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Nature cancer 2025年 2025 Jun 10页

作者： Jianping Liu Xiaoyuan Chen Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Biomedical Engineering College of Design and Engineering National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Theranostics Center of Excellence (TCE) Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore. chen.shawn@nus.edu.sg. Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore Singapore. chen.shawn@nus.edu.sg.

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The effectivity of Indonesian propolis from Tetragonula biroi bee as an antifungal agent for Candida sp. and Cryptococcus neoformans

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AIP Conference Proceedings 2021年第1期2344卷 040013页

作者： Robiatul Adawiyah Alifa Husnia AlHaq Davita Kristabel Mandala Muhammad Sahlan Diah Kartika Pratami Siti Farida Department of Parasitology Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Study Program of Clinical Parasitology Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 West Java Indonesia Undergraduate programm Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 West Java Indonesia Lab of Pharmacognosy and Phytochemistry Faculty of Pharmacy Pancasila University Jakarta 12640 Indonesia Department of Pharmacy Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia

In recent years, there has been an increase in the incidence of fungal infections accompanied by a decrease in susceptibility to fluconazole as one of the drug choices for fungal infections. So that it needs to be considered the existence of an alternative drug that is effective and also expected to have a minimal side effect, one of which is Propolis. This research was done to determine the effectivity of Indonesian Propolis from Tetragonula biroi bee on the growth of Candida sp. and Cryptococcus neoformans. An experimental study to test the susceptibility of Propolis using disc diffusion technique performed on six types of fungi, e.g. Candida albicans, Candida glabrata, Candida parapsilosis, Candida krusei, Candida tropicalis, dan Cryptococcus neoformans. The samples tested were Indonesian propolis emulsion from Tetragonula biroi bee with a concentration of 10 mg/ml, 50 mg/ml, and 70 mg/ml. The sample selection based on the result of “Exploration of Antifungal Potential of Indonesian Propolis from Tetragonula biroi Bee“ from the Faculty of engineering, University of Indonesia. Indonesian Propolis emulsion from Tetragonula biroi bee can inhibit the growth of Candida sp., especially Candida glabrata and Candida krusei, and also Cryptococcus neoformans with an optimum concentration of 10 mg/ml. The lower concentration than 10 mg/ml of Indonesian Propolis emulsion from Tetragonula biroi bee could be considered to provide more optimal results.

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Cucurbituril-Based Supramolecular Polymers for biomedical Applications

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Angewandte Chemie 2022年第38期134卷

作者： Ziyi Wang Prof. Dr. Chen Sun Prof. Dr. Kuikun Yang Prof. Dr. Xiaoyuan Chen Prof. Dr. Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau 999078 China Contribution: Writing - original draft (lead) Contribution: Writing - original draft (supporting) Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Contribution: Conceptualization (supporting) Writing - review & editing (equal) Contribution: Conceptualization (lead) Writing - review & editing (lead)

Supramolecular polymers (SPs) have attracted broad interest because of their intriguing features and functions. Host–guest interactions often impart tunable physicochemical properties, reversible hierarchical organization, and stimuli-responsiveness to SPs for diverse biomedical applications. Characterized by strong but dynamic interactions with guest molecules, cucurbit[n]uril (CB[n]) has shown great potential as an important building block of various functional polymers for biomedical applications. In this Minireview, we summarize the most recent examples regarding the design, fabrication, and biomedical applications of CB[n]-based supramolecular polymers (CSPs), which are categorized as noncovalent and covalent CSPs according to the interactions between the CB[n] and polymer backbones. The design principles of CSPs and their unique advantages for biomedical applications, as well as the developmental trends and future perspectives of this cross-disciplinary area are also discussed.

