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16th biomedical engineering International Conference, BMEiCON 2024

作者： Piyapan, Siriporn Aramwit, Pornanong Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand Chulalongkorn University Bioactive Resourse for Innovative Clinical Applications Research Unit Faculty of Pharmaceutical Sciences Bangkok Thailand

ISBN: (纸本)9798331505431

Sericin is a natural protein from silkworm cocoons. It is used in many biomedical applications as scaffolds, films, hydrogels, and micro/nanoparticles. This study was interested in fabricating a scaffold from sericin as a wound healing patch. The scaffold was fabricated, but sericin had poor properties, so it needed to be solved using another polymer. Poly(vinyl alcohol) (PV A) was chosen to improve their properties in conjunction with chemical (adding glutaraldehyde) and physical (freezing-thawing) crosslink. The cross-section of SEM showed high porous and good interconnectivity all around the sheet of both scaffolds. The chemical crosslink scaffold (CC scaffold) was smaller porous than the physical crosslink scaffold (PC scaffold). The result of FTIR showed that the specific absorption peaks of sericin were amide I at 1618-1640 cm-1 ( C=O stretching), amide II at 1518-1638 cm-1 (N-H bending and C-N stretching) and amide III at 1238 cm-1 (C-N and C=O stretching). Adding glutaraldehyde gave the two small peaks at 2830 -3000 cm-1, indicating the C-H bond of the aldehyde and alkyl functional group. The mechanical testing, crosslinking can resist deformation observed from Young's modulus. Young's modulus of non-crosslink, physical and chemical crosslink scaffolds were 1.4± 0.001,34.4± 0.004 and 7.5± 0.004 kPa, respectively. Elongation at break of scaffolds were 116.4 ± 11.1 %, 140.3 ± 13.2% and 22.7 ± 17%, respectively. These results suggested that the addition of glutaraldehyde had an impact on the brittleness of the scaffold. The swelling property indicated the wound healing patch's efficiency in absorbing liquids or exudate. There were two folds of swelling of the CC scaffold compared with the PC scaffold at intervals time after immersion. At the same time, sericin released more than 450 μ g mL from both scaffolds after 48 h. MTT assay showed that they were non-toxic at 2 4 and 4 8 h. Cell viability has been measured more than 70.0%. Moreover, our study wants to dev

关键词： Thawing

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Titanium Culture Vessel Presenting Temperature Gradation for the Thermotolerance Estimation of Cells

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Cyborg and Bionic Systems 2023年第1期4卷 166-177页

作者： Chikahiro Imashiro Yangyan Jin Motoaki Hayama Takahiro GYamada Akira Funahashi Katsuhisa Sakaguchi Shinjiro Umezu Jun Komotori Graduate School of Engineering The University of TokyoTokyo 113-0033Japan Department of Mechanical Engineering Keio UniversityYokohamaKanagawa 223-0061Japan School of Integrated Design Engineering Graduate School of Science and TechnologyKeio UniversityYokohamaKanagawa 223-0061Japan Department of Biosciences and Informatics Keio UniversityYokohamaKanagawa 223-0061Japan Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advanced Science and EngineeringWaseda UniversityTWInsTokyo 162-8480Japan Department of Modern Mechanical Engineering Waseda UniversityTokyo 169-8555Japan

Hyperthermia can be induced to exploit the thermal intolerance of cancer cells,which is worse than that of normal cells,as a potential noninvasive cancer *** develop an effective hyperthermia treatment,thermal cytotoxicity of cells should be comprehensively ***,to conduct such investigations,the culture temperature must be accurately *** previously reported a culture system in which the culture temperature could be accurately regulated by employing metallic culture ***,appropriate temperature conditions for hyperthermia depend on the cell ***,several experiments need to be conducted,which is a bottleneck of inducing ***,we developed a cell culture system with temperature gradation on a metallic culture *** Cancer Foundation-7 cells and normal human dermal fibroblasts were used as cancer and normal cell models,*** cells showed stronger thermal tolerance;this was because the novel system immediately exhibited a temperature ***,the developed culture system can be used to investigate the optimum thermal conditions for effective hyperthermia ***,as the reactions of cultured cells can be effectively assessed with the present results,further research involving the thermal stimulation of cells is possible.

关键词： stimulation culture Titanium

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Subject-Specific Pre-Processing Pipeline for EEG Artifact Removal Aimed at Enhancing SSVEP Detection 3

Subject-Specific Pre-Processing Pipeline for EEG Artifact Re...

