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Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome

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British journal of pharmacology 2023年第16期180卷 2120-2139页

作者： Shun-Chin Yang Yi-Hsuan Wang Chiu-Ming Ho Yung-Fong Tsai Ping-Jyun Sung Tony Eight Lin Tsong-Long Hwang Department of Anesthesiology Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei 112 Taiwan. Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. Department of Anesthesiology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan Taiwan. Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. National Museum of Marine Biology and Aquarium Pingtung 944 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Research Center for Chinese Herbal Medicine and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology 333 Taoyuan Taiwan. Healthy Aging Research Center Chang Gung University 333 Taoyuan Taiwan. Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243 Taiwan.

BACKGROUND AND PURPOSE:Acute respiratory distress syndrome (ARDS) is a catastrophic pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutrophils is a key feature in infective or sterile ARDS. The formyl peptide receptor 1 (FPR1) is a crucial damage-sensing receptor for inflammatory reactions in the initiation and progression of neutrophil-mediated ARDS. However, effective targets for controlling dysregulated neutrophilic inflammatory injuries in ARDS are limited. EXPERIMENTAL APPROACH:Human neutrophils were used to explore the anti-inflammatory effects of cyclic lipopeptide anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharide-induced model of ARDS in mice was used to determine the therapeutic potential of IA-1 in ARDS. Lung tissues were harvested for histology analyses. KEY RESULTS:The lipopeptide IA-1 inhibited immune responses of neutrophils, including respiratory burst, degranulation, and expression of adhesion molecules. IA-1 inhibited the binding of N-formyl peptides to FPR1 in human neutrophils and in hFPR1-transfected HEK293 cells. We identified IA-1 as a competitive FPR1 antagonist, thus diminishing the downstream signalling pathways involving calcium, mitogen-activated protein kinases and Akt. Furthermore, IA-1 ameliorated the inflammatory damage to lung tissue, by decreasing neutrophil infiltration, reducing elastase release and oxidative stress in endotoxemic mice. CONCLUSION AND IMPLICATIONS:The lipopeptide IA-1 could serve as a therapeutic option for ARDS by inhibiting FPR1-mediated neutrophilic injury.

关键词： ARDS FPR1 N-formyl peptides lipopeptide marine Bacillus neutrophils

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Lessons learned from a chemical engineering REU: The importance of training graduate students who are supervising reu students 125

Lessons learned from a chemical engineering REU: The importa...

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125th ASEE Annual Conference and Exposition

作者： Tise, Joseph C. Hochstedt, Kirsten Susan Zappe, Sarah E. Gomez, Esther W. Kumar, Manish Pennsylvania State University Educational Psychology Program United States Leonhard Center for the Enhancement of Engineering Education Penn State United States Pennsylvania State University Departments of Chemical Engineering and Biomedical Engineering United States Penn State REU United States

Research Experiences for Undergraduates (REU) programs have been shown to promote positive outcomes such as increased interest in graduate school and STEM careers for their participants. Research has also shown how graduate students benefit from mentoring undergraduate researchers-namely they receive instrumental research support, improve teaching skills, and develop socioemotionally. Less research, however, has investigated the ways in which graduate students mentor undergraduate REU participants, and how the mentoring role may impact the graduate students. To address this gap in the literature, the current study examines the way in which graduate students mentor, and the impact of the mentor role on graduate students participating in a chemical engineering REU program. The research questions were explored using a mixed-methods approach. REU students and mentors were asked to complete pre- and post-surveys, as well as participate in a brief interview at the end of the REU experience. Mentor pre- and post-surveys included measures of their interest in serving as a mentor, their previous experience as an REU student or mentor, their mentorship style, their confidence in their ability to mentor others, and their beliefs about the value of mentoring others. Interview questions further explored the approaches that mentors used as well as the perceived impact on the graduate student of the mentor role. Overall, the results indicate that training of graduate student mentors in mentorship approaches may help them to more effectively work with REU students. Findings, suggestions for future research, and implications are discussed. © American Society for engineering Education, 2018.

