an interaction between exchanged cations (e.g., Ca, Sc, or Mn) and sulfur, or between potassium cations and sulfur. Rather, XANES spectra at cation K-edges of freshly activated and activated/H2S-poisoned catalysts were virtually identical. Sulfur K-edge spectra showed line shapes consistent with platinum sulfide. In agreement with our prior study with Pt/KL catalysts, sulfur poisoning appears to involve direct poisoning of Pt, with detachment and agglomeration. © 2019 American chemical Society.

关键词： Positive ions

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1,3-Diketone Analogs as Selective Lysyl Hydroxylase 2 (Lh2) Antagonists

SSRN

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SSRN 2023年

作者： Lee, Juhoon Guo, Hou-Fu Maghsoud, Yazdan Vázquez-Montelongo, Erik Antonio Jing, Zhifeng Wang, Shike Sammons, Rachel M. Cho, Eun Jeong Ren, Pengyu Andrés, G. Cisneros Kurie, Jonathan M. Dalby, Kevin N. Division of Chemical Biology and Medicinal Chemistry College of Pharmacy University of Texas at Austin AustinTX78712 United States Targeted Therapeutic Drug Discovery and Development Program College of Pharmacy University of Texas AustinTX78712 United States Department of Molecular and Cellular Biochemistry University of Kentucky College of Medicine KY40536 United States Department of Chemistry and Biochemistry The University of Texas at Dallas RichardsonTX75080 United States Department of Physical Medicine and Rehabilitation The University of Texas Southwestern Medical Center DallasTX75390 United States Department of Biomedical Engineering The University of Texas at Austin AustinTX78712 United States Departmnt of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center HoustonTX77030 United States Department of Physics The University of Texas at Dallas RichardsonTX75080 United States

Lysyl hydroxylase 2 (LH2), an Fe(II) and α-ketoglutarate (αKG, also called 2-oxoglutarate, or 2OG)-dependent oxygenase, is an endoplasmic reticulum-resident enzyme that hydroxylates telopeptidyl lysine residues on fibrillar collagen molecules. It leads to the formation of hydroxylysine aldehyde-derived collagen cross-links (HLCCs), which are more stable than lysine aldehyde-derived collagen cross-links (LCCs) generated devoid of LH2. It has been reported that LH2 enhances lung cancer metastatic and invasive proclivity and modulates the types of collagen cross-links (HLCC-to-LCC) in the tumor stroma. Herein, we prepared a series of 1,3-diketone analogs 1–18 and identified 12 and 13 that inhibit the LH2-driven hydroxylation of a collagen peptide substrate with IC50 approximately 300 nM and 500 nM, respectively. 12 and 13 demonstrate a 9-fold selectivity for LH2 over LH1 and LH3. Quantum Mechanics/Molecular Mechanics (QM/MM) modeling indicates that in addition to the relatively stronger interactions between compounds 12 and 13 with the active site, the selectivity stems from non-covalent interactions like hydrogen bonding between the morpholine/piperazine rings with LH2-specific Arg661, where the corresponding residue in LH1 and LH3 is Pro. Migration assays in the 344SQ lung adenocarcinoma cell line reveal that 13 shows anti-migration activity. © 2023, The Authors. All rights reserved.

关键词： Aldehydes

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