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Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

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The Lancet 2020年第10258期396卷 1204-1222页

作者： Abbafati, Cristiana Abbas, Kaja M. Abbasi, Mohammad Abbasifard, Mitra Abbasi-Kangevari, Mohsen Abbastabar, Hedayat Abd-Allah, Foad Abdelalim, Ahmed Abdollahi, Mohammad Abdollahpour, Ibrahim Abedi, Aidin Abedi, Parisa Abegaz, Kedir Hussein Abolhassani, Hassan Abosetugn, Akine Eshete Aboyans, Victor Abrams, Elissa M. Abreu, Lucas Guimarães Abrigo, Michael R.M. Abu Haimed, Abdulaziz Khalid Abualhasan, Ahmed Abu-Gharbieh, Eman Abu-Raddad, Laith Jamal Abushouk, Abdelrahman I. Acebedo, Alyssa Ackerman, Ilana N. Adabi, Maryam Adair, Tim Adamu, Abdu A. Adebayo, Oladimeji M. Adedeji, Isaac Akinkunmi Adekanmbi, Victor Adelson, Jaimie D. Adeoye, Abiodun Moshood Adetokunboh, Olatunji O. Adham, Davoud Advani, Shailesh M. Afarideh, Mohsen Afshari, Mahdi Afshin, Ashkan Agardh, Emilie E. Agarwal, Gina Agasthi, Pradyumna Agesa, Kareha M. Aghaali, Mohammad Aghamir, Seyed Mohammad Kazem Agrawal, Anurag Ahmad, Tauseef Ahmadi, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadieh, Hamid Ahmadpour, Ehsan Ahmed, Muktar Beshir Aji, Budi Akalu, Temesgen Yihunie Akinyemi, Rufus Olusola Akinyemiju, Tomi Akombi, Blessing Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alanezi, Fahad Mashhour Alanzi, Turki M. Albertson, Samuel B. Alcalde-Rabanal, Jacqueline Elizabeth Alema, Niguse Meles Alemu, Biresaw Wassihun Alemu, Yihun Mulugeta Alhabib, Khalid F. Alhassan, Robert Kaba Ali, Muhammad Ali, Saqib Alicandro, Gianfranco Alijanzadeh, Mehran Alinia, Cyrus Alipour, Vahid Alizade, Hesam Aljunid, Syed Mohamed Alla, François Allebeck, Peter Almadi, Majid Abdulrahman Hamad Almasi, Ali Almasi-Hashiani, Amir Almasri, Nihad A. Al-Mekhlafi, Hesham M. Almulhim, Abdulaziz M. Alonso, Jordi Al-Raddadi, Rajaa M. Altirkawi, Khalid A. Alumran, Arwa Khalid Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Amare, Azmeraw T. Amare, Bekalu Amini, Saeed Amini-Rarani, Mostafa Aminorroaya, Arya Amiri, Fatemeh Amit, Arianna Maever L. Amugsi, Dickson A. Amul, Gianna Gayle Herrera Anbesu, Etsay Woldu Ancuceanu, Robert Anderl Department of Juridical and Economic Studies La Sapienza University Rome Italy Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine London United Kingdom Social Determinants of Health Research Center Tehran Iran Department of Neurology Cairo University Cairo Egypt School of Pharmacy Tehran Iran The Institute of Pharmaceutical Sciences (TIPS) Tehran Iran Neuroscience Research Center Isfahan University of Medical Sciences Isfahan Iran Biostatistics Department Near East University Nicosia Cyprus Biostatistics and Health Informatics Madda Walabu University Bale Robe Ethiopia Research Center for Immunodeficiencies Tehran Iran Karolinska University Hospital Huddinge Sweden Department of Cardiology Dupuytren University Hospital Limoges France University of Limoges Limoges France Department of Pediatric Dentistry Federal University of Minas Gerais Belo Horizonte Brazil Department of Research Philippine Institute for Development Studies Quezon City Philippines Department of Healthcare Policy and Research Weill Cornell Medical College in Qatar Doha Qatar Harvard Medical School Boston MA United States Department of Medicine Ain Shams University Cairo Egypt Hamadan University of Medical Sciences Hamadan Iran School of Medicine Cardiff University Cardiff United Kingdom School of Laboratory Medicine and Science University College Hospital Ibadan Ibadan Nigeria Institute of Cardiovascular Diseases University of Ibadan Ibadan Nigeria Centre of Excellence for Epidemiological Modelling and Analysis Stellenbosch University Cape Town South Africa Department of Global Health Stellenbosch University Cape Town South Africa School of Health Ardabil University of Medical Science Ardabil Iran Social Behavioral Research Branch National Institute of Health Bethesda MD United States Department of Oncology Georgetown University Washington DC DC United States Department of Health Metrics Sciences School of Medicine Seattle WA