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A Small-Molecule Drug for the Self-Checking of Mitophagy

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Angewandte Chemie 2025年第10期137卷

作者： Ms. Yanan Gao Mr. Qingjie Bai Ms. Youxiao Ren Dr. Xintian Shao Mr. Mengrui Zhang Dr. Luling Wu Prof. Simon E. Lewis Prof. Tony D. James Prof. Xiaoyuan Chen Prof. Qixin Chen State Key Laboratory of Advanced Drug Delivery and Release Systems School of Pharmaceutical Sciences Neck-Shoulder and Lumbocrural Pain Hospital Medical Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong 250117 PR China Department of Chemistry University of Bath Bath BA2 7AY U.K. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 People's Republic of China Departments of Diagnostic Radiology Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Theranostics Center of Excellence (TCE) Yong Loo Lin School of Medicine National University of Singapore 11 Biopolis Way Helios Singapore 138667 Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore Department of Pharmacy and Pharmaceutical Sciences National University of Singapore Lower Kent Ridge Road 4 Science Drive 2 117544 Singapore

Mitophagy, particularly in the context of drugs that disrupt mitochondrial membrane potential (MMP), represents a critical focus in pharmacology. However, the discovery and evaluation of MMP-disrupting drugs are often hampered using commercially available marker molecules that target similar or identical zones. These markers can significantly interfere with, obscure, or amplify the functional effects of MMP-targeting drugs, frequently leading to clinical failures. In response to this challenge, we propose a “one-two punch” drug design strategy that integrates both target-zone drug functionality and non-target zone biological reporting within a single small-molecule drug. We have developed a novel proof-of-concept mitophagy self-check drug ( MitoSC ) that exhibits dual-color and dual-localization properties. The functional component of this system is a variable MitoSC that disrupts mitochondrial membrane potential (MMP) homeostasis, thereby inducing mitophagy. Upon activation, this component transforms into a blue-fluorescent monomer ( MitoSC-fun ) specifically within the mitochondrial target zone. Concurrently, the biological reporting component is represented by a red-fluorescent monomer ( MitoSC-rep ) that localizes to lysosomes, the non-target zone. As mitophagy progresses, the fluorescent signals from MitoSC-rep (lysosomes) and MitoSC-fun (mitochondria) converge, enabling real-time monitoring of the mitophagic process. This strategy combines potent drug functionality with robust biological reporting, thereby minimizing interference and eliminating the complexities associated with external detection. Our findings underscore the potential of a single-molecule drug to exert target-zone specific actions while simultaneously providing non-target zone self-checking, offering a new perspective for drug design.

关键词： Mitochondria Lysosomes Subcellular dynamics Dual localization Self-checking drug

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Co-MOF-67/carbon black composite: A novel electrochemical platform for furazolidone detection for food analysis

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Food chemistry 2025年 489卷 145023页

作者： Arunkumar Selvam Meenakumari Gopakumar Gopika Chih-Yu Kuo Beena Saraswathyamma Kareem Yusuf Mani Govindasamy International Graduate Program in Energy and Optoelectronic Materials (EOMP) National Taipei University of Technology Taipei 10608 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan. Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kollam Kerala 690525 India Department of Chemistry Korea University Seongbuk-gu Seoul Republic of Korea. Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei 10608 Taiwan High-Value Biomaterials Research and Commercialization Center National Taipei University of Technology Taipei 106 Taiwan. Electronic address: chihyukuo@ntut.edu.tw. Department of Chemistry Amrita Vishwa Vidyapeetham Amritapuri campus Clappana P O Kollam Kerala 690525 India. Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia. International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan Research Center for Intelligent Medical Devices Ming Chi University of Technology New Taipei City 243303 Taiwan. Electronic address: manymany2025@mail.mcut.edu.tw.

Furazolidone (FZD), a nitrofuran antibiotic used for the treatment of bacterial and protozoal illnesses, generates apprehensions about its potential toxicity and mutagenicity. The swift and dependable identification of FZD in food and biological specimens is essential for public health and regulatory adherence. This study presents a novel electrochemical sensor using a glassy carbon electrode (GCE) modified with a cobalt-based metal-organic framework (Co-MOF) and carbon black (CB) composite (Co-MOF@CB/GCE) for the sensitive detection of FZD. The Co-MOF@CB composite enhances electron transport and expands the electroactive surface area. Characterization investigations confirmed the successful fabrication of the Co-MOF@CB/GCE sensor. Electrochemical analyses revealed an extensive detection range (0.4-610 μmolL) and a minimal detection limit (0.0875 μmolL). The sensor exhibited great repeatability, stability, and selectivity, demonstrating efficient FZD detection in milk, honey, and chicken. This sensor provides a reliable, economical tool for FZD detection in regulatory and public health contexts.

