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IEEE International Symposium on Applications of Ferroelectrics (ISAF)

作者： Malachy Newman Jiro Kusunose M. Anthony Phipps Allison Dockum Ainsley McDonald-Boyer Charles Caskey Department of Biomedical Engineering Vanderbilt University Nashville USA Department of Radiology Vanderbilt Institute of Imaging Science Vanderbilt University Nashville USA Program in Chemical and Physical Biology Vanderbilt University Nashville USA

ISBN: (数字)9798350371901

ISBN: (纸本)9798350371918

Transcranial focused ultrasound is an important tool for opening the blood brain barrier (BBB), which is typically performed by focusing ultrasonic energy through the skull into regions that have been perfused with microbubbles (MB). When sonicated, these MB oscillate and temporarily disrupt the local BBB. The procedure can be monitored for effectiveness and safety by analyzing the spectral content of echoes, and by using multiple receivers, where the active MB’s position can be triangulated, allowing for the localization of the BBB opening. The monitoring and localization of MB has been performed in rodents but translating into larger animals is a major challenge due to attenuation at the skull. Here, we used acoustic simulations to design a multi-element transmit array with multiple receivers and characterized its ability to generate a focus through the non-human primate (NHP) skull and assessed its performance in localizing MB activity while varying number and spatial arrangement of receivers, optimizing the focal gain, focal spot size, and ability to localize a MB. The resultant transducer allows for the delivery of high pressure at brain-region sized targets and can localize MB signals.

关键词： Location awareness Transducers Ultrasonic imaging Rodents Receivers Acoustics Safety In vitro Monitoring Frequency control

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Prediction tools for assessing functional impacts of gene mutations in Clear Cell Renal Cell Carcinoma: A comparative study

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Computers in Biology and Medicine 2025年第Pt A期192卷 110187-110187页

作者： Yang, Cheng-Hong Lin, Guan-Cheng Wu, Chih-Hsien Chen, Jin-Bor Chuang, Li-Yeh Department of Information Management Tainan University of Technology Tainan Taiwan Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Drug Development and Value Creation Research Center Kaohsiung Taiwan Ph. D. Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taiwan Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering I-Shou University Kaohsiung Taiwan Taiwan

Renal cell carcinoma (RCC) is a well-known malignancy characterized by specific gene mutations that elevate its occurrence. It can be categorized into clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC, which account for approximately 85 % of all primary RCC cases. The mutations typically involve single-nucleotide variants (SNVs) that lead to amino acid substitutions, which influence various biological functions, including gene expression. Therefore, predicting the functional consequences of RCC-related single-nucleotide polymorphisms (SNPs), including substitutions, insertions, deletions, and duplications, is crucial for the effective clinical management of RCC. In recent years, the accessibility and popularity of tools for predicting SNP functional variations have grown, especially in research concerning the potential risks associated with key gene mutations in cancer. Accordingly, this study focused on commonly mutated genes in ccRCC, namely VHL, BAP1, PBRM1, and SETD2. Public data from sources such as The Cancer Genome Atlas and the National Center for Biotechnology Information were used to identify 61 gene mutation positions. Nine nonsynonymous mutation prediction tools were used for analysis, namely SIFT, Polyphen-2, Mutation Assessor, Fathmm, MutPred, CHASM, Revel, Provean, and SNP&GO. The tools were evaluated by their statistical performance, prediction distribution, and receiver operating characteristic curves. The three tools with the highest accuracy for predicting the functional consequences of mutations in the four frequently mutated genes associated with ccRCC were SIFT (accuracy of 0.75), Provean (0.7), and Polyphen-2 (0.69). These findings offer valuable insights into predicting ccRCC-related gene mutation effects, but further research and validation are essential to support their clinical applications. © 2025

关键词： Transcription

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Targeted Liposomes Production in a Microfluidic Chip 15

Targeted Liposomes Production in a Microfluidic Chip

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15th IEEE International Conference on Nano/Molecular Medicine and engineering, NANOMED 2021

作者： Agam, Mohamed Paul, Vinod Abdelgawad, Mohamed Husseini, Ghaleb Biomedical Engineering Program American University of Shariah United Arab Emirates American University of Sharjah Department of Chemical Engineering Sharjah United Arab Emirates American University of Sharjah Department of Mechanical Engineering Sharjah United Arab Emirates

