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IEEE Electron Devices Technology and Manufacturing Conference (EDTM)

作者： Hisashi Kino Takafumi Fukushima Tetsu Tanaka Graduate School of Biomedical Engineering Tohoku University Japan Graduate School of Engineering Tohoku University Japan

Herein, the use of a negative-thermal-expansion (NTE) material as a gate electrode to introduce a large tensile strain into a MOSFET channel is proposed. Manganese nitride (MnN), which has an antiperovskite crystal structure, is an NTE material. MOSFETs with a MnN gate as the negative-thermal-expansion gate electrode (NTEG) are fabricated and evaluated. MOSFETs with an NTEG exhibit a 10% increase in electron mobility. The results indicate that the NTEG is promising as a mobility enhancement technology.

关键词： Electrodes Thermal expansion Tensile strain Crystals Logic gates Electron mobility FinFETs

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A Saliva Fern Recognition with Image Tone Equalization and Detection Method 18th

A Saliva Fern Recognition with Image Tone Equalization and D...

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18th International Conference on Intelligent Information Hiding and Multimedia Signal Processing, IIH-MSP 2022

作者： Chen, Jian-Yu Chuang, Hui-Yu Horng, Mong-Fong Shieh, Chin-Shiuh Department of Electronic Engineering National Kaohsiung University of Science and Technology Kaohsiung Taiwan Department of BS/GYN Kaohsiung Medical University Hospital Kaohsiung Taiwan Program in Biomedical Engineering Kaohsiung Medical University Kaohsiung Taiwan

ISBN: (纸本)9789819901043

Pregnancy preparation has become the daily work of many young married couples. How to know the ovulation period easily and conveniently, the image of fern-like crystals in female saliva is a valuable feature. However, due to the low accuracy of image detection, it is difficult to popularize. This study proposes to use image processing technology to recognize fern-like crystals in female saliva. Different from the previous practice, the preprocessing method of tone equalization and edge detection is proposed to improve recognition quality, particularly recognition sensitivity. The experimental results show that the achieved sensitivity is 100% for test data and the preprocessing, including tone equalization, median filtering, and erosion operations, contributes an improvement in accuracy by 26%. Consequently, the proposed methods are indeed helpful. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Median filters

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Intelligent reflux and suction detection system for ventricular assist devices: in silico study

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Research on biomedical engineering 2025年第1期41卷 1-23页

作者： Santos, Bruno J. Cestari, Idágene A. Biomedical Engineering Graduate Program Polythecnic School of Engineering University of Sao Paulo Av. Prof. Luciano Gualberto Travessa 3 nº380 Sao Paulo05508-010 Brazil Department of Information Technology of Universidade São Judas Tadeu Rua Taquari nº546 Sao Paulo03166-000 Brazil Faculdade de Medicina Bioengineering Division - Heart Institute Hospital das Clinicas HCFMUSP Universidade de Sao Paulo LIM Bioengenharia Sao Paulo Sao Paulo Brazil

Introduction: Left ventricular assist devices (LVADs) serve both as a bridge to transplantation and as destination therapy for the treatment of congestive heart failure (CHF). However, the inability of the existing control strategies to automatically adapt LVAD flow according to hemodynamic changes can significantly impact patient survival and quality of life. Physiological control strategies for LVAD show promising results, with reflux and suction detection (RSD) increasing device safety. Methods: This study presents in silico results of an RSD system based on measurements of inlet and outlet pressures in continuous-flow LVAD. Two strategies were used to investigate control feasibility, safety, and adjustments to nonlinear variations and comprehensively assess the system’s state considering a structured algorithm (SA) and ensembles of AI models (eAIm): K-nearest neighbors (KNN), support vector machine (SVM), and artificial neural network (ANN). Results: The SA submodule achieved an accuracy of 99.66% in suction detection but showed limitations in reflux events, with 80.04% accuracy and an F1-Score of 70.4%. The KNN and SVM models demonstrated performance exceeding 96% for both events, exhibiting more excellent stability than the SA submodule. The ANN excelled with low variability and an RMSE of 0.07 in R1, though its suction accuracy (96.7%) was slightly lower than for reflux (99.48%). The KNN was the most effective model, achieving 99.66% accuracy in suction and 98.44% in reflux. The SVM also produced competitive results but with variability across evaluations. The eAIm model showed satisfactory precision (97.78% for suction and 97.14% for reflux), with variations depending on the scenario. The eAIm is recommended for optimization in precision-critical situations. Discussion: These strategies are designed to fulfill the proposal’s feasibility, flexibility, and safety requirements. They address the challenges of achieving consistent reproduction using an SA and the

