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Food, Pharmaceutical and Bioengineering Division - Core programming Topic at the 2011 AIChE Annual Meeting

作者： Wilson, Kelly A. Lim, Mihyun Jackson, Kaliah Mahtab, Rahina Moss, Melissa A. Biomedical Engineering Program University of South Carolina ColumbiaSC United States Department of Biological Sciences University of South Carolina ColumbiaSC United States Department of Chemistry SC State University OrangeburgSC United States Chemical Engineering University of South Carolina ColumbiaSC United States

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Controlled release and intracellular delivery of small molecules using thermally responsive pluronic F127-chitosan nanocapsules

Controlled release and intracellular delivery of small molec...

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ASME 2011 Summer Bioengineering Conference, SBC 2011

作者： Zhang, Wujie Gilstrap, Kyle Wu, Laying Moss, Melissa A. He, Xiaoming Wang, Qian Lu, Xiongbin Department of Mechanical Engineering Univeristy of South Carolina United States Biomedical Engineering Program Univeristy of South Carolina United States Department of Chemistry and Biochemistry Univeristy of South Carolina United States Department of Chemical Engineering Univeristy of South Carolina United States Department of Cancer Biology University of Texas MD Anderson Cancer Center United States NanoCenter Univeristy of South Carolina United States

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Nanopatterned Hydrogel Probes for Rapid Detection of Staphylococcus aureus

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MRS Online Proceedings Library 2011年第1期954卷 3-8页

作者： Ishtiaq Saaem Barry Kreiswirth Matthew Libera Dept of Chemical Biomedical and Materials Engineering Stevens Inst. of Technology Hoboken USA Hospital Infections Program Public Health Research Institute Newark USA

We studied the use of nanopatterned hydrogels as a possible foundation for medical devices for the detection of Staphylococcus aureus. Nanopatterned hydrogels, approximately 200 nm in diameter, were created by locally crosslinking dry amine-terminated poly(ethylene glycol) [PEG] (6000 Da) thin films using a focused electron beam. These gels then had a dry height of 50 nm and a swell ratio of about five. They were patterned into arrays with approximately 500 nm inter-gel spacing. These arrayed gels were functionalized with Immunoglobulin G [IgG], a biomolecule that binds protein A. We are interested in seeing whether these arrayed gels can be used for bacterial capture and subsequent detection. We show, using an assay that binds IgG to protein A expressing Staphylococcus aureus [S. aureus], that nanopatterned hydrogels can indeed be used as probes for detection. We further show that the specificity of our assay by using a knock-out variant of S. aureus that doesn’t express protein A as a negative control.

关键词： biomedical nanostructure devices

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Effect of the electrostatic potential on the internalization mechanism of cell penetrating peptides

Effect of the electrostatic potential on the internalization...

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2011 AIChE Annual Meeting, 11AIChE

作者： Flores, Karen A. Salgado, J. Cristian Zapata-Torres, Gerald Gerdtzen, Ziomara P. Gonzalez, María-Julieta Hermoso, Marcela A. Laboratory of Process Modeling and Distributed Computing Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Millennium Institute for Cell Dynamics and Biotechnology Centre for Systems Biology University of Chile Santiago Chile Department of Inorganic and Analytical Chemistry Faculty of Chemical and Pharmaceutical Sciences University of Chile Santiago Chile Centre for Biochemical Engineering and Biotechnology Department of Chemical Engineering and Biotechnology University of Chile Santiago Chile Laboratory of Cell Biology Cell and Molecular Program Faculty of Medicine University of Chile Santiago Chile Laboratory of Innate Immunology Institute of Biomedical Sciences University of Chile Santiago Chile

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Biodegradable microfluidic scaffolds with tunable degradation properties from amino alcohol-based poly(ester amide) elastomers

Biodegradable microfluidic scaffolds with tunable degradatio...

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2010 MRS Fall Meeting

作者： Wang, Jane Kniazeva, Tatiana Campbell, Carly F. Langer, Robert Ustin, Jeffrey S. Borenstein, Jeffrey T. Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 United States Biomedical Engineering Charles Stark Draper Laboratory Cambridge MA 02139 United States Program of Polymer Science and Technology Massachusetts Institute of Technology Cambridge MA 02139 United States Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 United States Trauma Surgery Cleveland MetroHealth Hospital Cleveland OH 44106 United States

ISBN: (纸本)9781605112763

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable;the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements. © 2011 Materials Research Society.