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw value

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Fano Resonances: Tunable Fano Resonance and Plasmon–Exciton Coupling in Single Au Nanotriangles on Monolayer WS2at Room Temperature (Adv. Mater. 22/2018)

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Advanced Materials 2018年第22期30卷

作者： Mingsong Wang Alex Krasnok Tianyi Zhang Leonardo Scarabelli He Liu Zilong Wu Luis M. Liz‐Marzán Mauricio Terrones Andrea Alù Yuebing Zheng Department of Mechanical Engineering Materials Science and Engineering Program Texas Materials Institute The University of Texas at Austin Austin TX 78712 USA Department of Electrical and Computer Engineering The University of Texas at Austin Austin TX 78712 USA Department of Materials Science and Engineering The Pennsylvania State University University Park PA 16802 USA Bionanoplasmonics Laboratory CIC biomaGUNE Paseo de Miramón 182 20014 Donostia‐San Sebastián Spain Department of Chemistry and Biochemistry California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA Department of Chemistry The Pennsylvania State University University Park PA 16802 USA Ikerbasque Basque Foundation for Science 48013 Bilbao Spain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine CIBER‐BBN 20014 Donostia‐San Sebastián Spain Department of Physics and Center for 2‐Dimensional and Layered Materials The Pennsylvania State University University Park PA 16802 USA Department of Materials Science and Engineering & Chemical Engineering Carlos III University of Madrid Avenida Universidad 30 28911 Leganés Madrid Spain IMDEA Materials Institute Eric Kandel 2 Getafe Madrid 28005 Spain

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Bioprinting: Microfluidics‐Enabled Multimaterial Maskless Stereolithographic Bioprinting (Adv. Mater. 27/2018)

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Advanced Materials 2018年第27期30卷

作者： Amir K. Miri Daniel Nieto Luis Iglesias Hossein Goodarzi Hosseinabadi Sushila Maharjan Guillermo U. Ruiz‐Esparza Parastoo Khoshakhlagh Amir Manbachi Mehmet Remzi Dokmeci Shaochen Chen Su Ryon Shin Yu Shrike Zhang Ali Khademhosseini Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA Microoptics and GRIN Optics Group Applied Physics Department Faculty of Physics University of Santiago de Compostela Santiago de Compostela 15782 Spain Polymeric Materials Research Group Department of Materials Science and Engineering Sharif University of Technology Tehran *** Iran Department of Biomedical Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD 21218 USA Department of NanoEngineering University of California San Diego La Jolla CA 92093 USA Department of Bioengineering University of California San Diego La Jolla CA 92093 USA Materials Science and Engineering Program University of California San Diego La Jolla CA 92093 USA Center for Minimally Invasive Therapeutics (C‐MIT) University of California‐Los Angeles Los Angeles CA 90095 USA Department of Radiology David Geffen School of Medicine University of California‐Los Angeles Los Angeles CA 90095 USA Department of Bioengineering Department of Chemical and Biomolecular Engineering Henry Samueli School of Engineering and Applied Sciences University of California‐Los Angeles Los Angeles CA 90095 USA California NanoSystems Institute (CNSI) University of California‐Los Angeles Los Angeles CA 90095 USA Department of Bioindustrial Technologies Konkuk University Seoul 143‐701 Republic of Korea