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3rd International Congress of biomedical engineering and Bioengineering, CIIBBI 2024

作者： Ruiz-Olaya, Andres F. Beltran, Emma V. Pulido, Edith Antonio Nariño University Faculty of Mechanical Electronics and Biomedical Engineering Bogota Colombia Universidad El Bosque Bioenginering Program Bogota Colombia

ISBN: (纸本)9798331532352

Steady-State Visually Evoked Potentials (SSVEP) based Brain-Computer Interfaces (BCIs) offer significant potential in assistive and rehabilitation technologies. However, the performance of SSVEP detection is often compromised by artifacts in Electroencephalography (EEG) signals and inter-subject variability, among other factors. This study introduces a subject-specific p reprocessing p ipeline a imed a t enhancing SSVEP signal detection accuracy. The proposed method involves a dual-stage approach, utilizing EEG signals recorded both during a baseline rest state and during tasks known to induce artifacts. By establishing a personalized reference for each subject, the pipeline enables more accurate artifact detection and removal. The pipeline's efficacy w as e valuated u sing Canonical Correlation Analysis (CCA) on an open EEG dataset, with performance assessed across varying time segments (1, 2, 3 y 4 s). Detection accuracy was calculated to quantify performance in SSVEP detection. The performance of the proposed method for the 4-second time segment was superior (96.44%) compared to the standard method (93.78%). The results demonstrate the pipeline's potential to improve the reliability of SSVEP-based BCIs, particularly in highly contaminated signals. © 2024 IEEE.

关键词： Brain

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Relationship between short-term ozone exposure, cause-specific mortality, and high-risk populations: A nationwide, time-stratified, case-crossover study

Relationship between short-term ozone exposure, cause-specif...

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2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： Kang, Cinoo Kim, Yejin Oh, Jieun Yun, Hyewon Yang, Juyeon Park, Chaerin Kim, Sooyoung Ahn, Seoyeong Kim, Ayoung Kwon, Dohoon Park, Jinah Kim, Ejin Kim, Ho Lee, Whanhee Department of Public Health Sciences Graduate School of Public health Seoul National University Seoul Korea Republic of School of Biomedical Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan Korea Republic of Department of Information Convergence Engineering College of Information and Biomedical Engineering Pusan National University Yangsan Korea Republic of Institute of Health and Environment Graduate School of Public Health Seoul National University Seoul Korea Republic of Research and Management Center for Health Risk of Particulate Matter Seoul Korea Republic of

ISBN: (纸本)9798350386226

关键词： Nitrogen oxides

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Biosilica source converted into mesoporous bioactive glass implanted for tendon-bone healing

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Journal of the Chinese Chemical Society 2023年第5期70卷 1048-1054页

作者： Lin, Hsiu-Mei Chen, Chih-Hwa Hsu, Fu-Yin Wu, Zhi-Yuan Wong, Pei-Chun Department of Bioscience and Biotechnology National Taiwan Ocean University Keelung City Taiwan School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei Taiwan Department of Orthopedics Taipei Medical University Shuang Ho Hospital School of Medicine College of Medicine Research Center of Biomedical Device Taipei Medical University Taipei Taiwan School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Research Center of Biomedical Device Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei Taiwan

In this study, mesoporous bioactive glass (MBG) has been synthesized using a natural material, diatom. Then, the surface morphology, such as pore size and dimension, was observed by transmission electron microscope. The physical properties of MBG were quantitatively analyzed by X-ray diffraction. Thermal properties were analyzed by thermogravimetric analysis. The cytotoxicity test was carried out by the MTT (3-[4,5-dimethylthaizol-2-yl]-2,5-diphenyltetrazolium bromide) assay to ensure biocompatibility. After that, MBG was mixed with gelatin to synthesize nanofiber matrix by an electrospinning process. The growth factors of platelet-rich plasma have been activated by ethyl(dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide grafting on the surface of nanofiber matrix. Nanofiber structure of MBG has been observed by scanning electron microscope. In vivo biocompatibility and the situation of bone healing were analyzed by animal experiment;the histology result was observation by H&E and Masson's trichrome staining. The results show that the MBG has no residue of organic matter, pore size was around 10 nm. MBG nanofiber matrix can significantly improve the bone healing compared with control group (without MBG nanofiber matrix). In general, MBG nanofiber matrix can significantly enhance bone-tendon healing and has great potential to be applied in the orthopedic field. © 2023 Chemical Society Located in Taipei and Wiley-VCH GmbH.

