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Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision

Light(Science & Applications) 2022年第11期11卷 2817-2831页

作者： Yueming Li Ying Jiang Lu Lan Xiaowei Ge Ran Cheng Yuewei Zhan Guo Chen Linli Shi Runyu Wang Nan Zheng Chen Yang Ji-Xin Cheng Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Graduate Program for Neuroscience Boston UniversityBostonMA 02215USA Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Chemistry Boston UniversitBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA Division of Materials Science and Engineering Boston UniversityBostonMA 02215USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02142USA

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological *** non-invasive neuromodulation methods offer limited precision at the milimeter ***,we report opticallygenerated focused ultrasound(OFUS)for non-invasive brain stimulation with ultrahigh *** is generated by a soft optoacoustic pad(SOAP)fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane *** generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83μm,which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound(tFUS).Here,we show effective OFUS neurostimulation in vitro with a single ultrasound *** demonstrate submillimeter transcranial stimulation of the mouse motor cortex in *** acoustic energy of 0.6 mJ/cm?,four orders of magnitude less than that of tFUS,is suffcient for successful OFUS *** offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision noninvasively.

关键词： SOAP stimulation precision

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Super-assembly of integrated gold magnetic assay with loopmediated isothermal amplification for point-of-care testing

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Nano Research 2023年第1期16卷 1242-1251页

作者： Jianping Liang Jie Zeng Xiaojuan Huang Tengteng Zhu Yonglong Gong Chen Dong Xiangrong Wang Lingzhi Zhao Lei Xie Kang Liang Qiongxiang Tan Yali Cui Biao Kong Wenli Hui The College of life science Northwest UniversityXi’an 710069China Shaanxi Provincial Engineering Research Center for Nano-Biomedical Detection Xi’an 710077China Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationNorthwest UniversityXi’an 710069China Provincial Key Laboratory of Biotechnology of Shaanxi Province Northwest UniversityXi’an 710069China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesNSW 2052Australia

With the increasing global threat of various diseases and infections,it is essential to develop a fast,low-cost,and easy-to-use point-of-care testing(POCT)system for inspections at all levels of medical institutions and self-examination at *** this work,gold magnetic nanoparticles(GMNPs)are used as the key material,and a rapid visual detection method is designed through integrating loop-mediated isothermal amplification(LAMP)and lateral flow assay(LFA)biosensor for detecting a variety of analytes which includes whole blood,buccal swabs,and *** is worth to note that the proposed method does not need DNA ***,uracil DNA glycosylase(UDG)is employed to eliminate carrier contamination for preventing false positive *** whole detection process can be finished within 25 *** accuracy of detection is measured by assessing the polymorphisms of the methylenetetrahydrofolate reductase(MTHFR)*** detection limit of the newly developed extraction-free detection system for MTHFR C677T is 0.16 ng/μL.A preliminary clinical study of the proposed method is carried out by analyzing 600 clinical samples(including 200 whole blood samples,100 buccal swabs,and 300 genomic DNA samples).The results indicate that the proposed method is 100%consistent with the sequencing results which provides a new choice for POCT and shows a broad application prospect in all levels of medical clinics and at home.

关键词： gold magnetic nanoparticles loop-mediated isothermal amplification lateral flow assay system free extraction singlenucleotide polymorphisms genotyping

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High sound pressure piezoelectric micromachined ultrasonic transducers using sputtered potassium sodium niobate

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Microsystems & Nanoengineering 2024年第6期10卷 311-323页

作者： Fan Xia Yande Peng Wei Yue Mingze Luo Megan Teng Chun-Ming Chen Sedat Pala Xiaoyang Yu Yuanzheng Ma Megha Acharya Ryuichi Arakawa Lane W.Martin Liwei Lin Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA School of Electronic Science and Engineering Southeast UniversityNanjingJiangsu 210096China Bioengineering and Biomedical Engineering Xi’an Jiaotong UniversityXi’anShaanxi 710049China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Scientific Research Laboratory Div. Niterra Co.LtdNagoya 461-0005Japan Departments of Materials Science and NanoEngineering Chemistryand Physics and Astronomy and the Rice Advanced Materials InstituteRice UniversityHoustonTX 77005USA

