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12th International Conference on Physics and Its Applications, ICOPIA 2024

作者： Siswanto Qulub, Fitriyatul Junico, Vallery Ofelia Viannco Physics Program Study Faculty Science and Technology Universitas Airlangga Surabaya Indonesia Biomedical Engineering Program Study Faculty Science and Technology Universitas Airlangga Surabaya Indonesia

Cutaneous Lupus Erythematosus (CLE) is a form of lupus that affects the skin and is highly sensitive to ultraviolet (UV) light. UV-B. in particular. can trigger inflammation and apoptosis in CLE patients. making a sunscreen with effective UVB protection crucial. This study evaluates the effectiveness of zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles in sunscreen. ZnO and TiO2 nanoparticles were prepared using the High Energy Milling method. resulting in particle sizes of 7.77 nm and 4.44 nm. respectively. The creams containing these nanoparticles were tested for physical stability and UV protection. Results showed that the creams were physically stable and provided good UV protection. with ZnO and TiO2 nanoparticles making up 12.60% of the total cream ingredients. resulting in the highest SPF (Sun Protection Factor) value of 62.0 ± 1.37. © 2025 Institute of Physics Publishing. All rights reserved.

关键词： TiO2 nanoparticles

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Beyond skills: building research capacity through cognitive apprenticeship and social capital

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Australasian Journal of engineering Education 2023年第1期28卷 97-109页

作者： Jensen, Karin J. Miller, Isabel M. Suresh, Deepthi E. Martin, Julie P. Department of Biomedical Engineering University of Michigan Ann ArborMI United States Engineering Education Research Program University of Michigan Ann ArborMI United States Engineering Education Transformations Institute University of Georgia AthensGA United States

International calls for building capacity in engineering education research (EER) as a discipline have led to the development of workshops, training programs, and resources for scholars to learn and practice EER. Building capacity in EER as a discipline depends not only on the research skills of scholars, but also their sustained engagement in the discipline through the development of strong social networks. Understanding how scholars develop robust social networks through mentorship will support building research capacity in the field. This study was designed to answer the research question: How do established engineering education researchers help new engineering education researchers build social capital for EER through mentoring relationships? It draws on semi-structured interviews leveraging critical incident technique conducted with nine participants: two mentors and seven mentees. The findings suggest that mentors serve critical roles in the professional development of engineering faculty (academics) in EER as a discipline, providing training in methods and theories, developing mentees’ social networks, and providing moral support for entering a new field. Building capacity efforts and related structured mentoring programs (and mentoring training) should emphasise the importance of developing mentees’ social networks to support sustained engagement in EER. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： engineering education

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Synthesis of a Multifunctional Glyco-Block Copolymer through Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry for Enzyme and Drug Loading into MDA-MB-231 Cells

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ACS Applied Materials and Interfaces 2023年第51期15卷 59746-59759页

作者： Wu, Tzu-Chien Lai, Chiao-Ling Sivakumar, Govindan Huang, Yung-Hsin Lai, Chian-Hui Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung402 Taiwan Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung807 Taiwan

Reversible addition-fragmentation chain transfer polymerization has been used in various applications such as preparing nanoparticles, stimulus-responsive polymers, and hydrogels. In this study, the combination of this polymerization method and Cu(I)-catalyzed azide-alkyne cycloaddition click chemistry was used to prepare the multifunctional glyco-diblock copolymer P(PEG-co-AM)-b-PF, which is composed of mannosides for cell targeting, poly(ethylene glycol) (PEG) for biocompatibility, and aryl-aldehyde moieties for enzyme immobilization. The alkyne group in the polymer structure enables the alternation for other azide-conjugated monomers. The stepwise synthesis of the polymers was fully characterized. P(PEG-co-AM)-b-PF was self-assembled into polymeric nanoparticles (BDOX-GOx@NPs) for glucose oxidase immobilization through Schiff base formation and for encapsulating the prodrug of arylboronate-linked doxorubicin (BA-DOX) under optimal conditions. Glucose oxidase in BDOX-GOx@NPs catalyzes glucose oxidation to produce gluconic acid and H2O2, which cause oxidative stress. Glucose oxidase also consumes glucose, causing starvation in cancer cells. The produced H2O2 can selectively activate the anticancer prodrug BA-DOX for chemotherapy. In vitro data indicate that GOx and the prodrug BA-DOX present inside BDOX-GOx@NPs exhibit higher stability than free glucose oxidase with a favorable active DOX release profile. MDA-MB-231 cells, which express mannose receptors, were used to establish a model in this study. The bioactivity of the nanoplatform in the two- and three-dimensional models of MDA-MB-231 cancer cells was investigated to ascertain its antitumor efficacy. © 2023 American Chemical Society.

关键词： Glucose oxidase

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A Proposed Model for Calculate the Number of Mammography Machines for the South-West Area of Mexico 9th

A Proposed Model for Calculate the Number of Mammography Mac...

