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Correction: Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

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Genome medicine 2023年第1期15卷 38页

作者： Gabriella Assante Sriram Chandrasekaran Stanley Ng Aikaterini Tourna Carolina H Chung Kowsar A Isse Jasmine L Banks Ugo Soffientini Celine Filippi Anil Dhawan Mo Liu Steven G Rozen Matthew Hoare Peter Campbell J William O Ballard Nigel Turner Margaret J Morris Shilpa Chokshi Neil A Youngson Institute of Hepatology Foundation for Liver Research 111 Coldharbour Lane London SE5 9NT UK. Faculty of Life Sciences and Medicine King's College London London UK. Program in Chemical Biology University of Michigan Ann Arbor MI 48109 USA. Center for Bioinformatics and Computational Medicine Ann Arbor MI 48109 USA. Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 USA. Rogel Cancer Center University of Michigan Medical School Ann Arbor MI 48109 USA. Wellcome Trust Sanger Institute Cambridge UK. UNSW Sydney Sydney Australia. Cellular Bioenergetics Laboratory Victor Chang Cardiac Research Institute Darlinghurst NSW Australia. Institute of Liver Studies King's College Hospital London UK. Programme in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore. CRUK Cambridge Institute Cambridge UK. Department of Medicine University of Cambridge Addenbrooke's Hospital Cambridge UK. Department of Ecology Environment and Evolution La Trobe University Bundoora Melbourne VIC 3086 Australia. Institute of Hepatology Foundation for Liver Research 111 Coldharbour Lane London SE5 9NT UK. n.youngson@researchinliver.org.uk. Faculty of Life Sciences and Medicine King's College London London UK. n.youngson@researchinliver.org.uk. UNSW Sydney Sydney Australia. n.youngson@researchinliver.org.uk.

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A New Data-Driven Sparse-Learning Approach to Study chemical Reaction Networks

arXiv

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arXiv 2017年

作者： Harirchi, Farshad Kim, Doohyun Khalil, Omar Liu, Sijia Elvati, Paolo Hero, Alfred Violi, Angela Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109-2125 United States Department of Mechanical Engineering University of Michigan Ann ArborMI48109-2125 United States Biophysics Program Departments of Chemical Engineering Biomedical Engineering Macromolecular Science and Engineering University of Michigan Ann ArborMI48109-2125 United States

chemical kinetic mechanisms can be represented by sets of elementary reactions that are easily translated into mathematical terms using physicochemical relationships. The schematic representation of reactions captures the interactions between reacting species and products. Determining the minimal chemical interactions underlying the dynamic behavior of systems is a major task. In this paper, we introduce a novel approach for the identification of the inuential reactions in chemical reaction networks for combustion applications, using a data-driven sparse-learning technique. The proposed approach identifies a set of inuential reactions using species concentrations and reaction rates, with minimal computational cost without requiring additional data or simulations. The new approach is applied to analyze the combustion chemistry of H2andC3H8in a constant-volume homogeneous reactor. The inuential reactions identified by the sparse-learning method are consistent with the current kinetics knowledge of chemical mechanisms. Additionally, we show that a reduced version of the parent mechanism can be generated as a combination of the inuential reactions identified at different times and conditions and that for both H2andC3H8this reduced mechanism performs closely to the parent mechanism as a function of ignition delay over a wide range of conditions. Our results demonstrate the potential of the sparse-learning approach as an effective and efficient tool for mechanism analysis and mechanism reduction. Copyright © 2017, The Authors. All rights reserved.

关键词： Learning systems

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Promoting research and entrepreneurship skills in freshman engineering students: A strategy to enhance participation in graduate and enrichment programs 123

Promoting research and entrepreneurship skills in freshman e...