This work presents air-coupled piezoelectric micromachined ultrasonic transducers(pMUTs)with high sound pressure level(SPL)under low-driving voltages by utilizing sputtered potassium sodium niobate K0.34Na0.66NbO3(KNN)films.A prototype single KNN pMUT has been tested to show a resonant frequency at 106.3 kHz under 4 Vp-p with outstanding characteristics:(1)a large vibration amplitude of 3.74μm/V,and(2)a high acoustic root mean square(RMS)sound pressure level of 105.5 dB/V at 10 cm,which is 5–10 times higher than those of AlN-based pMUTs at a similar *** are various potential sensing and actuating applications,such as fingerprint sensing,touch point,and gesture *** this work,we present demonstrations in three fields:haptics,loudspeakers,and *** haptics,an array of 15×15 KNN pMUTs is used as a non-contact actuator to provide a focal pressure of around 160.3 dB RMS SPL at a distance of 15 *** represents the highest output pressure achieved by an airborne pMUT for haptic sensation on human *** used as a loudspeaker,a single pMUT element with a resonant frequency close to the audible range at 22.8 kHz is *** is shown to be able to generate a uniform acoustic output with an amplitude modulation *** the rangefinder application,pulse-echo measurements using a single pMUT element demonstrate good transceiving results,capable of detecting objects up to 2.82 m *** such,this new class of high-SPL and low-driving-voltage pMUTs could be further extended to other applications requiring high acoustic pressure and a small form factor.

关键词： potassium piezoelectric sound

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Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm for Parallel Imaging of Magnetic Resonance Imaging 5

Parameter Analysis on Sensitivity Encoding (SENSE) Algorithm...

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5th IEEE International Conference on Information Technology, Information Systems and Electrical engineering, ICITISEE 2021

作者： Ariani, Fitria Basari, Basari Universitas Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering 16424 Indonesia Biomedical Engineering Program Departmen Of Electrical Engineering Faculty Of Engineering Universitas Indonesia Indonesia

ISBN: (纸本)9781665401968

Magnetic Resonance Imaging (MRI) is one of the most prominent medical imaging technologies for examining human bones and soft tissues. However, it has a shortcoming of long scan time. To overcome this problem, parallel imaging is used to reduce scan time by using multiple coil receivers and under-sampled k-space data which lead to aliasing and artifact images. Sensitivity Encoding (SENSE) is one of the parallel imaging algorithms that work in the image domain to unfolding the aliased images. However, the use of SENSE algorithm is limited by its parameter. This study aims to investigate how parameters in the SENSE algorithm influence MRI image reconstruction via simulation. During the simulation, we used a variation of number of coils (nc) and acceleration factor (R). In order to analyze the data, we use structural similarity index measure (SSIM) and mean squared error (MSE) as the image quality assessment (IQA) methods. According to the IQA parameter, the results showed that number of coils and acceleration factor are correlated. The best IQA result in SENSE reconstructed image comes from the variation of nc = 16 and R = 2, which has the lowest MSE value (0.01405) and the highest SSIM value (0.8384). A higher acceleration factor number causes more aliasing and noise while more number of coils can make the reconstruction image better. Nevertheless, number of coils with the right number of acceleration factor will result in a good reconstructed image. This study showed that SENSE is capable of retrieving good reconstruction images by using the right parameters. © 2021 IEEE.

关键词： Magnetic resonance imaging

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Optimizing ultra-wideband balanced power amplifiers through the selection of different output impedance transformation based on SiP techniques

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AIP Advances 2024年第2期14卷 025234-025234页

作者： Hong, Chung-Hung Cheng, Sheng-Jen Shen, Pi-Neng Chen, Chung-Ping Department of Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404333 Taiwan Graduate Institute of Electronics Engineering National Taiwan University Taipei10617 Taiwan Electronic and Computer Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan

In this paper, two improved ultra-wideband (UWB) balanced power amplifiers based on the flip-chip system-in-package technique and electronic design automation (EDA) are proposed. The conventional approach to system-on-chip (SoC) involves integrating all sub-circuit designs into a single manufacturing process. However, in radio frequency circuits, adopting the SoC approach necessitates intricate matching designs, leading to an increase in development costs. In this study, two types of SiGe unit power amplifiers attempted to achieve a flat S21 response using simpler matching for input/output. The cascode architecture was adopted as the main structure for the first type of unit power amplifier (type I). Subsequently, the design of the second type unit power amplifier was built upon the foundation of the first type, with the only difference being the implementation of two parallel cascode structures (type II), and the primary goal is to enhance both gain and output power compared to the first type. In addition, for this second type unit power amplifier, in conjunction with a quadrature hybrid coupler, the optimal impedance matching value was selected to maintain the flatness of gain across the entire UWB range. Furthermore, the poor performance of S11,22 of these two types of unit power amplifiers was improved by using quadrature hybrid couplers using the WIPD process combined with EDA simulation. Therefore, using flip-chip packaging technology can effectively reduce the increased wafer fabrication costs caused by complex matching designs in active circuits. This improved system has the potential to offer a new practical application for UWB power amplifier design. © 2024 Author(s).