ISBN: (纸本)9781665458566

Liposomes are used and heavily researched in drug delivery. These nanocarriers encapsulate therapeutic agents efficiently and deliver their contents to tumors with minimal undesired side effects. In this study, we investigated the preparation of Estrone liposomes in a commercially available microfluidic chip (a Herringbone micromixer). Using this chip, we synthesized Estrone liposomes with high uniformity and reproducibility, contrary to conventional methods (e.g., the thin film hydration), which are cumbersome and non-reliable. In addition, we studied the effect of the lipids concentration and the flow rate ratio between the lipids stream and the aqueous stream on the size and polydispersity of the resulting liposomes. The smallest liposomes obtained were 91.8 ± 4.8nm in radius (mean ± SD) with a polydispersity of 17.2%. © 2021 IEEE.

关键词： Liposomes

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Incorporating self-assembled MXene to improve electrical conductivity of novel ZIF67 derivatives induced by NH4BF4 and NH4HF2 for energy storage

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Journal of Energy Storage 2024年 82卷

作者： Lee, Pin-Yan Chiou, Yu-Ren Cheng, Cheng-Siang Chen, Yu-Chun Kongvarhodom, Chutima Chen, Hung-Ming Yougbaré, Sibidou Husain, Sadang Ho, Kuo-Chuan Kuo, Tsung-Rong Lin, Lu-Yin Department of Chemical Engineering National Taiwan University Taipei Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Zeolitic imidazolate framework (ZIF-67) with high surface area and tunable pore size are considered as a promising active material for energy storage, but the low electrical conductivity restricts its performance. Developing ZIF67 derivatives with improved electrical conductivity is necessary to broaden its application in electrochemical fields. In this work, two strategies are applied to improve electrical conductivity and electrochemical performance of ZIF67. Novel structure directing agents of NH4BF4 and NH4HF2 are used to synthesize ZIF67 derivatives with higher theoretical capacitances and favorable layered structures. Self-assembled MXene with different amounts is further incorporated in ZIF67 derivatives to establish composites. The optimal composite electrode shows a high specific capacitance (CF) of 1410.4 F/g (775.6C/g) at 20 mV/s, while the ZIF67 derivative electrode without MXene only shows a CF value of 942.3 F/g (518.3C/g), due to the high surface area and better pore structure as well as the close combination of MXene and the layered ZIF67 derivative for the former case. An energy storage device with the optimal composite and carbon electrodes shows the maximum energy density of 32.40 Wh/kg at 375 W/kg. The Coulombic efficiency of 100% and the CF retention of 77.4% are also achieved after 10,000 cycles. © 2024 Elsevier Ltd

关键词： Energy storage

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In-situ growth of novel iron oxide/iron organic framework composites as efficient electroactive materials of battery supercapacitor hybrids

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Journal of Energy Storage 2024年 97卷

作者： Kuo, Tsung-Rong Saukani, Muhammad Kuo, Tsung-Rong Kubendhiran, Subbiramaniyan Wang, Yu-Min Tai, Po-Chun Wu, Chang-Feng Lin, Lu-Yin Kongvarhodom, Chutima Kongvarhodom, Chutima Husain, Sadang Yougbaré, Sibidou Chen, Hung-Ming International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering University of New Brunswick FrederictonNBE3B5A3 Canada Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Gingen technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan

Iron oxide (Fe2O3) with a high theoretical capacitance, wide potential ranges and easy availability has attracted much attentions as the electrode material of battery supercapacitor hybrids (BSH). Metal–organic framework (MOF) is one of the promising potential energy storage materials due to its large surface area and controllable pore structures. In this work, novel iron oxide/iron organic framework composites (Fe2O3/FeMOF) are in-situ grown on the Ni foam as efficient energy storage electrodes of BSH. By tuning the solvothermal durations, the morphology changes from random sizes of sheets, regular grown vertical sheets, to flower-like structures. The d-spacing also increases for the Fe2O3/FeMOF synthesized using longer solvothermal durations. The optimal Fe2O3/FeMOF electrode synthesized using 9 h shows a high areal capacitance of 10.97 F/cm2 along with an areal capacity of 5.49 F/cm2 at the current density of 35 mA/cm2, owing to the most regular growth of sheets, the large d-spacing, and the smallest charge-transfer resistances. A BSH composed of the Fe2O3/FeMOF positive electrode and a graphene negative electrode shows a maximum energy density of 0.76 mWh/cm2 at 22.5 mW/cm2. The excellent long-term cycling stability with the capacitance retention of 85% and Coulombic efficiency of 98% are also achieved after 10,000 charge/discharge cycles. © 2024 Elsevier Ltd

关键词： Supercapacitor

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Influence of multitasking-induced mental workload on electrodermal activity and human cortisol

Influence of multitasking-induced mental workload on electro...