关键词： Left ventricular assist devices

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Bioinspired MXene-Based Soft Actuators Exhibiting Angle-Independent Structural Color

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Nano-Micro Letters 2023年第1期15卷 1-13页

作者： Pan Xue Yuanhao Chen Yiyi Xu Cristian Valenzuela Xuan Zhang Hari Krishna Bisoyi Xiao Yang Ling Wang Xinhua Xu Quan Li School of Materials Science and Engineering Tianjin UniversityTianjin 300350People’s Republic of China Institute of Advanced Materials School of Chemistry and Chemical EngineeringTech Key Laboratory for Biomedical ResearchSoutheast Universityand Jiangsu Province HiNanjing 211189People’s Republic of China Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOH 44242USA

In nature,many living organisms exhibiting unique structural coloration and soft-bodied actuation have inspired scientists to develop advanced structural colored soft actuators toward biomimetic soft ***,it is challenging to simultaneously biomimic the angle-independent structural color and shape-morphing capabilities found in the plum-throated cotinga flying ***,we report biomimetic MXene-based soft actuators with angle-independent structural color that are fabricated through controlled self-assembly of colloidal SiO_(2) nanoparticles onto highly aligned MXene films followed by vacuum-assisted infiltration of polyvinylidene fluoride into the *** resulting soft actuators are found to exhibit brilliant,angle-independent structural color,as well as ultrafast actuation and recovery speeds(a maximum curvature of 0.52 mm−1 can be achieved within 1.16 s,and a recovery time of~0.24 s)in response to acetone *** proof-of-concept illustrations,structural colored soft actuators are applied to demonstrate a blue gripper-like bird’s claw that can capture the target,artificial green tendrils that can twine around tree branches,and an artificial multicolored butterfly that can flutter its wings upon cyclic exposure to acetone *** strategy is expected to offer new insights into the development of biomimetic multifunctional soft actuators for somatosensory soft robotics and next-generation intelligent machines.

关键词： Bioinspired soft actuator Angle-independent structural color MXene liquid crystals Soft robotics

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Modelling Mechanical Communication and Collective Motion of Cancer Cells 13

Modelling Mechanical Communication and Collective Motion of ...

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Joint 13th International Conference on Soft Computing and Intelligent Systems and 25th International Symposium on Advanced Intelligent Systems, SCIS and ISIS 2024

作者： Hosono, Ryousuke Nakano, Tadashi Hsu, Yu-Hsiang Tang, William C. Osaka City University Department of Electrical and Information Engineering Osaka Japan Graduate School of Informatics Osaka Metropolitan University Osaka Japan Institute of Applied Mechanics National Taiwan University Taipei Taiwan Graduate School of Advanced Technology Taipei Taiwan University of California Biomedical Engineering Department IrvineCA United States

ISBN: (纸本)9798350373332

Understanding the communication mechanisms that drive collective behaviors in cancer is crucial for elucidating cancer progression and metastasis. To investigate communication mechanisms and their impacts on collective cell behaviors in can-cer, our previous study employed time-lapse imaging techniques on cancer cells placed on substrates containing fluorescent beads. In these experiments, we observed bead movements that reflect mechanical cell communication through substrate dynamics and collective cell motions. In this study, our objective is to develop a computational model to reproduce the experimental observations from our previous study. We demonstrated that the model developed in this paper substantiated previous experimental findings and established a foundation for further investigations into the communication mechanisms and collective behaviors in cancer. © 2024 IEEE.

关键词： Lung cancer

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Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flexible Bioelectrodes for Neural Sensing

Mxene/Polydimethylsiloxane (PDMS) Based Implantable and Flex...