关键词： Biological analysis Carbon black Cobalt metal-organic framework Electrochemical detection Furazolidone Health care test

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Improving face alignment accuracy on clinical populations and its effect on the video-based detection of neurological diseases

TechRxiv

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TechRxiv 2020年

作者： Guarin, Diego L. Bandini, Andrea Dempster, Aidan Wang, Henry Rezaei, Siavash Taati, Babak Yunusova, Yana The Biomedical Engineering Program Department Of Biomedical And Chemical Engineering And Sciences Florida Institute of Technology 150 W. University Blvd MelbourneFL32901 United States The Vector Institute for Artificial Intelligence 661 University Ave Suite 710 TorontoONM5G 1M1 Canada KITE Toronto Rehabilitation Institute 550 University Ave. TorontoONM5G 2A2 Canada The Department of Speech Language Pathology University of Toronto 500 University Ave. TorontoONM5G 1V7 Canada The Hurvitz Brain Sciences Program Sunnybrook Research Institute 2075 Bayview Ave. Tonton ONM4N 3M5 Canada The Department of Computer Science The Institute of Biomedical Engineering University of Toronto 214 College St TorontoONM5T 3A1 Canada

Automatic facial landmark localization is an essential component in many computer vision applications, including video-based detection of neurological diseases. Machine learning models for facial landmarks localization are typically trained on faces of healthy individuals and model performance is inferior when applied to faces of people with neurological diseases. Fine-tuning pre-trained models with representative images improves performance on clinical populations significantly. However, questions related to the characteristics of the database used to fine-tune the model and the clinical impact of the improved model remain. We employed the Toronto NeuroFace dataset – a dataset consisting of videos of Healthy Controls (HC), individuals Post-Stroke, and individuals with Amyotrophic Lateral Sclerosis (ALS) performing speech and non-speech tasks with thousands of manually annotated frames – to fine-tune a well-known deep learning-based facial landmark localization model. The pre-trained and fine-tuned models were used to extract landmark-based facial features from videos, and the facial features were used to discriminate clinical groups from HC. Fine-tuning a facial landmark localization model with a diverse database that includes HC and individuals with neurological disorders resulted in significantly improved performance for all groups. Our results also demonstrated the clinical significance of such improvement. Specifically, fine-tuning the model with representative data greatly improved the ability of the subsequent classifier to separate clinical groups vs. HC from videos. © 2020, CC BY.

关键词： Computer aided diagnosis

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Tantalum oxide nanoparticles as versatile and high-resolution X-ray contrast agent for intraductal image-guided ablative procedure in rodent models of breast cancer

Npj imaging

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Npj imaging 2024年第1期2卷 3-3页

作者： Erin K Zaluzec Elizabeth Kenyon Maximilian Volk Hasaan Hayat Katherine Powell Alexander Loomis Shatadru Chakravarty Jeremy M L Hix Josh Schipper Chi Chang Matti Kiupel Ping Wang Erik M Shapiro Lorenzo F Sempere Precision Health Program Michigan State University East Lansing MI 48824 USA. Department of Pharmacology & Toxicology College of Veterinary Medicine Michigan State University East Lansing MI 48824 USA. These authors contributed equally: Erin K. Zaluzec Elizabeth Kenyon. Department of Radiology College of Human Medicine Michigan State University East Lansing MI 48824 USA. Institute for Quantitative Health Science and Engineering Michigan State University East Lansing MI 48824 USA. Van Andel Research Institute Grand Rapids MI 49503 USA. Department of Epidemiology and Biostatistics College of Human Medicine Michigan State University East Lansing MI 48824 USA. Veterinary Diagnostic Laboratory College of Veterinary Medicine Lansing MI 48910 USA. Departments of Biomedical Engineering Physiology and Chemical Engineering and Materials Science Michigan State University East Lansing MI 48824 USA.

