检索结果-内蒙古大学图书馆

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Laicong Qiao Tianruo Guo Ruier Xue Rui Sang Danting Yang Fei Deng Graduate School of Biomedical Engineering and Tyree Institute of Health Engineering UNSW Sydney Australia School of Medicine Ningbo University China

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Cytokines, essential regulatory proteins orchestrating various physiological processes and immune responses, play a pivotal role in assessing health status. Conventional cytokine detection methods, such as enzyme-linked immunosorbent assays, are reliable but time-consuming. Electrochemical aptamer-based sensors offer rapid response and higher selectivity, but fall short of achieving non-invasive detection. This study addresses these limitations by introducing a novel approach to improve cytokine detection performance. We employ a one-step electrodeposition method to synthesize and coat structured gold nanoparticles (Au NPs) onto a working electrode, optimizing surface morphology by manipulating applied voltage, deposition time, and reactant concentrations. The resulting nanostructured Au NPs exhibit diverse and previously unreported morphologies. Leveraging these advancements, we design a wearable device integrating the Au NPs-based sensor with structure-switch aptamers on a microfluidic chip. This wearable sensor shows a limit of detection of 0.3 pg/mL and a larger linear range of 0.3-100 pg/mL. This innovation allows for the non-invasive and continuous detection of cytokines, marking a significant step towards the development of wearable electrochemical biosensors for health *** Relevance— This research provides a novel wearable sensor for non-invasive continuous monitoring of cytokine IFN-γ from human sweat. This innovation holds immense clinical relevance, offering real-time insights into early disease responses and the onset of non-communicable health conditions. The advancement of wearable electrochemical biosensors, exhibiting enhanced performance, addresses a crucial need in clinical practice. This development offers a versatile and efficient tool for patient-friendly health monitoring, marking a significant step forward in the field.

关键词： Nanoparticles Gold Technological innovation Morphology Biosensors biomedical monitoring Wearable devices Wearable sensors Monitoring Immune system

来源：评论

学校读者我要写书评

暂无评论

Novel Fabrication of Ultra-thin Copper/SS304L Composite Microchannels 14th

Novel Fabrication of Ultra-thin Copper/SS304L Composite Micr...

引用

14th International Conference on Technology of Plasticity, ICTP 2023

作者： Ren, Mengyuan Xie, Haibo Lin, Fei Jia, Fanghui Huo, Mingshuai Wu, Hui Yuan, Shengnan Yang, Ming Manabe, Ken-ichi Jiang, Zhengyi School of Mechanical Materials Mechatronic and Biomedical Engineering University of Wollongong WollongongNSW2522 Australia Graduate School of System Design Tokyo Metropolitan University Tokyo Hino-Shi191-0065 Japan Department of Mechanical Engineering Tokyo Metropolitan University Tokyo Hachioji192-0397 Japan

ISBN: (纸本)9783031409196

Microchannels on metallic substrates are essential parts of microreactors, micro heat exchangers, micro heat sinks, and fuel cell bipolar plates. Because of superior properties, such as good corrosion resistance, excellent thermal conductivity, high strength, excellent ductility and structural stability, composite metal foils are gaining popularity as substrates for microchannels. With the increasing demands of low cost, high efficiency and accuracy, novel micro forming technologies must be capable of creating intricate and precise micro features of microchannels at a low cost. An ultra-thin metal foil rolling for the fabrication of micro composite channels is proposed in this study, which can improve product function and reduce operational costs. Copper/ stainless steel 304L (SS304L) composite foils with a thickness of 0.41 mm after annealing treatment at 800 ℃ and holding for 0.5 h, 1.0 h and 2.0 h are used to fabricate microchannels under the rolling reduction of 60.9%. The hardness of composite foils has been characterised before and after different annealing processes, in which the hardness decreases due to the synergistic effects of decreased dislocation density, grain coarsening and phase transformation. Further, the formability of composite foils after annealing is discussed. In addition, the processing characteristics, material deformation behaviours and mechanisms during micro rolling are also investigated. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Fabrication

来源：评论

学校读者我要写书评

暂无评论

The direct influence of retinal degeneration on electrical stimulation efficacy: Significant implications for retinal prostheses

The direct influence of retinal degeneration on electrical s...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Keith Ly Nigel H. Lovell Madhuvanthi Muralidharan Michael L. Italiano David Tsai Mohit N. Shivdasani Tianruo Guo Socrates Dokos Graduate School of Biomedical Engineering and Tyree Institute of Health Engineering UNSW Sydney NSW Australia