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2023 Advances in Science and engineering Technology International Conferences, ASET 2023

作者： Baz Khan, Kashif Rast Al-Othman, Amani Al-Nashash, Hasan Al-Sayah, Mohammad American University of Sharjah Biomedical Engineering Graduate Program Sharjah United Arab Emirates American University of Sharjah Department of Chemical and Biological Engineering Sharjah United Arab Emirates American University of Sharjah Department of Electrical Engineering Sharjah United Arab Emirates American University of Sharjah Chemistry and Environmental Sciences Sharjah United Arab Emirates

ISBN: (纸本)9781665454742

Research applications of neural sensing and muscle stimulation have been advanced by the development of bioelectrodes that are biocompatible, flexible and long lasting. The existing metallic made bioelectrodes exhibit extremely high electrochemical resistances that would interfere with the neural-electrode bridge and suffer from mechanical and immunological mismatch. Novel, flexible, implantable bioelectrodes based on MXenes (Ti3C2) and Polydimethylsiloxane (PDMS) composite are proposed. Mxenes possess the advantage of having metallic ultra-conductive transition metals consisting of large groups of carbides, nitrides, or carbonitrides, while PDMS has inherent biostability, flexibility and biocompatibility. In the current research, PDMS has been used as the supporting matrix for conductive fillers such as PMMA, PEDOT, and Mxenes. A series of characterization techniques were performed such as Electrochemical Impedance Spectroscopy (EIS), Cyclic Voltammetry (CV) and mechanical testing. The average results of triplicate samples exhibited samples' bulk impedance of 0.913 kΩ, an impedance of 1.612 MΩ, at 1 kHz frequency and a conductivity of 1.41x10-4S/cm, charge storage capacity of 0.056 mC/cm2 and Young's modulus of 3.81 MPa. © 2023 IEEE.

关键词： Elastic moduli

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Motor clustering enhances kinesin-driven vesicle transport

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Biophysical Journal 2025年第12期124卷 2033-2040页

作者： Jiang, Rui Feng, Qingzhou Nong, Daguan Kang, You Jung Sept, David Hancock, William O. Intercollege Program in Integrative and Biomedical Physiology Pennsylvania State University University Park PA United States Department of Biomedical Engineering Pennsylvania State University University Park PA United States Molecular Cellular and Integrative Biomedical Sciences Program Pennsylvania State University University Park PA United States Department of Biomedical Engineering University of Michigan Ann Arbor MI United States Department of Chemistry Pennsylvania State University University Park Pennsylvania United States

Intracellular vesicles are typically transported by a small number of kinesin and dynein motors. However, the slow microtubule binding rate of kinesin-1 observed in in vitro biophysical studies suggests that long-range transport may require a high number of motors. To address the discrepancy in motor requirements between in vivo and in vitro studies, we reconstituted motility of 120-nm-diameter liposomes driven by multiple GFP-labeled kinesin-1 motors. Consistent with predictions based on previous binding rate measurements, we found that long-distance transport requires a high number of kinesin-1 motors. We hypothesized that this discrepancy from in vivo observations may arise from differences in motor organization and tested whether motor clustering can enhance transport efficiency using a DNA scaffold. Clustering just three motors increased liposome travel distances across a wide range of motor numbers. Our findings demonstrate that, independent of motor number, the arrangement of motors on a vesicle regulates transport distance, suggesting that differences in motor organization may explain the disparity between in vivo and in vitro motor requirements for long-range transport. © 2025 Biophysical Society

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A high performance small animal PET/CT/MRI Scanner

A high performance small animal PET/CT/MRI Scanner

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IEEE Symposium on Nuclear Science (NSS/MIC)

作者： X. Yu Z. Zhao W. Zhu J. Zeng J. Xie H. Zhao J. Tao H. Liu J. Xu S. Xie W. Wang Q. Peng School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan China School of Biomedical Engineering Southern Medical University Guangzhou China Shenzhen Bay Laboratory Institute of Biomedical Engineering Shenzhen China School of Electronics and Institute of Biomedical Engineering Peking University Shenzhen Graduate School Shenzhen China School of Electronics and Institute of Biomedical Engineering Peking University Beijing China

