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Human Bone Xenografts: from Preclinical Testing for Regenerative Medicine to Modeling of Diseases

Current Molecular Biology Reports 2016年第3期2卷 158-170页

作者： Mark Seow Khoon Chong Chaolemeng Bao King Pan Ng Jing Lim Jerry Kok Yen Chan Division of Bioengineering School of Chemical and Biomedical Engineering Nanyang Technological University Singapore Singapore Department of Obstetrics and Gynaecology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Cancer and Stem Cell Biology Program Duke-NUS Graduate Medical School Singapore Singapore Department of Reproductive Medicine KK Women’s and Children’s Hospital Singapore Singapore

Xenografting involves the transplantation of human tissue or cells into animal models and is an important tool for regenerative medicine research. Implantation of engineered human bone tissues into animal models, for example, is performed in preclinical evaluations of product safety and efficacy. With the advent of improved experimental methodologies, these models are further being exploited to interrogate molecular mechanisms and physiological interactions in vivo. In parallel to these developments, patient-derived xenograft murine models of cancer are increasingly being studied for various applications in cancer research and therapy; it follows that xenograft models in tissue engineering may be adapted for such approaches. In this review, we first discuss the development of human bone xenograft models to recapitulate physiological states in regenerative medicine. Subsequently, we discuss the use of these techniques for applications in modeling pathological states in skeletal oncology, namely, hematopoietic malignancies, bone metastatic disease, and primary bone malignancy.

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Biomimetics: Sulfated Alginate as a Mimic of Sulfated Glycosaminoglycans: Binding of Growth Factors and Effect on Stem Cell Behavior (Adv. Biosys. 7/2017)

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Advanced Biosystems 2017年第7期1卷

作者： Rami Mhanna Jana Becher Matthias Schnabelrauch Rui L. Reis Iva Pashkuleva 3B's Research Group—Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark 4806–909 Taipas Guimarães Portugal ICVS/3B's PT Government Associate Laboratory Braga/Guimarães Portugal Biomedical Engineering and Chemical Engineering Program American University of Beirut Beirut 1107 2020 Lebanon INNOVENT e.V. Biomaterials Department Prüssingstraße 27 B D-07745 Jena Germany

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Long afterglow green phosphors functionalized with Fe-N doped TiO2 for the photocatalytic removal of emerging contaminants

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chemical engineering Transactions 2015年 43卷 2107-2112页

作者： Sacco, Olga Vaiano, Vincenzo Han, Changseok Sannino, Diana Dionysiou, Dionysios D. Ciambelli, Paolo 84084 Italy Environmental Engineering and Science Program Department of Biomedical Chemical and Environmental Engineering University of Cincinnati CincinnatiOH1045221-0012 United States

ISBN: (纸本)9788895608341

The aim of this work was to remove oxytetracycline and atrazine using novel catalytic composites consisting of a visible light-active photocatalyst (Fe-N doped TiO2) supported on visible excited long afterglow aluminatebased phosphors (green phosphors) emitting around 500 nm of wavelength. In the long afterglow Fe-N doped TiO2phosphors composites, the light energy (emitted by the lamps used in the tests) is accumulated in phosphors, and then the accumulated light energy emits visible luminescence in dark, which is used as light source for the visible light-active Fe-N doped TiO2inf photocatalysis when the external lamps are turned off. Copyright © 2015, AIDIC Servizi S.r.l.

关键词： Titanium dioxide

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Corrigendum to “Degradation of 1,4-dioxane from industrial wastewater by solar photocatalysis using immobilized NF-TiO 2 composite with monodisperse TiO 2 nanoparticles” [Appl. Catal. B: Environ. 180 (2016) 44–52]

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Applied Catalysis B: Environmental 2016年 196卷 232-232页

作者： Helen Barndõk Daphne Hermosilla Changseok Han Dionysios D. Dionysiou Carlos Negro Ángeles Blanco Department of Chemical Engineering Universidad Complutense de Madrid Avda. Complutense s/n 28040 Madrid Spain Environmental Engineering and Science Program Department of Biomedical Chemical and Environmental Engineering (DBCEE) University of Cincinnati Cincinnati OH USA