There are limited options for primary prevention of breast cancer (BC). Experimental procedures to locally prevent BC have shown therapeutic efficacy in animal models. To determine the suitability of FDA-approved iodine-containing and various metal-containing (bismuth, gold, iodine, or tantalum) preclinical nanoparticle-based contrast agents for image-guided intraductal (ID) ablative treatment of BC in rodent models, we performed a prospective longitudinal study to determine the imaging performance, local retention and systemic clearance, safety profile, and compatibility with ablative solution of each contrast agent. At least six abdominal mammary glands (>3 female FVB/JN mice and/or Sprague-Dawley rats, 10-11 weeks of age) were intraductally injected with commercially available contrast agents (Omnipaque 300, Fenestra VC, MVivoTM Au, MVivoTM BIS) or in-house synthesized tantalum oxide (TaOx) nanoparticles. Contrast agents were administered at stock concentration or diluted in 70% ethanol (EtOH) and up to 1% ethyl cellulose (EC) as gelling agent to assess their compatibility with our image-guided ablative procedure. Mammary glands were serially imaged by microCT for up to 60 days after ID delivery. Imaging data were analyzed by radiologists and deep learning to measure in vivo signal disappearance of contrast agents. Mammary glands and major organs were ultimately collected for histopathological examination. TaOx-containing solutions provided best imaging performance for nitid visualization of ductal tree immediately after infusion, low outward diffusion (<1 day) and high homogeneity. Of all nanoparticles, TaOx had the highest local clearance rate (46% signal decay as stock and 36% as ablative solution 3 days after ID injection) and exhibited low toxicity. TaOx-containing ablative solution with 1% EC caused same percentage of epithelial cell death (88.62% ± 7.70% vs. 76.38% ± 9.99%, value = 0.089) with similar minimal collateral damage (21.56 ± 5.28% vs. 21.50% ±

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Guaranteed methods based on constrained zonotopes for set-valued state estimation of nonlinear discrete-time systems

arXiv

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arXiv 2019年

作者： Rego, Brenner S. Raffo, Guilherme V. Scott, Joseph K. Raimondo, Davide M. Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte MG 31270-901 Brazil Department of Electronics Engineering Federal University of Minas Gerais Belo Horizonte MG 31270-901 Brazil Department of Chemical and Biomolecular Engineering Clemson University ClemsonSC United States Department of Electrical Computer and Biomedical Engineering University of Pavia Italy

This paper presents new methods for set-valued state estimation of nonlinear discrete-time systems with unknown-but-bounded uncertainties. A single time step involves propagating an enclosure of the system states through the nonlinear dynamics (prediction), and then enclosing the intersection of this set with a bounded-error measurement (update). When these enclosures are represented by simple sets such as intervals, ellipsoids, parallelotopes, and zonotopes, certain set operations can be very conservative. Yet, using general convex polytopes is much more computationally demanding. To address this, this paper presents two new methods, a mean value extension and a first-order Taylor extension, for efficiently propagating constrained zonotopes through nonlinear mappings. These extend existing methods for zonotopes in a consistent way. Examples show that these extensions yield tighter prediction enclosures than zonotopic estimation methods, while largely retaining the computational benefits of zonotopes. Moreover, they enable tighter update enclosures because constrained zonotopes can represent intersections much more accurately than zonotopes. Copyright © 2019, The Authors. All rights reserved.

关键词： Enclosures

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Corrigendum to “Novel fluorinated Bi 2 MoO 6 nanocrystals for efficient photocatalytic removal of water organic pollutants under different light source illumination” [Appl. Catal. B: Environ. 209 (2017) 1–11]

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Applied Catalysis B: Environmental 2020年 260卷

作者： Changlin Yu Zhen Wu Renyue Liu Dionysios D. Dionysiou Kai Yang Chunying Wang Hong Liu School of Metallurgy and Chemical Engineering Jiangxi University of Science and Technology Ganzhou 341000 China Environmental Engineering and Science Program Department of Biomedical Chemical and Environmental Engineering University of Cincinnati Cincinnati OH 45221 United States School of Resources and Environmental Engineering Jiangxi University of Science and Technology Ganzhou 341000 China School of Chemical Engineering and Technology Sun Yat-Sen University Zhuhai 519082 China

