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3D-printed porous titanium suture anchor: a rabbit lateral femoral condyle model

BMC Musculoskeletal Disorders 2024年第1期25卷 1页

作者： Wu, Lien-Chen Hsieh, Yueh-Ying Hsu, Ting-Shuo Liu, Po-Yi Tsuang, Fon-Yih Kuo, Yi-Jie Chen, Chia-Hsien Van Huynh, T.I.N. Chiang, Chang-Jung Department of Orthopaedics Shuang Ho Hospital Taipei Medical University Department of Orthopaedics School of Medicine College of Medicine Taipei Medical University Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Division of Neurosurgery Department of Surgery National Taiwan University Hospital Spine Tumor Center National Taiwan University Hospital Department of Orthopedic Surgery Wan Fang Hospital Taipei Medical University School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Department of Interventional Cardiology Thong Nhat Hospital International Ph.D program in medicine college of medicine Taipei medical university

Background: The inclusion of a connecting path in a porous implant can promote nutrient diffusion to cells and enhance bone ingrowth. Consequently, this study aimed to evaluate the biomechanical, radiographic, and histopathological performance of a novel 3D-printed porous suture anchor in a rabbit femur model. Methods: Three test groups were formed based on the type of suture anchor (SA): Commercial SA (CSA, Group A, n = 20), custom solid SA (CSSA, Group B, n = 20), and custom porous SA (CPSA, Group C, n = 20). The SAs were implanted in the lateral femoral condyle of the right leg in each rabbit. The rabbits (New Zealand white rabbits, male, mean body weight of 2.8 ± 0.5 kg, age 8 months) underwent identical treatment and were randomized into experimental and control groups via computer-generated randomization. Five rabbits (10 femoral condyles) were euthanized at 0, 4, 8, and 12 weeks post-implantation for micro-CT, histological analysis, and biomechanical testing. Results: At 12 weeks, the CPSA showed a higher BV/TV (median 0.7301, IQR 0.7276–0.7315) than the CSSA and CSA. The histological analysis showed mineralized osteocytes near the SA. At 4 weeks, new bone was observed around the CPSA and had penetrated its porous structure. By 12 weeks, there was no significant difference in ultimate failure load between the CSA and CPSA. Conclusions: We demonstrated that the innovative 3D-printed porous suture anchor exhibited comparable pullout strength to conventional threaded suture anchors at the 12-week postoperative time-point period. Furthermore, our porous anchor design enhanced new bone formation and facilitated bone growth into the implant structure, resulting in improved biomechanical stability. © The Author(s) 2024.

关键词： 3D-printed porous anchor Bone formation Bone ingrowth Suture anchor

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Medication Recording System Using Oral Image Acquisition and Image Recognition

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2024年第3期144卷 276-282页

作者： Kuang, Deshuai Tsuruoka, Noriko Haga, Yoichi Graduate School of Biomedical Engineering Tohoku University 6-6-12 Aza-Aoba Aramaki Aoba-ku Miyagi Sendai980-8579 Japan Graduate School of Engineering Tohoku University 6-6-12 Aza-Aoba Aramaki Aoba-ku Miyagi Sendai980-8579 Japan

In the aging society, especially those with eye diseases, often forget to take medicine or take wrong medicine. In the new drug approval process, objective and accurate medication records have become very important. To improve the reliability of medication recording, we have been developing a cup-shaped medication recording device by taking intraoral pictures. This device has a camera with a wireless transmitter and a rechargeable battery in the cup. To recognize oral medicine accurately, we used AI image recognition technology. We selected four representative drugs (500 images for each) for testing, and the recognition accuracy can reach more than 90%. While ensuring the recognition accuracy, we achieved real-time detection, which can reach the detection speed of 16 frames per second on smartphones. In addition, an Android application based on AI image recognition has been developed that is easier to use. The medication management application was equipped with image acquisition, image recognition, medication recording, forgetting of medication, and caution for wrong medication. © 2024 The Institute of Electrical Engineers of Japan.

关键词： Image recognition

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Explorations of using a convolutional neural network to understand brain activations during movie watching

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Psychoradiology 2024年第1期4卷 187-195页

作者： Wonbum Sohn Xin Di Zhen Liang Zhiguo Zhang Bharat B.Biswal Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ 07102USA Rutgers Biomedical and Health Sciences Rutgers School of Graduate StudiesNewarkNJ 07039USA School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen51806China School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518060China

Background Naturalistic stimuli,such as videos,can elicit complex brain ***,the intricate nature of these stimuli makes it challenging to attribute specific brain functions to the resulting activations,particularly for higher-level processes such as social *** We hypothesized that activations in different layers of a convolutional neural network(VGG-16)would correspond to varying levels of brain activation,reflecting the brain's visual processing ***,we aimed to explore which brain regions would be linked to the deeper layers of the *** This study analyzed functional MRI data from participants watching a cartoon *** a pre-trained VGG-16 convolutional neural network,we mapped hierarchical features of the video to different levels of brain *** maps from various kernels and layers were extracted from video frames,and the time series of average activation patterns for each kernel were used in a voxel-wise model to examine brain *** Lower layers of the network were primarily associated with activations in lower visual regions,although some kernels also unexpectedly showed associations with the posterior cingulate *** layers were linked to more anterior and lateral regions of the visual cortex,as well as the supramarginal *** This analysis demonstrated both the potential and limitations of using convolutional neural networks to connect video content with brain functions,providing valuable insights into how different brain regions respond to varying levels of visual processing.