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A Zero‐Dimensional Organic Seesaw‐Shaped Tin Bromide with Highly Efficient Strongly Stokes‐Shifted Deep‐Red Emission

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Angewandte Chemie 2017年第4期130卷

作者： Chenkun Zhou Haoran Lin Hongliang Shi Yu Tian Chongin Pak Michael Shatruk Yan Zhou Peter Djurovich Mao‐Hua Du Biwu Ma Department of Chemical and Biomedical Engineering FAMU-FSU College of Engineering Tallahassee FL 32310 USA Key Laboratory of Micro-Nano Measurement-Manipulation and Physics (Ministry of Education) Department of Physics Beihang University Beijing 100191 China Materials Science and Engineering Program Florida State University Tallahassee FL 32306 USA Department of Chemistry and Biochemistry Florida State University Tallahassee FL 32306 USA Department of Chemistry University of Southern California Los Angeles CA 90089 USA Materials Science & Technology Division and Center for Radiation Detection Materials and Systems Oak Ridge National Laboratory Oak Ridge TN 37831 USA

The synthesis and characterization is reported of (C 9 NH 20 ) 2 SnBr 4 , a novel organic metal halide hybrid with a zero‐dimensional (0D) structure, in which individual seesaw‐shaped tin (II) bromide anions (SnBr 4 2− ) are co‐crystallized with 1‐butyl‐1‐methylpyrrolidinium cations (C 9 NH 20 + ). Upon photoexcitation, the bulk crystals exhibit a highly efficient broadband deep‐red emission peaked at 695 nm, with a large Stokes shift of 332 nm and a high quantum efficiency of around 46 %. The unique photophysical properties of this hybrid material are attributed to two major factors: 1) the 0D structure allowing the bulk crystals to exhibit the intrinsic properties of individual SnBr 4 2− species, and 2) the seesaw structure enabling a pronounced excited state structural deformation as confirmed by density functional theory (DFT) calculations.

关键词： Nulldimensionale Materialien Organisch-anorganische Hybride Stokes-Verschiebung Tiefrote Emission Wippenstruktur

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Author Correction: π-HuB: the proteomic navigator of the human body

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Nature 2025年第8046期637卷 E22页

作者： Fuchu He Ruedi Aebersold Mark S Baker Xiuwu Bian Xiaochen Bo Daniel W Chan Cheng Chang Luonan Chen Xiangmei Chen Yu-Ju Chen Heping Cheng Ben C Collins Fernando Corrales Jürgen Cox Weinan E Jennifer E Van Eyk Jia Fan Pouya Faridi Daniel Figeys George Fu Gao Wen Gao Zu-Hua Gao Keisuke Goda Wilson Wen Bin Goh Dongfeng Gu Changjiang Guo Tiannan Guo Yuezhong He Albert J R Heck Henning Hermjakob Tony Hunter Narayanan Gopalakrishna Iyer Ying Jiang Connie R Jimenez Lokesh Joshi Neil L Kelleher Ming Li Yang Li Qingsong Lin Cui Hua Liu Fan Liu Guang-Hui Liu Yansheng Liu Zhihua Liu Teck Yew Low Ben Lu Matthias Mann Anming Meng Robert L Moritz Edouard Nice Guang Ning Gilbert S Omenn Christopher M Overall Giuseppe Palmisano Yaojin Peng Charles Pineau Terence Chuen Wai Poon Anthony W Purcell Jie Qiao Roger R Reddel Phillip J Robinson Paola Roncada Chris Sander Jiahao Sha Erwei Song Sanjeeva Srivastava Aihua Sun Siu Kwan Sze Chao Tang Liujun Tang Ruijun Tian Juan Antonio Vizcaíno Chanjuan Wang Chen Wang Xiaowen Wang Xinxing Wang Yan Wang Tobias Weiss Mathias Wilhelm Robert Winkler Bernd Wollscheid Limsoon Wong Linhai Xie Wei Xie Tao Xu Tianhao Xu Liying Yan Jing Yang Xiao Yang John Yates Tao Yun Qiwei Zhai Bing Zhang Hui Zhang Lihua Zhang Lingqiang Zhang Pingwen Zhang Yukui Zhang Yu Zi Zheng Qing Zhong Yunping Zhu State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. hefc@***. International Academy of Phronesis Medicine (Guangdong) Guangdong China. hefc@***. Department of Biology Institute of Molecular Systems Biology ETH Zurich Zurich Switzerland. aebersold@imsb.biol.ethz.ch. Macquarie Medical School Macquarie University Sydney New South Wales Australia. Institute of Pathology and Southwest Cancer Center Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Ministry of Education of China Chongqing China. Institute of Health Service and Transfusion Medicine Beijing China. Department of Pathology and The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA. State Key Laboratory of Medical Proteomics Beijing Proteome Research Center National Center for Protein Sciences (Beijing) Beijing Institute of Lifeomics Beijing China. Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai China. Department of Nephrology First Medical Center of Chinese PLA General Hospital Nephrology Institute of the Chinese People's Liberation Army State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China. Institute of Chemistry Academia Sinica Taipei China. National Biomedical Imaging Center State Key Laboratory of Membrane Biology Institute of Molecular Medicine Peking-Tsinghua Center for Life Sciences College of Future Technology Peking University Beijing China. School of Biological Sciences Queen's University of Belfast Belfast UK. Functional Proteomics Laboratory Centro Nacional de Biotecnología-CSIC Madrid Spain. Computational Systems Biochemistry Research Group Ma