关键词： Power amplifiers

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Room-Temperature and Compressive Force-Free Metal-Metal Direct Bonding for Heterogeneous Integration of Micro-LED Array on 3D-IC

Room-Temperature and Compressive Force-Free Metal-Metal Dire...

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IEEE International Conference on 3D System Integration, 3DIC

作者： Jiayi Shen Chang Liu Tetsu Tanaka Takafumi Fukushima Dept. Mechanical Systems Engineering Graduate School of Engineering Tohoku University Sendai Japan Dept. Mechanical Systems Engineering Dept. Mechanical Systems Engineering Graduate School of Engineering Graduate School of Engineering Tohoku University Sendai Japan Dept. of Biomedical Engineering Dept. Mechanical Systems Engineering Graduate School of Biomedical Engineering Graduate School of Engineering Tohoku University Sendai Japan

ISBN: (数字)9798331516505

ISBN: (纸本)9798331516512

This paper presents enhanced room-temperature bonding for micro-LEDs tailored to Smart Skin Display applications. While our prior work utilizing a Semi-Additive Plating (SAP) process achieved a micro-LED bonding yield of 90%, further advancements necessitate addressing challenges in sidewall GaN layer insulation deposition and complete seed layer removal. We propose an enhanced SAP (eSAP) process incorporating a novel micro-LED structure and a well-designed Cu seed pattern. Successful illumination of the fabricated micro-LEDs was demonstrated. Furthermore, we investigated the possibility of an advanced SAP (aSAP) with electroless Ni plating, eliminating the need for final seed layer removal, thereby simplifying the process and enhancing reliability. This approach represents a promising solution for room- or low-temperature micro-LED bonding.

关键词： Electric potential Insulation Three-dimensional displays System integration Plating Nickel Skin Reliability Yield estimation Bonding

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Contactless Seismocardiography Via Gunnar-Farneback Optical Flow

Contactless Seismocardiography Via Gunnar-Farneback Optical ...

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International Workshop on Wearable and Implantable Body Sensor Networks (BSN)

作者： Mohammad Muntasir Rahman Amirtahà Taebi Biomedical Engineering Program Mississippi State University Mississippi State MS USA

ISBN: (数字)9798331530143

ISBN: (纸本)9798331530150

Seismocardiography (SCG) has gained significant attention due to its potential applications in monitoring cardiac health and diagnosing cardiovascular conditions. Conventional SCG methods rely on accelerometers attached to the chest, which can be uncomfortable or inconvenient. In recent years, researchers have explored non-contact methods to capture SCG signals, and one promising approach involves analyzing video recordings of the chest. In this study, we investigate a vision-based method based on the Gunnar-Farneback optical flow to extract SCG signals from the chest skin movements recorded by a smart-phone camera. We compared the SCG signals extracted from the chest videos of four healthy subjects with those obtained from accelerometers and our previous method based on sticker tracking. Our results demonstrated that the vision-based SCG signals extracted by the proposed method closely resembled those from accelerometers and stickers, although these signals were captured from slightly different locations. The mean squared error between the vision-based SCG signals and accelerometer-based signals was found to be within a reasonable range, especially between signals on head-to-foot direction (0.2

关键词： Accelerometers Heart rate Seismic measurements Tracking Electrocardiography Skin Robustness Optical flow Monitoring Video recording

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Extracting Cardiovascular-Induced Chest Vibrations from Ordinary Chest Videos: A Comparative Study

Extracting Cardiovascular-Induced Chest Vibrations from Ordi...

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IEEE Signal Processing in Medicine and Biology Symposium (SPMB)

作者： M. Rahman A. Taebi Biomedical Engineering Program Mississippi State University Mississippi State Mississippi USA

