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Electrogelated drug-embedded silk/gelatin/rGO degradable electrode for anti-inflammatory applications in brain-implant systems

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Journal of Materials Chemistry B 2024年第5期12卷 1361-1371页

作者： Lin, Zhen-Kai Lin, Jing-Syu Chen, Zih-Huei Cheng, Hung-Wei Huang, Wei-Chen Chen, San-Yuan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Graduate Institute of Biomedical Science China Medical University Taichung Taiwan School of Dentistry College of Dental Medicine Kaohsiung Medical University Kaohsiung Taiwan

Implantable electrodes have raised great interest over the last years with the increasing incidence of neurodegenerative disorders. For brain implant devices, some key factors resulting in the formation of glial scars, such as mechanical mismatch and acute injury-induced inflammation, should be considered for material design. Therefore, in this study, a new biocompatible flexible electrode (e-SgG) with arbitrary shapes on a positive electrode was developed via electrogelation by applying a direct electrical voltage on a silk fibroin/gelatin/reduced graphene oxide composite hydrogel. The implantable flexible e-SgG-2 film with 1.23% rGO content showed high Young's modulus (11-150 MPa), which was sufficient for penetration under dried conditions but subsequently became a biomimetic brain tissue with low Young's modulus (50-3200 kPa) after insertion in the brain. At the same time, an anti-inflammatory drug (DEX) incorporated into the e-SgG-2 film can be electrically stimulated to exhibit two-stage release to overcome tissue inflammation during cyclic voltammetry via degradation by applying an AC field. The results of cell response to the SF/gelatin/rGO/DEX composite film showed that the released DEX could interrupt astrocyte growth to reduce the inflammatory response but showed non-toxicity toward neurons, which demonstrated a great potential for the application of the biocompatible and degradable e-SgG-D electrodes in the improvement of nerve tissue repair. © 2024 The Royal Society of Chemistry

关键词： Electrodes

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Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

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Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

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Phasor-FSTM:a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing

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Light(Science & Applications) 2025年第1期14卷 258-270页

作者： Luwei Wang Yue Chen Jiaqing Guo Xiaoyu Weng Wei Yan Jun Song Tong Ye Junle Qu Center for Biomedical Optics and Photonics&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen518060China The Photonics Center of Shenzhen University Shenzhen UniversityShenzhen518060China Department of Bioengineering CU-MUSC Bioengineering ProgramClemson UniversityCharlestonSouth Carolina29634USA

Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular *** methods have individually transformed cellular imaging by allowing detailed visualization of cellular and subcellular structures,as well as organelle ***,integrating multicolor and super-resolution microscopy into a single method remains challenging due to issues like spectral overlap,crosstalk,photobleaching,phototoxicity,and technical *** challenges arise from the conflicting requirements of using different fluorophores for multicolor labeling and fluorophores with specific properties for super-resolution *** propose a novel multicolor super-resolution imaging method called phasor-based fluorescence spatiotemporal modulation(Phasor-FSTM).This method uses time-resolved detection to acquire spatiotemporal data from encoded photons,employs phasor analysis to simultaneously separate multiple components,and applies fluorescence modulation to create super-resolution ***-FSTM enables the identification of multiple structural components with greater spatial accuracy on an enhanced laser scanning confocal microscope using a single-wavelength *** demonstrate the capabilities of Phasor-FSTM,we performed two-color to four-color super-resolution imaging at a resolution of~λ/5 and observed the interactions of organelles in live cells during continuous imaging for a duration of over 20 *** method stands out for its simplicity and adaptability,seamlessly fitting into existing laser scanning microscopes without requiring multiple laser lines for excitation,which also provides a new avenue for other super-resolution imaging technologies based on different principles to build multi-color imaging systems with the requirement of a lower budget.

关键词： resolution lifetime simplicity

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ECG-Free Assessment of Cardiac Valve Events Using Seismocardiography

ECG-Free Assessment of Cardiac Valve Events Using Seismocard...

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International Workshop on Wearable and Implantable Body Sensor Networks (BSN)

作者： Mohammad Muntasir Rahman Aysha Mann Amirtahà Taebi Biomedical Engineering Program Mississippi State University Mississippi State USA

ISBN: (数字)9798331530143

ISBN: (纸本)9798331530150

Seismocardiogram (SCG) signals can play a crucial role in remote cardiac monitoring, capturing important events such as aortic valve opening (AO) and mitral valve closure (MC). However, existing SCG methods for detecting AO and MC typically rely on electrocardiogram (ECG) data. In this study, we propose an innovative approach to identify AO and MC events in SCG signals without the need for ECG information. Our method utilized a template bank, which consists of signal templates extracted from SCG waveforms of 5 healthy subjects. These templates represent characteristic features of a heart cycle. When analyzing new, unseen SCG signals from another group of 6 healthy subjects, we employ these templates to accurately detect cardiac cycles and subsequently pinpoint AO and MC events. Our results demonstrate the effectiveness of the proposed template bank approach in achieving ECG-independent AO and MC detection, laying the groundwork for more convenient remote cardiovascular assessment.