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123rd ASEE Annual Conference and Exposition

作者： Saylor, Greg L. Kukreti, Anant R. University of Cincinnati Environmental Engineering Program CincinnatiOH United States University of Cincinnati Department of Biomedical Chemical and Environmental Engineering CincinnatiOH United States

This paper describes the structure, implementation strategy, and early results of an undergraduate NSF Scholarships in Science, Technology, engineering, and Mathematics (S-STEM) program aimed at: (a) increasing the number of graduating engineers with research and entrepreneurship experience, (b) preparing students for the future needs of their fields through graduate study, and (c) increasing the low on-time completion rates of current dual degree (BS+MS and BS+MBA) programs. The scholarship program, in addition to a series of tailor-made undergraduate research courses and activity offerings, provides a comprehensive system of regular academic advising, mentoring, and opportunities for professional and social development. Students are guided from the beginning to develop ownership in their education by documenting their participation in a personal e-Portfolio, along with the attainment of the necessary academic, research, and entrepreneurship skills needed to excel in today's fast changing work environment. This SSTEM program provides stipend support for 32 students for the sophomore to senior years for students selected through a competitive application process. To build interest in the scholarship program and develop a diverse cohort of students to compete for acceptance into the program, two distinct but interrelated programs were executed during the 2014-2015 school year. The first program integrated the Challenge Based Learning pedagogy into the required freshman course engineering Foundations to build a learning community of students with exposure to the engineering Research and the Entrepreneurial Processes. The results of this were successful in both developing interest in the scholarship program, 89 of 222 (40%) students in the course expressed interest in applying, and providing the students with exposure to research and entrepreneurship. The second program involved the recruitment of a cohort of five underrepresented minority freshman engineering students

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Decellularization of porcine aorta using supercritical carbon dioxide

Decellularization of porcine aorta using supercritical carbo...

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engineering Sciences and Fundamentals 2016 - Core programming Area at the 2016 AIChE Annual Meeting

作者： Casali, Dominic M. Matthews, Michael A. Department of Chemical Engineering University of South Carolina ColumbiaSC United States Biomedical Engineering Program University of South Carolina ColumbiaSC United States

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Immunotherapy: engineering an Artificial T‐Cell Stimulating Matrix for Immunotherapy (Adv. Mater. 23/2019)

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Advanced Materials 2019年第23期31卷

作者： John W. Hickey Yi Dong Jae Wook Chung Sebastian F. Salathe Hawley C. Pruitt Xiaowei Li Calvin Chang Andrew K. Fraser Catherine A. Bessell Andrew J. Ewald Sharon Gerecht Hai‐Quan Mao Jonathan P. Schneck Department of Biomedical Engineering School of Medicine Baltimore MD 21218 USA Institute for Cell Engineering School of Medicine Baltimore MD 21205 USA Department of Pathology School of Medicine Baltimore MD 21287 USA Translational Tissue Engineering Center Baltimore MD 21287 USA Institute for NanoBioTechnology Baltimore MD 21218 USA Graduate Program in Immunology School of Medicine Baltimore MD 21205 USA Department of Chemical and Biomolecular Engineering Whiting School of Engineering Baltimore MD 21218 USA Department of Biology Krieger School of Arts and Sciences Baltimore MD 21218 USA Department of Materials Science and Engineering Whiting School of Engineering Baltimore MD 21218 USA Department of Cell Biology and Center for Cell Dynamics School of Medicine Baltimore MD 21205 USA Department of Oncology School of Medicine Baltimore MD 21205 USA Physical Sciences‐Oncology Center Baltimore MD 21218 USA Department of Medicine School of Medicine Johns Hopkins University Baltimore MD 21205 USA

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Acute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil Against Female Winstar Rats

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IOP Conference Series: Earth and Environmental Science 2019年第1期353卷

作者： H N Andjani Y Sentosa K Yati A Fauzantoro M Gozan Y J Yoo Chemical Engineering Department Faculty of Engineering Universitas Indonesia Kampus Baru UI Depok 16424 Indonesia Faculty of Pharmacy and Science Universitas Muhammadiyah Prof. DR. HAMKA Jakarta 13460 Indonesia Development and Pharmaceutical Technology Laboratory Faculty of Pharmacy Universitas Indonesia Kampus Baru UI Depok 16424 Indonesia Laboratory for Biotechnology Agency for the Assessment and Application of Technology (BPPT) 630 Bld. Kawasan Puspitek Serpong Tangerang Selatan Banten 15314 Indonesia Research Center for Biomedical Engineering (RCBE) Universitas Indonesia Kampus UI Depok 16424 Indonesia Program of Bioengineering Seoul National University I Gwanak-gu Seoul 08826 Republic of Korea