关键词： biomedical Applications Cucurbituril Host–Guest Interactions Supramolecular Polymers

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Influence of hydration shell of hemodialysis clinical membranes on surrogate biomarkers activation in uremic serum of dialysis patients

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biomedical engineering Advances 2022年 4卷

作者： Amira Abdelrasoul Ahmed Shoker Department of Chemical and Biological Engineering University of Saskatchewan 57 Campus Drive Saskatoon Saskatchewan S7N 5A9 Canada Division of Biomedical Engineering University of Saskatchewan 57 Campus Drive Saskatoon Saskatchewan S7N 5A9 Canada Nephrology Division College of Medicine University of Saskatchewan 107 Wiggins Rd Saskatoon SK S7N 5E5 Canada Saskatchewan Transplant Program St. Paul's Hospital 1702 20th Street West Saskatoon Saskatchewan S7M 0Z9 Canada

End-stage renal disease (ESRD) patients depend on hemodialysis (HD) as a life-sustaining treatment. Cytokines are essential mediators of immune response and inflammatory reactions. Our goal is to study the impact of known properties of commercially available clinical HD membranes on the activation of inflammatory biomarkers. Two common clinical HD membranes of cellulose triacetate and polyarylethersulfone were thoroughly characterized. Surrogate biomarkers were studied at different time points after in vitro exposure of normal and uremic serum to hydrated and unhydrated membranes. In vitro adsorption of fibrinogen (FB) by hydrated and unhydrated CTA and PAES membranes was also compared at similar clinical practices. The inflammatory biomarkers released in HD patients after 30 min of dialysis were also compared to those induced in uremic samples incubated with HD membranes for 30 min to determine the influence of shear rate and membrane roughness. Samples from male and female patients were collected to assess the influence of patient sex on inflammatory and thrombotic responses. The results obtained indicate CTA membranes have a smoother surface and are more hemocompatible, while PAES membranes had a rougher surface and greater hydrophilicity, which resulted in a significant increase in red blood cell (RBC) rupture and promoted protein adsorption and higher cytokines levels. Unhydrated PAES membranes adsorbed more protein than all other membranes tested, and unhydrated CTA and PASE membranes induced more cytokines compared to hydrated counterparts. Overall, hydrating the membrane materials was determined to alter their adsorptive behavior.

关键词： Hemodialysis membrane Inflammatory biomarkers Complement activation, Cytokines Hydrated Membrane charge Fibrinogen adsorption, Hydrodynamics

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Engineered extracellular vesicles carrying let-7a-5p for alleviating inflammation in acute lung injury

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Journal of biomedical Science 2024年第1期31卷 1页

作者： Chen, Sin-Yu Chen, Yi-Ling Li, Po-Chen Cheng, Tai-Shan Chu, Yeh-Shiu Shen, Yi-Shan Chen, Hsin-Tung Tsai, Wei-Ni Huang, Chien-Ling Sieber, Martin Yeh, Yuan-Chieh Liu, Hsiao-Sheng Chiang, Chi-Ling Chang, Chih-Hung Lee, Andrew S. Tseng, Yen-Han Lee, Ly James Liao, Hsiu-Jung Yip, Hon-Kan Huang, Chi-Ying F. Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Division of Cardiology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung 833401 Taiwan Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung 833401 Taiwan Department of Orthopedic Surgery Far Eastern Memorial Hospital New Taipei City 220216 Taiwan Brain Research Center National Yang Ming Chiao Tung University Taipei 112304 Taiwan Department of Biomedical Engineering National Taiwan University Taipei 106319 Taiwan Bionet Therapeutics Taipei 114065 Taiwan Department of Traditional Chinese Medicine Chang Gung Memorial Hospital Keelung 204201 Taiwan Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Department of Microbiology and Immunology College of Medicine National Cheng Kung University Tainan 701401 Taiwan Center for Cancer Research College of Medicine Kaohsiung Medical University Kaohsiung 807378 Taiwan Teaching and Research Center Kaohsiung Municipal Siaogang Hospital Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung 812015 Taiwan Department of Chemical and Biomolecular Engineering The Ohio State University Columbus 43210 OH United States Comprehensive Cancer Center College of Medicine The Ohio State University Columbus 43210 OH United States Graduate School of Biotechnology and Bioengineering Yuan Ze University Taoyuan 320315 Taiwan Spot Biosystems Ltd. Palo Alto 94305 CA United States Department of Chest Medicine Taipei Veterans General Hospital Taipei 112201 Taiwan Department of Medical Research Far Eastern Memorial Hospital New Taipei City 220216 Taiwan Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial Hospital Kaohsiung 833401 Taiwan Departme

