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Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study (vol 2, pg 144, 2021)

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LANCET GLOBAL HEALTH 2021年第4期9卷 E408-E408页

作者： Steinmetz, Jaimie D. Vision and Eye Research Institute Anglia Ruskin University Cambridge United Kingdom Biomedical Informatics Seoul National University Hospital Seoul South Korea Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute of Health Services Research Yonsei University Seoul South Korea Department of Ophthalmology University of Washington Seattle WA United States Department of Mathematics Imperial College London London United Kingdom WHO Collaborating Centre for Public Health Education and Training Imperial College London London United Kingdom Department of Primary Care and Public Health Imperial College London London United Kingdom School of Population and Global Health University of Melbourne Carlton VIC Australia School of Optometry and Vision Science UNSW Sydney NSW Australia Brien Holden Vision Institute Sydney Australia Department of Ophthalmology University of Adelaide Adelaide SA Australia Department of Parasitology and Mycology Jahrom University of Medical Sciences Jahrom Iran Department of Clinical Sciences University of Sharjah Sharjah United Arab Emirates Ophthalmic Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Ophthalmology Shahid Beheshti University of Medical Sciences Tehran Iran Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Ophthalmic Epidemiology Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Health Services Management Department Qazvin University of Medical Sciences Qazvin Iran Department of Systems Populations and Leadership University of Michigan Ann Arbor MI United States Department of Medicine Sofia Ismail Memorial Medical Centre Bogura Bangladesh The Fred Hollows Foundation Sydney NSW Australia Berhan Public Health & Eye Care Consultancy Addis A

Hospital El Salvador: a novel paradigm of intensive care in response to COVID-19 in central America. Lancet Glob Health 2021;9: e241?42?In this Comment, the conflict of interest statement should have included the following: ?By virtue of their roles within a public hospital or the Ministry of Health, MB, LC, WH, and XS are government employees. The findings and conclusions in the Comment are only those of the authors.? This correction has been made as of Feb 26, 2021.

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DNA Origami: Daunorubicin-Loaded DNA Origami Nanostructures Circumvent Drug-Resistance Mechanisms in a Leukemia Model (Small 3/2016)

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Small 2016年第3期12卷

作者： Patrick D. Halley Christopher R. Lucas Emily M. McWilliams Matthew J. Webber Randy A. Patton Comert. Kural David M. Lucas John C. Byrd Carlos E. Castro Department of Mechanical and Aerospace Engineering College of Engineering The Ohio State University Columbus OH 43210 USA Department of Chemical and Biomolecular Engineering College of Engineering The Ohio State University Columbus OH 43210 USA Biomedical Sciences Graduate Program Department of Internal Medicine College of Medicine The Ohio State University Columbus OH 43210 USA Biophysics Graduate Program The Ohio State University Columbus OH 43210 USA Biophysics Graduate Program Department of Physics The Ohio State University Columbus OH 43210 USA Department of Internal Medicine College of Medicine College of Pharmacy The Ohio State University Columbus OH 43210 USA Department of Mechanical and Aerospace Engineering College of Engineering Biophysics Graduate Program The Ohio State University Columbus OH 43210 USA

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Development of hydroxyapatite-mediated synthesis of collagen-based copolymers for application as bio scaffolds in bone regeneration

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Journal of Fluid Mechanics 2014年第1期1621卷 53-58页

作者： Bhuiyan, Didarul Middleton, John Tannenbaum, Rina Department of Biomedical Engineering University of Alabama at Birmingham BirminghamAL35924 United States Department of Materials Science and Engineering Program in Chemical and Molecular Engineering Stony Brook University Stony BrookNY11794 United States

Hydroxyapatite (HAP) is a biocompatible bio-ceramic whose structure and composition is similar to bone. However, its lack of strength and toughness have seriously hampered its applications as a bone graft substitute material. Attempts have been made to overcome these mechanical properties deficiencies by combining HAP bioceramic material with absorbable polymers in order to improve its mechanical properties. However, poor interfacial bonding between the HAP and the polymers has limited the benefits of such biocomposite structures. At the other end of the biomaterials spectrum is collagen, which constitutes the most abundant proteins in the body and exhibits properties such as biodegradability, bioadsorbability with low antigenicity, high affinity to water, and the ability to interact with cells through integrin recognition. These favorable properties renders collagen as a natural candidate for the modification and compatibilization of the polymer-HAP biocomposite. In this study, we developed a novel approach to the synthesis of a potential bone graft material, where the HAP moiety acts not only as a bioceramic filler, but also constitutes the initiator surface that promotes the in-situ polymerization of the adsorbable polymer of choice. The synthesis of poly(D,L-lactide-co-glycolide) (PLGA) polymer was catalyzed by nano-hydroxyapatite (nHAP) particles and upon reaction completion, the biocomposite material was tethered with collagen. The synthesis was monitored by 1H NMR and FTIR spectroscopies and the products after each step were characterized by thermal analysis to probe both thermal stability, morphological integrity and mechanical properties. Copyright © Materials Research Society 2014.

