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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Ticllacuri, Victor Mio, Renato Biomedical Engineering Program PUCP-UPCH Lima Peru Pontificia Universidad Catolica del Peru Laboratory of Biomechanics and Applied Robotics Lima Peru Universidad Peruana Cayetano Heredia Laboratory of Biomedical Engineering Lima Peru University of Bayreuth Germany

ISBN: (纸本)9798350371499

Studying the soft robot-tissue mechanical interaction in muscle stimulation devices poses a significant challenge due to the complex behavior of the materials involved. To advance this field, this paper models computationally three types of soft elastomeric actuators designed to perform deep cyclic compression stimuli on human soft tissues for muscle rehabilitation by mechanotherapy. The analysis focuses on the interaction between a phantom representing transversely isotropic muscle and homogeneous skin, with a soft robotic device comprised of a hyperelastic actuator and a rigid support. Results from deformation, stress-strain and surface pressure analysis demonstrate efficient actuation, suggesting deep and focused stimulation on the muscle, while actuators exhibit reliable safety factors and load distribution, implying longer operational life. This lightweight and compact soft robotic device is suitable for integration into a wearable suit for targeted muscle groups stimulation in the lower limbs. Furthermore, this computational approach represents a significant advance in the biomechanical study of soft robot-human tissues interaction, with potential for generalization in similar biomedical device applications. Keywords - Soft Robotics, Mechanotherapy, Transversely Isotropic Muscle, Human-Robot interaction. © 2024 IEEE.

关键词： Phantoms

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Time-Multiplexed Miniaturized Two-Photon Microscopy

Time-Multiplexed Miniaturized Two-Photon Microscopy

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Optics and the Brain, BRAIN 2024 - Part of Optica Biophotonics Congress: biomedical Optics

作者： Liu, Shing-Jiuan Zhang, Zixiao Mattison, Ben Yang, Weijian Department of Electrical and Computer Engineering University of California Davis DavisCA95616 United States Department of Biomedical Engineering University of California Davis DavisCA95616 United States Biomedical Engineering Graduate Group University of California Davis DavisCA95616 United States

We propose a time-multiplexed miniaturized two-photon microscope (TM-MINI2P), enabling a two-fold increase in imaging speed while maintaining a high spatial resolution. Using TM-MINI2P, we conducted high-speed in-vivo... 详细信息

ISBN: (纸本)9781957171340

关键词： Two photon processes

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Analyzing Significance of Facial Features for Detection of Parkinson's Disease via Static Images 4

Analyzing Significance of Facial Features for Detection of P...

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4th IEEE International Conference on Electronic Communications, Internet of Things and Big Data, ICEIB 2024

作者： Chiu, Chuang-Chien Yeh, Shoou-Jeng Sun, Yen-Chi Feng Chia University Department of Automatic Control Engineering Taichung Taiwan Cheng-Ching General Hospital Section of Neurology and Neurophysiology Taichung Taiwan Feng Chia University Master's Program of Biomedical Informatics and Biomedical Engineering Taichung Taiwan

ISBN: (纸本)9798350360721

Parkinson's disease (PD) is a neurodegenerative disorder often characterized by motor symptoms such as hypomimia, and a reduction in facial expression. We explored the significance of facial features in identifying PD through static images, focusing on detecting hypomimia. A dataset comprised of PD patients and healthy controls' static facial images were collected and analyzed. Facial feature detection was conducted using OpenCV and Dlib libraries for the precise localization of key landmarks. In the subsequent feature extraction, parameters such as symmetry, eye aspect ratio, mouth corner distance, muscle tension, and mouth aperture ratio were used. Through the standardization of these features, meaningful comparisons across diverse images were made. By analyzing hypomimia-related features alongside traditional facial parameters, the results provide a comprehensive understanding of the role of facial expressions in PD diagnosis. The findings suggested that examining facial features in static images enhances the accuracy of PD detection and understanding of the nuanced motor symptoms associated with the disease. © 2024 IEEE.