Background: Acute lung injury (ALI) is a life-threatening respiratory condition characterized by severe inflammation and lung tissue damage, frequently causing rapid respiratory failure and long-term complications. The microRNA let-7a-5p is involved in the progression of lung injury, inflammation, and fibrosis by regulating immune cell activation and cytokine production. This study aims to use an innovative cellular electroporation platform to generate extracellular vesicles (EVs) carring let-7a-5p (EV-let-7a-5p) derived from transfected Wharton’s jelly-mesenchymal stem cells (WJ-MSCs) as a potential gene therapy for ALI. Methods: A cellular nanoporation (CNP) method was used to induce the production and release of EV-let-7a-5p from WJ-MSCs transfected with the relevant plasmid DNA. EV-let-7a-5p in the conditioned medium were isolated using a tangential flow filtration (TFF) system. EV characterization followed the minimal consensus guidelines outlined by the International Society for Extracellular Vesicles. We conducted a thorough set of therapeutic assessments, including the antifibrotic effects using a transforming growth factor beta (TGF-β)-induced cell model, the modulation effects on macrophage polarization, and the influence of EV-let-7a-5p in a rat model of hyperoxia-induced ALI. Results: The CNP platform significantly increased EV secretion from transfected WJ-MSCs, and the encapsulated let-7a-5p in engineered EVs was markedly higher than that in untreated WJ-MSCs. These EV-let-7a-5p did not influence cell proliferation and effectively mitigated the TGF-β-induced fibrotic phenotype by downregulating SMAD2/3 phosphorylation in LL29 cells. Furthermore, EV-let-7a-5p regulated M2-like macrophage activation in an inflammatory microenvironment and significantly induced interleukin (IL)-10 secretion, demonstrating their modulatory effect on inflammation. Administering EVs from untreated WJ-MSCs slightly improved lung function and increased let-7a-5p expression in

关键词： Acute lung injury Anti-inflammation Cellular nanoporation Extracellular vesicles Let-7a-5p Mesenchymal stem cells

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Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy

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Angewandte Chemie 2023年第12期135卷

作者： Yang Zhu Peng Gong Jun Wang Junjie Cheng Wenyu Wang Huilan Cai Rujiang Ao Hongwei Huang Meili Yu Prof. Lisen Lin Prof. Xiaoyuan Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of Chemistry Fuzhou University Fuzhou 350108 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos Singapore 138673 Singapore Contribution: Conceptualization (lead) Investigation (lead) Writing - original draft (lead) Contribution: Investigation (supporting) CAS Key Laboratory of Soft Matter Chemistry University of Science and Technology of China Hefei 230026 China Contribution: Conceptualization (supporting) Funding acquisition (lead) Supervision (equal) Contribution: Funding acquisition (supporting) Supervision (equal) Writing - review & editing (lead)

Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it is well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there is no study exploring the effect of cell membrane unsaturation degree on CDT. Here, we report a self-reinforcing CDT agent (denoted as OA@Fe-SAC@EM NPs), consisting of oleanolic acid (OA)-loaded iron single-atom catalyst (Fe-SAC)-embedded hollow carbon nanospheres encapsulated by an erythrocyte membrane (EM), which promotes LPO to improve chemodynamic efficacy via modulating the degree of membrane unsaturation. Upon uptake of OA@Fe-SAC@EM NPs by cancer cells, Fe-SAC-catalyzed conversion of endogenous hydrogen peroxide into hydroxyl radicals, in addition to initiating the chemodynamic therapeutic process, causes the dissociation of the EM shell and the ensuing release of OA that can enrich cellular membranes with PUFAs, enabling LPO amplification-enhanced CDT.

