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Nanomedicine-mediated immunogenic cell death and its combination with immune checkpoint blockade therapy

Science China(Technological Sciences) 2024年第8期67卷 2350-2362页

作者： CHEN JunBin ZHANG YuXi SU Miao ZHU YueQiang YANG XianZhu School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhou 511442China National Engineering Research Center for Tissue Restoration and Reconstruction Guangdong Provincial Key Laboratory of Biomedical EngineeringKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhou 510006China

Cancer immunotherapies, which train the natural immune system to specifically kill tumor cells while sparing the healthy cells,have helped revolutionize cancer treatments and demonstrated promising clinical therapeutic benefits for decades. However, the therapeutic outcome of immunotherapies, even for the most successful immune checkpoint blockade(ICB) therapy, remains unsatisfactory in the clinical practice, mainly due to the low immunogenicity of solid tumors and its immunosuppressive tumor microenvironment(TME). Notably, several cancer treatment modalities, including chemotherapy, radiotherapy, and phototherapy, have been revealed to evoke tumor immunogenicity and reverse immunosuppressive TME via inducing immunogenic cell death(ICD) of tumor cells, which synergistically sensitized tumors to ICB therapy. Nanomedicines have been extensively applied to augment ICD-inducing treatment modalities and potentiate ICB therapeutic efficacy therapy due to the opportune convergence of immunotherapy and nanotechnology. Here, we discuss the recent advances in nanomedicine-mediated ICD and its combination with ICB therapy.

关键词： cancer immunotherapy nanomedicine immunogenic cell death immune checkpoint blockade

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Fully automated in vivo screening system for multi-organ imaging and pharmaceutical evaluation

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Microsystems & Nanoengineering 2025年第1期11卷 301-311页

作者： Junhan Duan Guanming Lin Kangjian Jiao Xiaohui Hong Xudong Lin Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen University518000 ShenzhenChina

Advancements in screening technologies employing small organisms have enabled deep profiling of compounds in ***,current strategies for phenotyping of behaving animals,such as zebrafish,typically involve tedious ***,we develop and validate a fully automated in vivo screening system(AISS)that integrates microfluidic technology and computer-vision-based control methods to enable rapid evaluation of biological responses of non-anesthetized zebrafish to molecular *** precise fluidic control,the AISS allows automatic loading,encapsulation,transportation and immobilization of single-larva in droplets for multi-organ imaging and chemical gradients generation inaccessible in previous *** this platform,we examine the cardiac sensitivity of an antipsychotic drug with multiple concentration gradients,and reveal dramatic diversity and complexity in the accurate chemical regulation of cardiac functions in *** proposed system expands the arsenal of tools available for in vivo screening and facilitates comprehensive profiling of pharmaceuticals.

关键词： small organisms automated vivo screening system screening technologies microfluidic technology deep profiling compounds precise flui evaluation biological responses automated vivo screening system aiss

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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia Xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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Ultra-low frequency magnetic energy focusing for highly effective wireless powering of deep-tissue implantable electronic devices

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National Science Review 2024年第5期11卷 272-290页

作者： Yuanyuan Li Zhipeng Chen Yuxin Liu Zijian Liu Tong Wu Yuanxi Zhang Lelun Peng Xinshuo Huang Shuang Huang Xudong Lin Xi Xie Lelun Jiang Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringShenzhen Campus of Sun Yat-Sen University School of Mechanical and Electrical Engineering Guangzhou University State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-Sen University

The limited lifespan of batteries is a challenge in the application of implantable electronic devices. Existing wireless power technologies such as ultrasound, near-infrared light and magnetic fields cannot charge devices implanted in deep tissues, resulting in energy attenuation through tissues and thermal ***, an ultra-low frequency magnetic energy focusing(ULFMEF) methodology was developed for the highly effective wireless powering of deep-tissue implantable devices. A portable transmitter was used to output the low-frequency magnetic field(<50 Hz), which remotely drives the synchronous rotation of a magnetic core integrated within the pellet-like implantable device, generating an internal rotating magnetic field to induce wireless electricity on the coupled coils of the device. The ULFMEF can achieve energy transfer across thick tissues(up to 20 cm) with excellent transferred power(4–15 mW) and non-heat effects in tissues, which is remarkably superior to existing wireless powering technologies. The ULFMEF is demonstrated to wirelessly power implantable micro-LED devices for optogenetic neuromodulation, and wirelessly charged an implantable battery for programmable electrical stimulation on the sciatic nerve. It also bypassed thick and tough protective shells to power the implanted devices. The ULFMEF thus offers a highly advanced methodology for the generation of wireless powered biodevices.