关键词： Hydroxyapatite

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Phenylethanoids can modulate amyloid-β aggregation associated with Alzheimer's disease

Phenylethanoids can modulate amyloid-β aggregation associat...

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Food, Pharmaceutical and Bioengineering Division 2014 - Core programming Area at the 2014 AIChE Annual Meeting

作者： Vance, S. Zeb Pate, Kayla Moss, Melissa Biomedical Engineering Program University of South Carolina ColumbiaSC United States Department of Chemical Engineering Unviersity of South Carolina ColumbiaSC United States

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Long time Cola beverages consumption aggravates the pathogenesis of EAE through modulating intestinal microbiota.

Long time Cola beverages consumption aggravates the pathogen...

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第十届全国免疫学学术大会

作者： Guangchao Cao Wanjun Huang Zonghua Liu Jiyu Tong Hao Cheng Yiming Wen Hengwen Yang Zhenzhou Wu Liqing Zhao Richard A.Flavell Zhinan Yin State Key Laboratory of Medicinal Chemical Biology College of Life Sicences Nankai University Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Biomedical Translational Innovative Entrepreneurial Team of Pearl River Talent ProgramBiomedical Translational Research Institute Jinan University Department of Immunology Yale School of Medicine

Epidemiological evidence has linked dietary changes,which may greatly disturb the homeostasis between immune system and microbiota,to the increasing incidence of autoimmune diseases in developed countries over recent *** Cola beverages had dramatically changed the dietary component all over the world in the past *** hypothesized that these commercial drinks may affect the pathogenesis of autoimmune diseases via modulating the composition of microbiota.

关键词： Cola beverages Microbiota EAE ATP

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Creation and analysis of biochemical constraint-based models: The COBRA Toolbox v3.0

arXiv

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arXiv 2017年

作者： Heirendt, Laurent Arreckx, Sylvain Pfau, Thomas Mendoza, Sebastián N. Richelle, Anne Heinken, Almut Haraldsdóttir, Hulda S. Wachowiak, Jacek Keating, Sarah M. Vlasov, Vanja Magnusdóttir, Stefania Ng, Chiam Yu Preciat, German Žagare, Alise Chan, Siu H.J. Aurich, Maike K. Clancy, Catherine M. Modamio, Jennifer Sauls, John T. Noronha, Alberto Bordbar, Aarash Cousins, Benjamin El Assal, Diana C. Valcarcel, Luis V. Apaolaza, Iñigo Ghaderi, Susan Ahookhosh, Masoud Guebila, Marouen Ben Kostromins, Andrejs Sompairac, Nicolas Le, Hoai M. Ma, Ding Sun, Yuekai Wang, Lin Yurkovich, James T. Oliveira, Miguel A.P. Vuong, Phan T. El Assal, Lemmer P. Kuperstein, Inna Zinovyev, Andrei Scott Hinton, H. Bryant, William A. Aragón Artacho, Francisco J. Planes, Francisco J. Stalidzans, Egils Maass, Alejandro Vempala, Santosh Hucka, Michael Saunders, Michael A. Maranas, Costas D. Lewis, Nathan E. Sauter, Thomas Palsson, Bernhard Ø. Thiele, Ines Fleming, Ronan M.T. Luxembourg Centre for Systems Biomedicine University of Luxembourg 6 avenue du Swing BelvauxL-4367 Luxembourg Life Sciences Research Unit University of Luxembourg 6 avenue du Swing BelvauxL-4367 Luxembourg University of Chile Blanco Encalada 2085 Santiago Chile Department of Pediatrics University of California San Diego School of Medicine San DiegoCA92093 United States Hinxton CambridgeCB10 1SD United Kingdom Department of Chemical Engineering Pennsylvania State University University University ParkPA16802 United States Department of Physics University of California San Diego 9500 Gilman Dr. San DiegoCA92093 United States Bioinformatics and Systems Biology Program University of California San Diego San DiegoCA United States Sinopia Biosciences San DiegoCA United States School of Computer Science Algorithms and Randomness Center Georgia Institute of Technology AtlantaGA United States Biomedical Engineering and Sciences Department TECNUN University of Navarra Paseo de Manuel Lardizabal 13 San Sebastian20018 Spain Institute of Microbiology and Biotechnology University of Latvia Jelgavas iela 1 RigaLV-1004 Latvia Department of Management Science and Engineering Stanford University StanfordCA94305-4026 United States Bioengineering Department University of California San Diego San DiegoCA United States Utah State University Research Foundation 1695 North Research Park Way North LoganUT84341 United States Centre for Integrative Systems Biology and Bioinformatics Department of Life Sciences Imperial College London London United Kingdom Department of Mathematics University of Alicante Spain California Institute of Technology Computing and Mathematical Sciences MC 305-16 1200 E. California Blvd. PasadenaCA91125 United States Mathomics Center for Mathematical Modeling University of Chile Beauchef 851 Santiago Chile Novo Nordisk Foundation Center for Biosustainability University of California San Diego San DiegoCA92093 Uni

