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作者： Rhee, Minsoung Burns, Mark A. Department of Chemical Engineering University of Michigan 3074 H.H. Dow Building 2300 Hayward St. Ann Arbor MI 48109-2136 United States Bioinformatics Program Medical School University of Michigan 100 Washtenaw Avenue Ann Arbor MI 48109-2218 United States Department of Biomedical Engineering University of Michigan 2200 Bonisteel Blvd. Ann Arbor MI 48109-2099 United States

ISBN: (纸本)9780816910502

We propose a method for microdevice construction where non-expert users can assemble the blocks on glass slides to build their custom devices in minutes without any complicated fabrication steps. This approach involves prefabrication of individual microfluidic assembly blocks (MABs) in PDMS are pre-fabricated and readily assembled to form microfluidic systems. We describe the construction process, the assembly of the devices, and various bonding techniques to accomplish hermetic assembly. Finally, we demonstrate common microfluidic applications including laminar flow development, valve control, and cell culture.

关键词： Microfluidics

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Discourse-based communities of practice: Developing graduate students' abilities to communicate their research across disparate disciplines and experience levels

Discourse-based communities of practice: Developing graduate...

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2008 ASEE Annual Conference and Exposition

作者： Anthony, Linda Palius, Marjory Maher, Carolyn Moghe, Prabhas Rutgers The State University of New Jersey NSF IGERT Program on Integratively Engineered Biointerfaces Rutgers State University of New Jersey Rutgers University 599 Taylor Road Piscataway NJ 08854 United States Robert B. Davis Institute for Learning Graduate School of Education of Rutgers State University of New Jersey Rutgers University 303 George Street New Brunswick NJ 08901 United States Department of Mathematics Education Rutgers University 10 Seminary Place New Brunswick NJ 08901 United States Department of Biomedical Engineering and Chemical and Biochemical Engineering Rutgers The State University of New Jersey Rutgers-NSF IGERT Program on Integratively Engineered Biointerfaces

Ours is a research endeavor with two distinct but related foci: We are developing and studying a discourse based community of practice (the IRIF) to address the particular learning and dissemination of challenges of doctoral graduate students in STEM fields. We also are developing a research tool and methodology (GROD) to enable more effective analyses of the rich data sets that such learning communities generate. The IRIF provides a model for convening a semi-structured discourse-based community of practice in which graduate students can develop their skills for disseminating their own research while learning from the research presentations made by others. For researchers interested in studying how such learning transpires, the IRIF or some adaptation of it may provide a useful context for research not only among graduate students but also for undergraduates and other levels as well. The GROD may also offer advantages to other education researchers as a methodological tool for discourse analysis, because variables other than disciplinary background - e.g. level of expertise, time in program, first language, etc. - could be plotted along the attribute axis. Thus, the methodology could be generalized and adapted for use in tracing the flow of ideas in a classroom setting or interactions in a group discussion. Both the IRIF model and the GROD methodology may be particularly relevant for those working in increasingly cross-disciplinary environments, such as those that IGERT programs and other educational initiatives are designed to promote. © American Society for engineering Education, 2008.

关键词： Students

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Cardtovascular engineering: Current status, future trends, and its emergence as a discipline

Cardtovascular engineering: Current status, future trends, a...

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114th Annual ASEE Conference and Exposition, 2007

作者： VanAuker, Michael Strom, Joel Lee, William University of South Florida United States Department of Chemical Engineering University of South Florida United States Cardiovascular Engineering Group University of South Florida United States University of South Florida Biomedical Engineering Program United States