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Martinez-Licona, Fabiola M. Martinez-Vazquez, Cipactli M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Breast cancer is a global health problem. Mexican statistics show that 28.2% of new cancer cases in women come from the breast, so efforts must be made to control the burden of the disease. Early detection is an essential part of the social programs aimed at female populations at potential risk, and mammography machines are the technology used to perform screening methods. The possible coverage of a region is mainly affected by the available technological resources. This paper presents a proposal model to determine the number of mammography machines required to meet the State’s requirements of Guerrero, Oaxaca and Chiapas, as those in which there are municipalities with the highest social backwardness. The socioeconomic and demographic determinants, as well as the screening mammography demand data, were extracted from official Mexican agencies. The model variables were selected from the categories of target population, epidemiological indicators and infrastructure. Under the author’s heuristic assumptions, the analytic hierarchy process produced the weight that led to selecting the final set of variables. The resource allocation principles were used to adapt the Resource Allocation Working Party (RAWP) focus formula from population to equipment to calculate the State Weighted Machines using the mentioned category adjustments. Model results with 2017 and 2020 data showed that, on average, 50% more mammography machines are needed to cover around 46% of the female population 50–64 years old in the studied States. Further study and analysis of the determinants of access to the service and the equipment proposals are necessary. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Resource allocation

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Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity

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Cellular & Molecular Immunology 2022年第2期19卷 296-298页

作者： Bokyung Min Bitna Yang You-Sun Kim Gyeong Min Park HyunAh Kim Hyojin Kim Eun-Ji Kim Yu Kyeong Hwang Eui-Cheol Shin Sungyoo Cho BioMedical Science and Engineering Interdisciplinary Program KAISTDaejeonKorea Cell Therapy Research Center GC LabCellYonginKorea Laboratory of Immunology and Infectious Diseases Graduate School of Medical Science and EngineeringKAISTDaejeonKorea

Natural killer(NK)cells play an important role in the antitumor immune response as the major cytotoxic lymphocytes in the innate immune *** cells without any genetic modifications have been used for both autologous and allogeneic ***,many reports have suggested that allogeneic NK cells can reduce the recurrence of disease and improve survival through a graft-versus-leukemia effect without GVHD[1,2].

关键词： killer expressing optimal

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Analysis of Failure Causes in the Mammography Machines 9th

Analysis of Failure Causes in the Mammography Machines

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9th Latin American Congress on biomedical engineering, CLAIB 2022 and 28th Brazilian Congress on biomedical engineering, CBEB 2022

作者： Hernandez-Contreras, Indira Martinez-Licona, Fabiola M. Electrical Engineering Department Universidad Autonoma Metropolitana Iztapalapa Mexico City Mexico Universidad Autonoma Metropolitana Biomedical Engineering Academic Program Iztapalapa Mexico City Mexico

ISBN: (纸本)9783031494093

Patient safety arises from the need to prevent and protect patients from avoidable mistakes. Two fundamental concepts that shape patient safety are error and adverse events, the consequences may range from potentially dangerous complications, slow recoveries, high medical costs, or unnecessary deaths. Breast cancer has become a global health problem with one of the most expensive burdens among non-communicative diseases. Since screening mammography is the most used method for tumor identification, patient safety applied to this technology is focused on delivering safe and effective service that results in an accurate and reliable diagnosis. This paper presents the analysis of the causes that can induce a potential failure in the mammography machine, and the actions to correct them. We used a risk analysis approach to identify the failures that may occur while using a mammography machine in screening programs. We extracted the information about the failures from specialized consultation and discussion forums and technical and operation manuals. We adapted the concepts of severity, occurrence, and detection involved in calculating the risk priority number according to the Failure Mode and Effects Analysis method, assigning them one of three levels (low, medium, and high). The adapted risk priority level was calculated from the averaged product of levels from the mentioned components. The results were mapped into an Ishikawa diagram, and an action procedure proposal was shown. The causes found are defined mainly concerning the handling of the equipment components, although causes related to the acquisition technique, patient handling, and availability of support information. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Risk assessment

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A Comprehensive Technique Based on Machine Learning for Device and Circuit Modeling of Gate-All-Around Nanosheet Transistors

IEEE Open Journal of Nanotechnology

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IEEE Open Journal of Nanotechnology 2023年 4卷 181-194页

作者： Butola, Rajat Li, Yiming Kola, Sekhar Reddy National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Institute of Communications Engineering the Institute of Biomedical Engineering the Department of Electronics and Electrical Engineering the Institute of Pioneer Semiconductor Innovation and the Institute of Artificial Intelligence Innovation Hsinchu300093 Taiwan

Machine learning (ML) is poised to play an important part in advancing the predicting capability in semiconductor device compact modeling domain. One major advantage of ML-based compact modeling is its ability to capture complex relationships and patterns in large datasets. Therefore, in this paper a novel design scheme based on dynamically adaptive neural network (DANN) is proposed to develop fast and accurate compact model (CM). This framework constitutes a powerful yet computationally efficient methodology and exhibits emergent dynamic behaviors. This paper demonstrates that the compact model based on ML can be designed to replicate the performance of conventional compact model for nanodevices. For this work, gate-all-around (GAA) nanosheet (NS) device characteristics are comprehensively analyzed for process variability sources using the proposed model. The device geometry parameters such as channel length, nanosheet width and nanosheet thickness are fed as input features to the DANN model. The adaptive neural network learns dynamically by updating weights of the model in accordance with the input features and achieves accurate neural weight convergence. The proposed model predicted the electrical characteristics of NS devices with less than 1% error rate. The model is also implemented and validated for the simulations of digital circuit designs such as inverter, and logic gates. ©;2023 The Authors.