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Front Cover: From Textile Coloring to Light-emitting Electrochemical Devices: Upcycling of the Isoviolanthrone Vat Dye (Chem. Asian J. 6/2023)

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Chemistry – An Asian Journal 2023年第6期18卷

作者： Tatiana Ghanem Kwang Keat Leong Hwandong Jang Alexis Hardouin Dr. Philippe Blanchard Prof. Dominik Lungerich Dr. Pierre Josse Prof. Eunkyoung Kim Dr. Clément Cabanetos University of Angers CNRS MOLTECH-ANJOU SFR MATRIX F-49000 Angers France Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu 03722 Seoul South Korea Center for Nanomedicine (CNM) Institute for Basic Science (IBS) IBS Hall 50 Yonsei-ro Seodaemun-gu 03722 Seoul South Korea Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University 50 Yonsei-ro Seodaemun-gu 03722 Seoul South Korea Building Blocks for FUture Electronics Laboratory (2BFUEL) IRL2002 CNRS-Yonsei University Seodaemun-gu 03722 Seoul South Korea

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Enhanced exopolysaccharide production of Cordyceps militaris via mycelial cell immobilization on plastic composite support in repeated-batch fermentation

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International Journal of Biological Macromolecules 2023年第1期250卷 126267页

作者： Lin, Shin-Ping Sung, Ting-Hsuan Angkawijaya, Artik Elisa Go, Alchris Woo Hsieh, Chang-Wei Hsu, Hsien-Yi Santoso, Shella Permatasari Cheng, Kuan-Chen School of Food Safety Taipei Medical University #250 Wuxing Street Xinyi Dist. Taipei11042 Taiwan Research Center of Biomedical Device Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan TMU Research Center for Digestive Medicine Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Ph.D. Program in Drug Discovery and Development Industry Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Institute of Food Science and Technology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Nutrition and Health Sciences Taipei Medical University #250 Wu-Hsing Street Taipei11031 Taiwan Center for Sustainable Resource Science RIKEN Yokohama230-0045 Japan Department of Chemical Engineering National Taiwan University of Science and Technology #43 Sec. 4 Keelung Rd Taipei10607 Taiwan Department of Food Science and Biotechnology National Chung Hsing University South Dist. Taichung City40227 Taiwan Department of Medical Research China Medical University Hospital North Dist. Taichung City404333 Taiwan Taiwan Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan School of Energy and Environment Department of Materials Science and Engineering City University of Hong Kong Kowloon Tong Hong Kong Shenzhen Research Institute of City University of Hong Kong Shenzhen518057 China Department of Chemical Engineering Widya Mandala Surabaya Catholic University Kalijudan 37 Surabaya60114 Indonesia Collaborative Research Center for Zero Waste and Sustainability Jl. Kalijudan 37 East Java Surabaya60114 Indonesia Institute of Biotechnology National Taiwan University #1 Sec. 4 Roosevelt Rd. Taipei10617 Taiwan Department of Medical Research China Medical University Hospital China Medical University 91 Hsueh-Shih Road Taichung40

Repeated-batch fermentation with fungal mycelia immobilized in plastic composite support (PCS) eliminates the lag phase during fermentation and improves metabolite productivity. The strategy is implemented herein, and a novel modified PCS is developed to enhance exopolysaccharide (EPS) production from the medicinal fungus Cordyceps militaris. A modified PCS (SYE + PCS) was made by compositing polypropylene (PP) with a nutrient mixture containing soybean hull, peptone, yeast extract, and minerals (SYE+). The use of SYE + PCS has consistent cell productivity throughout the multiple fermentation cycles, which resulted in a more higher cell productivity after second batch compared to unmodified PCS. The cell grown on SYE + PCS also generates a higher yield of EPS (3.36, 6.93, and 5.72 g/L in the first, second, and third fermentation cycles, respectively) up to three-fold higher than the cell immobilized on unmodified PCS. It is also worth noting that the EPS from mycelium grown on SYE + PCS contains up to 2.3-fold higher cordycepin than those on unmodified PCS. The presence of nutrients in SYE + PCS also affects the hydrophobicity and surface roughness of the PC, improving mycelial cell adhesion. This study also provides a preliminary antioxidant activity assessment of EPS from immobilized C. militaris grown with SYE + PCS. © 2023

关键词： Mycelium

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