ISBN: (数字)9798350388152

ISBN: (纸本)9798350388169

PET, CT, and MRI are essential imaging technologies widely used in both clinical diagnostics and biological research. PET scans detect metabolic activity in the body and are commonly used for the diagnosis of cancer, cardiovascular diseases, and brain disorders. CT scans can identify structural abnormalities such as fractures, tumors, and internal bleeding, and are also the most effective method for attenuation correction in PET imaging. MRI is particularly effective for imaging soft tissues, such as the brain, spinal cord, muscles, and joints. We have developed a PET/CT/MRI tri-modality small animal imaging system that uses a mechanical arm to switch between imaging modes, ultimately achieving tri-modal imaging in mice. The PET component was developed in-house by our team. It features an imaging field of view with a diameter of 78mm and an axial field of view of 84mm. LYSO is used as the scintillator crystal. Image reconstruction is performed using the OSEM algorithm with five iterations, achieving a spatial resolution of approximately 0.7mm within the field of view. In the future, we plan to integrate these tri-modal systems to enhance image reconstruction, image correction, and support biological research.

关键词： Spinal cord Magnetic resonance imaging Computed tomography Imaging Switches Biology Spatial resolution

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NIR regeneration and visible luminescence modification in photochromic glass:A novel encryption and 3D optical storage medium

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InfoMat 2024年第9期6卷 123-134页

作者： Heping Zhao Yuewei Li Chao Mi Yingzhu Zi Xue Bai Asif Ali Haider Yangke Cun Anjun Huang Yue Liu Jianbei Qiu Zhiguo Song Jiayan Liao Ji Zhou Zhengwen Yang College of Materials Science and Engineering Kunming University of Science and TechnologyKunmingPeople's Republic of China Southwest United Graduate School KunmingPeople's Republic of China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNew South WalesAustralia State Key Lab of New Ceramics and Fine Processing Department of Materials Science and EngineeringTsinghua UniversityBeijingPeople's Republic of China

Photochromic glass shows great promise for 3D optical information encryption and storage *** formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochromic glass ***,extending this approach to other metal nanoclusters remains a *** this study,we present a pioneering method for crafting photochromic glass with reliably adjustable dual-mode luminescence in both the NIR and visible *** was achieved by leveraging bimetallic clusters of bismuth,resulting in a distinct and novel photochromic *** rare-earth-doped,bismuth-based glass is irradiated with a 473 nm laser,and it undergoes a color transformation from yellow to red,accompanied by visible and broad NIR *** phenomenon is attributed to the formation of laserinduced(Bi^(+),Bi^(0))*** achieved reversible manipulation of the NIR luminescence of these nanoclusters and visible rare-earth luminescence by alternating exposure to a 473 nm laser and thermal *** patterns can be inscribed and erased on a glass surface or in 3D space,and the readout is enabled by modulating visible and NIR *** study introduces a pioneering strategy for designing photochromic glasses with extensive NIR luminescence and significant potential for applications in highcapacity information encryption,optical data storage,optical communication,and NIR *** exploration of bimetallic cluster formation in Bi represents a vital contribution to the advancement of multifunctional glass systems with augmented optical functionalities and versatile applications.

关键词： optical storage photochromic glass reproducible NIR luminescence

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Estimation of Fractional Flow Reserve in Coronary Artery Based on Serial Intravascular Ultrasound Images*

Estimation of Fractional Flow Reserve in Coronary Artery Bas...

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IEEE Symposium (IUS) Ultrasonics

作者： Yoshifumi Saijo Takashi Orihara Naoya Kanno Hiroyuki Yagami Takuro Ishii Graduate School of Biomedical Engineering Tohoku University Sendai Japan

Fractional flow reserve (FFR) is used to determine the indication of percutaneous coronary intervention (PCI). Serial intravascular ultrasound (IVUS) images were obtained with an IVUS system with the central frequency of 60-MHz using an automatic pull-back (0.5 mm/s) system. 1) Lumen of coronary artery was segmented by U-Net neural network to optimize the intersection over union (IoU) loss function. 2) The centroid of the segmented lumen was used to reconstruct 3D morphology of coronary artery. 3) Finally, computed fluid dynamics (CFD) was applied to the 3D morphology of coronary artery to visualize the pressure distribution in coronary artery. IVUS provides the mechanical properties of the vascular wall by elastography or palpography techniques. Because both the 3D geometry and the wall properties are obtainable with serial IVUS images, better CFD simulation would be available. This study showed that the principles of intracoronary blood flow and pressure drop estimation were possible from serial IVUS images. Clinical application of IVUS-based estimation of FFR is expected in the near future.

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