COnstraint-Based Reconstruction and Analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive software suite of interoperable COBRA methods. It has found widespread applications in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. Version 3.0 includes new methods for quality controlled reconstruction, modelling, topological analysis, strain and experimental design, network visualisation as well as network integration of chemoinformatic, metabolomic, transcriptomic, proteomic, and thermochemical data. New multi-lingual code integration also enables an expansion in COBRA application scope via high-precision, high-performance, and nonlinear numerical optimisation solvers for multi-scale, multi-cellular and reaction kinetic modelling, respectively. This protocol can be adapted for the generation and analysis of a constraint-based model in a wide variety of molecular systems biology scenarios. This protocol is an update to the COBRA Toolbox 1.0 and 2.0. The COBRA Toolbox 3.0 provides an unparalleled depth of constraint-based reconstruction and analysis methods. Copyright © 2017, The Authors. All rights reserved.

关键词： Data integration

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The influence of structured interfacial water on the photoluminescence of carboxyester-terminated oligo-p-phenylene ethynylenes

The influence of structured interfacial water on the photolu...

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作者： Hill, Eric H. Evans, Deborah G. Whitten, David G. Center for Biomedical Engineering Department of Chemical and Nuclear Engineering University of New Mexico Albuquerque NM 87131-1341 United States Nanoscience and Microsystems Engineering Program Department of Chemistry and Chemical Biology University of New Mexico Albuquerque NM 87131-1341 United States

Oligo-p-phenylene ethynylenes have been shown to be useful for their sensing and biocidal capabilities. In this study, we examine the influence of interfacial water on the photophysical properties of a carboxyester-substituted compound in this class through analysis of the aggregation with ionic surfactants, solvent isotope effects, and classical molecular dynamics simulations. The results of this study reveal that the presence of carboxyester groups leads to highly structured interfacial water and results in quenched fluorescence. In addition, the results indicate that hydrogen bonding is essential for aggregate formation. © 2014 John Wiley & Sons, Ltd.

关键词： Aggregates

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Development of hydroxyapatite-mediated synthesis of collagen-based copolymers for application as bio scaffolds in bone regeneration

Development of hydroxyapatite-mediated synthesis of collagen...

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2013 MRS Fall Meeting

作者： Bhuiyan, Didarul Middleton, John Tannenbaum, Rina Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL 35924 United States Department of Materials Science and Engineering Program in Chemical and Molecular Engineering Stony Brook University Stony Brook NY 11794 United States

关键词： Hydroxyapatite

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Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

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Nature medicine 2018年第9期24卷 1482页

作者： Russell A Miller Yuji Shi Wenyun Lu David A Pirman Aditi Jatkar Matthew Blatnik Hong Wu César Cárdenas Min Wan J Kevin Foskett Junyoung O Park Yiyi Zhang William L Holland Joshua D Rabinowitz Morris J Birnbaum Institute for Diabetes Obesity and Metabolism Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. russell.miller@***. Pfizer Internal Medicine Research Units Cambridge Massachusetts USA. russell.miller@***. Pfizer Internal Medicine Research Units Cambridge Massachusetts USA. Chemistry and Integrative Genomics Princeton University Princeton New Jersey USA. Pfizer Worldwide Research and Development Groton Connecticut USA. Anatomy and Developmental Biology Program Institute of Biomedical Sciences University of Chile Santiago Chile. Geroscience Center for Brain Health and Metabolism Santiago Chile. Buck Institute for Research on Aging Novato California USA. Department of Chemistry and Biochemistry University of California Santa Barbara Santa Barbara California USA. Department of Physiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. Department of Chemical and Biological Engineering Princeton University Princeton New Jersey USA. Touchstone Diabetes Center Department of Internal Medicine University of Texas Southwestern Medical Center Dallas Texas USA. Institute for Diabetes Obesity and Metabolism Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. morris.birnbaum@***. Pfizer Internal Medicine Research Units Cambridge Massachusetts USA. morris.birnbaum@***. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. morris.birnbaum@***.

In the version of this article initially published, the "[13C2]α-ketoglutarate" label on Fig. 1g is incorrect. It should be "[13C5]α-ketoglutarate". Additionally, in Fig. 3b, the "AAV-GFP&qu...

In the version of this article initially published, the "[13C2]α-ketoglutarate" label on Fig. 1g is incorrect. It should be "[13C5]α-ketoglutarate". Additionally, in Fig. 3b, the "AAV-GFP" group is missing a notation for significance, and in Fig. 3c, the "AAV-GLS2-sh" group is missing a notation for significance. There should be a double asterisk notating significance in both panels. Finally, in the Fig. 4g legend, "[13C6]UDP-glucose" should be "[13C3]UDP-glucose", and in the Fig. 4h legend, "[13C6]hexose" should be "[13C3]hexose". The errors have been corrected in the HTML and PDF versions of this article.

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