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Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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CLEO: Applications and Technology in CLEO 2024, CLEO: A and T 2024 - Part of Conference on Lasers and Electro-Optics

作者： Hao, Senyue Adkins, Aaron J. Zhang, Yitian Zhou, Chao Department of Electrical & Systems Engineering Washington University Saint Louis United States Imaging Science PhD Program Washington University Saint Louis United States Department of Biomedical Engineering Washington University Saint Louis United States

To implement optical coherence tomography on photonic chips, we developed optimized and experimentally validated silicon nitride-based components for photonic integrated circuits in order to achieve high sensitivity a... 详细信息

关键词： Photonic integrated circuits

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Development of a Water-Soluble BODIPY Photosensitizer for Photodynamic Therapy 9th

Development of a Water-Soluble BODIPY Photosensitizer for Ph...

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9th International Conference on the Development of biomedical engineering in Vietnam, BME 2022

作者： Kuo, Yu-Hsuan Hsieh, Chia-Feng Chen, Xuan-Yu Chang, Cheng-Chung Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung City Taiwan Intelligent Minimally-Invasive Device Center National Chung Hsing University Taichung City Taiwan

ISBN: (纸本)9783031446290

In this study, we reported a photosensitizer design strategy that utilizes a lipophilic cation to enhance the cellular uptake of BODIPY photosensitizers. We designed and synthesized 8-Anisole-3,5-bis-(4-((12-(1-methyl-piperidinium iodide)dodecyl)oxy)phenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (short as BO2), and investigated the solvent effect and singlet oxygen generation based on its absorption and emission spectra. Our experiments showed that BO2 maintains bright fluorescence, environmental insensitivity, photostability, and excellent singlet oxygen generation properties. In addition, cellular experiments demonstrated that BO2 exhibits good cellular uptake and photodamage. Therefore, we conclude that BO2 has potential applications in photodynamic therapy. © The Author(s), under exclusive license to Springer Nature Switzerland AG. 2024.

关键词： Photodynamic therapy

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Optimized photonic integrated circuit components for optical coherence tomography at 1060 nm

Optimized photonic integrated circuit components for optical...

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2024 Conference on Lasers and Electro-Optics, CLEO 2024

ISBN: (纸本)9781957171395

关键词： Photonic integrated circuits

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Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering

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Regenerative Biomaterials 2023年第1期10卷 1604-1617页

作者： Katie J.Hogan Hayriye Oztatlı Marissa R.Perez Sophia Si Reyhan Umurhan Elysa Jui Ziwen Wang Emily Y.Jiang Sa R.Han Mani Diba K.Jane Grande-Allen Bora Garipcan Antonios G.Mikos Department of Bioengineering Rice UniversityMS-1426500 Main StreetHoustonTX 77030USA Baylor College of Medicine Medical Scientist Training Program HoustonTX 77030USA Institute of Biomedical Engineering Bo�gazic¸i University_Istanbul34684Turkey

Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and *** methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and ***,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP *** objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal *** addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or *** crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked *** incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase *** in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examine

关键词： demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering

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A biogenesis construction of CuO@MWCNT via Chenopodium album extract: an effective electrocatalyst for synaptic plasticity neurodegenerative drug pollutant detection

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Environmental Science and Pollution Research 2023年第33期30卷 79744-79757页

作者： Pandiyarajan, Sabarison Velayutham, Gurunathan Liao, Ai-Ho Manickaraj, Shobana Sebastin Mary Ramachandran, Balaji Lee, Kuo-Yu Chuang, Ho-Chiao Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Mechanical Engineering National Taipei University of Technology Taipei Taiwan PG & Research Department of Chemistry Bishop Heber College Tamil Nadu Tiruchirappalli India Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Biomedical Engineering National Defense Medical Center Taipei Taiwan SV Probe Technology Taiwan Co. Ltd Taipei10453 Taiwan