关键词： Body sensor networks Accuracy Electrocardiography Valves Feature extraction Heart rate variability Monitoring Heart valves

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Cytometry in the Short-Wave Infrared

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ACS Nano 2024年第28期18卷 18534-18547页

作者： Liu, Te-I Wang, Jhih-Shan Nguyen, Ai-Phuong Raabe, Marco Quiroz Reyes, Carlos Jose Lin, Chih-Hsin Lin, Ching-Wei Institute of Atomic and Molecular Sciences Academia Sinica Taipei City106319 Taiwan Department of Materials Science and Engineering National Taiwan University Taipei City106319 Taiwan Department of Physics University of Stuttgart Stuttgart70174 Germany Department of Chemistry National Tsing Hua University Hsinchu300044 Taiwan International Ph.D. Program in Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University New Taipei City235603 Taiwan

Cytometry plays a crucial role in characterizing cell properties, but its restricted optical window (400-850 nm) limits the number of stained fluorophores that can be detected simultaneously and hampers the study and utilization of short-wave infrared (SWIR;900-1700 nm) fluorophores in cells. Here we introduce two SWIR-based methods to address these limitations: SWIR flow cytometry and SWIR image cytometry. We develop a quantification protocol for deducing cellular fluorophore mass. Both systems achieve a limit of detection of ∼0.1 fg cell-1 within a 30 min experimental time frame, using individualized, high-purity (6,5) single-wall carbon nanotubes as a model fluorophore and macrophage-like RAW264.7 as a model cell line. This high-sensitivity feature reveals that low-dose (6,5) serves as an antioxidant, and cell morphology and oxidative stress dose-dependently correlate with (6,5) uptake. Our SWIR cytometry holds immediate applicability for existing SWIR fluorophores and offers a solution to the issue of spectral overlapping in conventional cytometry. © 2024 The Authors. Published by American Chemical Society.

关键词： Oxygen

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Optimizing optical pulse breakup for efficient supercontinuum generation in an all-fiber system

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Optics Continuum 2024年第2期3卷 164-175页

作者： Chang, Kuan-Yuan Gong, Chen-Jia Liu, Jia-Ming Institute of Photonic System National Yang Ming Chiao Tung University Tainan Taiwan Institute of Imaging and Biomedical Photonics National Yang Ming Chiao Tung University Tainan Taiwan Electrical and Computer Engineering Department University of California Los AngelesCA United States Graduate Institute of Optoelectronic Engineering National Chung Hsing University Taichung Taiwan

Ultra-broadband supercontinuum (SC) is generated by an all-fiber system with well-defined pulses (WDPs) as a seed laser. Through properly adjusting the lengths of the fiber segments in the system, sub-pulses with high peak powers are generated through the process of optical pulse breakup. Then, the broken optical pulses are launched into a hybrid nonlinear, which consists of a highly nonlinear optical fiber and a photonic crystal fiber, generating a SC of 1.8 W covering a spectral range from 554 nm to 2.17 µm. In this study, it is demonstrated through experimental observation that optical pulse breakup is an essential process for WDPs before the pulses are launched into a nonlinear optical fiber to generate SC. However, pulse breakup must not happen before the amplification of the WDPs;otherwise, the amplification efficiency is decreased, leading to a subsequent low efficiency of SC generation. The proper breakup of the WDPs after they are efficiently amplified is accomplished by sending these pulses through an optimum length of regular optical fiber, which depends on the peak power of the amplified WDPs. An optical fiber of an insufficient length leads to insufficient pulse breakup, which does not significantly increase the peak power of the pulses, resulting in little enhancement of SC generation. An excessively long fiber leads to excessive pulse breakup, which stretches the pulsewidth and splits the pulse energy, resulting in decreasing the efficiency of SC generation. © 2024 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Supercontinuum generation

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The influence of phosphoric acid and primer treatment on the evaluation of the adhesive resin cement/enamel interface

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Dental Materials Journal 2025年第1期44卷 52-59页

作者： Zhao, Mengtian Sato, Takaaki Khaled, Abu Hasan Mohammad Ikeda, Masaomi Shimada, Yasushi Department of Cariology and Operative Dentistry Graduate School of Medical and Dental Sciences Institute of Science Tokyo 1-5-45 Yushima Bunkyo-ku Tokyo113-8510 Japan Department of Oral Biomedical Engineering Graduate School of Medical and Dental Sciences Institute of Science Tokyo 1-5-45 Yushima Bunkyo-ku Tokyo113-8549 Japan

This study evaluated the influence of phosphoric acid and primer on enamel bonding performance using Panavia V5. Ground bovine enamels were assigned: using K-etchant syringe and Tooth Primer (CT), using K-etchant syringe (PA), using Tooth Primer (TP), neither K-etchant syringe nor Tooth Primer was used (NC). The micro-tensile bond strength values of CT and PA were significantly higher than TP. After thermal cycling, the values were higher in CT and PA. In the leakage test, line-shaped signal pattern at the adhesive interface was detected in NC, and the signal was partially detected in PA and TP. Observation of the adhesive interface after acid and base challenge confirmed tooth-like structures in groups except NC. Large spaces were observed between the enamel and cement in NC. Limited in this study, the lack of application of phosphoric acid or Tooth Primer may affect the enamel bonding performance. © 2025, Japanese Society for Dental Materials and Devices. All rights reserved.

