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Titelbild: Precise Design of Phosphorescent Molecular Butterflies with Tunable Photoinduced Structural Change and Dual Emission (Angew. Chem. 33/2015)

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Angewandte Chemie 2015年第33期127卷

作者： Chenkun Zhou Yu Tian Zhao Yuan Mingu Han Jamie Wang Lei Zhu Maliheh Shaban Tameh Chen Huang Biwu Ma Chemical and Biomedical Engineering FAMU‐FSU College of Engineering (USA) Materials Science Program Florida State University (USA) Department of Chemistry and Biochemistry Florida State University (USA) Department of Scientific Computing Florida State University (USA)

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Precise Design of Phosphorescent Molecular Butterflies with Tunable Photoinduced Structural Change and Dual Emission

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Angewandte Chemie 2015年第33期127卷

Photoinduced structural change (PSC) is a fundamental excited‐state dynamic process in chemical and biological systems. However, precise control of PSC processes is very challenging, owing to the lack of guidelines for designing excited‐state potential energy surfaces (PESs). A series of rationally designed butterfly‐like phosphorescent binuclear platinum complexes that undergo controlled PSC by Pt–Pt distance shortening and exhibit tunable dual (greenish‐blue and red) emission are herein reported. Based on the Bell–Evans–Polanyi principle, it is demonstrated how the energy barrier of the PSC, which can be described as a chemical‐reaction‐like process between the two energy minima on the first triplet excited‐state PES, can be controlled by synthetic means. These results reveal a simple method to engineer the dual emission of molecular systems by manipulating PES to control PSC.

关键词： Angeregte Zustände Duale Emission Moleküldynamik Photochemie Platinkomplexe

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Characteristics and Osteoconductivity of Bone Composite Scaffolds Made of Thai Silk Fibroin, Gelatin and Inorganic Compounds: A Comparative Study of β-Tricalcium Phosphate and Hydroxyapatite

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Macromolecular Symposia 2015年第1期354卷

作者： Chotika Dararutana Juthamas Ratanavaraporn Sittisak Honsawek Sorada Kanokpanont Siriporn Damrongsakkul Department of Chemical Engineering Faculty of Engineering Chulalongkorn University PhayaThai Road Phatumwan Bangkok 10330 Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University PhayaThai Road Phatumwan Bangkok 10330 Thailand Department of Biochemistry Faculty of Medicine Chulalongkorn University Rama IV Road Phatumwan Bangkok 10330 Thailand

We developed the composite scaffolds made of Thai silk fibroin, gelatin, and inorganic compounds e.g. β-tricalcium phosphate (β-TCP) and hydroxyapatite (HA). The organic component of Thai silk fibroin/gelatin (50/50) was mixed with the inorganic β -TCP or HA at different mixing ratios. It was found that all scaffolds possessed porous structure with uniform distribution of β-TCP and HA (pore size ∼56–150 μm, porosity ∼87–94%). The Thai silk fibroin/gelatin scaffolds incorporating β-TCP or HA showed higher compressive modulus but lower water absorption ability than the pure protein scaffolds. Human periosteum-derived stem cells were isolated and cultured in the scaffold under osteogenic differentiation induction. The cells showed the greater ability of osteogenic differentiation when cultured in the Thai silk fibroin/gelatin scaffolds incorporating β-TCP, comparing with those of the pure protein scaffolds and the scaffolds incorporating HA, as confirmed by alkaline phosphatase activity and calcium production. The scaffolds incorporating β-TCP also supported cell spreading and deposition of calcium phosphate nodules. The promoted osteogenic differentiation of human periosteum-derived stem cells could be explained by the bioresorbable property and the high osteoinductive potential of β-TCP itself. Therefore, the Thai silk fibroin/gelatin (50/50) scaffolds incorporating β-TCP would be novel candidates for bone tissue engineering applications.

关键词： β-tricalcium phosphate gelatin human periosteum-derived stem cells hydroxyapatite silk fibroin

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Avidity-driven targeting of a novel biohybrid nanoscale carrier engineered for high therapeutic payload and extended release of anticancer drugs to treat small cell lung cancer

Avidity-driven targeting of a novel biohybrid nanoscale carr...