Clioquinol (CLQ) is one of the most toxic halogenated neurodegenerative drugs, and its synaptic plasticity effect directly affects human health and the environment. Cupric oxide (CuO) is an ideal electrocatalyst owing to its earth-abundance, non-toxic nature, and cost-effectiveness. Since phenolate oxygen and pyridine nitrogen in CLQ act as an electron donor and pave the way for detection with Cu2+ ions in the CuO. Designing the architecture of CuO with a multi-walled carbon nanotube (MWCNT) is a sensible strategy to improve the electrochemical activity of the developed sensor. Inspired by the bio-synthesis and green processing, we have demonstrated the in-situ synthesis of CuO nanosphere-decorated MWCNT by Chenopodium album leaf extract through a sonochemical approach and explored its electrochemical sensing performance toward CLQ. The physical comprehensive characterization of prepared nanocomposite was investigated by various microscopic and spectroscopic techniques. For comparison studies, the CuO nanosphere was prepared by the same preparation process without MWCNT. Based on the physical characterization outcomes, the morphological nature of CuO was observed to be a sphere-like structure, which was decorated on the MWCNT with an average crystallite size of 16 nm (± 1 nm). Based on the electrochemical studies, the fabricated nanocomposite exhibits a wider linear range of 0.025–1375 μM, with a minimum detection limit of 4.59 nM L–1 toward CLQ. The viability examination on the biological matrix obtained considerable spike recoveries. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Nanospheres

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Point-of-care testing of Procalcitonin using lateral flow assay

Point-of-care testing of Procalcitonin using lateral flow as...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Jovita Rajesh Deodhar Chengchen Zhang Tianruo Guo Ruier Xue Mohit N. Shivdasani Fei Deng Graduate School of Biomedical Engineering and Tyree Institute of Health Engineering UNSW Sydney NSW Australia

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

This study presents a novel gold nano shells (GNS)-assisted paper-based lateral flow assay (LFA) for the detection of procalcitonin (PCT). PCT is a biomarker of infection, originating from the C cells of the thyroid gland and functioning as a precursor to the hormone calcitonin. Its concentration in the blood is known to increase in line with the progression of infectious diseases. Conventional techniques for assessing PCT levels in the blood encompass culture-based methods, enzyme-linked immunosorbent assay (ELISA) and electrochemical immunoassays. These methods are characterized by either prolonged processing times, high costs, or dependence on laboratory infrastructure. These limitations hinder their practical implementation in point-of-care settings. As a result, the development of a LFA for detecting PCT levels proves to be well-suited for point-of-care settings, serving as a valuable diagnostic tool for infectious diseases. This study focuses on comparing the efficacy of GNS and gold nanoparticle (GNP)-assisted lateral flow assays (LFA) to ascertain the lower limit of detection (LOD) for PCT and assess their overall reliability. Our findings indicate that GNS-assisted LFA achieved a lower LOD of 1 ng/mL, surpassing GNP, which exhibited a LOD of 5 ng/mL. Furthermore, outstanding specificity was demonstrated and clinical application capability in human serum was confirmed, reinforcing its efficacy as a reliable *** Relevance—GNS-assisted LFA provides a simple, rapid, and cost-effective method for detecting PCT levels from clinical samples

关键词： Gold Infectious diseases Point of care Reliability engineering Nanobioscience engineering in medicine and biology Blood Immune system Thyroid Testing

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Neural Networks and Explainable Artificial Intelligence for Breast Cancer Prediction and Classification

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Procedia Computer Science 2025年 256卷 1159-1166页

作者： Erika Yahata Pablo Deoclecia dos Santos Maria Marlene de Souza Pires Ricardo Suyama Priscyla Waleska Simoes Graduate Program in Information Engineering Federal University of ABC Santo André SP Brazil Graduate Program in Biomedical Engineering Federal University of ABC São Bernardo do Campo SP Brazil Pediatrics Department Federal University of Santa Catarina Florianópolis Santa Catarina Brazil

Solutions based on Artificial Intelligence techniques have been proposed in the healthcare sector, however the lack of understanding of the results has been a cause for concern and one of the main barriers to their effective use. To fill the gap in understanding these models considered black boxes, the Explainable Artificial Intelligence was proposed to explain the relationship between input data and the prediction results made by the Artificial Intelligence models. In this study, we present the use of explainability techniques for a black box machine learning model in breast cancer classification. Breast cancer is the type of cancer that causes the most deaths among women in the world and early diagnosis is essential to increase the chances of survival. The study evaluated the explainability of breast tumor predictions based on the Multilayer Perceptron artificial neural networks algorithm, considering a sample that contained data from 164 female patients undergoing Core Biopsy in the southern region of Brazil. The SHAP, LIME, PDP and ICE methods were used for the global and local explainability of the predictions. The results showed that in the global assessment, the BI-RADS® 5 ultrasound and mammography attributes were considered the most important for predicting the malignant tumor. Nodule size greater than 2 cm, presence of a family history and palpable nodule were also considered important for the prediction. In the local evaluation, it was found that the model correctly classified the tumors considering different characteristics of the patients. Through the results presented, the methods of explicability show evidence that the predictive model for breast cancer can be interpreted and understood, overcoming the barrier of lack understanding of the results of a black box model.