关键词： Degradation

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Corrigendum to “Paclitaxel/sirolimus combination coated drug-eluting stent: In vitro and in vivo drug release studies” [J. Pharm. Biomed. Anal. 54 (2011) 807–811]

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Journal of Pharmaceutical and biomedical Analysis 2012年 59卷 217-217页

作者： Xiaodong Ma Shizu Oyamada Fan Gao Tim Wu Michael P. Robich Hao Wu Xingwei Wang Bryan Buchholz Stephen McCarthy Zhiyong Gu Cesario F. Bianchi Frank W. Sellke Roger Laham Biomedical Engineering and Biotechnology Doctoral Program University of Massachusetts Lowell MA 01854 USA VasoTech Inc. Lowell MA 01854 USA Division of Cardiothoracic Surgery Brown Medical School Providence RI 02903 USA Department of Chemical Engineering University of Massachusetts Lowell MA 01854 USA Department of Cardiology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA

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Biodegradable Microfluidic Scaffolds with Tunable Degradation Properties from Amino Alcohol-based Poly(ester amide) Elastomers

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MRS Online Proceedings Library 2011年第1期1299卷 1-6页

作者： Jane Wang Tatiana Kniazeva Carly F. Campbell Robert Langer Jeffrey S. Ustin Jeffrey T. Borenstein Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge USA Biomedical Engineering Charles Stark Draper Laboratory Cambridge USA Program of Polymer Science and Technology Massachusetts Institute of Technology Cambridge USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge USA Trauma Surgery Cleveland MetroHealth Hospital Cleveland USA

Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery systems. In this work, microfluidic devices have been fabricated from elastomeric scaffolds with tunable degradation properties for applications in tissue engineering and regenerative medicine. Most biodegradable polymers suffer from short half life resulting from rapid and poorly controlled degradation upon implantation, exceedingly high stiffness, and limited compatibility with chemical functionalization. Here we report the first microfluidic devices constructed from a recently developed class of biodegradable elastomeric poly(ester amide)s, poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s (APS), showing a much longer and highly tunable in vivo degradation half-life comparing to many other commonly used biodegradable polymers. The device is molded in a similar approach to that reported previously for conventional biodegradable polymers, and the bonded microfluidic channels are shown to be capable of supporting physiologic levels of flow and pressure. The device has been tested for degradation rate and gas permeation properties in order to predict performance in the implantation environment. This device is high resolution and fully biodegradable; the fabrication process is fast, inexpensive, reproducible, and scalable, making it the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds and vasculature and tissue and organ replacements.

关键词： biomaterial microelectro-mechanical (MEMS) polymer

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Innenrücktitelbild: In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles (Angew. Chem. 13/2012)

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Angewandte Chemie 2012年第13期124卷

作者： Yanmei Yang Qing Shao Renren Deng Chao Wang Xue Teng Kai Cheng Zhen Cheng Ling Huang Zhuang Liu Xiaogang Liu Bengang Xing Division of Chemistry and Biological Chemistry School of Physical & Mathematical Sciences Nanyang Technological University Singapore 637371 (Singapore) Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 (Singapore) Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Soochow University (P. R. China) Division of Biomedical Engineering School of Chemical and Biomedical Engineering Nanyang Technological University (Singapore) Molecular Imaging Program at Stanford (MIPS) Department of Radiology Stanford University Medical Center (USA) Institute of Materials Research and Engineering Agency for Science Technology and Research (A*STAR) 3 Research Link Singapore 117602 (Singapore)

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In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles†

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Angewandte Chemie 2012年第13期124卷

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Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015

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BMC genomics 2016年第6期17 Suppl 6卷 487页