Cardiovascular (CV) engineering is emerging as a defined discipline in engineering educational programs due to rapid advances in CV diagnostics, therapeutics, and rehabilitation. The growth in science and technology has in turn catalyzed significant industrial expansion as a wide variety of companies develop the high-tech products of the present and future. These advances require engineers capable of intimate interdisciplinary collaborations, particularly with CV physicians at each stage of research, but especially in the translational phase of product development. CV engineering education programs, whether defined as such or embedded in broader engineering educational programs include the following areas of study: underlying basic science issues involving CV anatomy and physiology, fluid characterization and flow, systems engineering, materials aspects of prosthetic devices, sensor devices, MEMS technology, drug delivery, imaging, etc. The purpose of this presentation is to define the current state of CV educational programs in engineering. All biomedical engineering programs identified by the Whitaker Foundation were reviewed to determine the extent of CV engineering education. The goals of this analysis are: 1) understand the extent to which "cardiovascular engineering" is indeed an emerging engineering discipline;2) determine the extent to which academic programs in biomedical, mechanical, and other areas of engineering are starting to provide curriculum in this area (along with future trends);3) determine the extent to which (like other established disciplines) a broader infrastructure exists (societies, journals, technical meetings, etc.);4) provide information on the extent to which formal research groups focusing on cardiovascular engineering have been established;and 5) develop foundational arguments why cardiovascular engineering should indeed continue to become its own discipline. Information regarding the parallel growth in the industrial sector will be

关键词： engineering education

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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

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Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

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Preliminary studies on the rapid detection of staphylococcus aureus using a microfluidic device and nanopatterned hydrogels

Preliminary studies on the rapid detection of staphylococcus...

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Annual Northeast Bioengineering Conference

作者： I. Saaem B. Kreiswirth M. Libera Department of Chemical Biomedical and Materials Engineering Stevens Institute of Technology Hoboken NJ USA Hospital Infections Program Public Health Research Institute Newark NJ USA

We studied the use of nanopatterned hydrogels as a possible foundation for medical devices for the detection of Staphylococcus aureus. Nanopatterned hydrogels, approximately 200 nm in diameter, were created by locally crosslinking dry amine-terminated poly(ethylene glycol) [PEG] (6000 Da) thin films using a focused electron beam. These gels then had a dry height of 50 nm and a swell ratio of about five. They were patterned into arrays with approximately 500 nm inter-gel spacing and functionalized with Immunoglobulin G [IgG], a biomolecule that binds protein A. We then placed these arrayed gels into a simple microfluidic device and exposed them to various bacterial samples. We show, using an assay that binds IgG to protein A expressing Staphylococcus aureus [***], that nanopatterned hydrogels can be used as probes for detection. We further show the specificity of our assay by using a protein A knock-out variant of S. aureus, Staphylococcus Epidermidis and Escherichia coli as negative controls.

关键词： Microfluidics Nanopatterning Probes Microorganisms Glass Immune system Proteins chemical technology Biological materials biomedical materials

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Hydrodynamic Surface Interactions Enable Escherichia Coli to Seek Efficient Routes to Swim Upstream

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Physical Review Letters 2007年第6期98卷 068101-068101页

作者： Jane Hill Ozge Kalkanci Jonathan L. McMurry Hur Koser Yale University Department of Chemical Engineering Environmental Engineering Program Mason Laboratory Room 318 New Haven Connecticut 06520-8286 USA Bogazici University Department of Biomedical Engineering Bebek Istanbul Turkey Yale University Molecular Biophysics & Biochemistry Department 266 Whitney Avenue New Haven Connecticut 06520-8114 USA Yale University Department of Electrical Engineering 15 Prospect Street Becton 507 New Haven Connecticut 06520-8284 USA

Escherichia coli in shear flow near a surface are shown to exhibit a steady propensity to swim towards the left (within the relative coordinate system) of that surface. This phenomenon depends solely on the local shear rate on the surface, and leads to cells eventually aligning and swimming upstream preferentially along a left sidewall or crevice in a wide range of flow conditions. The results indicate that flow-assisted translation and upstream swimming along surfaces might be relevant in various models of bacterial transport, such as in pyelonephritis and bacterial migration in wet soil and aquatic environments in general.

