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Degradation of Tattoo Inks by Cold Atmospheric Plasma Treatment: A Proof-of-Concept Study

Plasma Medicine 2022年第3期12卷 1-21页

作者： Çukur, Elif Ercan, Utku Kürşat Department of Biomedical Engineering School of Engineering and Architecture İzmir Katip Çelebi University Çiğli İzmir35620 Turkey Isparta University of Applied Sciences Uluborlu Vocational School Biomedical Device Technologies Program Isparta32200 Turkey

Tattoos have been a part of the culture and a way of expression for a remarkable portion of society throughout history. However, different dissatisfactions related to tattoos lead people to tattoo removal procedures that can be carried out in various ways. Among them, laser tattoo removal is the most common technique. However, laser tattoo removal could have downsides;thus, novel technologies that either support or replace conventional methods are needed. In the present study, the degradation of red, yellow, green, blue, black and white tattoo inks by plasma treatment was evaluated for possible future use of cold plasma in tattoo removal. Tattoo inks were treated with DBD air plasma in the aqueous form and in the agarose gel. Furthermore, also tattoo pigments were exposed to plasma-treated water. The KI-starch reagent was used to correlate the oxidative strength of plasma-treated water with the degradation of tattoo inks. Degradation of tattoo inks was determined by reflectance measurements and was measured as color change with respect to plasma treatment time. Color changes of tattoo inks were represented using the CIELAB color system and CIE xyY color space. Our results suggest that air DBD plasma treatment and plasma-treated water are capable of degrading tattoo inks. The color change of tattoo inks due to degradation by plasma was clearly distinguishable by the naked eye, and the maximum value corresponding to color change was measured for red tattoo ink. © 2022 by Begell House, Inc.

关键词： Color

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Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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Bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang Department of Biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The Biomedical Sciences Graduate Program(BIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of Biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK Biomimetic nanomedicine Targeted delivery

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Multiplexed Nanoscopy via Buffer Exchange

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ACS Nano 2024年第34期18卷 23445-23456页

作者： Chang, Ting-Jui Ben Yang, T. Tony Department of Electrical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei10617 Taiwan

Understanding cellular functions, particularly in their intricate complexity, can greatly benefit from the spatial mapping of diverse molecules through multitarget single-molecule localization microscopy (SMLM). Existing methodologies, primarily restricting the encoding dimensions to color and lifetime or requiring cyclic staining, often involve broad chromatic detection, specialized optical configurations, or sophisticated labeling techniques. Here, we propose a simple approach called buffer-exchange stochastic optical reconstruction microscopy (beSTORM), which introduces an additional dimension to differentiate between single molecules irrespective of their spectral properties. This method leverages the distinguishable photoblinking responses to distinct buffer conditions, offering a straightforward yet effective means of fluorophore discrimination. Through buffer exchanges, beSTORM achieves multitarget SMLM imaging with minimal crosstalk. Direct integration with expansion microscopy (ExM) demonstrates its capability to resolve up to six proteins at the molecular level within a single emission color without chromatic aberration. Overall, beSTORM presents a highly compatible imaging platform, promising significant advancements in highly multiplexed nanoscopy for exploring multiple targets in biological systems with nanoscale precision. © 2024 The Authors. Published by American Chemical Society.

关键词： Stochastic systems

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Effects of the Types of Headphones and Sound Sources on Spatial Audio Quality

Effects of the Types of Headphones and Sound Sources on Spat...

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2023 Immersive and 3D Audio: from Architecture to Automotive, I3DA 2023

作者： Soeta, Yoshiharu Nishiura, Takanobu Biomedical Research Institute Osaka Japan Ritsumeikan University Graduate School of Information Science and Engineering Shiga Japan

ISBN: (纸本)9798350311044

Acoustic characteristics of sound fields reproduced by headphones are a major concern to evaluate spatial audio quality. Several specifications exist for acoustic attributes, including frequency response, impedance, and sensitivity. While prior research has illuminated these acoustic features, it falls short in evaluating the spatial audio quality produced by headphones. Such studies don't sufficiently detail the impact of headphones and sound sources. In this study, we carried out psychological evaluations and acoustical measurements of sound fields reproduced by headphones to identify the acoustic elements that account for the spatial audio quality rendered by the headphones. Three types of sound excerpts were played with seven types of headphones, and the psychological evaluations were carried out by 30 participants. Envelopment and apparent source width were evaluated as psychological evaluations. From the binaural impulse response, we determined the center time (Ts), the maximum value (IACC) of the interaural cross-correlation function (IACF), and the IACC width (WIACC). We derived the IACF and auto-correlation function (ACF) parameters from the recorded sound sources. The traits of both the headphones and the sound source influenced the psychological assessments. The variation in spatial audio quality across headphones and sound sources can be attributed to the peak value of the initial maximum amplitude of the ACF, Ts, and WIACC © 2023 IEEE.