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Combined functional and anatomical diagnostic endpoints for assessing arteriovenous fistula dysfunction

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World Journal of Nephrology 2015年第1期4卷 6-18页

作者： Ehsan Rajabi-Jaghargh Rupak K Banerjee Mechanical Engineering Program Department of Mechanical and Materials EngineeringUniversity of CincinnatiCincinnatiOH 45221-0072United States Biomedical Engineering Program Department of BiomedicalChemicalUniversity of CincinnatiCincinnatiOH 45221-0072United States Environmental Engineering University of CincinnatiCincinnatiOH 45221-0072United States Cincinnati Veterans Administration Medical Center CincinnatiOH 45221-0072United States

Failure of arteriovenous fistulas(AVF) to mature and thrombosis in matured fistulas have been the major causes of morbidity and mortality in hemodialysis patients. Stenosis, which occurs due to adverse remodeling in AVFs, is one of the major underlying factors under both scenarios. Early diagnosis of a stenosis in an AVF can provide an opportunity to intervene in a timelymanner for either assisting the maturation process or avoiding the thrombosis. The goal of surveillance strategies was to supplement the clinical evaluation(i.e., physical examination) of the AVF for better and earlier diagnosis of a developing stenosis. Surveillance strategies were mainly based on measurement of functional hemodynamic endpoints, including blood flow(Q a) to the vascular access and venous access pressure(VAP). As the changes in arterial pressure(MAP) affects the level of VAP, the ratio of VAP to MAP(VAPR = VAP/MAP) was used for diagnosis. A Q a < 400-500 m L/min or a VAPR > 0.55 is considered sign of significant stenosis, which requires immediate intervention. However, due to the complex nature of AVFs, the surveillance strategies have failed to consistently detect stenosis under different scenarios. VAPR has been primarily developed to detect outflow stenosis in arteriovenous grafts, and it hasn't been successful in accurate diagnosis of outflow lesions in AVFs. Similarly, AVFs can maintain relatively high blood flow despite the presence of a significant outflow stenosis and thus, Q a has been found to be a better predictor of only inflow lesions. Similar shortcomings have been reported in the detection of functional severity of coronary stenosis using diagnostic endpoints that were based on either flow or pressure. This limitation has been associated with the fact that both pressure and flow change in the presence of a stenosis and thus, hemodynamic diagnostic endpoints that employ only one of these parameters are inherently prone to inaccuracies. Recent attempts have resulted in

关键词： Arteriovenous fistula Dysfunctional arte-riovenous fistulas Stenosis Surveillance Flow rate Pressure