Photoreceptor loss and inner retinal network remodeling severely impacts the ability of retinal prosthetic devices to create artificial vision. We developed a computational model of a degenerating retina based on rodent data and tested its response to retinal electrical stimulation. This model includes detailed network connectivity and diverse neural intrinsic properties, capable of exploring how the degenerated retina influences the performance of electrical stimulation during the degeneration process. Our model suggests the possibility of quantitatively modulating retinal ON and OFF pathways between phase II and III of retinal degeneration without requiring any differences between ON and OFF RGC intrinsic cellular properties. The model also provided insights about how remodeling events influence stage-dependent differential electrical responses of ON and OFF *** Relevance—This data-driven model can guide future development of retinal prostheses and stimulation strategies that may benefit patients at different stages of retinal disease progression, particularly in the early and mid-stages, thus increasing their global acceptance.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Universal nanocomposite coating with antifouling and redox capabilities for electrochemical affinity biosensing in complex biological fluids

引用

Nanoscale Horizons 2024年第5期9卷 843-852页

作者： Bharti, Aditya Manu Rakesh Kumar, R.K. Chuang, Cheng-Hsin Shaikh, Muhammad Omar International PhD Program for Science National Sun Yat-sen University Kaohsiung80424 Taiwan Institute of Medical Science and Technology National Sun Yat-sen University Kaohsiung80424 Taiwan Department of Chemical Engineering National Taiwan University Taipei City10617 Taiwan Institute of Biomedical Engineering and Nanomedicine National Healthcare Research Institutes Miaoli County350 Taiwan National Sun Yat-sen University Kaohsiung80424 Taiwan Sustainability Science and Management Program Tunghai University Taichung407224 Taiwan

Electrochemical affinity biosensors have the potential to facilitate the development of multiplexed point-of-care diagnostics in complex biological fluids. However, their commercial viability has been hindered by challenges such as electrode biofouling and the lack of inherent redox properties. To address this unmet need, we have developed a universal nanocomposite coating which is unique in its ability to not only allow oriented conjugation of the biorecognition element but also specific detection directly in complex biological fluids like serum and urine owing to its built-in antifouling and redox capabilities, thus improving suitability for point of care testing. This multifunctional coating comprises a 3D porous crosslinked bovine serum albumin matrix for oriented conjugation and antifouling properties with embedded graphene nanosheets modified with amino-ferrocene for enhanced conductivity and mediator-free biosensing. The coating showed minimal signal degradation despite prolonged exposure to 1% bovine serum albumin, artificial urine and untreated human serum for up to 30 days. To demonstrate its utility, we fabricated and tested proof-of-concept electrochemical immunosensors for bladder cancer protein biomarkers, specifically interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF). The practical feasibility was highlighted by the excellent sensitivity and specificity observed for IL-8 and VEGF with a limit of detection of 41 pg mL−1 and 67 pg mL−1, respectively. Consequently, this universal nanocomposite-based electrochemical biosensing platform can be extended to the point of care testing of a broad spectrum of biomarkers present in complex biological fluids, thus enabling reliable and early diagnostics. © 2024 The Royal Society of Chemistry

关键词： Biomarkers

来源：评论

学校读者我要写书评

暂无评论

A Computer Simulation Test for Validation of Linear Model Predictive Control with Nonlinear Transformation for FES in Wrist Joint Control 6

A Computer Simulation Test for Validation of Linear Model Pr...

引用

6th International Conference on Intelligent Informatics and biomedical Sciences, ICIIBMS 2021

作者： Arrofiqi, Fauzan Watanabe, Takashi Arifin, Achmad Tohoku University Graduate School of Biomedical Engineering Sendai Japan Institut Teknologi Sepuluh Nopember Department of Biomedical Engineering Surabaya Indonesia

ISBN: (纸本)9781728167145

Functional Electrical Stimulation (FES) can be effectively utilized to restore a paralyzed motor function. The purpose of this paper is to examine the developed FES controller based on a linear Model Predictive Control (MPC) using an average subject model and a simple nonlinear transformation for FES. The configuration of the proposed controller was aimed to make a simple design procedure with fewer parameters adjustments than the general method, thus reducing the time-consuming at the initial setup for practical application. The controller was tested in controlling the 1-DOF movement of the wrist joint (palmar flexion) by stimulating flexor carpi radialis (FCR) through computer simulation. The computer simulation test showed that the proposed controller worked well and was able to track the target movement trajectory with a small tracking error. An average model in MPC and a simple nonlinear transformation were suggested to be useful for FES application. © 2021 IEEE.