Tobacco plants are notably known for its pesticidal properties, particularly due to its nicotine content. In this study, Nicotiana tabacum L. bio-oil was obtained using pyrolysis technique. The safety of the bio-oil to be used as bioinsecticide was analyzed through acute oral toxicity test by administering 5000 mg bio-oil/kg body weight of female winstar rats that were analogous to humans. It was concluded that the bio-oil was not toxic due to absence of mortality and no significant change in the body weight and behavior of the rats.

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Targeting hepatic glutaminase activity to ameliorate hyperglycemia (vol 24, pg 518, 2018)

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NATURE MEDICINE 2018年第9期24卷 1482-1482页

作者： Miller, Russell A. Shi, Yuji Lu, Wenyun Pirman, David A. Jatkar, Aditi Blatnik, Matthew Wu, Hong Cardenas, Cesar Wan, Min Foskett, J. Kevin Park, Junyoung O. Zhang, Yiyi Holland, William L. Rabinowitz, Joshua D. Birnbaum, Morris J. Institute for Diabetes Obesity and Metabolism Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Pfizer Internal Medicine Research Units Cambridge Massachusetts USA. Chemistry and Integrative Genomics Princeton University Princeton New Jersey USA. Pfizer Worldwide Research and Development Groton Connecticut USA. Anatomy and Developmental Biology Program Institute of Biomedical Sciences University of Chile Santiago Chile. Geroscience Center for Brain Health and Metabolism Santiago Chile. Buck Institute for Research on Aging Novato California USA. Department of Chemistry and Biochemistry University of California Santa Barbara Santa Barbara California USA. Department of Physiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Chemical and Biological Engineering Princeton University Princeton New Jersey USA. Touchstone Diabetes Center Department of Internal Medicine University of Texas Southwestern Medical Center Dallas Texas USA.

Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic flux, including from an increase in the hepatic consumption of amino acids¹. In type 2 diabetes, dysregulated glucagon signaling contributes to the elevated hepatic glucose output and fasting hyperglycemia that occur in this condition. Yet, the mechanism by which glucagon stimulates gluconeogenesis remains incompletely understood. Contrary to the prevailing belief that glucagon acts primarily on cytoplasmic and nuclear targets, we find glucagon-dependent stimulation of mitochondrial anaplerotic flux from glutamine that increases the contribution of this amino acid to the carbons of glucose generated during gluconeogenesis. This enhanced glucose production is dependent on protein kinase A (PKA) and is associated with glucagon-stimulated calcium release from the endoplasmic reticulum, activation of mitochondrial α-ketoglutarate dehydrogenase, and increased glutaminolysis. Mice with reduced levels of hepatic glutaminase 2 (GLS2), the enzyme that catalyzes the first step in glutamine metabolism, show lower glucagon-stimulated glutamine-to-glucose flux in vivo, and GLS2 knockout results in higher fasting plasma glucagon and glutamine levels with lower fasting blood glucose levels in insulin-resistant conditions. As found in genome-wide association studies (GWAS), human genetic variation in the region of GLS2 is associated with higher fasting plasma glucose^2,3; here we show in human cryopreserved primary hepatocytes in vitro that these natural gain-of-function missense mutations in GLS2 result in higher glutaminolysis and glucose production. These data emphasize the importance of gluconeogenesis from glutamine, particularly in pathological states of increased glucagon signaling, while suggesting a possible new therapeutic avenue to

关键词： Endocrinology Metabolic syndrome Metabolomics Molecular biology

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Initial performance evaluation of a 3D gel dosimeter based on modified tetrazolium compounds

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Journal of Physics: Conference Series 2019年第1期1305卷