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Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis

arXiv

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arXiv 2017年

作者： Sung, Jaeyun Kim, Seunghyeon Cabatbat, Josephine Jill T. Jang, Sungho Jin, Yong-Su Jung, Gyoo Yeol Chia, Nicholas Kim, Pan-Jun Asia Pacific Center for Theoretical Physics Pohang Gyeongbuk37673 Korea Republic of Center for Computational and Integrative Biology Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Broad Institute of MIT and Harvard CambridgeMA02142 United States Department of Physics Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Abdus Salam International Centre for Theoretical Physics Trieste34151 Italy Department of Chemical Engineering Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Department of Food Science and Human Nutrition University of Illinois at Urbana-Champaign UrbanaIL61801 United States Carl R. Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign UrbanaIL61801 United States School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and Technology Pohang Gyeongbuk37673 Korea Republic of Microbiome Program Center for Individualized Medicine Mayo Clinic RochesterMN55905 United States Department of Surgery Mayo Clinic RochesterMN55905 United States Department of Biomedical Engineering Mayo College RochesterMN55905 United States Department of Physics Korea Advanced Institute of Science and Technology Daejeon34141 Korea Republic of

A system-level framework of complex microbe-microbe and host-microbe chemical cross-talk would help elucidate the role of our gut microbiota in health and disease. Here we report a literature-curated interspecies network of the human gut microbiota, called NJS16. This is an extensive data resource composed of ~570 microbial species and 3 human cell types metabolically interacting through >4,400 small-molecule transport and macromolecule degradation events. Based on the contents of our network, we develop a mathematical approach to elucidate representative microbial and metabolic features of the gut microbial community in a given population, such as a disease cohort. Applying this strategy to microbiome data from type 2 diabetes patients reveals a context-specific infrastructure of the gut microbial ecosystem, core microbial entities with large metabolic influence, and frequently-produced metabolic compounds that might indicate relevant community metabolic processes. Our network presents a foundation towards integrative investigations of community-scale microbial activities within the human gut. Copyright © 2017, The Authors. All rights reserved.

关键词： Bacteria

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Photonic Crystals: Light‐Patterned Crystallographic Direction of a Self‐Organized 3D Soft Photonic Crystal (Adv. Mater. 42/2017)

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Advanced Materials 2017年第42期29卷

作者： Zhi‐Gang Zheng Cong‐Long Yuan Wei Hu Hari Krishna Bisoyi Ming‐Jie Tang Zhen Liu Pei‐Zhi Sun Wei‐Qiang Yang Xiao‐Qian Wang Dong Shen Yannian Li Fangfu Ye Yan‐Qing Lu Guoqiang Li Quan Li Department of Physics East China University of Science and Technology Shanghai 200237 China Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent OH 44242 USA National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and College of Engineering and Applied Sciences Nanjing University Nanjing 210093 China Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Visual and Biomedical Optics Lab Department of Ophthalmology and Visual Science and Department of Electrical and Computer Engineering Ohio State University Columbus OH 43212 USA

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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

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Nature communications 2025年第1期16卷 4235-4235页