关键词： Acoustic fields

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Coevolution of Myoelectric Hand Control under the Tactile Interaction among Fingers and Objects

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Cyborg and Bionic Systems 2022年第1期2022卷 285-302页

作者： Yuki Kuroda Yusuke Yamanoi Shunta Togo Yinlai Jiang Hiroshi Yokoi Joint Doctoral Program for Sustainability Research Graduate School of Informatics and Engineering The University of Electro-CommunicationsTokyoJapan Department of Mechan ical and Intelligent System Engineering Graduate School of Informatics and Engineering The University of Electro Communications TokyoJapan Center for Neuroscience and Biomedical Engineering The University of Electro Communications TokyoJapan Bejing Innovation Center for Inelligent Robots and Systems BeijingChina

The usability of a prosthetic hand difers significantly from that of a real ***,the complexity of manipulation increases as the number of degrees of freedom to be controlled increases,making manipulation with biological signals extremely *** overcome this problem,users need to select a grasping posture that is adaptive to the object and a stable grasping method that prevents the object from *** previous studies,these have been left to the operating skills of the user,which is extremely difficult to *** this study,we demonstrate how stable and adaptive grasping can be achieved according to the object regardless of the user's operation *** required grasping technique is achieved by determining the correlation bet ween the motor output and each sensor through the interaction between the prosthetic hand and the surrounding stimuli,such as myoelectricity,sense of touch,and grasping *** agents of the 16 DOF robot hand were trained with the myoelectric signals of six participants,including one child with a congenital forearm ***,each agent could open and close the hand in response to the myoeletric stimuli and could accomplish the object pickup *** the tasks,the agents successfully identified grasping patterns suitable for practical and stable positioning of the *** addition,the agents were able to pick up the object in a similar posture regardless of the partiipant,suggesting that the hand was optimized by evolutionary computation to a posture that prevents the object from being dropped.

关键词： robot Objects overcome

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A Physical-Based Artificial Neural Networks Compact Modeling Framework for Emerging FETs

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IEEE Transactions on Electron Devices 2024年第1期71卷 223-230页

作者： Yang, Ya-Shu Li, Yiming Kola, Sekhar Reddy Reddy National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory The Institute of Communications Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Institute of Communications Engineering Institute of Biomedical Engineering Department of Electronics and Electrical Engineering Hsinchu300093 Taiwan National Yang Ming Chiao Tung University Parallel and Scientific Computing Laboratory Electrical Engineering and Computer Science International Graduate Program Hsinchu300093 Taiwan

We report a compact modeling framework based on the Grove-Frohman (GF) model and artificial neural networks (ANNs) for emerging gate-all-around (GAA) MOSFETs. The framework consists of two ANNs;the first ANN constructed with the drain current model not only can capture the main trend of device I - V characteristics but also can predict its variation even when the amount of training data for the ANN is insufficient or outside the range of applied biases. The second one is then designed to improve the model accuracy by further minimizing the errors between the target and the model outputs. We implement the proposed framework to accurately model emerging GAA nanosheet (NS) MOSFETs and complementary FETs (CFETs) without suffering from divergent issues in circuit simulation. In addition, nonphysical behaviors, such as nonzero current at zero bias, do not occur in the modeling framework. Compared to recently reported machine-learning (ML) models, our approach can achieve a similar level of model accuracy with merely 20% amount of the training data. © 1963-2012 IEEE.

关键词： Neural networks

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Enzyme Electrode Sensor with Two-layer Bubble-removal Flow Channel for use Even in Negative-pressure Systems

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IEEJ Transactions on Sensors and Micromachines 2023年第9期143卷 285-292页

作者： Noriko, Tsuruoka Kenta, Tsugueda Yoichi, Haga Graduate School of Engineering Tohoku Universiry 6-6 Aza-Aoba Aramaki Aoba-ku Sendai Miyagi980-8579 Japan Graduate School of Biomedical Engineering Tohoku Universiry 6-6 Aza-Aoba Aramaki Aoba-ku Sendai Miyagi980-8579 Japan

In this research, an enzyme electrode sensor with a two-layer bubble-removal flow channel that can be used in a skin microperfusion system was fabricated. The first layer of the channel is placed on enzyme electrodes. The flow channel is connected to the second layer which has an outlet. A hydrophobic porous membrane is placed on the channel wall between the two layers on the inlet side of the electrodes. Thus, bubbles can bypass the electrodes by taking a shortcut through the hydrophobic porous membrane into the second layer. Since bubble removal results from the pressure difference between the layers, this flow channel can be used in both positive- and negative-pressure systems. The flow channel height and the pore size in the hydrophobic porous membrane were selected by measuring pressure differences between the two layers using different pumping methods. The bubble removal performance was evaluated during microperfusion measurements on porcine skin. In addition, the effect of the bubble-removal flow channel on lactate concentration measurements using an enzyme electrode was evaluated. © 2023 The Institute of Electrical Engineers of Japan.