关键词： ultra-low frequency transcutaneous energy transmission electromagnetic generator implantable electronic device deep tissue

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NIR-Ⅱ responsive Janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

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Science China(Technological Sciences) 2024年第1期67卷 321-329页

作者： CHEN BeiBei GUO KangLi WANG HaoRan XU Fu-Jian WANG JuLin ZHAO NaNa State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology) Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials Sciences and Engineering Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical TechnologyBeijing 100029China

Immunotherapy brings new hope for tumor treatment by inducing immunogenic cell death(ICD)of tumor ***,insufficient immunogenicity and low immune response rate greatly limit antitumor ***,by optimizing the composition and morphology,the rational design of Janus nanoparticles composed of Fe_(3)O_(4) nanospheres and SiO_(2)nanorods was realized for enhanced cancer immunotherapy through amplified *** glucose oxidase(GOx)was loaded by the Janus nanoparticles,the resultant M-FS-GOx consumes glucose at tumor sites to generate gluconic acid and hydrogen peroxide(H_(2)O_(2))for starvation therapy while the H_(2)O_(2)supply promotes the production of highly toxic·OH to achieve effective chemodynamic therapy(CDT).Under a 1064 nm light irradiation,the photothermal effect of M-FS-GOx enhances the enzyme activity of GOx for improved starvation ***,both tumor-associated antigens released during the process of ICD and the intrinsic immunoadjuvant property of M-FS-GOx stimulate dendritic cell maturation to activate antitumor immune *** work provides a promising strategy for the construction of Janus nanoparticles to achieve enhanced cancer immunotherapy through combination therapy-amplified ICD.

关键词： Janus nanoparticles immunogenic cell death cancer immunotherapy

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Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy

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Rare Metals 2025年第1期44卷 417-429页

作者： Xiao-Xia Wu Ding-Hu Zhang Yi-Nan Ding Fei Cao Yang Li Jun-Lie Yao Xin-Yu Miao Lu-Lu He Jun Luo Jian-Wei Li Jie Lin Ai-Guo Wu Jia-Ping Zheng Department of Interventional Radiology Zhejiang Key Laboratory of Imaging and Interventional MedicineZhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China Laboratory of Advanced Theranostic Materials and Technology Ningbo Key Laboratory of Biomedical Imaging Probe Materials and TechnologyZhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationNingbo Cixi Institute of Biomedical EngineeringNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China MediCity Research Laboratory University of TurkuTurku 20520Finland

Recently,stimuli-responsive nanocarriers capable of precision drug release have garnered significant attention in the field of drug ***,an in-situ dynamic covalent self-assembled(DCS)strategy was utilized to develop a co-delivery *** assembly was based on a thiol-disulfide-exchange reaction,producing disulfide macrocycles in an oxidizing aerial *** macrocycles encapsulated the anti-cancer drug(paclitaxel,PTX)on the surface of gold nanoparticles,which served as photothermal therapy agents during the *** the DCS process,the kinetic control over the concentration of each building unit within the reaction system led to the formation of a stable co-delivery nanosystem with optimal drug-loading ***,the high glutathione(GSH)concentrations in tumor cells caused the disulfide macrocycles in nanostructures to break,resulting in drug *** stimuli-responsive performances of the prepared nanosystems were determined by observing the molecular structures and drug *** results revealed that the self-assembled nanosystem exhibited GSH-triggered drug release and good photothermal conversion capability under near-infrared ***,the in vitro and in vivo results revealed that conjugating the targeting molecule of cRGD with co-delivery nanosystem enhanced its biocompatibility,chemo-photothermal anti-cancer ***,our findings indicated that in-situ DCS strategy enhanced the control over drug loading during the construction of the co-delivery system,paving a way for the development of more functional carriers in nanomedicine.

关键词： in-situ dynamic covalent self-assembly(DCS) Disulfide macrocycles Host-guest interaction Glutathione(GSH)stimuli-response Chemo-photothermal therapy

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Remarks of Optical Fibers and Devices for Microfluidic Sensing:Preparation and Processing

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Photonic Sensors 2025年第2期15卷 70-89页

作者： Xiaotong ZHANG Tingting YUAN Center for Advanced Manufacturing and Future Industry Future Technology SchoolShenzhen Technology UniversityShenzhen 518118China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional KeyTechnology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen UniversityMedical SchoolShenzhen UniversityShenzhen 518060China

With the gradual maturity of the microfluidic technology,the integration of the microfluidic chip technology and optofluidic methods in microstructured optical fibers(MOFs)has gradually formed a highly attractive new research *** this paper,we summarize our recent work focusing on the microfluidic sensing technology based on microhole *** design and fabrication of such microfluidic fibers,device processing and fabrication techniques based on microfluidic fibers,and surface modification and coating methods for fibers are systematically ***,several typical cases combining the optical fiber and microfluidic substance detection are presented.