关键词： Antitumor Agents Chemodynamic Therapy Lipid Peroxidation Polyunsaturated Fatty Acids Single-Atom Catalysts

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Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

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Angewandte Chemie 2021年第32期133卷

作者： Dr. Kuikun Yang Dr. Guocan Yu Zhiqing Yang Ludan Yue Dr. Xiangjun Zhang Chen Sun Jianwen Wei Dr. Lang Rao Prof. Xiaoyuan Chen Prof. Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Science University of Macau Avenida da Universidade Taipa Macau China MoE Frontiers Science Center for Precision Oncology University of Macau Avenida da Universidade Taipa Macau China Key Lab of Organic Optoelectronics & Molecular Engineering Department of Chemistry Tsinghua University Beijing China Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory Shenzhen China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

The clinical application of chemodynamic therapy is impeded by the insufficient intracellular H 2 O 2 level in tumor tissues. Herein, we developed a supramolecular nanoparticle via a simple one-step supramolecular polymerization-induced self-assembly process using platinum (IV) complex-modified β-cyclodextrin-ferrocene conjugates as supramolecular monomers. The supramolecular nanoparticles could dissociate rapidly upon exposure to endogenous H 2 O 2 in the tumor and release hydroxyl radicals as well as platinum (IV) prodrugs in situ, which is reduced into cisplatin to significantly promote the generation of H 2 O 2 in the tumor tissue. Thus, the supramolecular nanomedicine overcomes the limitation of conventional chemodynamic therapy via the self-augmented cascade radical generation and drug release. In addition, dissociated supramolecular nanoparticles could be readily excreted from the body via renal clearance to effectively avoid systemic toxicity and ensure long term biocompatibility of the nanomedicine. This work may provide new insights on the design and development of novel supramolecular nanoassemblies for cascade chemo/chemodynamic therapy.

关键词： drug delivery self-amplified dissociation self-assembly supramolecular polymerization synergistic chemo/chemodynamic therapy

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Correction: Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer

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Cell Death Discovery 2025年第1期11卷 1-2页

作者： Yen-Han Tseng Yuh-Min Chen Tzu-Yi Huang Peter Mu-Hsin Chang Trieu Thi My Tran Yu-Tang Huang Anh Thuc Nguyen Chi-Ying F. Huang Jinghua Tsai Chang Ian Yi-Feng Chang Yi-Tung Chen Hsuan Liu Hao-Wen Hsieh Yue-Li Juang Ying-Chih Chang Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan Program in Molecular Medicine College of Life Sciences National Yang Ming Chiao Tung University Taipei Taiwan School of Medicine College of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Biopharmaceutical Sciences College of Pharmaceutical Sciences National Yang Ming Chiao Tung University Taipei Taiwan Department of Oncology Taipei Veterans General Hospital Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei 11529 Taiwan Biomedical Industry Ph.D. Program College of Life Sciences National Yang Ming Chiao Tung University Taipei 112304 Taiwan Program in Molecular Medicine Taiwan International Graduate Program in Molecular Medicine National Yang Ming Chiao Tung University and Academia Sinica Taipei Taiwan Department of Biochemistry School of Medicine Kaohsiung Medical University Kaohsiung Taiwan Chong Hin Loon Memorial Cancer and Biotherapy Research Center National Yang Ming Chiao Tung University Taipei Taiwan Institute of Medicine Chung Shan Medical University 110 Sec.1 Chien-Kuo N. Road Taichung City 402306 Taiwan Molecular Medicine Research Center Chang Gung University Taoyuan Taiwan Department of Neurosurgery Lin-Kou Medical Center Chang Gung Memorial Hospital Taoyuan Taiwan Department of Cell and Molecular Biology College of Medicine Chang Gung University Taoyuan Taiwan Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan Taiwan Division of Hematology-Oncology Department of Internal Medicine Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan Institute of Biomedical Sciences Mackay Medical College New Taipei City Taiwan Genomics Research Center Academia Sinica Taipei 115 Taiwan Department of Chemical Engineering Stanford University Stanford CA 94305 USA