关键词： bone-tendon healing diatom electrospinning mesoporous bioactive glass platelet-rich plasma

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Mathematical Modeling and Characterization of a Wearable Soft Robotic Device for Muscle Mechanotherapy 46

Mathematical Modeling and Characterization of a Wearable Sof...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Ticllacuri, Victor Mio, Renato Biomedical Engineering Program PUCP-UPCH Lima Peru Pontificia Universidad Catolica del Peru Laboratory of Biomechanics and Applied Robotics Lima Peru Universidad Peruana Cayetano Heredia Laboratory of Biomedical Engineering Lima Peru University of Bayreuth Digital Health with a Focus on Data Science Germany

ISBN: (纸本)9798350371499

Treatments of disuse-induced muscle atrophy entail unmet clinical needs due to the lack of medical devices capable of mimicking physicians manual therapies. Therefore, in this paper we develop and model a wearable soft pneumatic elastomeric actuator to perform deep cyclic compression stimuli on human soft tissues for muscle rehabilitation by mechanotherapy. Static and dynamic characterization of the prototype demonstrate a 2.5 mm active deformation at 100 kPa with 600 mm3/s and a 5 Hz bandwidth. We estimate the transfer function of the experimentally acquired pressure, flow and deformation signals, processed by a Gaussian kernel-based approach. Our mathematical model accurately describes the actuator behavior and enables to extract its mechanical parameters. Then, through computational simulations, we illustrate its efficacy in emulating multiple complex bio-inspired movements. Our proposed methodology aims to improve the control efficiency in wearable soft robotics for muscle atrophy treatment. © 2024 IEEE.

关键词： Pneumatic actuators

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Extracellular matrix-templating fibrous hydrogels promote ovarian tissue remodeling and oocyte growth

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Bioactive Materials 2024年第2期32卷 292-303页

作者： Claire E.Nason-Tomaszewski Emily E.Thomas Daniel L.Matera Brendon M.Baker Ariella Shikanov Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA Department of Chemical Engineering University of MichiganAnn ArborMI 48109USA Department of Obstetrics and Gynecology University of MichiganAnn ArborMI 48109USA Cellular and Molecular Biology Program University of MichiganAnn ArborMI 48109USA

Synthetic matrices which mimic the extracellular composition of native tissue create a comprehensive model for studying development and ***,we have engineered a composite material which retains cell-secreted ECM for the culture of ovarian follicles by embedding electrospun dextran fibers functionalized with basement membrane binder(BMB)peptide in PEG *** the presence of ECM-sequestering fibers,encapsulated immature primordial follicles and ovarian stromal cells aggregated into large organoid-like structures with dense deposition of laminin,perlecan,and collagen I,leading to steroidogenesis and significantly greater rates of oocyte survival and *** determined that cell aggregation restored key cell-cell interactions critical for oocyte survival,whereas oocyte growth was dependent on cell-matrix interactions achieved in the presence of *** we have shown that sequestration and retention of cell-secreted ECM along synthetic fibers mimics fibrous ECM structure and restores the cell-cell and cell-matrix interactions critical for engineering an artificial ovary.

关键词： Biomimetic matrix Ovarian follicle Fibrous hydrogels

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Microstructural and electrochemical investigations of conductive bio-nanocomposite hydrogel based biosensing device

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Materials Today: Proceedings 2022年 62卷 638-643页

作者： Rani, Seema Gupta, Tanmay Garg, Vivek Bandyopadhyay-Ghosh, Sanchita Bandhu Ghosh, Subrata Liu, Guozhen Manipal University Jaipur Rajasthan Jaipur 303007 India Graduate School of Biomedical Engineering Faculty of Engineering The University of New South Wales Sydney NSW 2052 Australia