ISBN: (数字)9798350388572

ISBN: (纸本)9798350388589

Seismocardiography (SCG) has attracted significant interest for monitoring cardiac health and diagnosing cardiovascular conditions. While traditional SCG methods rely on uncomfortable chest-mounted accelerometers, recent research explores non-contact approaches, including analyzing video recordings of the chest. In this study, three computer vision-based methods including Lucas-Kanade optical flow, template tracking, and Gunnar-Farneback optical flow were evaluated for extracting SCG signals from ordinary camera-recorded chest videos. The study focused on right-to-left and head-to-foot SCG signals obtained from 13 healthy subjects during breath-hold at the end of exhalation and inhalation. Comparative analysis was performed by calculating the mean squared error (MSE) and root MSE (RMSE) between the vision-based SCG signals and the gold-standard accelerometer signals. Visual and quantitative analyses showed that the Lucas-Kanade and template tracking methods estimated vision-based SCG signals closely resembling the accelerometer data, particularly in the head-to-foot direction. The Lucas-Kanade method had MSE values ranging from 0.14 to 0.93, RMSE values from 0.38 to 0.96, average correlation values of 0.82±0.09. The template tracking method showed MSE values between 0.12 to 0.94, RMSE values from 0.35 to 0.97, and average correlation values of 0.83±0.10. In comparison, the Farneback method had higher MSE values ranging from 0.20 to 1.07, RMSE values from 0.44 to 1.03, and average correlation values of 0.76±0.11. These results suggest the effectiveness of Lucas-Kanade and template tracking methods for non-contact SCG signal extraction from chest video data.

关键词： Accelerometers Vibrations Visualization Correlation Statistical analysis Vibration measurement Distance measurement Optical flow Monitoring Video recording

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Dynamic Insights into Lower Urinary Tract Function: Exploring Intraindividual and Interindividual Variability through Personalized Mathematical Modeling 46

Dynamic Insights into Lower Urinary Tract Function: Explorin...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Zaid, Mohamed Hendrick, Caleb Alhajjar, Elie Yin, John Danziger, Zachary C. Guidoboni, Giovanna University of Maine Graduate School of Biomedical Science and Engineering OronoME United States Maine College of Engineering and Computing OronoME United States Rand Engineering and Applied Sciences Department ArlingtonVA United States University of Wisconsin-Madison Wisconsin Institute for Discovery MadisonWI United States Emory University Division of Physical Therapy Department of Rehabilitation Medicine GA United States Emory University W.H. Coulter Department of Biomedical Engineering GA United States

ISBN: (纸本)9798350371499

This study proposes a novel approach to obtain personalized estimates of Lower Urinary Tract Function leveraging on the simulated and experimentally acquired bladder pressure. Our findings reveal the model's adaptability across intraindividual cycles and consistency within specific cohorts, shedding light on the importance of variability in the micturition process. The study emphasizes the significance of intraindividual and interindividual variability, paving the way for improved diagnostics and therapeutic strategies in the field of lower urinary function. © 2024 IEEE.

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Corrigendum to "Effect of cell imprinting on viability and drug susceptibility of breast cancer cells to doxorubicin" [Acta Biomaterialia, 2020, 113, 119-129] (Acta Biomaterialia (2020) 113 (119–129), (S1742706120303287), (10.1016/***.2020.06.007))

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Acta Biomaterialia 2025年 198卷 571-572页

作者： Shahriyari, Fatemeh Janmaleki, Mohsen Sharifi, Shahriar Hesar, Milad Eyvazi Hoshian, Sasha Taghiabadi, Reza Razaghian, Ahmad Ghadiri, Majid Peirovi, Afshin Mahmoudi, Morteza Nezhad, Amir Sanati Khademhosseini, Ali Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School CambridgeMA United States Division of Health Sciences & Technology Harvard-Massachusetts Institute of Technology Massachusetts Institute of Technology CambridgeMA United States Department of Materials Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Biomedical Engineering Graduate Program University of Calgary Canada Precision Health Program and Department of Radiology Michigan State University East LansingMI48824 United States RWTH Aachen University Templergraben 55 Aachen52062 Germany Department of Chemistry and Materials Science Aalto University School of Chemical Engineering Espoo Finland Department of Mechanical Engineering Faculty of Engineering Imam Khomeini International University Qazvin Iran Nano-Biotechnology Department Pasteur Institute of Iran Tehran Iran Departments of Bioengineering Chemical and Biomolecular Engineering and Radiological Sciences Center for Minimally Invasive Therapeutics California NanoSystems Institute University of California – Los Angeles Los AngelesCA United States Terasaki Institute for Biomedical Innovation Los AngelesCA United States

The authors regret to report that the images for panels h (Plain PDMS) and I (MCF7-imprinted PDMS) in Fig. 3 were mistakenly taken from the same dataset, resulting in the omission of the correct image in panel h for the Plain PDMS day 7 image. We sincerely apologize for this error. For an accurate representation, please see the corrected Fig. 3 provided here along with its original figure caption. This does not affect the validity of the statistical analyses or the overall conclusions drawn from the study. © 2025

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