关键词： Escherichia coli

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Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

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Current Applied Physics 2007年第SUPPL.1期7卷 e28-e32页

作者： Kim, Gun-Woo Choi, Yoon-Jeong Kim, Mi-Sook Park, Yongdoo Lee, Kyu-Back Kim, In-Sook Hwang, Soon-Jung Noh, Insup Department of Chemical Engineering Seoul National University of Technology Seoul 139-743 Korea Republic of Korea Artificial Organ Center Korea University Seoul 136-705 Korea Republic of Department of Biomedical Engineering College of Medicine Korea University Seoul 136-705 Korea Republic of Brain Korea 21 Program for Biomedical Science Korea University College of Medicine Seoul 136-705 Korea Republic of Dental Research Institute Seoul National University Seoul 110-749 Korea Republic of Department of Oral and Maxillofacial Surgery College of Dentistry Seoul National University Seoul 110-749 Korea Republic of

Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups. © 2006 Elsevier B.V. All rights reserved.

关键词： Hydrogels

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Immuno‐Polymeric Nanoparticles by Diels–Alder Chemistry†

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Angewandte Chemie 2007年第32期119卷

作者： Meng Shi Jordan H. Wosnick Karyn Ho Armand Keating Molly S. Shoichet Department of Chemical Engineering and Applied Chemistry Department of Chemistry Institute for Biomaterials and Biomedical Engineering Terrence Donnelly Centre for Cellular and Biomolecular Research University of Toronto 160 College Street Toronto ON M5S 3E1 Canada Fax: (+1) 416‐978‐4317 http://www.ecf.utoronto.ca/∼molly Cell Therapy Program Princess Margaret Hospital/Ontario Cancer Institute University Health Network 620 University Avenue Toronto ON Canada

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Nanopatterned hydrogel probes for rapid detection of staphylococcus aureus

Nanopatterned hydrogel probes for rapid detection of staphyl...

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2006 MRS Fall Meeting

作者： Saaem, Ishtiaq Kreiswirth, Barry Libera, Matthew Dept. of Chemical Biomedical and Materials Engineering Stevens Inst. of Technology Hoboken NJ 07030 United States Hospital Infections Program Public Health Research Institute Newark NJ 07103 United States

ISBN: (纸本)9781604234107

We studied the use of nanopatterned hydrogels as a possible foundation for medical devices for the detection of Staphylococcus aureus. Nanopatterned hydrogels, approximately 200 nm in diameter, were created by locally crosslinking dry amine-terminated poly(ethylene glycol) [PEG] (6000 Da) thin films using a focused electron beam. These gels then had a dry height of 50 nm and a swell ratio of about five. They were patterned into arrays with approximately 500 nm inter-gel spacing. These arrayed gels were functionalized with Immunoglobulin G [IgG], a biomolecule that binds protein A. We are interested in seeing whether these arrayed gels can be used for bacterial capture and subsequent detection. We show, using an assay that binds IgG to protein A expressing Staphylococcus aureus [S. aureus], that nanopatterned hydrogels can indeed be used as probes for detection. We further show that the specificity of our assay by using a knock-out variant of S. aureus that doesn't express protein A as a negative control. © 2007 Materials Research Society.

关键词： Hydrogels

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Fluorescence lifetime imaging microscopy (FLIM) measures oxygen gradients in microfluidic bioreactors

Fluorescence lifetime imaging microscopy (FLIM) measures oxy...

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biomedical Topical Meeting, BIO 2006

作者： Sud, Dhruv Mehta, Geeta Mehta, Khamir Linderman, Jennifer Takayama, Shuichi Mycek, Mary-Ann Dept. of Biomedical Engineering University of Michigan Ann Arbor MI 48109-2099 United States Dept. of Chemical Engineering University of Michigan Ann Arbor MI 48109-2099 United States Macromolecular Science and Engineering Program University of Michigan Ann Arbor MI 48109-2099 United States Applied Physics Program University of Michigan Ann Arbor MI 48109-2099 United States Comprehensive Cancer Center University of Michigan Ann Arbor MI 48109-2099 United States

A unique FLIM system was employed to quantitatively image extracellular oxygen distributions in perfused micro-bioreactors. We report effects of cell density on oxygen consumption and the first such measurement of oxy... 详细信息

ISBN: (纸本)1557528071

关键词： Oxygen

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