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Food, Pharmaceutical and Bioengineering Division 2014 - Core programming Area at the 2014 AIChE Annual Meeting

作者： Whitener, Ricky J. Wower, Jacek Byrne, Mark E. RNA Biochemistry Laboratories Department of Animal and Dairy Sciences United States Biomimetic and Biohybrid Materials Biomedical Devices and Drug Delivery Laboratories Department of Chemical Engineering United States US Department of Education GAANN Graduate Fellowship Program Biological and Pharmaceutical Engineering Auburn University AuburnAL United States Auburn University Research Initiative in Cancer United States

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Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

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eClinicalMedicine 2023年 64卷 102193-102193页

作者： Wu, Dongze Jin, Yingzhao Xing, Yuhan Abate, Melsew Dagne Abbasian, Mohammadreza Abbasi-Kangevari, Mohsen Abbasi-Kangevari, Zeinab Abd-Allah, Foad Abdelmasseh, Michael Abdollahifar, Mohammad-Amin Abdulah, Deldar Morad Abedi, Aidin Abedi, Vida Abidi, Hassan Aboagye, Richard Gyan Abolhassani, Hassan Abuabara, Katrina Abyadeh, Morteza Addo, Isaac Yeboah Adeniji, Kayode Nelson Adepoju, Abiola Victor Adesina, Miracle Ayomikun Adnani, Qorinah Estiningtyas Sakilah Afarideh, Mohsen Aghamiri, Shahin Agodi, Antonella Agrawal, Anurag Arriagada, Constanza Elizabeth Aguilera Ahmad, Aqeel Ahmad, Danish Ahmad, Sohail Ahmadi, Ali Ahmed, Ayman Aithala, Janardhana P. Ajadi, Abdullateef Abiodun Ajami, Marjan Akbarzadeh-Khiavi, Mostafa Alahdab, Fares AlBataineh, Mohammad T. Alemi, Sharifullah Al-Gheethi, Adel Ali Saeed Ali, Liaqat Alif, Sheikh Mohammad Almazan, Joseph Uy Almustanyir, Sami Alqahtani, Jaber S. Alqasmi, Ibrahim Altaf, Ihsan Ullah Khan Alvis-Guzman, Nelson Alvis-Zakzuk, Nelson J. Al-Worafi, Yaser Mohammed Aly, Hany Amani, Reza Amu, Hubert Amusa, Ganiyu Adeniyi Andrei, Catalina Liliana Ansar, Adnan Ansariniya, Hossein Anyasodor, Anayochukwu Edward Arabloo, Jalal Arefnezhad, Reza Arulappan, Judie Asghari-Jafarabadi, Mohammad Ashraf, Tahira Atata, Jamila Abdulhamid Athari, Seyyed Shamsadin Atlaw, Daniel Atout, Maha Moh'd Wahbi Aujayeb, Avinash Awan, Asma Tahir Ayatollahi, Haleh Azadnajafabad, Sina Azzam, Ahmed Y. Badawi, Alaa Badiye, Ashish D. Bagherieh, Sara Baig, Atif Amin Bantie, Berihun Bantie Barchitta, Martina Bardhan, Mainak Barker-Collo, Suzanne Lyn Barone-Adesi, Francesco Batra, Kavita Bayileyegn, Nebiyou Simegnew Behnoush, Amir Hossein Belgaumi, Uzma Iqbal Bemanalizadeh, Maryam Bensenor, Isabela M. Beyene, Kebede A. Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhaskar, Sonu Bhat, Ajay Nagesh Bitaraf, Saeid Bitra, Veera R. Boloor, Archith Bora, Kaustubh Botelho, João Silva Buchbinder, Rachelle Calina, Daniela Cámera, Luis Alberto Carvalho, Andre F. Chan, Jeffrey Shi Kai Chattu, Vijay Kumar Abebe, Endeshaw Chekol Department of Rheumatology and Immunology Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China China Department of Medicine & Therapeutics The Chinese University of Hong Kong Hong Kong Department of Paediatrics The Chinese University of Hong Kong Hong Kong School of Pharmacy The Chinese University of Hong Kong Hong Kong Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong Department of Nursing Woldia University Woldia Ethiopia Department of Orthopedic Surgery Harvard University Boston MA United States Postgraduate Medical Education Harvard University Boston MA United States Maternal Fetal Care Center Harvard University Boston MA United States Department of Health Policy and Oral Epidemiology Harvard University Boston MA United States Division of General Internal Medicine Harvard University Boston MA United States Department of Orthopaedic Surgery Shahid Beheshti University of Medical Sciences Tehran Iran Social Determinants of Health Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Epidemiology Shahid Beheshti University of Medical Sciences Tehran Iran National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran Department of Immunology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Neurology Shahid Beheshti University of Medical Sciences Tehran Iran Department of Medical Genetics Shahid Beheshti University of Medical Sciences Tehran Iran Center for Comprehensive Genetic Services Shahid Beheshti University of Medical Sciences Tehran Iran Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran Department of Health Economics and Statistics Shahid Beheshti University of Medical Sciences Tehran Iran Functional Neuro

Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings: In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation: The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rh

关键词： Global burden of disease study Immune-mediated inflammatory disease Incidence Trend

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Characterization of a commercially-produced chemically stable Fricke gel dosimeter

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Journal of Physics: Conference Series 2015年第1期573卷

作者： K I Penev K Mequanint Department of Chemical and Biochemical Engineering University of Western Ontario London Ontario N6A 5B9 Canada Biomedical Engineering Program University of Western Ontario London Ontario N6A 5B9 Canada

The successful manufacturing of a modified Fricke gel with increased shelf life in a pilot scale (20-liter) commercial production facility is reported. The gels remained chemically stable and usable for over 30 days. Linear dose dependence was observed for cumulative doses up to 30 Gy. Dose-depth studies showed a good correlation between the experimental data and theoretical expectations, but the dose response appeared to be energy-dependent.

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Methylthymol blue in Fricke gels

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Journal of Physics: Conference Series 2015年第1期573卷

The initial trial of methylthymol blue (MTB) as a chelator for ferric iron in Fricke gel dosimeters, used for three-dimensional (3D) dosimetry in cancer radiotherapy, is reported. MTB is a structural analogue of the conventionally used xylenol orange (XO); however, the absorbance spectrum of the ferric-MTB complex is shifted to higher wavelengths, which should allow for lower amount of light scattering during gel scanning. In this study, two gelatin substrates, two sources of XO and one source of MTB have been compared. The MTB- containing gels exhibited similar dose response and diffusion coefficient to the XO-containing gels at their wavelengths of maximum absorption (620 and 585 nm, respectively). In addition, the MTB gels gave an excellent dose response at 633 nm, which is an important wavelength that is already used with other 3D dosimeters.

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Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

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Nature communications 2019年第1期10卷 2956页

作者： Lohith Madireddy Kicheol Kim Xiaoming Jia Adam Santaniello Stacy J. Caillier Bruce A. C. Cree Roland Henry Stephen L. Hauser Jorge R. Oksenberg Sergio E. Baranzini Nikolaos A. Patsopoulos Philip De Jager Chris Cotsapas Matthew R. Lincoln David A. Hafler Steffan D. Bos Hanne F. Harbo Tone Berge Elisabeth G. Celius Ashley Beecham Jacob McCauley Margaret A. Pericak-Vance Till F. M. Andlauer Christiane Gasperi Bernhard Hemmer Lisa F. Barcellos Luisa Bernardinelli Filippo Martinelli-Boneschi David R. Booth Graeme J. Stewart Farren Briggs Jonathan Haines Manuel Comabella Giancarlo Comi Federica Esposito Sandra D’Alfonso Katrina Dedham Pierre Duquette Efthimios Dardiotis Bertrand Fontaine An Goris Bénédicte Dubois Pierre-Antoine Gourraud Georgios Hadjigeorgiou Clive Hawkins Seema Kalra Rogier Hintzen Dana Horakova Noriko Isobe Jun-ichi Kira Michael Khalil Ingrid Kockum Tomas Olsson Christina M. Lill Felix Luessi Frauke Zipp Roland Martin Annette Oturai Aarno Palotie Janna Saarela Adrian Ivinson Bruce V. Taylor Alastair Compston Stephen Sawcer Weill Institute for Neurosciences Department of Neurology University of California San Francisco San Francisco CA 94158 USA Bakar Institute for Computational Health Science. University of California San Francisco San Francisco CA 94158 USA Systems Biology and Computer Science Program Ann Romney Center for Neurological Diseases Department of Neurology and Division of Genetics Department of Medicine Brigham & Women’s Hospital Harvard Medical School Boston MA 02115 USA Broad Institute of Harvard University and Massachusetts Institute of Technology Cambridge MA 02142 USA Department of Neurology Center for Translational and Computational Neuroimmunology and Multiple Sclerosis Center Columbia University Medical Center New York NY 10032 USA Departments of Neurology Yale School of Medicine 300 George St New Haven CT 06511 USA Department of Genetics Yale School of Medicine 300 George St New Haven CT 06511 USA Institute of Clinical Medicine University of Oslo Oslo 0318 Norway Department of Neurology Oslo University Hospital Oslo 0424 Norway Department of Mechanical Electronics and Chemical Engineering Oslo Metropolitan University Oslo 0167 Norway Institute of Health and Society University of Oslo Oslo 0318 Norway John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine Miami FL 33136 USA Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine Miami FL 33136 USA Department of Neurology Klinikum rechts der Isar School of Medicine Technical University of Munich 81675 Munich Germany Munich Cluster for Systems Neurology (SyNergy) 81377 Munich Germany Division of Epidemiology School of Public HealthUniversity of California 324 Stanley Hall MC#3220 Berkeley CA 94720 USA Section of Biostatistics Neurophyisiology and Psychiatry Unit of medical and genomic statistics Universita of Pavia Pavia 27100 Italy Department of Biomedical Sciences for Health Univers