作者： Jerry W. Shay Noriko Homma Ruyun Zhou Muhammad Imran Naseer Adeel G. Chaudhary Mohammed Al-Qahtani Nobutaka Hirokawa Maryam Goudarzi Albert J. Fornace Saleh Baeesa Deema Hussain Mohammed Bangash Fahad Alghamdi Hans-Juergen Schulten Angel Carracedo Ishaq Khan Hanadi Qashqari Nawal Madkhali Mohamad Saka Kulvinder S. Saini Awatif Jamal Jaudah Al-Maghrabi Adel Abuzenadah Adeel Chaudhary Mohammed Al Qahtani Ghazi Damanhouri Heba Alkhatabi Anne Goodeve Laura Crookes Nikolas Niksic Nicholas Beauchamp Adel M. Abuzenadah Jim Vaught Bruce Budowle Mourad Assidi Abdelbaset Buhmeida Leena Merdad Sudhir Kumar Sayaka Miura Karen Gomez Mahmood Rasool Ahmed Rebai Sajjad Karim Hend F. Nour Eldin Heba Abusamra Elham M. Alhathli Nada Salem Mohammed H. Al-Qahtani Hossam Faheem Ashok Agarwa Eberhard Nieschlag Joachim Wistuba Oliver S. Damm Mohd A. Beg Taha A. Abdel-Meguid Hisham A. Mosli Osama S. Bajouh Serdar Coskun Muhammad Abu-Elmagd Ashraf Dallol Sahar Hakamy Wejdan Al-Qahtani Asia Al-Harbi Shireen Hussain Burak Ozkosem Rick DuBois Safia S. Messaoudi Maryam T. Dandana Touhami Mahjoub Wassim Y. Almawi S. Abdalla M. Nabil Al-Aama Asmaa Elzawahry Tsuyoshi Takahashi Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Isao Kurosaka Takahiko Nishigaki Hiromi Nakamura Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato Sajid Mehmood Naeem Mahmood Ashraf Awais Asif Muhammad Bilal Malik Siddique Mehmood Aadil Hussain Qazi Mohammad Sajid Jamal Mughees Uddin Siddiqui Mohammad A. Alzohairy Mohammad A. Al Karaawi Taoufik Nedjadi Heba Al-Khattabi Adel Al-Ammari Ahmed Al-Sayyad Hédia Zitouni Nozha Raguema Marwa Ben Ali Wided Malah Raja Lfalah Wassim Almawi Mohammed Elanbari Andrey Ptitsyn Sana Mahjoub Rabeb El Ghali Bechir Achour Nidhal Ben Amor Brahim N’siri Hamid Morjani Esam Azhar Vera Chayeb Maryam Dendena Hedia Zitouni Khedija Zouari-Limayem Bassem Refaat Ahmed M. Ashshi Sarah A. Batwa Hazem Ramadan Amal Awad Ahmed Ateya Adel Galal Ahmed El-Shemi Ahmad Ashshi Mohammed Basalamah Youjin Na Cha University of Texas Southwestern Medical Center Dallas USA Department of Cell Biology and Anatomy Graduate School of Medicine the University of Tokyo Tokyo Japan Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Department of Biochemistry and Molecular & Cellular Biology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Oncology Lombardi Comprehensive Cancer Center Georgetown University Washington USA Department of Radiation Medicine Lombardi Comprehensive Cancer Center Georgetown University Washington USA Center of Excellence in Genomic Medicine Research (CEGMR) King Abdulaziz University Jeddah Kingdom of Saudi Arabia King Fahd Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia Centre of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia Sheffield Diagnostic Genetic Service Sheffield Children’s NHS Foundation Trust Western Bank Sheffield UK Center of Innovations in Personalized Medicine King Abdulaziz University Jeddah Saudi Arabia President ISBER Editor-in-Chief Biopreservation & Biobanking ᅟ USA Institute of Applied Genetics Department of Molecular and Medical Genetics University of North Texas Health Science Center Fort Worth USA Department of Dental Public Health Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia Institute for Genomics and Evolutionary Medicine Temple University Philadelphia USA Center of Excellence in Genomic Medicine King Abdulaziz University Jeddah Kingdom of Saudi Arabia Laboratory of Molecular and Cellular Screening Processes (Bioinformatics Group) Centre of Biotechnology of Sfax Sfax Tunisia Fujitsu Technology Solutions International ᅟ ᅟ Case Western Reserve University School of Medicine and Lerner College of Medicine Cleveland Clinic Foundation Cleveland USA American Center for Reproductive Medicine Andrology Center Cleveland USA Center for Reproductive Medicine and

O1 Regulation of genes by telomere length over long distances Jerry W. Shay O2 The microtubule destabilizer KIF2A regulates the postnatal establishment of neuronal circuits in addition to prenatal cell survival, cell migration, and axon elongation, and its loss leading to malformation of cortical development and severe epilepsy Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa O3 Integration of metagenomics and metabolomics in gut microbiome research Maryam Goudarzi, Albert J. Fornace Jr. O4 A unique integrated system to discern pathogenesis of central nervous system tumors Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan, Hanadi Qashqari, Nawal Madkhali, Mohamad Saka, Kulvinder S. Saini, Awatif Jamal, Jaudah Al-Maghrabi, Adel Abuzenadah, Adeel Chaudhary, Mohammed Al Qahtani, Ghazi Damanhouri O5 RPL27A is a target of miR-595 and deficiency contributes to ribosomal dysgenesis Heba Alkhatabi O6 Next generation DNA sequencing panels for haemostatic and platelet disorders and for Fanconi anaemia in routine diagnostic service Anne Goodeve, Laura Crookes, Nikolas Niksic, Nicholas Beauchamp O7 Targeted sequencing panels and their utilization in personalized medicine Adel M. Abuzenadah O8 International biobanking in the era of precision medicine Jim Vaught O9 Biobank and biodata for clinical and forensic applications Bruce Budowle, Mourad Assidi, Abdelbaset Buhmeida O10 Tissue microarray technique: a powerful adjunct tool for molecular profiling of solid tumors Jaudah Al-Maghrabi O11 The CEGMR biobanking unit: achievements, challenges and future plans Abdelbaset Buhmeida, Mourad Assidi, Leena Merdad O12 Phylomedicine of tumors Sudhir Kumar, Sayaka Miura, Karen Gomez O13 Clinical implementation of pharmacogenomics for colorectal cancer treatment Angel Carracedo, Mahmood Rasool O14 From association to causality: translation of GWAS findings for genomic me

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