Wearable devices seem to have great potential that could result in a revolutionary non-clinical approach to continuous health monitoring. Stretchable biosensors in this regard have shown promising potential for their use in wearable devices owing to their ability to act as an interface between physiological environment and electronically generated signals. Such stretchable biosensors should be made of nontoxic, non-irritant, conductive, and flexible materials. Recently conductive hydrogel-based stretchable biosensors are gaining huge interest due to their potential for immobilization of analytes, biocompatibility, water retention ability and stretchability like skin, in addition to their tuneable physical and electrochemical properties. Nano-enabled hydrogels have further demonstrated enhanced sensitivity and selectivity in biosensors. To this end, this study focused on development of novel bio-nanocomposite hydrogel substrate as wearable biosensing devices and its systematic investigation of microstructure and electrochemical behaviour. Thermally exfoliated graphene oxide (TEGO) was synthesized and incorporated as a nanofiller within the hybrid biopolymer matrix consisting of polyvinyl alcohol (PVA) and conductive polyaniline (PANI). The synthesised TEGO was found to have intercalated nanostructure, and were dispersed uniformly within the hybrid matrix, as confirmed by FE-SEM investigation, anticipated to impart increased interfacial adhesion. Physical crosslinking of polymer networks was achieved by repetitive freeze thaw cycle. The flexible and unique hierarchical structure developed by incorporating TEGO within the conductive biopolymer system also enhanced the electrical conductivity in a significant way as indicated by the electrochemical impedance spectroscopy (EIS). This study, therefore, could establish the promising potential of developed bio-nanocomposite hydrogels in wearable biosensing devices. © 2022

关键词： Hydrogels

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Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 378-391页

作者： Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen Department of Biomedical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 211198China School of Mechanical Engineering Southeast UniversityNanjing 211189China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore Nanomedicine Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)ProteosSingapore 138673Singapore

Gas therapy is emerging as a highly promising therapeutic strategy for cancer ***,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,associated with gas *** this study,we developed a series of photoactivatable nitric oxide(NO)donors NRh-R-NO(R=Me,Et,Bn,iPr,and Ph)based on an N-nitrosated upconversion luminescent rhodamine *** the irradiation of 808 nm light,only NRh-Ph-NO could effectively release NO and NRh-Ph with a significant turn-on frequency upconversion luminescence(FUCL)signal at 740 nm,ascribed to lower N-N bond dissociation *** also investigated the involved multistage near-infrared-controlled cascade release of gas therapy,including the NO released from NRh-Ph-NO along with one NRh-Ph molecule generation,the superoxide anion O_(2)^(⋅−)produced by the photodynamic therapy(PDT)effect of NRh-Ph,and highly toxic peroxynitrite anion(ONOO‒)generated from the co-existence of NO and O_(2)^(⋅−).After mild nano-modification,the nanogenerator(NRh-Ph-NO NPs)empowered with superior biocompatibility could target *** an 808 nm laser irradiation,NRh-Ph-NO NPs could induce NO/ROS to generate RNS,causing a decrease in the mitochondrial membrane potential and initiating apoptosis by caspase-3 activation,which further induced tumor immunogenic cell death(ICD).In vivo therapeutic results of NRh-Ph-NO NPs showed augmented RNS-potentiated gas therapy,demonstrating excellent biocompatibility and effective tumor inhibition guided by real-time FUCL ***,this versatile strategy defines the targeted RNS-mediated cancer therapy.

关键词： Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging Peroxynitrite Nanogenerator Gas therapy In vivo

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Longitudinal study of the mechanical properties of rat abdominal aortas incubated in ex vivo conditions

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Journal of Biorheology 2023年第2期37卷 36-43页

作者： Sugita, Shukei Kawai, Hinase Ujihara, Yoshihiro Nakamura, Masanori Department of Electrical and Mechanical Engineering Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan Center of Biomedical Physics and Information Technology Nagoya Institute of Technology Nagoya Japan Department of Nanopharmaceutical Sciences Nagoya Institute of Technology Nagoya Japan

Aortic disease is often associated with tissue degradation. However, the changes in the mechanical properties of the aorta occurring in accordance with tissue degradation remain unclear. This study explored the time course of the natural decay of aortic tissues in terms of mechanical and histological properties. Aortas excised from mice were incubated under ex vivo conditions, and their mechanical properties were assessed using a pressure– diameter test. Two linear lines were fitted to the pressure– diameter curve;the pressure at which the lines crossed was defined as the "collagen recruitment pressure". During incubation, the aortas suddenly changed in stiffness, and the collagen recruitment pressure dropped abruptly. These rapid changes occurred significantly earlier under an intraluminal pressure of 0 than 100 mmHg. Histological examination revealed the loss of elastic laminas (ELs) and smooth muscle cells in the aorta, coinciding with the changes in mechanical properties. Thus, the rapid change was caused by sudden structural failure of the ELs, in which damage accumulated at the microscopic level over the incubation period. Additionally, the tissue degradation rate was dependent on the mechanical environment. These findings provide insight into the etiology of aortic diseases. © Japanese Society of Biorheology 2023.

关键词： Biomechanics

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