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Author Correction: Hybrid PET/MRI enables high-spatial resolution, quantitative imaging of amyloid plaques in an Alzheimer's disease mouse model

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Scientific reports 2020年第1期10卷 13826页

作者： Georgia R Frost Valerie Longo Thomas Li Lauren A Jonas Martin Judenhofer Simon Cherry Jason Koutcher Carl Lekaye Pat Zanzonico Yue-Ming Li Chemical Biology Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Program of Neuroscience Weill Graduate School of Medical Sciences of Cornell University New York NY 10021 USA. Small Animal Imaging Core Facility Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Program of Pharmacology Weill Graduate School of Medical Sciences of Cornell University New York NY 10021 USA. Department of Biomedical Engineering University of California Davis CA 95616 USA. Departments of Medical Physics Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Departments of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA. Departments of Medical Physics Memorial Sloan Kettering Cancer Center New York NY 10065 USA. zanzonip@***. Chemical Biology Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA. liy2@***. Program of Neuroscience Weill Graduate School of Medical Sciences of Cornell University New York NY 10021 USA. liy2@***. Program of Pharmacology Weill Graduate School of Medical Sciences of Cornell University New York NY 10021 USA. liy2@***.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Gas-Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

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Angewandte Chemie 2023年第27期135卷

作者： Junjie Cheng Yang Zhu Yi Dai Li Li Miya Zhang Duo Jin Manman Liu Jiaji Yu Wenxin Yu Dan Su Jianhua Zou Xiaoyuan Chen Yangzhong Liu Department of Pharmacy The First Affiliated Hospital of USTC Division of Life Sciences and Medicine Department of Chemistry University of Science and Technology of China 230026 Hefei China Contribution: Conceptualization (lead) Investigation (lead) Writing - original draft (lead) Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore 119074 Singapore Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore 117599 Singapore Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore 117597 Singapore Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive Proteos 138673 Singapore Singapore Contribution: Investigation (supporting) College of Pharmaceutical Sciences Anhui Xinhua University 230088 Hefei China Contribution: Supervision (supporting) Writing - review & editing (lead) Contribution: Funding acquisition (lead) Supervision (supporting)

The metabolic reprogramming of tumors requires high levels of adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads to severe side effects. Therefore, improving the therapeutic response and promoting healing are critical considerations in the development of PTT. Here, we proposed a gas-mediated energy remodeling strategy to improve mild PTT efficacy while minimizing side effects. In the proof-of-concept study, a Food and Drug Administration (FDA)-approved drug-based hydrogen sulfide (H 2 S) donor was developed to provide a sustained supply of H 2 S to tumor sites, serving as an adjuvant to PTT. This approach proved to be highly effective in disrupting the mitochondrial respiratory chain, inhibiting ATP generation, and reducing the overexpression of heat shock protein 90 (HSP90), which ultimately amplified the therapeutic outcome. With the ability to reverse tumor thermotolerance, this strategy delivered a greatly potent antitumor response, achieving complete tumor ablation in a single treatment while minimizing harm to healthy tissues. Thus, it holds great promise to be a universal solution for overcoming the limitations of PTT and may serve as a valuable paradigm for the future clinical translation of photothermal nanoagents.

关键词： Heat Shock Proteins Nanoagents Near-Infrared-II Window Photothermal Therapy Tumor Therapy

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