作者： Cecilia Anza-Ramirez J. Jaime Miranda Benedetta Armocida Jorge César Correia Harriette Gillian Christine Van Spall David Beran Amirali Aali Kalkidan Hassen Abate Semagn Mekonnen Abate Cristiana Abbafati Mohsen Abbasi-Kangevari Zeinab Abbasi-Kangevari Zahra Aryan Sina Azadnajafabad Mohammadreza Azangou-Khyavy Seyyed-Hadi Ghamari Mohammad Keykhaei Javad Khanali Sara Momtazmanesh Fateme Montazeri Shayan Rahmani Mohammad-Mahdi Rashidi Nazila Rezaei Negar Rezaei Sahar Saeedi Moghaddam Hossein Hassanian-Moghaddam Ali-Asghar Kolahi Ali Nikoobar Hedayat Abbastabar Ahmed M. Abdel-Azeem Michael Abdelmasseh Juan Sanabria Sherief Abd-Elsalam Ahmed Abdelwahab Gholamreza Abdoli Mohammad Abdollahi Meriem Abdoun Deldar Morad Abdulah Abu Yousuf Md Abdullah Ame Mehadi Abdurehman Getachew Abebe Aidin Abedi Chirag P. Doshi Vida Abedi Hassan Abidi Richard Gyan Aboagye Hassan Abolhassani Nima Rezaei Lucas Guimarães Abreu Michael R. M. Abrigo Yonas Derso Abtew Hiwa Abubaker Ali Eman Abu-Gharbieh Hiba Jawdat Barqawi Rabih Halwani Maha Mohamed Saber-Ayad Iman M. Talaat Ahmed Abu-Zaid Manfred Mario Kokou Accrombessi Juan Manuel Acuna Denberu Eshetie Adane Tigist Demssew Adane Isaac Yeboah Addo Giovanni Addolorato Oluwafemi Atanda Adeagbo Victor Adekanmbi Miracle Ayomikun Adesina Isaac Iyinoluwa Olufadewa Olatunji O. Adetokunboh Daniel Adedayo Adeyinka Qorinah Estiningtyas Sakilah Adnani Aanuoluwapo Adeyimika Afolabi Olayinka Stephen Ilesanmi Muhammad Sohail Afzal Saira Afzal Gina Agarwal Prerna Agarwal Pradyumna Agasthi Anurag Agrawal Marcela Agudelo-Botero Adolfo Martinez-Valle Bright Opoku Ahinkorah Aqeel Ahmad Sajjad Ahmad Sohail Ahmad Tauseef Ahmad Ali Ahmadi Siamak Sabour Keivan Ahmadi Sanjay Basu Sepideh Ahmadi Ali Ahmed Shaun Wen Huey Lee Ayman Ahmed Haroon Ahmed Jivan Qasim Ahmed Gahin Abdulraheem Tayib Yahya Yahya Luai A. Ahmed Iffat Elbarazi Syed Mahboob Shah Janardhana P. Aithala Marjan Ajami Budi Aji Hossein Akbarialiabad Yibeltal Akelew Meisam Akhlaghdoust Elham Jamshidi Addis Aklilu Azene Tesfaye Melat Woldemariam Maxwell Ak CRONICAS Center of Excellence in Chronic Diseases Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Peruana Cayetano Heredia Lima Peru Sydney School of Public Health Faculty of Medicine and Health University of Sydney Sydney NSW Australia Faculty of Epidemiology and Population Health London School of Hygiene & Tropical Medicine London UK Division of Tropical and Humanitarian Medicine University of Geneva Geneva Switzerland Department of Cardiovascular Endocrine-metabolic Diseases and Aging Istituto Superiore di Sanità Rome Italy Division of Endocrinology Diabetology Nutrition and Therapeutic Patient Education Department of Medicine Geneva University Hospitals Geneva Switzerland Department of Medicine and Department of Health Research Evidence and Impact McMaster University Hamilton ON Canada Research Institute of St. Joe’s Hamilton ON Canada Population Health Research Institute Hamilton Canada Geneva University Hospitals Geneva Switzerland Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Nutrition and Dietetics Jimma University Jimma Ethiopia Anesthesiology Department Dilla University Addis Ababa Ethiopia Department of Juridical and Economic Studies La Sapienza University Rome Italy Non-Communicable Diseases Research Center Tehran University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Brigham and Women’s Hospital Harvard University Boston MA USA Students’ Scientific Research Center (SSRC) Tehran University of Medical Sciences Tehran Iran School of Medicine Tehran University of Medical Sciences Tehran Iran School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran Endocrinology and Metabolism Research Institute Tehran University of Medical Sciences Tehran Iran Chapter of Addiction Medicine University of Sydney Sydney NSW Australia Advanced Diagnostic and Intervent

Chronic care manages long-term, progressive conditions, while acute care addresses short-term conditions. Chronic conditions increasingly strain health systems, which are often unprepared for these demands. This study examines the burden of conditions requiring acute versus chronic care, including sequelae. Conditions and sequelae from the Global Burden of Diseases Study 2019 were classified into acute or chronic care categories. Data were analysed by age, sex, and socio-demographic index, presenting total numbers and contributions to burden metrics such as Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLD), and Years of Life Lost (YLL). Approximately 68% of DALYs were attributed to chronic care, while 27% were due to acute care. Chronic care needs increased with age, representing 86% of YLDs and 71% of YLLs, and accounting for 93% of YLDs from sequelae. These findings highlight that chronic care needs far exceed acute care needs globally, necessitating health systems to adapt accordingly. © 2025. The Author(s).

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