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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： J.L. Myles B.T. Burgess R.B. Dickinson Department of Chemical Engineering & Biomedical Engineering Program University of Florida Gainesville FL USA

Adhesion of cells to the substratum is critical for cell migration. The authors have developed a three-dimensional migration assay consisting of collagen covalently coupled with RGD peptides to directly measure cell migration as a function of substratum adhesiveness. The random motility coefficient, a measure of the rate of cell dispersion by random migration, was found to have a biphasic dependence on increasing adhesiveness. To further understand the different modes of cell motility observed, a mechanistic model has been developed which predicts stochastic multi-dimensional cell migration as a function of receptor-ligand binding kinetics and pseudopod protrusion and retraction dynamics. Model predictions agree with the experimental results.

关键词： Adhesives Predictive models biomedical engineering Peptides biomedical measurements Extracellular chemical engineering Dispersion Stochastic processes Kinetic theory

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ANALYSIS OF GENDER BASED THERMAL REGULATION

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ASME 1999 International Mechanical engineering Congress and Exposition, IMECE 1999

作者： Spieker, Michael A. Hayes, Linda J. Wissler, Eugene H. Colvin, David P. Biomedical Engineering Program University of Texas at Austin AustinTX78712 United States Aerospace Engineering and Engineering Mechanics Program University of Texas at Austin AustinTX78712 United States Chemical Engineering Program University of Texas at Austin AustinTX78712 United States Triangle Research and Development Corp. P.O. Box 12696 Research TriangleNC27709 United States

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Analysis of gender based thermal regulation

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American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 1999年 44卷 25-29页

作者： Spieker, Michael A. Hayes, Linda J. Wissler, Eugene H. Colvin, David P. Biomedical Engineering Program University of Texas at Austin Austin TX 78712 United States Chemical Engineering Program University of Texas at Austin Austin TX 78712 United States Aerosp. Eng. Eng. Mechanics Prog. University of Texas at Austin Austin TX 78712 United States Triangle R. and D. Corp. P.O. Box 12696 Research Triangle NC 27709 United States

A whole body thermal regulation model is used to analyze the gender based thermal responses of men and women subjected to medium-high work levels in several thermal environments. The results serve as bases in estimati... 详细信息

ISBN: (纸本)0791816435

关键词： Physiology

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Analysis of gender based thermal regulation

American Society of Mechanical Engineers, Bioengineering Div...

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American Society of Mechanical Engineers, Bioengineering Division (Publication) BED 1999年 42卷 705-706页

作者： Spieker, Michael A. Hayes, Linda J. Wissler, Eugene H. Colvin, David P. Biomedical Engineering Program University of Texas at Austin Austin TX 78712 United States Aerosp. Eng. Eng. Mechanics Prog. University of Texas at Austin Austin TX 78712 United States Chemical Engineering Program University of Texas at Austin Austin TX 78712 United States Triangle Res. and Development Corp. P.O. Box 12696 Research Triangle NC 27709 United States

ISBN: (纸本)0791816117

The Wissler model is used to analyze the gender based thermal responses of men and women subjected to medium-high work levels in various thermal environments. This model efficiently analyzes the potential performance of men and women in several thermal environments, including, a thermally neutral environment, a desert environment, and a jungle environment. Core body temperatures and skin temperatures are monitored to determine how men and women respond to various levels of exercise.

关键词： biomedical engineering

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A fluorescent glucose assay using poly-L-lysine and calcium alginate microencapsulated TRITC-succinyl-concanavalin A and FITC-dextran

A fluorescent glucose assay using poly-L-lysine and calcium ...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： R. Russell M. Pishko C. Gefrides G. Cote Department of Chemical Engineering Texas A and M University College Station TX USA Biomedical Engineering Program Texas A and M University College Station TX USA

Glucose assays based on fluorescent quenching of fluorophores due to Fluorescent Resonance Energy Transfer (FRET) has previously been successfully developed in an aqueous medium. TRITC-succinyl-Con A and FITC-Dextran have been used to determine physiological glucose concentrations, based upon competitive binding between Con A, dextran, and glucose. In the absence of glucose, TRITC-succinyl-Con A binds with FITC-Dextran, and the FITC fluorescence is quenched. As glucose binds to TRITC-succinyl-Con A, FITC-Dextran is liberated. The resulting increase in FITC fluorescence is proportional to the concentration of glucose. The authors report on attempts to develop a polymer-based fluorescent sensor using FITC-Dextran and TRITC-Succinyl-Con A encapsulated in calcium alginate gel spheres surface modified with a sodium alginate and poly-L-lysine coating to stabilize the gel. In vitro experiments of the polymer spheres in a solution of dH/sub 2/O and glucose were conducted. The fluorescence change with increasing glucose concentration, ranging from 0 to 800 mg/mL, was linear from 0 to 600 mg/mL, with a reduced response at 800 mg/mL. This reduced response is likely due to the majority of the initially bound FITC-Dextran having been released.