关键词： Circuit simulation

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Design method of surface receive coil with high SNR for various field intensities in MRI

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Journal of the Magnetics Society of Japan 2024年第3期48卷 53-59页

作者： Takahashi, Masaharu Fushimi, Motofumi Yabukami, Shin Sekino, Masaki Kuwahata, Akihiro Graduate School of Engineering Tohoku Univ. 6-6-05 Aramaki-aza-Aoba Aoba-ku Sendai980-8579 Japan Graduate School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo113-8656 Japan Graduate School of Biomedical Engineering Tohoku Univ. 6-6-05 Aramaki-aza-Aoba Aoba-ku Sendai980-8579 Japan

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technology with a high spatial resolution. We aim to design a single-channel radiofrequency receive coil with an optimized signal-to-noise ratio (SNR) for various field intensities in MRI. We propose a method that maximizes the SNR through surface current optimization using the target field method. The proposed method can design a dedicated coil shape by solving an objective function with terms related to the signal, coil resistance noise and sample resistance noise. We found coil shapes for a rat kidney model in the case of static magnetic field intensity |B0| = 7 T, 0.3 T and 6.5 mT as an example. Our method will enable the design of single channel receive coil for preclinical applications of small animals. © 2024 by the Magnetics Society of Japan.

关键词： Magnetic resonance imaging

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Biodegradable hafnium-doped CaCO₃ nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy

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Nanomedicine 2024年第13期19卷 1133-1144页

作者： Chen, Min-Hua Zeng, Xiang-Hao Shu, Yi-Ting Liang, Hsiang-Kuang Chen, Ching-Yun Lin, Chun-Yu Lin, Cheng-An J. Chen, Jen-Kun Department of Biomedical Engineering Chung Yuan Christian University Taoyuan City 320314 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes Miaoli County 35053 Taiwan Department of Materials & Textiles Asia Eastern University of Science & Technology New Taipei County 220303 Taiwan Department of Biomedical Engineering National Taiwan University Taipei City 10617 Taiwan Department of Biomedical Sciences & Engineering National Central University Taoyuan City 320317 Taiwan Center for Biomedical Engineering in Cancer Chung Yuan Christian University Taoyuan City 320314 Taiwan Biotechnology Center National Chung Hsing University Taichung City 40227 Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei City 11490 Taiwan

Aim: Radiotherapy employs high-energy ionizing radiation to inflict DNA damage on cancer cells, thereby causing their demise. However, this procedure can inadvertently harm healthy tissue. Thus, this study aimed to develop biodegradable radiosensitizers that counteract these adverse effects by enhancing the radiation sensitivity of tumor cells and safeguarding normal cells. Materials & methods: A biodegradable radiosensitizer was engineered by incorporating hafnium ions (Hf) into calcium carbonate (CaCO₃) nanoparticles via a chemical precipitation technique, resulting in the formation of Hf:CaCO₃ nanoparticles. Results & conclusion: Our findings demonstrate that Hf:CaCO₃ nanoparticles exhibit pH-dependent solubility and can augment the efficacy of radiotherapy in treating cancer cells. This research underscores the potential of Hf:CaCO₃ nanoparticles as a dual-modality radiosensitizer in radiotherapy. © 2024 Expert Publishing Medicine Ltd trading as Taylor & Francis.

关键词： bioceramics cancer/oncology nanomaterials nanoparticles therapeutics

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Construction Method of Acoustic Metadata on an Object-Based Audio Utilizing Coordinate Estimation of a Moving Sound Source 13

Construction Method of Acoustic Metadata on an Object-Based ...

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13th IEEE Global Conference on Consumer Electronic, GCCE 2024

作者： Kato, Subaru Iwai, Kenta Nishiura, Takanobu Soeta, Yoshiharu Ritsumeikan University Graduate School of Information Science and Engineering Ibaraki Japan Ritsumeikan University College of Information Science and Engineering Ibaraki Japan Biomedical Research Institute Ikeda Japan

ISBN: (纸本)9798350355079

An object-based audio is a system that reproduces a highly immersive sound experience on multichannel audio systems. However, the production time for constructing acoustic metadata increases as the number of audio objects increases. In this paper, we propose a method for constructing acoustic metadata by coordinate estimation. The proposed method estimates the position of moving sound sources from video and utilizes it as the position of the audio objects, thereby reducing the production time. The subjective evaluation experiment was conducted to access the accuracy of the sound image localization constructed by the proposed method. The results of the evaluation experiment show almost all moving sound sources and sound images can be felt in the same direction. © 2024 IEEE.

关键词： Audio systems

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