关键词： Feature extraction

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In-vivo evaluation of molybdenum as bioabsorbable stent candidate

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Bioactive Materials 2022年第8期7卷 262-271页

作者： Malgorzata Sikora-Jasinska Lea M.Morath Maria P.Kwesiga Margaret E.Plank Alexia L.Nelson Alexander A.Oliver Martin L.Bocks Roger J.Guillory II Jeremy Goldman Department of Biomedical Engineering Michigan Technological UniversityUSA Department of Biomedical Engineering and Physiology Mayo Clinic Graduate School of Biomedical SciencesUSA Case Western Reserve University School of Medicine UH Rainbow Babies&Children’s HospitalClevelandOHUSA

Biodegradable stents have tremendous theoretical potential as an alternative to bare metal stents and drug-eluting stents for the treatment of obstructive coronary artery *** bioresorbable or biodegradable scaffold material needs to possess optimal mechanical properties and uniform degradation behavior that avoids local and systemic ***,molybdenum(Mo)has been investigated as a potential novel biodegradable material for this *** its proven moderate degradation rate and excellent mechanical properties,Mo may represent an ideal source material for clinical cardiac and vascular *** present study was performed to evaluate the mechanical performance of metallic Mo in vitro and the biodegradation properties in *** results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradable endovascular stent ***,Mo implants in mouse arteries avoided the typical cellular response that contributes to *** was minimal neointimal hyperplasia over 6 months,an absence of excessive smooth muscle cell(SMC)proliferation or inflammation near the implant,and avoidance of significant harm to regenerating endothelial cells(EC).Qualitative inspection of kidney sections showed a potentially pathological remodeling of kidney Bowman’s capsule and glomeruli,indicative of impaired filtering function and development of kidney disease,although quantifications of these morphological changes were not statistically ***,the results suggest that the products of Mo corrosion may exert beneficial or inert effects on the activities of inflammatory and arterial cells,while exerting potentially toxic effects in the kidneys that warrant further investigation.

关键词： Biodegradable stent Molybdenum Biocompatibility Degradation

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Design of a Self-Locking Component for McKibben Muscle Back-Stretchablility 17

Design of a Self-Locking Component for McKibben Muscle Back-...

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17th International Convention on Rehabilitation engineering and Assistive Technology, i-CREATe 2024

作者： Mao, Shuai Zhou, Zhongchao Villarroel, Mauricio He, Liang The Graduate School of Science and Engineering Chiba University Chiba2638522 Japan The Institute Biomedical Enginnering University of Oxford United Kingdom

ISBN: (纸本)9798350355154

McKibben muscles are widely utilised in biorobotics due to their high contraction ratio, remarkable power-to-weight ratio, and resemblance to skeletal muscles. However, the original design, constrained by the braided net, prevents elongation (back-stretchability) when inactive. This limitation means that McKibben muscles lack an essential characteristic of skeleton muscles: the ability to elongate when relaxed. This shortage results in the fact that when the McKibben muscles are used to mimic the antagonist muscle drives, they must be installed loosely (the McKibben muscle will sag while inactivated because the length of the McKibben muscle should be longer than the distance of two fixed points) to ensure the realization of antagonistic muscle movements. However, this compromise inevitably results in the waste of the contraction length of the McKibben muscle, leading to a reduction in the range of motion of the robot joints and the response speed. This paper proposed a Self-locking Component (SLC) enabling back-stretchability of McKibben muscle. When the McKibben muscle is inactivated, the component can contract with different stiffness springs to allow for elongation. Whenever the McKibben muscle with SLC is activated, the SLC will be locked with the McKibben muscle contracting. The elongation-load curve and max tensile force were tested. The results show a strong linear relationship with a max tensile force 50 N. Proposed self-locking component can achieve the self-locking and back-stretchable function. © 2024 IEEE.

关键词： Elongation

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Caffeic acid-vanadium nanozymes treat skin flap ischemia-reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins

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Acta Pharmaceutica Sinica B 2025年第1期15卷 592-610页

作者： Xinyu Zhao Jie Shan Hanying Qian Xu Jin Yiwei Sun Jianghao Xing Qingrong Li Xu-Lin Chen Xianwen Wang Department of Burns The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Graduate School Anhui University of Chinese MedicineHefei 230022China School of Biomedical Engineering Anhui Medical UniversityHefei 230032China

Ischemia-reperfusion(I/R)injury following skin flap transplantation is a critical factor leading to flap necrosis and transplant *** inflammatory responses and oxidative stress are regarded as crucial targets for mitigating reperfusion injury and enhancing flap *** this study,caffeic acid-vanadium metal polyphenol nanoparticles(CA-V NPs)were prepared for the treatment of skin flap ischemia and *** study was conducted using a one-step method to prepare new types of CA-V NPs with uniform sizes and stable *** vitro,the CA-V NPs exhibited CATlike and SOD-like activities and could effectively scavenge ROS,generate oxygen,and alleviate oxidative *** the H_(2)O_(2)-induced cellular oxidative stress model,CA-V NPs effectively reduced ROS levels and inhibited apoptosis through the XIAP/Caspase-3 *** the cellular inflammation model induced by LPS combined with IFN-g,CA-V NPs reprogrammed macrophage polarization toward the M2 phenotype and reduced inflammatory responses by reducing the expression of the chemokines CCL4 and *** addition,animal experiments have shown that CA-V NPs can alleviate oxidative stress in skin flap tissues,inhibit apoptosis,promote angiogenesis,and ultimately improve the survival rate of skin ***-V NPs provide a new target and strategy for the treatment of flap I/R injury。

关键词： Caffeic acid-vanadium Nanozymes Skin flap Ischemia-reperfusion Oxidative stress Inflammation Chemokines Apoptosis

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The Design and Optimisation of W-Angular Plate on Quadrilateral Surface 1

The Design and Optimisation of W-Angular Plate on Quadrilate...

