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arXiv 2017年

作者： Şen, Mustafa Biomedical Engineering Department Izmir Katip Celebi University Izmir Turkey Biomedical Technologies Graduate Program Izmir Katip Celebi University Izmir Turkey

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Safety Issue of Changed Nanotoxicity of Zinc Oxide Nanoparticles in the Multicomponent System

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Particle and Particle Systems Characterization 2019年第10期36卷 1900214-1900214页

作者： Huang, Yanan Ding, Lin Li, Chenchen Wu, Min Wang, Mimi Yao, Chenjie Yin, Xuelian Zhang, Junfeng Liu, Jinliang Zhang, Yong Wu, Minghong Wang, Yanli Institute of Nanochemistry and Nanobiology Shanghai University Shanghai 200444 China Tumor Precision Targeting Research Center Shanghai University Shanghai 200444 China Program in Molecular and Integrative Physiological Sciences Harvard T. H. Chan School of Public Health Harvard University Boston 02115 MA United States Department of Biomedical Engineering National University of Singapore Singapore 119077 Singapore

When nanomaterials are exposed to complex systems, such as food, they may cause significant changes in physical and chemical properties and even toxicity. The toxicity evaluation of complex systems is urgent. Unfortunately, so far, there is no database established about the toxicity changes of nanoparticles in composite systems. In this paper, the changes and toxicity mechanism of zinc oxide nanoparticles (ZnO NPs) in a composite system are studied. The results show that the dissolution of zinc ions (Zn²⁺) in acidic systems (vitamin C, tartaric acid, or citric acid) increases the toxicity of ZnO NPs. However, the toxicity of ZnO NPs is reduced by the complexation effect with Zn²⁺ in phosphoric acid, phosphate, and glutathione systems. The influence of titanium dioxide nanoparticles (TiO₂ NPs) on the toxicity of ZnO NPs depends on size and surface properties. In brief, the intracellular Zn²⁺ homeostasis level is the decisive factor in determining the toxicity change in complex systems. The results indicate that the toxicity changes are very different in combined systems, which may have potential food safety issues, especially for unstable nanoparticles. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

关键词： combined toxicity toxicity mechanism zinc oxide nanoparticles

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Drug delivery behavior of titania nanotube arrays coated with chitosan polymer

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Materials Discovery 2017年 8卷 9-17页

作者： Shidfar, Shahrzad Tavangarian, Fariborz Nemati, Nahid Hassanzadeh Fahami, Abbas Department of Biomedical Engineering Science and Research Branch Islamic Azad University Tehran Iran Mechanical Engineering Program School of Science Engineering and Technology Pennsylvania State University Harrisburg Middletown 17057 PA United States Department of Mechanical Engineering Texas A&M University College Station 77843-3123 TX United States

Titania nanotube (TNT) arrays with the length to diameter ratio of 85:1 were synthetized after anodizing the specimens at the anodizing voltage of 55 V for 2 h. Ultrasonic cleaning procedure in deionized water caused the formation of micro-cracks, clusters of TNT bundles and distortion of the nanotubes;however, acetone medium decreased the risk of fracture and the formation of clusters. To control the drug delivery rate, chitosan polymer was deposited on the surface of TNTs using dip-coating process. The total release of TNTs with 0, 0.29 and 0.45 μm chitosan coating thickness was about 6, 8 and 12 days, respectively. © 2017 Elsevier Ltd

关键词： Acetone Anodization Chitosan polymer Drug delivery Gentamicin Titania nanotube

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Experimental and numerical evaluations of the viscoelastic mechanical behavior of arterial tissue

arXiv

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arXiv 2018年

作者： Leng, Xiaochang Deng, Xiaomin Ravindran, Suraj Kidane, Addis Lessner, Susan M. Sutton, Michael A. Shazly, Tarek School of Civil Engineering and Architecture Nanchang University Jiangxi330031 China College of Engineering and Computing Department of Mechanical Engineering University of South Carolina ColumbiaSC29208 United States School of Medicine Department of Cell Biology & Anatomy University of South Carolina ColumbiaSC29208 United States College of Engineering and Computing Biomedical Engineering Program University of South Carolina ColumbiaSC29208 United States