关键词： Pore size

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View-Invariant Object Representation in Anterior and Posterior Inferotemporal Cortex: A Machine Learning Approach

SSRN

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SSRN 2025年

作者： Okamura, Jun-Ya Fukano, Daisuke Wang, Gang Information Science and Biomedical Engineering Program Graduate School of Science and Engineering Kagoshima University Kagoshima890-0065 Japan

Inferotemporal (IT) cortex is the final visual area in the ventral stream where object information is processed. Previous electrophysiological studies showed viewing angle tolerance of 30-60° of single IT cells to the objects experienced in discrimination at each of several viewing angles, and to the objects experienced in learning association of different views. IT is divided into anterior (cytoarchitectonic area TE) and posterior (TEO) parts. It was reported that single cells in area TE showed the viewing angle tolerance while those in area TEO did not. In the present study population activities were compared between cell populations in area TE and those in area TEO using machine learning algorithm. An object set consisted of four similar objects created by deforming a prototype object, and four views each separated by 30°. A population vector was created by aligning responses of the cells to each object image. A classifier was trained by support vector machine (SVM) to create a hyperplane that separated one object from the other three objects at the same viewing angles, and then tested by response vectors to the object images at different viewing angles. In area TE, dynamics of the performance evaluated by d’ showed viewing angle tolerance of 30-60° to the objects with prior experience in learning association of different views. In area TEO, populations of the cells did not show the viewing angle tolerance. Significant increase of the d’ values in area TE in the late time period for the objects with prior experience in learning association of different views may suggest view-invariance is more represented in late time period than early time period. These results suggest that viewpoint invariance is expressed more strongly in the TE region, providing new insights into the neural basis of object recognition © 2025, The Authors. All rights reserved.

关键词： Support vector machines

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Effect of High-Flow Nasal Cannula on Capnogram Waveform for Studying Non-Invasive Human Ventilation 2

Effect of High-Flow Nasal Cannula on Capnogram Waveform for ...

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2nd IEEE National biomedical engineering Conference, NBEC 2023

作者： Tirta Nindhia, Tjokorda Gde Aqila Mohammed, Nursyasa Jamaludin, Julia Jais Devandran, Pagupathi Angel Bhaswara, Nabiel Rafa Hutajulu, Thalitakum Malarvili, M.B. Udayana University Jimbaran Study Program of Mechanical Engineering Engineering Faculty Bali Indonesia Universiti Teknologi Malaysia School of Biomedical and Health Science Engineering Johor Malaysia

ISBN: (纸本)9798350338546

This study is conducted to compare three different cannulas;all purpose nasal cannula with 2 prongs, nasal pressure cannula with 2 prongs and single port nasal cannula which are commonly used for capnography device. These cannulas or sometimes called as nasal prong is connected to the device via nose of subjects studied. This procedure is a part of respiratory study to monitor lungs condition and breathing pattern. This study involves 47 subject where the exhaled breath was recorded to make comparison and choose the most suitable and effective for capnography waveform analysis. Utilizing Statistical Package for the Social Sciences (SPSS) to find the normality of all the nasal cannula data based on capnogram waveform. The result from the analysis shows that the frequency distribution for type 1 nasal cannula which is also known as all-purpose nasal cannula had the feature values closer to the standard value. Our study proofs that all purpose nasal cannula sampling is the most suitable to capture exhaled breath for monitoring respiratory conditions. © 2023 IEEE.

关键词： capnography CO2 monitoring, feature extraction nasal cannula

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Effects of Tecartherapy on Body Tissue: A Systematic Review

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Journal of biomedical Science and engineering 2023年第10期16卷 133-148页

作者： Adriana Mitie Ida Eduardo Borba Neves Adriana Maria Wan Stadnik Graduate Program in Biomedical Engineering Universidade Tecnológica Federal do Paraná Curitiba Brazil

Electrophysical devices based on diathermy are one of the modalities used by many professionals to treat pain. The objective of this study was to identify the effects of Tecartherapy on healthy and unhealthy tissues. A systematic review of Tecartherapy technology was carried out. Articles published up to the year 2023 were investigated. The search argument used was “Capacitive-resistive electrical transfer” OR “Tecar” OR “Therapy Tecar” OR “CRET” in the BVS, Cochrane, PEDro, PubMed, IEEE Explore databases, Scielo and Web of Science. As for the main results of using Tecartherapy, there is an increase in temperature. In healthy tissues there is an increase in local blood flow, a decrease in muscle fatigue and an increase in muscle flexibility. In addition to the effects observed on healthy tissues, pain reduction and improved joint function were also observed. It was concluded that this technology has similar effects to other diathermy, but Tecartherapy proved to be safer and more comfortable. .

关键词： CRET Electrical Transfer Diathermy Capacitive-Resistive

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