关键词： Model predictive control

来源：评论

学校读者我要写书评

暂无评论

GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics

引用

Cancer Science 2025年第4期116卷 862-870页

作者： Furukawa, Koichi Ohmi, Yuhsuke Hamamura, Kazunori Ohkawa, Yuki Hashimoto, Noboru Tajima, Orie Kaneko, Kei Furukawa, Keiko Department of Biomedical Sciences Chubu University College of Life and Health Sciences Matsumoto Kasugai Japan Department of Molecular Biochemistry Nagoya University Graduate School of Medicine Nagoya Japan Department of Clinical Engineering Chubu University College of Life and Health Sciences Matsumoto Kasugai Japan Department of Pharmacology Aichi Gakuin University School of Dentistry Nagoya Japan Department of GlycoOncology Osaka International Cancer Center Institute Osaka Japan Department of Tissue Regeneration Tokushima University Graduate School of Biomedical Science Tokushima Japan

While various glycosphingolipids were identified as cancer-associated carbohydrate antigens to be used as tumor markers, disialylated gangliosides such as GD3 and GD2 have particularly attracted attention from many researchers as promising cancer-associated antigens. Simultaneously, their functions in cancer and normal tissues have also been reported. Although GD3 is expressed at the early neural developmental stage and in various cancers, it is also found in the activated status of some normal cells such as astrocytes and lymphocytes. On the other hand, GD2 is expressed in more restricted cells than GD3, enabling anti-GD2 immune therapy to be more applicable for immunotherapy. Recently, the expression of GD2 has been reported in various epithelial cancers and neuroectoderm-derived tumors. The involvement of GD2 in cancer stem cell propertiesand the roles of GD2 in the signal modulation to bring about cancer stemness are now some of the most fascinating research topics. Cancer immunotherapy targeting GD2 by anti-GD2 antibody or anti-GD2 CAR-T is now widely being challenged with various modifications such as combination with cytokines, chemotherapy, or immune checkpoint blocking. © 2025 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

关键词： cancer antigen ganglioside immunotherapy lipid rafts signal

来源：评论

学校读者我要写书评

暂无评论

Towards a Healthy AI Tradition: Lessons from Biology and biomedical Science

arXiv

引用

arXiv 2024年

作者： Kasif, Simon Department of Biomedical Engineering Bioinformatics Graduate Program Department of Computer Science Boston University United States Department of Computer Science Tel Aviv University

AI is a magnificent field that directly and profoundly touches on numerous disciplines ranging from philosophy, computer science, engineering, mathematics, decision and data science and economics, to cognitive science, neuroscience and more. The number of applications and impact of AI is second to none and the potential of AI to broadly impact future science developments is particularly thrilling. While attempts to understand knowledge, reasoning, cognition and learning go back centuries, AI remains a relatively new field. In part due to the fact it has so many wide-ranging overlaps with other disparate fields it appears to have trouble developing a robust identity and culture. Here we suggest that contrasting the fast-moving AI culture to biological and biomedical sciences is both insightful and useful way to inaugurate a healthy tradition needed to envision and manage our ascent to AGI and beyond (independent of the AI Platforms used). After all, the human brain is a biological organ produced by evolution and human intelligence is a remarkable bi-product of nature and nurture and their complex interaction. In this perspective, we focus on traditions and culture, namely the commonly observed practices of evaluating, recognizing applauding, critiquing, debating and managing all progress including useful advances and discovery of challenging limitations. We are not discussing specific scientific exchanges between AI and Biology that include interdisciplinary cross fertilization of scientific methods, technology, ideas and applications that have been amply demonstrated and will continue to be transformative in the future. In a previous perspective, we suggested that biomedical laboratories or centers can usefully embrace logistic traditions in AI labs that will allow them to be highly collaborative, improve the reproducibility of research, reduce risk aversion and produce faster mentorship pathways for PhDs and fellows. This perspective focuses on the benefits of AI a

关键词： Biological organs

来源：评论

学校读者我要写书评

暂无评论

Design and Feasibility Test of In-House Indirect Perfusion Bioreactor for 3-D Cell Culture 15

Design and Feasibility Test of In-House Indirect Perfusion B...