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Semiconducting Polymer Nanoparticles with Persistent Near‐Infrared Luminescence for In Vivo Optical Imaging

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Angewandte Chemie 2015年第39期127卷

作者： Mikael Palner Kanyi Pu Shirley Shao Jianghong Rao Department of Radiology Molecular Imaging Program at Stanford Stanford University School of Medicine Stanford CA 94395‐5484 (USA) http://www.raolab.stanford.edu Current address: School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 637459 (Singapore)

Materials with persistent luminescence are attractive for in vivo optical imaging since they have a long lifetime that allows the separation of excitation of fluorophores and image acquisition for time‐delay imaging, thus eliminating tissue autofluorescence associated with fluorescence imaging. Persistently luminescent nanoparticles have previously been fabricated from toxic rare‐earth metals. This work reports that nanoparticles made of the conjugated polymer MEH‐PPV can generate luminescence persisting for an hour upon single excitation. A near‐infrared dye was encapsulated in the conjugated polymer nanoparticle to successfully generate persistent near‐infrared luminescence through resonance energy transfer. This new persistent luminescence nanoparticles have been demonstrated for optical imaging applications in living mice.

关键词： Fluoreszenz In‐vivo‐Bildgebung MEH‐PPV Persistente Lumineszenz Polymernanopartikel

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Self-propelled particles that transport cargo through flowing blood and halt hemorrhage

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Science Advances 2015年第9期1卷 e1500379页

作者： Baylis, James R. Yeon, Ju Hun Thomson, Max H. Kazerooni, Amir Wang, Xu John, Alex E. St. Lim, Esther B. Chien, Diana Lee, Anna Zhang, Jesse Q. Piret, James M. Machan, Lindsay S. Burke, Thomas F. White, Nathan J. Kastrup, Christian J. Michael Smith Laboratories University of British Columbia VancouverBCV6T 1Z4 Canada Biomedical Engineering Program University of British Columbia VancouverBCV6T 1Z4 Canada Department of Biochemistry and Molecular Biology University of British Columbia VancouverBCV6T 1Z4 Canada Department of Radiology Faculty of Medicine University of British Columbia VancouverBCV6T 1Z4 Canada Division of Emergency Medicine University of Washington SeattleWA98195 United States Department of Chemical and Biological Engineering University of British Columbia VancouverBCV6T 1Z4 Canada Division of Global Health and Human Rights Department of Emergency Medicine Massachusetts General Hospital Harvard Medical School BostonMA02114 United States

Delivering therapeutics deep into damaged tissue during bleeding is challenging because of the outward flow of blood. When coagulants cannot reach and clot blood at its source, uncontrolled bleeding can occur and increase surgical complications and fatalities. Self-propelling particles have been proposed as a strategy for transporting agents upstream through blood. Many nanoparticle and microparticle systems exhibiting autonomous or collective movement have been developed, but propulsion has not been used successfully in blood or used in vivo to transport therapeutics. We show that simple gas-generating microparticles consisting of carbonate and tranexamic acid traveled through aqueous solutions at velocities of up to 1.5 cm/s and delivered therapeutics millimeters into the vasculature of wounds. The particles transported themselves through a combination of lateral propulsion, buoyant rise, and convection. When loaded with active thrombin, these particles worked effectively as a hemostatic agent and halted severe hemorrhage in multiple animal models of intraoperative and traumatic bleeding. Many medical applications have been suggested for self-propelling particles, and the findings of this study show that the active self-fueled transport of particles can function in vivo to enhance drug delivery. 2015 © The Authors, some rights reserved;exclusive licensee American Association for the Advancement of Science.

关键词： Propulsion

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