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Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021

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The Lancet Public Health 2025年第3期10卷 e172-e188页

作者： Steel, Nicholas Bauer-Staeb, Clarissa Maria Mercedes Ford, John A. Abbafati, Cristiana Abdalla, Mohammed Altigani Abdelkader, Atef Abdi, Parsa Zuñiga, Roberto Ariel Abeldaño Abiodun, Olugbenga Olusola Abolhassani, Hassan Abu-Gharbieh, Eman Abukhadijah, Hana J. Abu-Zaid, Ahmed Addo, Isaac Yeboah Addolorato, Giovanni Adekanmbi, Victor Adetunji, Juliana Bunmi Adeyeoluwa, Temitayo Esther Agardh, Emilie E. Agyemang-Duah, Williams Ahmad, Danish Ahmed, Ayman Ahmed, Syed Anees Akinosoglou, Karolina Akkaif, Mohammed Ahmed Al Awaidy, Salah Al Hasan, Syed Mahfuz Al Zaabi, Omar Ali Mohammed Aldridge, Robert W. Algammal, Abdelazeem M. Al-Gheethi, Adel Ali Saeed Ali, Abid Ali, Mohammed Usman Ali, Syed Shujait Ali, Waad Alicandro, Gianfranco Alif, Sheikh Mohammad Al-Jumaily, Adel Allebeck, Peter Alrawashdeh, Ahmad Al-Rifai, Rami H. Alsabri, Mohammed A. Alshahrani, Najim Z. Aluh, Deborah Oyine Al-Wardat, Mohammad Al-Zyoud, Walid A. Amiri, Sohrab Anderlini, Deanna Andrei, Catalina Liliana Anil, Abhishek Anvari, Saeid Anyasodor, Anayochukwu Edward Appiah, Seth Christopher Yaw Aquilano, Michele Arabloo, Jalal Arafat, Mosab Areda, Demelash Aremu, Abdulfatai Armani, Keivan Armocida, Benedetta Ärnlöv, Johan Asaduzzaman, Muhammad Astell-Burt, Thomas Aujayeb, Avinash Ausloos, Marcel Azadnajafabad, Sina Aziz, Shahkaar Azzam, Ahmed Y. Babu, Giridhara Rathnaiah Badache, Andreea Corina Badiye, Ashish D. Bahramian, Saeed Baig, Atif Amin Baker, Jennifer L. Bansal, Hansi Bärnighausen, Till Winfried Barone, Mark Thomaz Ugliara Barrow, Amadou Barteit, Sandra Bashir, Shahid Bashiru, Hameed Akande Basso, João Diogo Bastan, Mohammad-Mahdi Basu, Sanjay Batra, Kavita Bauckneht, Matteo Baune, Bernhard T. Beghi, Massimiliano Beiranvand, Maryam Béjot, Yannick Bell, Michelle L. Bello, Olorunjuwon Omolaja Belo, Luis Beloukas, Apostolos Beneke, Alice A. Bettencourt, Paulo J.G. Bhagavathula, Akshaya Srikanth Bhala, Neeraj Bhaskar, Sonu Bisulli, Francesca Bjørge, Tone Bodunrin, Aadam Olalekan Carvajal, Alejandro Botero Bouaoud, Souad Brayne, Carol Brenner, H Department of Primary Care and Public Health University of East Anglia Norwich United Kingdom Office for Health Improvement and Disparities Department of Health and Social Care London United Kingdom Department of Legal and Economic Studies La Sapienza University Rome Italy Rome Italy Hull York Medical School University of Hull Hull United Kingdom Department of Mathematics and Sciences Ajman University Ajman United Arab Emirates Department of Medicine Memorial University St. John's NL Canada Postgraduate Department University of Sierra Sur Miahuatlan de Porfirio Diaz Mexico Yhteiskuntadatatieteen keskus (Centre for Social Data Science) Helsinki Finland Department of Internal Medicine Federal Medical Centre Abuja Nigeria Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Medical Biochemistry and Biophysics Karolinska Institutet (Karolinska Institute) Stockholm Sweden Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Department of Biopharmaceutics and Clinical Pharmacy University of Jordan Amman Jordan Medical Research Center Hamad Medical Corporation Doha Qatar Department of Biochemistry and Molecular Medicine Alfaisal University Riyadh Saudi Arabia College of Graduate Health Sciences University of Tennessee Memphis TN United States School of Medicine Sydney NSW Australia Centre for Social Research in Health University of New South Wales Sydney NSW Australia Internal Medicine and Alcohol Related Disease Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Department of Medical and Surgical Sciences Università Cattolica di Roma (Catholic University of Rome) Rome Italy Department of Obstetrics and Gynecology University of Texas Medical Branch Galveston TX United States Department of Biochemistry Osun State University Osogbo Nigeria Department of Pharmacology and Therapeutics University of Medical Sciences Ondo Ondo Nigeria Department of Veteri