关键词： Explainable Artificial Intelligence Predictive Model Explainability Machine Learning Breast Cancer

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Fabrication of Concave Microwells and Microchannels by Off-stoichiometry Thiol-ene (OSTE) Backside Lithography 18

Fabrication of Concave Microwells and Microchannels by Off-s...

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18th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2023

作者： Zhang, Muyang Li, Haonan Xiao, Zhiqing Feng, Zitao Yu, Shangneng Chen, Zejingqiu Zhang, Huiru Guo, Weijin Shantou University Department of Electronic Engineering Shantou China Shantou University Department of Biomedical Engineering Shantou China Shantou University Department of Biology Shantou China Guangdong Foshan Lianchuang Graduate School of Engineering Foshan China

ISBN: (纸本)9798350333480

Many applications in micro-tissue engineering need to use concave microwells and microchannels to mimic the in vivo microenvironment, such as the culture of spheroids and construction of artificial blood vessels. Here, we propose a novel method of fabrication of concave microwells and microchannels by off-stoichiometry thiol-ene (OSTE) backside lithography. At first, we use OSTE backside lithography to fabricate convex microstructures on a solid substrate assisted by a diffusing glass. Then we use the solid substrate for replica molding of gelatin or agarose gel to get concave microwells and microchannels on a gel substrate. Our method brings convenience for the fabrication of concave microwells and microchannels, and can find potential applications in micro-tissue engineering immediately. © 2023 IEEE.

关键词： Microchannels

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Pilot study of using transcranial temporal interfering theta-burst stimulation for modulating motor excitability in rat

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Journal of Neuroengineering and Rehabilitation 2024年第1期21卷 147页

作者： Wu, Chun-Wei Lin, Bor-Shing Zhang, Zhao Hsieh, Tsung-Hsun Liou, Jian-Chiun Lo, Wei-Lun Li, Yu-Ting Chiu, Shao-Chu Peng, Chih-Wei School of Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan Department of Computer Science and Information Engineering National Taipei University New Taipei City 237303 Taiwan School of Mechanical and Electrical Engineering Wuyi University Fujian Province Wuyishan City China School of Physical Therapy and Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan Taiwan Neuroscience Research Center Chang Gung Memorial Hospital Linkou Taiwan Department of Surgery Division of Neurosurgery Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Taiwan Instrument Research Institute National Applied Research Laboratories Hsinchu Taiwan School of Gerontology and Long-Term Care College of Nursing Taipei Medical University Taipei Taiwan Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

Transcranial temporal interference stimulation (tTIS) is a promising brain stimulation method that can target deep brain regions by delivering an interfering current from surface electrodes. Most instances of tTIS stimulate the brain with a single-frequency sinusoidal waveform generated by wave interference. Theta burst stimulation is an effective stimulation scheme that can modulate neuroplasticity by generating long-term potentiation- or depression-like effects. To broaden tTIS application, we developed a theta burst protocol using tTIS technique to modulate neuroplasticity in rats. Two cannula electrodes were unilaterally implanted into the intact skull over the primary motor cortex. Electrical field of temporal interference envelopes generated by tTIS through cannula electrodes were recorded from primary motor cortex. Theta burst schemes were characterized, and motor activation induced by the stimulation was also evaluated simultaneously by observing electromyographic signals from the corresponding brachioradialis muscle. After validating the stimulation scheme, we further tested the modulatory effects of theta burst stimulation delivered by tTIS and by conventional transcranial electrical stimulation on primary motor cortex excitability. Changes in the amplitude of motor evoked potentials, elicited when the primary motor cortex was activated by electrical pulses, were measured before and after theta burst stimulation by both techniques. Significant potentiation and suppression were found at 15 to 30 min after the intermittent and continuous theta burst stimulation delivered using tTIS, respectively. However, comparing to theta burst stimulations delivered using conventional form of transcranial electrical stimulation, using tTIS expressed no significant difference in modulating motor evoked potential amplitudes. Sham treatment from both methods had no effect on changing the motor evoked potential amplitude. The present study demonstrated the feasibility of usin

关键词： Brain stimulation Motor evoked potential Neuroplasticity Theta burst stimulation Transcranial electrical stimulation Transcranial temporal interference stimulation

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