关键词： Syringes

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Rheology modifiers in Fricke – gelatin dosimeters 12

Rheology modifiers in Fricke – gelatin dosimeters

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12th International Conference on 3D and Advanced Dosimetry, IC3DDose 2022

作者： Penev, Kalin I. Mequanint, Kibret Department of Chemical and Biochemical Engineering The University of Western Ontario London Canada Modus Medical Devices Inc. London Canada Biomedical Engineering Program The University of Western Ontario London Canada

Fricke gel dosimeters, while very sensitive and versatile, continue to suffer from one major issue – the diffusion of the dose signal. To tackle that problem, here we present the use of inert, linear polymers with very high molecular weights as rheology modifiers that can slow the diffusion in weak gels, based on 4% gelatin. At 0.2% loading of polyacrylamide (with mol. wt. 5×106 Da), a moderate, 20% decrease of the diffusion coefficient was achieved. This effect is compared to that of adding a crosslinker, such as glyoxal or increasing the concentration of gelatin by 1%. © 2023 Institute of Physics Publishing. All rights reserved.

关键词： Diffusion

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Estimation of gaseous polycyclic aromatic hydrocarbons(PAHs)and characteristics of atmospheric PAHs at a traffic site in Kanazawa,Japan

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Journal of Environmental Sciences 2025年第3期149卷 57-67页

作者： Xuan Zhang Hao Zhang YanWang Pengchu Bai Lulu Zhang Akira Toriba Seiya Nagao Nobuo Suzuki Masato Honda Zhijun Wu Chong Han Min Hu Ning Tang Graduate School of Medical Sciences Kanazawa UniversityKanazawa 920-1192Japan School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China Institute of Nature and Environmental Technology Kanazawa UniversityKanazawa 920-1192Japan Graduate School of Biomedical Sciences Nagasaki UniversityNagasaki 852-8521Japan College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China School of Metallurgy Northeastern UniversityShenyang 110819China Institute of Medical Pharmaceutical and Health ScienceKanazawa UniversityKanazawa 920-1192Japan

Size-fractionated particulate matter(PM_(2.5)and PM>_(2.5))was collected at a traffic site in Kanazawa,Japan in a seasonal sampling work in *** polycyclic aromatic hydrocarbons(4-to 6-ring PAHs)were determined in fine and coarse *** gas/particle partitioning coefficients(K_(p))of the PAHs were calculated from the supercooled liquid vapour pressure and octanol-air partitioning coefficient based on the relationships obtained in previous traffic pollution-related *** PAHs were estimated by K_(p) and the concentrations of PM and particulate *** concentrations of total PAHs were 32.5,320.1 and 5646.2 pg/m^(3) in the PM>_(2.5),PM_(2.5) and gas phases,*** seasonal trends in PAHs were observed(particle phase:lowest in summer,gas phase:lowest in spring,particle and gas phase:lowest in spring).Compared to 2019,the total PAH concentrations(in particles)decreased in 2020,especially in spring and summer,which might be due to reduced traffic trips during the COVID-19 *** incremental lifetime cancer risk(ILCR)calculated from the toxic equivalent concentrations relative to benzo[a]pyrene(BaP_(eq))was lower than the acceptable limit issued by the US Environmental Protection Agency,indicating a low cancer risk in long-term exposure to current PAH *** is notable that gaseous PAHs considerably contributed to BaP_(eq) and ILCR(over 50%),which highlighted the significance of gaseous PAH monitoring for public health *** low-cost estimation method for gaseous PAHs can be expected to reliably and conveniently obtain PAH concentrations as a surrogate for traditional sampling in the future work.

关键词： Polycyclic aromatic hydrocarbons Gas-particle partitioning Traffic Exposure-response relationship COVID-19

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Molecular Imprinted Polymer Based Optical Sensor for Methanol Vapor Detection

Molecular Imprinted Polymer Based Optical Sensor for Methano...

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Optica Sensing Congress 2023, AIS, FTS, HISE, Sensors, ES 2023 - Part of Optical Sensors and Sensing Congress 2023

作者： Leelasirinuwong, Mintra Denkasineecharoen, Phebe Yungyuentrrakoon, Pin Jitpratak, Pannathorn Kongsawang, Nuntaporn Pathak, Akhilesh Kumar Viphavakit, Charusluk Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Biomedical Engineering Program Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand Intelligent Control Automation of Process Systems Research Unit Faculty of Engineering Chulalongkorn University Bangkok10330 Thailand

A molecular imprinted polymer-based optical sensor is proposed to detect methanol. The sensor is tested with different concentrations of methanal vapour for sensitivity and ethanol for selectivity. The result shows a ... 详细信息

ISBN: (纸本)9781957171241

关键词： Optical sensors

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