Background: Decades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and cause-specific death rates in different European countries related to changes in life expectancy in those countries before and during the COVID-19 pandemic. Methods: We used data and methods from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to compare changes in life expectancy at birth, causes of death, and population exposure to risk factors in 16 European Economic Area countries (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, and Sweden) and the four UK nations (England, Northern Ireland, Scotland, and Wales) for three time periods: 1990–2011, 2011–19, and 2019–21. Changes in life expectancy and causes of death were estimated with an established life expectancy cause-specific decomposition method, and compared with summary exposure values of risk factors for the major causes of death influencing life expectancy. Findings: All countries showed mean annual improvements in life expectancy in both 1990–2011 (overall mean 0·23 years [95% uncertainty interval [UI] 0·23 to 0·24]) and 2011–19 (overall mean 0·15 years [0·13 to 0·16]). The rate of improvement was lower in 2011–19 than in 1990–2011 in all countries except for Norway, where the mean annual increase in life expectancy rose from 0·21 years (95% UI 0·20 to 0·22) in 1990–2011 to 0·23 years (0·21 to 0·26) in 2011–19 (difference of 0·03 years). In other countries, the difference in mean annual improvement between these periods ranged from –0·01 years in Iceland (0·19 years [95% UI 0·16 to 0·21] vs 0·18 years [0·09 to 0·26]), to –0·18 years in England (0·25 years [0·24 to 0·25] vs 0·07 years [0·06 to 0·08]). In 2019–21, there was an overall decrease in mean annual life expectancy a

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Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

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Nature nanotechnology 2019年第8期14卷 811页