作者： Rubin Hazarika Kalin I Penev Kibret Mequanint Kevin Jordan London Regional Cancer Program London Health Sciences Centre London ON N6A 4L6 Canada Modus Medical Devices Inc. 1570 N Routledge Park London ON N6H 5L6 Canada Department of Chemical and Biochemical Engineering The University of Western Ontario London ON N5A 5B9 Canada Biomedical Engineering Program The University of Western Ontario London ON N5A 5B9 Canada Dept of Medical Biophysics The University of Western Ontario London ON N6A 5B9 Canada

Tetrazolium-based 3D gellan gum gel dosimeters have been reported previously and tested at several sites. They show no image diffusion and excellent stability; however, the dose sensitivity of the current commercial product, ClearView™, is relatively low for routine clinical applications. Here we report initial testing of a second generation product with increased sensitivity and retained non-diffusive properties. This formulation has a 25% increase in sensitivity relative to ClearView™. However, the sample has a higher initial attenuation and the background attenuation increases faster than ClearView™. The composition was tested in a 1-liter sealed container using a 2x2 cm, 6MV, x-ray beam, and show agreement between Monte Carlo simulation and measurements.

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Explore type and concentration of Indonesian propolis wax in inhibiting Candida albicans: In vitro study anti-candidiasis

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AIP Conference Proceedings 2019年第1期2193卷

作者： Robiatul Adawiyah Muhamad Sahlan Sri A. Soekanto Diah K. Pratami Faiqueen D. S. F. Adnan Silvana Saputri Redita N. Putri Siti Farida 1Parasitology Department Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia 2Parasitology Clinical Program Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia 9Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Depok West Java 16425 Indonesia 3Department of Chemical Engineering Majoring Technology Bioprocess Faculty of Engineering Universitas Indonesia Depok West Java 16424 Indonesia 4Faculty of Dentistry Universitas Indonesia Jakarta 10430 Indonesia 5Lab of Pharmacognosy and Phytochemistry Faculty of Pharmacy Pancasila University Jakarta 12640 Indonesia 6Undergraduate program Faculty of Medicine Universitas Indonesia Jakarta Indonesia 7Department of Medical Pharmacy Faculty of Medicine Universitas Indonesia Jakarta 10430 Indonesia 8Drug Development Cluster Indonesia Medical Education and Research Institute Universitas Indonesia Jakarta 10430 Indonesia

Candida sp. is the most aetiology of superficial and systemic fungal infection in human. The rising number of Candida albicans resistant as antifungal has drawn attention to a new alternative treatment’s finding. Natural substances like propolis become a preferred option due to the expectation of having fewer side effects. Propolis as one substance products of bees, containing polyphenols and flavonoids was already known to have anti-inflammatory, anti-viral, antioxidant, and antimicrobial activities. Propolis wax from Sulawesi, Indonesia has never been tested on Candida albicans. The aim of this study is to determine the best concentration of propolis, which effective against Candida albicans. This study was conducted at the Parasitology Laboratory, Faculty of Medicine, Universitas Indonesia. Candida albicans on Mueller-Hinton agars were tested to a disk diffusion that contains three types of Propolis wax (regular, coral, mixed) with different concentrations, 1%, 5%, and 7%. The result indicated that 5% and 7% were the effective concentration for every type of propolis wax and no difference between the type of Propolis wax (Kruskal Wallis and Mann Whitney). Propolis wax at concentration 5% and 7% could be an alternative substance in overcoming candidiasis infections.

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Light‐Emitting Diodes: Highly Efficient Spectrally Stable Red Perovskite Light‐Emitting Diodes (Adv. Mater. 20/2018)

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Advanced Materials 2018年第20期30卷

作者： Yu Tian Chenkun Zhou Michael Worku Xi Wang Yichuan Ling Hanwei Gao Yan Zhou Yu Miao Jingjiao Guan Biwu Ma Materials Science and Engineering Program Florida State University Tallahassee FL 32306 USA Department of Chemical and Biomedical Engineering FAMU‐FSU College of Engineering Tallahassee FL 32310 USA Department of Physics Florida State University Tallahassee FL 32306 USA Department of Chemistry and Biochemistry Florida State University Tallahassee FL 32306 USA

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