关键词： convolutional neural network deep learning default mode network lateral occipital complex naturalistic condition supramarginal gyrus visual cortex

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Performance test of brushless direct current (BLDC) generator in micro hydro power plant (MHPP) with Archimedes screw turbine 1

Performance test of brushless direct current (BLDC) generato...

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1st International Seminar on Physics and Its Application, IsoPA 2024

作者： Bustomi, M.A. Setiawan, F.B. Indarto, B. Purwanti, E. Department of Physics Institut Teknologi Sepuluh Nopember Surabaya Indonesia Biomedical Engineering Program Universitas Airlangga Surabaya Indonesia

Brushless Direct Current (BLDC) generators have many advantages over DC generators that use brushes. In this research, the advantages of the BLDC generator are applied as a generator for a micro-hydro power plant (MHPP) that uses an Archimedes screw turbine. The study aims to test the performance of the BLDC generator as a generator on the Archimedes screw turbine MHPP. The MHPP specifications for the Archimedes screw turbine used in this research are an Archimedes screw turbine with three blades, an elevation angle of 40◦ and a transmission gear ratio of 2.8:1. The screw turbine has an inner diameter of 14.02 cm, an outer diameter of 23.9 cm, a pitch of 25.67 cm and a length of 51.34 cm. The generator used is a 3-phase Brushless Direct Current (BLDC) generator. The load used is a 12 Volt LED lamp with a 5 to 20 Watts power. The test results at a discharge of 0.00634 m3/s showed that the mechanical power was (36.408 ± 0.202) Watts and the highest electrical power was (7.86 ± 0.03) Watts. Based on these results, the efficiency of electrical power on mechanical power is around 22%. © 2024 Institute of Physics Publishing. All rights reserved.

关键词： Hydroelectric power plants

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A Generic Technique to Remove a Variety of Electrical Stimulation Artifacts and Detect Stimulus-Embedded Neural Activity 46

A Generic Technique to Remove a Variety of Electrical Stimul...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Italiano, Michael L. Lee, Jae-Ik Guo, Tianruo Tsai, David Fried, Shelley I. Lovell, Nigel H. Shivdasani, Mohit N. Tyree Institute of Health Engineering Unsw Graduate School of Biomedical Engineering Australia Harvard Medical School Massachusetts General Hospital Department of Neurosurgery United States

ISBN: (纸本)9798350371499

Investigating neural activity is critical to advancing neuroscience and informing clinically-relevant neuromodulation, but it is often burdened by the presence of recording artifacts resulting from electrical stimulation. We developed and evaluated a generalizable method for removing the electrical artifacts elicited by various neurostimulation waveforms. This investigation of a novel variety of stimulation waveforms was facilitated by obtaining and labelling the neural activity of 15 loose cell-attached patch clamp recordings of retinal ganglion cells. These labelled recordings provided 5785 peristimulus spikes for which the pipeline exhibited a true positive rate of 88.7%, false discovery rate of 2.9%, and d-prime of 3.11, far superseding interpolation (of which bore a d-prime of 0.32). We additionally utilized synthesized spike trains to demonstrate recovery of low-amplitude stimulus-embedded spikes with negligible waveform distortion (low root mean square error). This technique could better enable a rich variety of neurostimulation investigations, and aid in the development of clinical neurostimulation strategies. © 2024 IEEE.

关键词： Neurons

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Simultaneous Dual-region Functional Imaging in Miniaturized Two-photon Microscopy

Simultaneous Dual-region Functional Imaging in Miniaturized ...

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Optics and the Brain, BRAIN 2024 - Part of Optica Biophotonics Congress: biomedical Optics

作者： Zhang, Zixiao Liu, Shing-Jiuan Mattison, Ben Yang, Weijian Department of Electrical and Computer Engineering University of California Davis DavisCA95616 United States Department of Biomedical Engineering University of California Davis DavisCA95616 United States Biomedical Engineering Graduate Group University of California Davis DavisCA95616 United States

We demonstrate simultaneous dual-region in-vivo imaging of brain activity in mouse cortex through a miniaturized spatial-multiplexed two-photon microscope platform, which doubles the imaging speed. Neuronal signals fr... 详细信息

ISBN: (纸本)9781957171340

关键词： Brain imaging Femtosecond lasers In vivo imaging Multiphoton microscopy Spatial resolution Ultrafast lasers

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A Pulsed Electrochemistry Readout IC with Slew-rate Booting Technique and Phase-domain ΔΣ ADC for Si-Nanowire Electrical Double-layer Capacitance Measurement

A Pulsed Electrochemistry Readout IC with Slew-rate Booting ...