作者： Hon S Leong Kimberly S Butler C Jeffrey Brinker May Azzawi Steve Conlan Christine Dufès Andrew Owen Steve Rannard Chris Scott Chunying Chen Marina A Dobrovolskaia Serguei V Kozlov Adriele Prina-Mello Ruth Schmid Peter Wick Fanny Caputo Patrick Boisseau Rachael M Crist Scott E McNeil Bengt Fadeel Lang Tran Steffen Foss Hansen Nanna B Hartmann Lauge P W Clausen Lars M Skjolding Anders Baun Marlene Ågerstrand Zhen Gu Dimitrios A Lamprou Clare Hoskins Leaf Huang Wantong Song Huiliang Cao Xuanyong Liu Klaus D Jandt Wen Jiang Betty Y S Kim Korin E Wheeler Andrew J Chetwynd Iseult Lynch Sayed Moein Moghimi André Nel Tian Xia Paul S Weiss Bruno Sarmento José das Neves Hélder A Santos Luis Santos Samir Mitragotri Steve Little Dan Peer Mansoor M Amiji Maria José Alonso Alke Petri-Fink Sandor Balog Aaron Lee Barbara Drasler Barbara Rothen-Rutishauser Stefan Wilhelm Handan Acar Roger G Harrison Chuanbin Mao Priyabrata Mukherjee Rajagopal Ramesh Lacey R McNally Sara Busatto Joy Wolfram Paolo Bergese Mauro Ferrari Ronnie H Fang Liangfang Zhang Jie Zheng Chuanqi Peng Bujie Du Mengxiao Yu Danielle M Charron Gang Zheng Chiara Pastore Department of Urology Mayo Clinic Rochester MN USA. Department of Physiology and Biomedical Engineering Mayo Clinic Rochester MN USA. Department of Nanobiology Sandia National Laboratories Albuquerque NM USA. Center for Micro-Engineered Materials University of New Mexico Albuquerque Albuquerque NM USA. Departments of Chemical and Biological Engineering University of New Mexico Albuquerque NM USA. Department of Molecular Genetics and Microbiology University of New Mexico Albuquerque NM USA. UNM Comprehensive Cancer Center University of New Mexico Albuquerque NM USA. Cardiovascular Research Group School of Healthcare Science Manchester Metropolitan University Manchester UK. British Society for Nanomedicine Liverpool UK. Institute of Life Science Swansea University Medical School Swansea University Swansea UK. Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK. Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool UK. Department of Chemistry School of Physical Sciences University of Liverpool Liverpool UK. Centre for Cancer Research and Cell Biology Queen's University of Belfast Belfast UK. National Center for Nanoscience and Technology of China Beijing China. Cancer Research Technology Program Nanotechnology Characterization Laboratory Frederick National Laboratory for Cancer Research Frederick MD USA. Laboratory of Animal Sciences Program Center for Advanced Preclinical Research Frederick National Laboratory for Cancer Research Frederick National Laboratory for Cancer Research Frederick MD USA. Trinity Translational Medicine Institute Department of Clinical Medicine Trinity College Dublin Dublin Ireland. Laboratory for Biological Characterisation of Advanced Materials Trinity Translational Medicine Institute Trinity College Dublin Dublin Ireland. Nanomedicine Group Advanced Materials and Bioengineering Research (AMBER) centre Centre

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Tetrazolium salt monomers for gel dosimetry II: Dosimetric characterization of the ClearView™ 3D dosimeter

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Journal of Physics: Conference Series 2017年第1期847卷

作者： Yudy Ascención Jennifer Dietrich Kibret Mequanint Kalin I Penev Modus Medical Devices Inc. 1570 N Routledge Park London ON N6H 5L6 Canada Department of Chemical and Biochemical Engineering The University of Western Ontario London ON N5A 5B9 Canada Biomedical Engineering Program The University of Western Ontario London Ontario N6A 5B9 Canada

ClearView is a colourless radiochromic 3D dosimeter that is chemically and mechanically stable before and after irradiation. Upon irradiation, colour is generated from the radiochemical reduction of a tetrazolium salt suspended within a gellan gum gel. Here we present the dosimetric characterization of small and large volume samples (4 mL and 1 L, respectively) from three different batches of ClearView. The dose sensitivity was linear up to 80 Gy and constant within a batch but varied among batches between 3.4×10-3 and 4.1×10-3 Gy-1cm-1. Once generated, the radiation signal within the large samples remained unchanged for at least 58 days. Both electrons and photons produced the same signal at different energy levels; however, at dose rates below 400 cGy/min, a drop in sensitivity was observed. Overall, ClearView is best suited for relative dosimetry up to 80 Gy at high dose rates.