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1st IEEE International Conference on Communication engineering and Emerging Technologies, ICoCET 2024

作者： Rajan, Riya Letchumi Bin Mohd Nasir, Nashrul Fazli Mamat, Normahira Binti Yahaya, Sahran Bin Tan, Eugene Chin, Lim Chee Meng, Cheng Ee Sharifah Robiah, Che Wan Bin Abdul Kadir, Mohd Rafiq Universiti Malaysia Perlis Biomedical Electronic Engineering Program Faculty of Electronic Engineering and Technology Perlis Malaysia Universiti Sains Malaysia Department of Orthopaedics Kubang Kerian Malaysia Leonix Sdn. Bhd. Batu Maung Malaysia Universiti Malaya Faculty of Engineering Biomedical Engineering Department Kuala Lumpur Malaysia

ISBN: (纸本)9798331504144

This study focuses on the design, optimization, and biomechanical evaluation of a W-angular hip plate intended for the quadrilateral surface of the human pelvis. The W angular configuration is chosen for its potential to enhance stability and load distribution across the complex pelvic anatomy. The primary objective is to investigate and refine the screw insertion technique that maximizes the plate's stability on the quadrilateral surface. This involves evaluating various parameters such as screw placement angles and depths to achieve optimal fixation. Mechanical behavior of the W-angular hip plate is comprehensively assessed under diverse loading conditions simulating activities essential to daily living, including walking, standing, and sitting. The evaluation encompasses the analysis of stress distribution, strain patterns, and deformation characteristics within the implant structure. Both male and female anatomical variations are considered to ensure a thorough assessment of performance across different patient demographics. The outcomes of this study aim to deepen the understanding of how the W-angular hip plate interacts with the pelvic bone and surrounding tissues under realistic conditions. © 2024 IEEE.

关键词： Titanium alloys

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Tuning the intentional corona of cerium oxide nanoparticles to promote angiogenesis via fibroblast growth factor 2 signalling

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Regenerative Biomaterials 2022年第1期9卷 963-978页

作者： Lu Fu Rupeng Li John M.Whitelock Megan S.Lord Graduate School of Biomedical Engineering UNSW SydneySydneyNSW 2052Australia School of Minerals and Energy Resources Engineering UNSW SydneySydneyNSW 2052Australia

Inadequate angiogenesis is a hallmark of conditions including cardiovascular diseases,stroke and chronic diabetic wounds,which exhibit tissue ischaemia ensuring that therapeutic strategies to promote angiogenesis are of great ***,many angiogenic treatments involve the delivery of growth factors which have limited clinical success due to poor stability,high manufacturing cost and poor *** oxide nanoparticles(nanoceria)can either promote or inhibit angiogenesis depending on their surface corona ***,nanoceria were functionalized with an intentional heparin corona,a polysaccharide which binds and signals growth factors,of different chain lengths and surface grafting density to establish their effect on *** nanoparticles promoted angiogenesis in vivo with the surface grafting density positively correlated with angiogenesis over the widest concentration range;however,chain length did not play a *** heparin–nanoceria supported fibroblast growth factor 2(FGF2)signalling in vitro and promoted FGF2-mediated angiogenesis in *** nanoparticles were internalized by endothelial cells in vitro where they trafficked to the lysosomes and reduced cell viability suggesting that the angiogenic activity of heparin–nanoceria is mediated in the extracellular ***,this study adds to our knowledge of the angiogenic effects of heparin–nanoceria towards finding new angiogenic treatments.

关键词： cerium oxide nanoparticle endothelial angiogenesis

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Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(Life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng Yuan Xihao Liao Shuang Li Xin-Hui Xing Chong Zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

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Bioactive Materials 2023年第5期23卷 471-507页

作者： Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos Department of Biomedical Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic *** addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in *** this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer ***,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles ***,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this *** review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer.

关键词： Phototherapy Cancer Nanoparticles Therapeutic effect Clinical potential

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