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biomedical engineering International Conference (BMEiCON)

作者： Jutamas Pidech Manida Swangnetr Neubert Oranat Chuchuen Biomedical Engineering Program Faculty of Engineering Khon Kaen University Khon Kaen Thailand Department of Industrial Engineering Faculty of Engineering Chulalongkorn University Bangkok Thailand Human-Robot Collaboration and Systems Integration Research Unit Chulalongkorn University Bangkok Thailand Department of Chemical Engineering Faculty of Engineering Khon Kaen University Khon Khon Kaen Thailand

Current work environments have undergone a noticeable shift towards higher cognitive demands and increased involvement in multitask performance. It has therefore become crucial to investigate the levels of mental workload experienced by operators. Simulated cognitive multitasking, with varying workload intensity, duration and work order, was tested in 18 volunteers to determine its impact on task performance, perceived workload, galvanic skin response; GSR, and cortisol levels in sweat and saliva. The results showed that as workload intensity increased, there was a concurrent increase in perceived workload and a significant negative impact on task performance. As time progressed, there was a notable increase in performance. Differences in GSR can be observed based on time on task and order of stressor levels delivered to the participants. Preliminary results of cortisol levels in sweat and saliva showed distinct trends in relation to workload intensity.

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Novel synthesis of nickel-based bimetallic compounds using ammonium tetrafluoroborate and ammonium bifluoride as structure directing agents for energy storage application

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Journal of Energy Storage 2024年 75卷

作者： Kuo, Tsung-Rong Yu, You Zher Lee, Pin-Yan Wu, Chung-Hsien Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Ho, Kuo-Chuan Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering National Taiwan University Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand

Nickel-based compounds are widely applied as the active material for energy storage devices, owing to high theoretical capacity and easy-fabricated process. Bimetallic compounds having multiple redox states can provide abundant redox reactions for charge storage. Structure directing agent (SDA) can promote the preferable growth of active materials and to enhance energy storage abilities. In this work, NH4BF4 and NH4HF2 are firstly used as SDA to synthesize nickel-based compounds along with 2-methylmidozole in the one-step solution process for energy storage applications. The bimetallic compounds are synthesized by incorporating Al, Mn, Co, Cu and Zn salts in the precursor solution including the Ni salt. The system with Al, Cu or Zn possesses single metal compound and barely nickel compound. Mn and Co-incorporated systems present clear bimetallic components with nickel hydroxide. The highest specific capacitance (CF) of 1336.3 F/g (297.0 mAh/g) are achieved at 20 mV/s for the NiCo-based electrode, owing to the bimetallic feature and favorable two-dimensional sheet-like structures. An energy storage device is assembled using the NiCo-based compound and reduced graphene oxide electrodes. The maximum energy density of 10.5 Wh/kg at 0.3 kW/kg, and the CF retention of 78.5% and Coulombic efficiency of 85.2% are achieved after 10,000 times charge/discharge cycles. © 2023 Elsevier Ltd

关键词： Energy storage

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pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

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Bioactive Materials 2024年第4期34卷 414-421页

作者： Jianhua Zou Zheng Li Yang Zhu Yucen Tao Qing You Fangfang Cao Qinghe Wu Min Wu Junjie Cheng Jianwei Zhu Xiaoyuan Chen Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore119074Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore117597Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore117599Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)61 Biopolis DriveProteosSingapore138673Singapore Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong UniversityShanghai200011PR China Department of Chemistry Center for Bioanalytical Chemistry University of Science and Technology of ChinaHefei230026PR China College of Life Science Nanjing Normal University1 Wenyuan RoadNanjing210023PR China