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Tetrazolium salt monomers for gel dosimetry I: Principles

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Journal of Physics: Conference Series 2017年第1期847卷

作者： Kalin I Penev Meng Wang Kibret Mequanint Department of Chemical and Biochemical Engineering University of Western Ontario London ON N5A 5B9 Canada Modus Medical Devices Inc. 1570 N Routledge Park London ON N6H 5L6 Canada Biomedical Engineering Program The University of Western Ontario London Ontario N6A 5B9 Canada

Tetrazolium salts (TS) have been previously used for radiochromic dosimetry in solutions, films and three dimensional (3D) gelatine-based gels. However, widespread application for 3D dosimetry has not been achieved due to the required high concentrations and associated high costs of the TS dimer used in prior research. Through careful selection of TS monomer, sensitivity-enhancing additives and inert gel forming material, we report the preparation of a non-diffusing, chemically stable, 3D dosimeter with linear sensitivity between 0 and 80 Gy with submillimolar requirements for the active TS.

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A comparative study in treating disinfection byproducts using aerobic and anaerobic biotrickling filters 108

A comparative study in treating disinfection byproducts usin...

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108th Air and Waste Management Association Annual Conference and Exhibition - Connecting the Dots: Environmental Quality to Climate, ACE 2015

作者： Mezgebe, Bineyam Palanisamy, Keerthisaranya Sorial, George A. Sahle-Demessie, Endalkachew Department of Biomedical Chemical and Environmental Engineering Environmental Engineering Program University of Cincinnati CincinnatiOH United States Office of Research and Development NRMRL U.S. Environmental Protection Agency CincinnatiOH United States

ISBN: (纸本)9781510815582

Presently, water treatment plants use advanced aeration processes to remove DBPs from treated drinking water. The off gas from the process carries high concentrations of DBPs to the atmosphere. This study involved the application of two Bio Trickling Filters to investigate the removal of chloroform under different environmental conditions. Under anaerobic conditions, the removal efficiency of chloroform was relatively high with a stable elimination capacity of 0.17 g/m3/hr at the critical loading rate of 0.27 g/m3/hr. Upon the combined addition of the co metabolite and the surfactant, the elimination capacity further improved to 0.18 g/m3/h. As for the aerobic acidic BTF, significant improvement in the elimination capacity to 0.24 g/*** was achieved. This provides substantial evidence that the BTF developed for the removal of DBPs has a potential large scale application. Further studies will be continued in the biological determination of the microbial diversity within both Biotrickling Filters. © World Petroleum Council.

关键词： Chlorine compounds

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Author Correction: The power of genetic diversity in genome-wide association studies of lipids

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Nature 2023年第7965期618卷 E19-E20页