引用

15th biomedical engineering International Conference, BMEiCON 2023

作者： Suwannaphan, T. Tharasanit, T. Wongpakham, T. Pimpin, A. Chessadangkul, K. King Mongkut's University of Technology North Bangkok Department of Mechanical Engineering Technology Bangkok Thailand Faculty of Veterinary Science Chulalongkorn University Department of Obstetrics Gynaecology and Reproduction Bangkok Thailand Chulalongkorn University Faculty of Engineering Department of Mechanical Engineering Bangkok Thailand Chulalongkorn University Biomedical Engineering Program Faculty of Engineering Bangkok Thailand

ISBN: (纸本)9798350345247

Selection of bioreactor system depends on many factors such as type of products, process of culture, and product density. No standard for development methodology is available nowadays. This work demonstrated the development of multi mini-chamber indirect perfusion bioreactor to support 3-D cell culture. The systems consisted of scaffolds, cell/scaffold retainers, culture tanks with a single peristaltic pump. Flow simulation was conducted to investigate the effects of flow rate and inlets/outlets' position on the distribution of shear stresses on the cell/scaffold cassettes installed inside the bioreactor. The prototype with 4 culture tanks connected in series was tested for long period operation. Lastly, preliminary experiments to culture and differentiate pig muscle stem cells were conducted. The results showed that muscle cells were successfully differentiated both on glass slides and aloe vera scaffolds inside the developed bioreactor. © 2023 IEEE.

关键词： Flow simulation

来源：评论

学校读者我要写书评

暂无评论

Artificial intelligence-based ultrasound imaging technologies for hepatic diseases

引用

iLIVER 2022年第4期1卷 252-264页

作者： Longfei Ma Rui Wang Qiong He Lijie Huang Xingyue Wei Xu Lu Yanan Du Jianwen Luo Hongen Liao Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing100084China Graduate School at Shenzhen Tsinghua UniversityShenzhen518055GuangdongChina

Ultrasound(US)imaging is a non-invasive,real-time,economical,and convenient imaging modality that has been widely used in diagnosing and treating hepatic *** intelligence(AI)technology can predict or make decisions based on the experience of clinical experts and knowledge obtained from training *** technology can help clinicians improve the detection efficiency and evaluate hepatic diseases,promote clinical treatment of the liver,and predict the response of the liver after *** review summarizes the current rapid development of US technology and related AI methods in the diagnosis and treatment of hepatic *** topics include steatosis grading,fibrosis staging,detection of focal liver lesions,US image segmentation,multimodal image registration,and other *** present,the field of AI in US imaging is still in its early *** the future progress of AI technology,AI-based US imaging can further improve diagnosis,reduce medical costs,and optimize US-based clinical *** technology has broad prospects for application to hepatic diseases.

关键词： Artificial intelligence Ultrasound imaging Hepatic diseases Diagnosis and treatment

来源：评论

学校读者我要写书评

暂无评论

Integrated Skin Microperfusion System for Lactate Concentration Monitoring

Integrated Skin Microperfusion System for Lactate Concentrat...

引用

IEEE SENSORS

作者： Noriko Tsuruoka Kenta Tsugueda Yoichi Haga Graduate School of Engineering Tohoku University Sendai Japan Graduate School of Biomedical Engineering Tohoku University Sendai Japan

We developed a continuous lactate measurement system that integrates a microperfusion needle, a bubble removal channel, and an enzyme electrode sensor. The microperfusion needle has a microflow channel fabricated around a thin steel needle, which is covered by a perforated membrane. Using this flow channel, lactate can be collected from subepidermal tissue using the microperfusion method. The needle has sufficient rigidity to be inserted through the skin using an acupuncture needle. The concentration of collected lactate is measured by the enzyme electrode sensor, placed outside the body. This sensor is covered by a bubble-removal flow channel to remove bubbles and prevent them causing measurement noise on the electrode. Integration of the system allows real-time monitoring of lactate concentration in the skin. The bubble-removal flow channel removed bubbles effectively and the sensor had a sufficient measurement range to measure lactate concentration sampled by skin microperfusion. By measuring the perfusion pressure, we demonstrated that there was no leakage or clogging of the perfusate in this system.

关键词：

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：