关键词： Fluorescence Sugar Calcium Energy exchange Resonance Polymers Diabetes chemical engineering biomedical engineering Electronic mail

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Effect of electrostatic interactions in recognition of acetylcholine by acetylcholinesterase

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Journal of Molecular Structure: THEOCHEM 1998年第1-2期425卷 81-85页

作者： Linaras, Charilaos E. Singh, Kamalendra Kristol, David Ritter, Arthur B. Department of Chemical Engineering New Jersey Institute of Technology Newark NJ 07102 United States Department of Opthalmology UMD-New Jersey Medical School Newark NJ 07103 United States Biomedical Engineering Program New Jersey Institute of Technology Newark NJ 07102 United States Dept. of Pharmacology and Physiology UMD-New Jersey Medical School Newark NJ 07103 United States

The role of electrostatic interactions in the steering of acetylcholine to the active site of acetylcholinesterase is investigated in this study. The results obtained suggest that acetylcholinesterase's catalytic processes involve more than two steps, one of which appears to be diffusion-controlled, while the others are influenced by electrostatic interactions. The results also support the concept that the electrostatic field contributes to the guidance of the ligand upon its close proximity to the entrance of the active site gorge. On the basis of the data obtained, a prehydrolysis (pre-transition state) structure for this catalytic reaction is also proposed. The root mean square deviation of the Ca atoms of the amino acid residues of the active site between the proposed transition state and a recently proposed transition state based on experimental data is 0.379 Å. © 1998 Elsevier Science B.V.

关键词： Acetylcholinesterase Catalytic reactions Electrostatic interactions Molecular model Transition state

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Contributory presentations/posters

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Journal of Biosciences 1999年第1期24卷 33-198页

作者： N. Manoj V. R. Srinivas A. Surolia M. Vijayan K. Suguna R. Ravishankar R. Schwarzenbacher K. Zeth Diederichs G. M. Kostner A. Gries P. Laggner R. Prassl Madhusudan Pearl Akamine Nguyen-huu Xuong Susan S. Taylor M. Bidva Sagar K. Saikrishnan S. Roy K. Purnapatre P. Handa U. Varshney B. K. Biswal N. Sukumar J. K. Mohana Rao A. Johnson Vasantha Pattabhi S. Sri Krishna Mira Sastri H. S. Savithri M. R. N. Murthy Bindu Pillai Kannan M. V. Hosur Mukesh Kumar Swati Patwardhan K. K. Kannan B. Padmanabhaa S. Sasaki-Sugio M. Nukaga T. Matsuzaki S. Karthikevan S. Sharma A. K. Sharma M. Paramasivam P. Kumar J. A. Khan S. Yadav A. Srinivasan T. P. Singh S. Gourinath Neelima Alam A. Srintvasan Vikas Chandra Punit Kaur Ch. Betzel S. Ghosh A. K. Bera S. Bhattacharya S. Chakraborty A. K. Pal B. P. Mukhopadhyay I. Dey U. Haldar Asok Baneriee Jozef Sevcik Adriana Solovicova K. Sekar M. Sundaralingam N. Genov Dong-cai Liang Tao Jiang Ji-ping Zhang Wen-rui Chang Wolfgang Jahnke Marcel Blommers S. C. Panchal R. V. Hosur Bindu Pillay Puniti Mathur S. Srivatsun Ratan Mani Joshi N. R. Jaganathan V. S. Chauhan H. S. Atreya S. C. Sahu K. V. R. Chary Girjesh Govil Elisabeth Adjadj Éric Quinjou Nadia Izadi-Pruneyre Yves Blouquit Joël Mispelter Bernadette Heyd Guilhem Lerat Philippe Milnard Michel Desmadreil Y. Lin B. D. Nageswara Rao Vidva Raghunathan Mei H. Chau Prashant Pesais Sudha Srivastava Evans Coutinho Anil Saran Leizl F. Sapico Jayson Gesme Herbert Lijima Raymond Paxton Thamarapu Srikrishnan C. R. Grace G. Nagenagowda A. M. Lynn Sudha M. Cowsik Sarata C. Sahu S. Chauhan A. Bhattacharya G. Govil Anil Kumar Maurizio Pellecchia Erik R. P. Zuiderweg Keiichi Kawano Tomoyasu Aizawa Naoki Fujitani Yoichi Hayakawa Atsushi Ohnishi Tadayasu Ohkubo Yasuhiro Kumaki Kunio Hikichi Katsutoshi Nitta V. Rani Parvathy R. M. Kini Takumi Koshiba Yoshihiro Kobashigawa Min Yao Makoto Demura Astushi Nakagawa Isao Tanaka Kunihiro Kuwajima Jens Linge Seán O. Donoghue Michael Nilges G. Chakshusmathi Girish S. Ratnaparkhi P. K. Madhu R. Varadarajan C. Tetreau Molecular Biophysics Unit Indian Institute of Science Bangalore India Austrian Academy of Sciences Institute of Biophysics and X-ray Structure Research Graz Austria Faculty of Biology University of Konstanz Germany Institute of Medical Biochemistry University of Graz Austria Howard Huges Medical Institute Department of Chemistry & Biochemistry University of California La Jolla USA Department of Chemistry & Biochemistry University of California San Diego La Jolla USA Molecular Biophysics Unit India Department of Microbiology &Cell Biology Indian Institute of Science Bangalore India Macromolecular Structure Laboratory NCI - Frederick Cancer Research and Development Center ABL - Basic Research Program Frederick USA Department of Crystallography and Biophysics University of Madras Chennai Biochemistry Department Indian Institute of Science Bangalore India Condensed Matter Physics Division B.A.R.C. Trombay Mumbai Condensed Matter Physics Division Bhabha Atomic Research Centre Trombay Mumbai IMCB The University of Tokyo Tokyo Japan Mitsubishi Chemical Corporation Yokohama Research Center Yokohama Japan Faculty of Pharmaceutical Sciences Chiba University Chiba Japan Department of Biophysics All India Institute of Medical Sciences New Delhi India Department of Biophysics All India Institute of Medical sciences New Delhi India Institüt Physiologische Chemie Hamburg Germany Biophysics Department Bose Institute Calcutta India Slovak Academy of Sciences Institute of Molecular Biology Bratislava Slovakia Indian Institute of Science Bioinformatics Centre Bangalore Departments of Chemistry and Biochemistry Biological Macromolecular Structure Center USA Bulgarian Academy of Sciences Institute of Organic Chemistry Sofia Bulgaria Chinese Academy of Sciences Institute of Biophysics Beijing China Novartis Pharma AG Preclinical Research Basel Switzerland Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India Solid State Physics Div