作者： Sarah E Graham Shoa L Clarke Kuan-Han H Wu Stavroula Kanoni Greg J M Zajac Shweta Ramdas Ida Surakka Ioanna Ntalla Sailaja Vedantam Thomas W Winkler Adam E Locke Eirini Marouli Mi Yeong Hwang Sohee Han Akira Narita Ananyo Choudhury Amy R Bentley Kenneth Ekoru Anurag Verma Bhavi Trivedi Hilary C Martin Karen A Hunt Qin Hui Derek Klarin Xiang Zhu Gudmar Thorleifsson Anna Helgadottir Daniel F Gudbjartsson Hilma Holm Isleifur Olafsson Masato Akiyama Saori Sakaue Chikashi Terao Masahiro Kanai Wei Zhou Ben M Brumpton Humaira Rasheed Sanni E Ruotsalainen Aki S Havulinna Yogasudha Veturi QiPing Feng Elisabeth A Rosenthal Todd Lingren Jennifer Allen Pacheco Sarah A Pendergrass Jeffrey Haessler Franco Giulianini Yuki Bradford Jason E Miller Archie Campbell Kuang Lin Iona Y Millwood George Hindy Asif Rasheed Jessica D Faul Wei Zhao David R Weir Constance Turman Hongyan Huang Mariaelisa Graff Anubha Mahajan Michael R Brown Weihua Zhang Ketian Yu Ellen M Schmidt Anita Pandit Stefan Gustafsson Xianyong Yin Jian'an Luan Jing-Hua Zhao Fumihiko Matsuda Hye-Mi Jang Kyungheon Yoon Carolina Medina-Gomez Achilleas Pitsillides Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood Yingji Ji Zishan Gao Simon Haworth Ruth E Mitchell Jin Fang Chai Mette Aadahl Jie Yao Ani Manichaikul Helen R Warren Julia Ramirez Jette Bork-Jensen Line L Kårhus Anuj Goel Maria Sabater-Lleal Raymond Noordam Carlo Sidore Edoardo Fiorillo Aaron F McDaid Pedro Marques-Vidal Matthias Wielscher Stella Trompet Naveed Sattar Line T Møllehave Betina H Thuesen Matthias Munz Lingyao Zeng Jianfeng Huang Bin Yang Alaitz Poveda Azra Kurbasic Claudia Lamina Lukas Forer Markus Scholz Tessel E Galesloot Jonathan P Bradfield E Warwick Daw Joseph M Zmuda Jonathan S Mitchell Christian Fuchsberger Henry Christensen Jennifer A Brody Mary F Feitosa Mary K Wojczynski Michael Preuss Massimo Mangino Paraskevi Christofidou Niek Verweij Jan W Benjamins Jorgen Engmann Rachel L Kember Roderick C Slieker Ken Sin Lo Nuno R Zilhao Phuong Le Marcus E Kleber Graciela E Delgado Shaofeng Huo Dai Department of Internal Medicine Division of Cardiology University of Michigan Ann Arbor MI USA. VA Palo Alto Health Care System Palo Alto CA USA. Department of Medicine Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA. Department of Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI USA. William Harvey Research Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Department of Biostatistics and Center for Statistics Genetics University of Michigan Ann Arbor MI USA. Department of Genetics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Clinical Pharmacology William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK. Endocrinology Boston Children's Hospital Boston MA USA. Medical and Population Genetics Broad Institute Cambridge MA USA. Department of Genetic Epidemiology University of Regensburg Regensburg Germany. McDonnell Genome Institute and Department of Medicine Washington University St Louis MO USA. Department of Precision Medicine Division of Genome Science National Institute of Health Cheongju-si South Korea. Tohoku Medical Megabank Organization Tohoku University Sendai Japan. Sydney Brenner Institute for Molecular Bioscience Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa. Center for Research on Genomics and Global Health National Human Genome Research Institute National Institutes of Health Bethesda MD USA. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London London UK. Wellcome Sanger Institute Hinxton UK. Department of Epidemiology Emory University Rollins School of Public Health Atlanta GA USA. Atlanta VA Health Care System Decatur GA USA. Malcolm Randall VA Medical Center Gainesville FL USA. Division of Vascular Sur

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Behaviors of stem cells on carbon nanotube

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Biomaterials Research 2015年第1期19卷 1-6页

作者： Lee, Ju-Ro Ryu, Seungmi Kim, Soojin Kim, Byung-Soo School of Chemical and Biological Engineering Seoul National University Seoul 151-744 South Korea Interdisciplinary Program for Bioengineering Seoul National University Seoul 151-744 South Korea Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL United States

Regulating stem cell microenvironment is one of the essential elements in stem cell culture. Recently, carbon nanotube (CNT) has come into the spotlight as a biomaterial that retains unique properties. Based on its high chemical stability, elasticity, mechanical strength, and electrical conductivity, CNT shows great potential as an application for biomedical substrate. Also, properties of CNT could be further regulated by appropriate chemical modifications of CNT. Recent studies reported that modulating the cellular microenvironment through the use of CNT and chemically modified CNT as cell culture substrates can affect proliferation and differentiation of various types of stem cells. This review summarizes the unique biological effects of CNT on stem cells. © 2015 Lee et al.

关键词： Carbon nanotube Differentiation Stem cell Substrate

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