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy(PDT)due to oxygen *** I PDT,which can operate independently of oxygen,is a viable option for treating hypoxic *** this study,we have designed and synthesized JSK@PEG-IR820 NPs that are responsive to the tumor microenvironment(TME)to enhance type I PDT through glutathione(GSH)*** approach aims to expand the sources of therapeutic benefits by promoting the generation of superoxide radicals(O_(2)^(-).)while minimizing their *** diisopropyl group within PEG-IR820 serves a dual purpose:it functions as a pH sensor for the disassembly of the NPs to release JSK and enhances intermolecular electron transfer to IR820,facilitating efficient O_(2)^(-).***,the release of JSK leads to GSH depletion,resulting in the generation of nitric oxide(NO).This,in turn,contributes to the formation of highly cytotoxic peroxynitrite(ONOO^(-).),thereby enhancing the therapeutic efficacy of these ***-II fluorescence imaging guided therapy has achieved successful tumor eradication with the assistance of laser therapy.

关键词： TME responsive NO gas therapy NIR-II imaging Type I PDT

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Circularly polarized luminescent self-organized helical superstructures:From materials and stimulus-responsiveness to applications

Aggregate

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Aggregate 2021年第6期2卷 60-81页

作者： Yanrong He Siyang Lin Jinbao Guo Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Educationand College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Institute of Advanced Materials School of Chemistry and Chemical Engineeringand Jiangsu Province Hi-Tech Key Laboratory for Biomedical ResearchSoutheast UniversityNanjingChina Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOhioUSA

Circularly polarized luminescence(CPL)has gained considerable attention in various systems and has rapidly developed into an emerging research *** meet the needs of actual applications in diverse fields,a high luminescence dissymmetry factor(glum)and tunable optical performance of CPL would be the most urgent pursuit for ***,many emerging CPL materials and various strategies have been developed to address these critical *** cholesteric liquid crystals(CLCs),that is,luminescent self-organized helical superstructures,are considered to be ideal candidates for constructing CPL-active materials,as they not only exhibit high glum values,but also enable flexible optical control of *** review mainly summarizes the characteristics of CPL based on CLCs as the bulk phase doped with different emitters,including aggregated induced emission molecules,conventional organic small molecules,polymer emitters,metal-organic complex emitters,and luminescent *** addition,the recent significant progress in stimulus-responsive CPL based on emissive CLCs in terms of several types of stimuli,including light,electricity,temperature,mechanical force,and multiple stimuli is ***,a short perspective on the opportunities and challenges associated with CPL-active materials based on the CLC field is *** review is anticipated to offer new insights and guidelines for developing CLC-based CPL-active materials for broader applications.

关键词： amplifying dissymmetry factor cholesteric liquid crystal circularly polarized luminescence self-organized helical superstructure stimulus-responsiveness

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Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flexible Bioelectrodes for Neural Sensing

Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flex...

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Advances in Science and engineering Technology International Conferences (ASET)

作者： Kashif Rast Baz Khan Amani Al-Othman Hasan Al-Nashash Mohammad Al-Sayah Biomedical Engineering Graduate Program American University of Sharjah Sharjah UAE Department of Chemical and Biological Engineering American University of Sharjah Sharjah UAE Department of Electrical Engineering American University of Sharjah Sharjah UAE Chemistry and Environmental Sciences American University of Sharjah Sharjah UAE

Research applications of neural sensing and muscle stimulation have been advanced by the development of bioelectrodes that are biocompatible, flexible and long lasting. The existing metallic made bioelectrodes exhibit extremely high electrochemical resistances that would interfere with the neural-electrode bridge and suffer from mechanical and immunological mismatch. Novel, flexible, implantable bioelectrodes based on MXenes (Ti 3 C 2 ) and Polydimethylsiloxane (PDMS) composite are proposed. Mxenes possess the advantage of having metallic ultra-conductive transition metals consisting of large groups of carbides, nitrides, or carbonitrides, while PDMS has inherent biostability, flexibility and biocompatibility. In the current research, PDMS has been used as the supporting matrix for conductive fillers such as PMMA, PEDOT, and Mxenes. A series of characterization techniques were performed such as Electrochemical Impedance Spectroscopy (EIS), Cyclic Voltammetry (CV) and mechanical testing. The average results of triplicate samples exhibited samples' bulk impedance of 0.913 kΩ, an impedance of 1.612 MΩ, at 1 kHz frequency and a conductivity of 1.41x10 -4 S/cm, charge storage capacity of 0.056 mC/cm 2 and Young's modulus of 3.81 MPa.

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