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Modeling of human thermal regulation for liquid cooling garment applications

Modeling of human thermal regulation for liquid cooling garm...

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Proceedings of the 1997 ASME International Mechanical engineering Congress and Exposition

作者： Nyberg, Karen L. Diller, Kenneth R. Wissler, Eugene H. Biomedical Engineering Program Department of Mechanical Engineering University of Texas at Austin Austin 78712 TX United States Biomedical Engineering Program Department of Chemical Engineering University of Texas at Austin Austin 78712 TX United States

ISBN: (纸本)9780791818442

The Wissler Human Thermoregulation Model has been adapted for use in the design of control schemes for regulating liquid cooling garment (LCG) inlet coolant temperature. The model was used to simulate various activity scenarios in a space suit while both liquid coolant and ventilation gas were in thermal communication with the human subject. Model parameters were identified which best represent the actual LCG system currently used by NASA. Simulations were performed for the metabolic and thermal activity histories of two different sets of test data available from the Johnson Space Center (JSC). It was demonstrated that the modified Wissler model, incorporating the LCG and ventilation flow effects, simulates actual human thermal and metabolic responses over a broad range of transient work loads and can therefore be reliably applied for design of a future automated thermal control scheme.

关键词： Heat transfer

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Protein at interfaces II. Fundamentals and applications

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Journal of Controlled Release 1997年第1期45卷 113-113页

作者： Joseph Kost Ben Gurion University of the Negev Department of Chemical Engineering Center for Biomedical Engineering and Program for Biotechnology Beer-Sheva 84105 Israel

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Molecular modeling studies of AChE inhibition by sarin

Molecular modeling studies of AChE inhibition by sarin

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Annual Northeast Bioengineering Conference

作者： C.E. Linaras A. Ritter D. Kristol Department of chemical Engineering New Jersey Medical School University of Medicine and Dentistry of New Jersey Newark NJ USA Department of Physiology New Jersey Institute of Technology Newark NJ USA Biomedical Engineering Program New Jersey Medical School University of Medicine and Dentistry of New Jersey Newark NJ USA

In the present study molecular modeling and molecular mechanics methods using the crystal structure coordinates for acetylcholinesterase (AChE) from Torpedo Californica were employed to demonstrate the behavior of key residues of the enzyme upon inhibition by both the P/sub R/ and P/sub S/ diastereomers of isopropylmethylphosphonofluoridate (sarin). Comparative studies between both the adducts of AChE with P/sub S/ and P/sub R/ sarin and with the native enzyme indicate the important role of the aromatic residues in the vicinity of the active site as well as that of His-440 which catalyzes both the C-O bond breaking in the dealkylation reaction and the reaction of bond breaking to the Ser /spl gamma/-O in reactivation. In contrast to previous studies, the role of Glu-199 in stabilizing the developing positive charge on the incipient carbonium ion in the dealkylation reaction was not verified in this study.

关键词： Biochemistry Bonding Integrated circuit modeling Aging Electrostatics chemical engineering biomedical engineering chemical technology Crystallography Proteins

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