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2024 IEEE Symposium on VLSI Technology and Circuits, VLSI Technology and Circuits 2024

作者： Chu, Po- Hsun Tsai, Cheng- Tse Chou, Yu-Siang Kumar, Nitish Lin, Shu-Ping Liao, Yu-Te Institute of Electrical and Computer Engineering National Yang Ming Chiao Tung University Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taiwan

ISBN: (纸本)9798350361469

This paper presents a pulse-driven method for detecting Cardiac Troponin I using an electrical double-layer (EDL) capacitance sensing readout circuit and an on-chip pattern generator. The pattern generator is equipped with a slew rate-boosting driver circuit capable of handling EDL capacitance ranging up to 100 nF with a slew rate greater than 6.6 V /us while consuming only 13.5 μW. Additionally, the design achieves a dynamic range (DR) of 77.4 dB by implementing an oscillator-based readout circuit and a limit of detection (LoD) of 200 fg/mL in an undiluted PBS solution with a total power consumption of 120 μW. © 2024 IEEE.

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Interfering with sleep apnea

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Bioelectronic Medicine 2024年第1期10卷 1-3页

作者： Pedersen, Nigel Paul Astorga, Raul Castillo Department of Neurology School of Medicine and Center for Neuroscience University of California Davis 1515 Newton Court DavisCA95618 United States Graduate Program in Biomedical Engineering University of California DavisCA95618 United States

The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect of non-invasive stimulation of the hypoglossal nerve by an interference envelope of interfering carrier waves is examined in mice and participants with sleep apnea. This stimulation is capable of activating the nerve and reducing apnea-hypopnea events. Temporally interfering electric fields have potential applications far beyond hypoglossal stimulation and may represent a revolutionary new approach to treating illness and understanding the functional organization of the nervous system. © 2024, The Author(s).

关键词： Electric fields

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Quantifying changes in oxygen saturation of the internal jugular vein in vivo using deep neural networks and subject-specific three-dimensional Monte Carlo models

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Optics Letters 2024年第10期49卷 2669-2672页

作者： Sun, Chin-Hsuan Lee, Hao-Wei Tsai, Ya-Hua Luo, Jia-Rong Sung, Kung-Bin Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei106319 Taiwan Department of Electrical Engineering National Taiwan University Taipei106319 Taiwan

Central venous oxygen saturation (ScvO2) is an important parameter for assessing global oxygen usage and guiding clinical interventions. However, measuring ScvO2 requires invasive catheterization. As an alternative, we aim to noninvasively and continuously measure changes in oxygen saturation of the internal jugular vein (SijvO2) by a multichannel near-infrared spectroscopy system. The relation between the measured reflectance and changes in SijvO2 is modeled by Monte Carlo simulations and used to build a prediction model using deep neural networks (DNNs). The prediction model is tested with simulated data to show robustness to individual variations in tissue optical properties. The proposed technique is promising to provide a noninvasive tool for monitoring the stability of brain oxygenation in broad patient populations. © 2024 Optica Publishing Group (formerly OSA). All rights reserved.

关键词： Deep neural networks

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Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release

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Bioactive Materials 2023年第3期21卷 284-298页

作者： Jing-Jing Ye Long-Fei Li Rui-Nan Hao Min Gong Tong Wang Jian Song Qing-Han Meng Na-Na Zhao Fu-Jian Xu Yuri Lvov Li-Qun Zhang Jia-Jia Xue Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing100029PR China College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing100029PR China Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing100029PR China Institute for Micromanufacturing and Biomedical Engineering Program Louisiana Tech UniversityRustonLA71272USA

It is of great importance to treat a bacterial-infected wound by a smart dressing capable of delivering antibiotics in a smart manner without causing drug *** construction of smart release nanocontainers responsive to near-infrared(NIR)laser irradiation in an on-demand and stepwise way is a promising strategy for avoiding the emergence of multidrug-resistant ***,we develop a hydrogel composite made of alginate and nanotubes with an efficient NIR-triggered release of rifampicin and outstanding antibacterial *** composite hydrogel is prepared through co-encapsulating antibacterial drug(rifampicin),NIR-absorbing dye(indocyanine green),and phase-change materials(a eutectic mixture of fatty acids)into halloysite nanotubes,followed by incorporation into alginate hydrogels,allowing the in-situ gelation at room temperature and maintaining the integrity of drug-loaded *** them,the eutectic mixture with a melting point of 39℃ serves as the biocompatible phase-change material to facilitate the NIR-triggered drug *** resultant phase-change material gated-nanotubes exhibit a prominent photothermal efficiency with multistep drug release under laser *** an in vitro assay,composite hydrogel provides good antibacterial potency against Staphylococcus aureus,one of the most prevalent microorganisms of dangerous gas gangrene.A bacterial-infected rat full-thickness wound model demonstrates that the NIR-responsive composite hydrogel inhibits the bacteria colonization and suppresses the inflammatory response caused by bacteria,promoting angiogenesis and collagen deposition to accelerate wound *** NIR-responsive composite hydrogel has a great po-tential as an antibacterial wound dressing functionalized with controlled multistep treatment of the infected sites.

关键词： Anti-bacteria Clay nanotubes Alginate hydrogel Phase-change material NIR-Triggered drug release Infected wound healing

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