关键词： Microfluidic microfluidic optical fiber optical fiber sensor optical fiber device

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Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition

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Chinese Chemical Letters 2024年第4期35卷 292-297页

作者： Yi Cao Xiaojiao Ge Yuanyuan Wei Lulu He Aiguo Wu Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences Beijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Peptide-drug conjugates have achieved considerable development and application as a novel strategy for targeted delivery of anticancer drugs. Bioactive peptides induced calcium deposition can irreversibly assist inhibition of tumors. However, active regulation of calcium level through signal transduction of bioactive substances has not been reported yet. In this study, novel neuropeptide-doxorubicin conjugates(NP-DOX) with lysosome-specific acid response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-negative breast cancer. The delivery mechanism of NP-DOX was clarified that diverse pathways were involved, including intracellular and intercellular transport. Importantly, up-regulation of Y_1 R-mediated intracellular calcium level via second messenger inositol triphosphate was presented in NP-DOX treated MDA-MB-231 cells. In vivo antitumor efficacy demonstrated that NP-DOX showed less organ toxicity and enhanced tumor inhibition benefited from its controlled release and Y_1R-mediated calcium deposition, compared with free DOX. This bioconjugate is a proof-of-concept confirming that neuropeptide-mediated control of signaling responses in neuropeptide-drug conjugates enables great potential for further applications in tumor chemotherapy.

关键词： Neuropeptide-drug conjugate Tumor penetration Calcium deposition Tumor inhibition Triple-negative breast cancer

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Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

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Bioactive Materials 2024年第3期33卷 497-505页

作者： Zihao Liu Yu Wang Yuhan Zhang Liufu Hu Bozhi Chen Yang Li Xindong Guo Bingran Yu Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)and Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China

High levels of cell-free DNA(cfDNA)induce ***,the treatment of psoriasis has the disadvantages of penetration difficulty,suppression of normal immunity,and skin *** this study,biguanide chitosan microneedles(BGC-MNs)were prepared to treat psoriasis by removing cfDNA from the dermis through the skin *** effects of chitosan with different bisguanidine contents on DNA-binding capacity,biocompatibility,and inflammation inhibition were compared,revealing that chitosan containing 20%bisguanidine(BGC2)was found to have the best overall *** vitro,BGC2 effectively cleared cfDNA and inhibited the production of inflammatory ***-MN made from BGC2 had good mechanical and solubility *** vivo,BGC-MNs cleared cfDNA,reduced the level of inflammatory factors in the dermis,and exerted a good therapeutic effect on mice with *** results suggested that BGC-MNs provided a new approach to treating psoriasis in terms of scavenging cfDNA and exerting anti-inflammatory effects.

关键词： Biguanide chitosan cfDNA Microneedles Psoriasis

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Mussel-inspired Methacrylic Gelatin-dopamine/Ag Nanoparticles/Graphene Oxide Hydrogels with Improved Adhesive and Antibacterial Properties for Applications as Wound Dressings

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Journal of Wuhan University of technology(Materials Science) 2024年第2期39卷 512-521页

作者：宿正楠 HU Yanru MENG Lihui OUYANG Zhiyuan LI Wenchao ZHU Fang XIE Bin 吴庆知 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Material and Engineering Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China

A novel strategy was developed to prepare the methacrylic gelatin-dopamine(GelMA-DA)/Ag nanoparticles(NPs)/graphene oxide(GO) composite hydrogels with good biocompatibility,mechanical properties,and antibacterial ***-inspired DA was utilized to modify the GelMA molecules,which imparts good adhesive performance to the ***,interfacial enhancer,not only improves mechanical properties of the hydrogels,but also provides anchor sites for loading Ag NPs through numerous oxygencontaining functional groups on the *** experimental results show that the GelMA/Ag NPs/GO hydrogels have good biocompatibility,and exhibit a swelling rate of 202±16%,the lap shear strength of 147±17 kPa,and compressive modulus of 136±53 kPa,in the case of the Ag NPs/GO content of 2 mg/*** activity of the hydrogels against both gram-negative and gram-positive bacteria is dependent on the Ag NPs/GO content derived from the release of Ag^(+).Furthermore,the GelMA/Ag NPs/GO hydrogels possess good adhesive ability,which is resistant to highly twisted state when stuck on the surface of *** results demonstrate promising potential of the GelMA-DA/Ag NPs/GO hydrogels as wound dressings for biomedical applications in clinical and emergent treatment.

关键词： GelMA dopamine,graphene oxide adhesion antibacterial ability

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