The viscoelastic properties of arterial tissue dictate vessel behavior in certain disease states, injury modalities, and during some endovascular procedures. In this study, we characterized the viscoelastic mechanical response of porcine abdominal aortic tissue via uniaxial mechanical experiments on vascular tissue samples coupled with full-field surface strain measurements using the 2-D digital image correlation (DIC) technique. The measured stress relaxation response and intimal surface strain field were used to identify material parameters for a proposed viscoelastic anisotropic (VA) constitutive model of the passive arterial wall. The obtained results show that the VA constitutive model is able to capture the viscoelastic mechanical behavior of the arterial tissue over clinically-relevant time scales. The identified material model and numerical simulations provide a comprehensive description of the passive viscoelastic tissue properties of the arterial wall, and a quantitative understanding of the spatial and directional variability underlying arterial tissue mechanical behavior. Copyright © 2018, The Authors. All rights reserved.

关键词： Finite element method

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Author Correction: KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

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Nature medicine 2024年第3期30卷 906页

作者： Ye Li Rafet Basar Guohui Wang Enli Liu Judy S Moyes Li Li Lucila N Kerbauy Nadima Uprety Mohsen Fathi Ali Rezvan Pinaki P Banerjee Luis Muniz-Feliciano Tamara J Laskowski Emily Ensley May Daher Mayra Shanley Mayela Mendt Sunil Acharya Bin Liu Alexander Biederstädt Hind Rafei Xingliang Guo Luciana Melo Garcia Paul Lin Sonny Ang David Marin Ken Chen Laura Bover Richard E Champlin Navin Varadarajan Elizabeth J Shpall Katayoun Rezvani Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA. UTHealth Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center Houston TX USA. Human Genome and Stem Cell Research Center Department of Genetics and Evolutionary Biology Biosciences Institute University of Sao Paulo Sao Paulo Brazil. Department of Stem Cell Transplantation and Cellular Therapy Hospital Israelita Albert Einstein Sao Paulo Brazil. Department of Chemical and Biomolecular Engineering University of Houston Houston TX USA. Department of Medicine III: Hematology and Oncology Technical University of Munich Munich Germany. Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Immunology The University of Texas MD Anderson Cancer Center Houston TX USA. Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston TX USA. KRezvani@***.

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A miniaturized clark oxygen sensor for organ-on-chip devices 22

A miniaturized clark oxygen sensor for organ-on-chip devices

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22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018

作者： Bossink, Elsbeth G.B.M. Henry, Olivier Y.F. Benz, Maximilian A. Segerink, Loes I. Ingber, Donald E. Odijk, Mathieu BIOS Lab on a Chip group MESA+ Institute of Nanotechnology MRA Institute for Biomedical Technology and Technical Medicine Max Planck Center for Complex Fluid Dynamics University of Twente Netherlands Wyss Institute for Biologically Inspired Engineering Harvard University BostonMA02115 United States Harvard John A. Paulson School of Engineering and Applied Sciences CambridgeMA02138 United States Vascular Biology Program and Department of Surgery Boston Children’s Hospital Harvard Medical School BostonMA02115 United States

ISBN: (纸本)9781510897571

Oxygen concentration is an essential regulatory parameter in cell culture and organ-on-chip devices. Measuring variations in oxygen concentration near cells during cell culture can provide a wealth of information on cell viability, cellular activity, cell differentiation and response to external stimuli. Here, we present a miniaturized three-electrode Clark oxygen sensor, which is shown to be biocompatible, protected from biofouling and has a 7.5s response time. This miniaturized sensor allows to measure the oxygen concentration in a microfluidic channel of an organ-on-chip, whereby this chemical microenvironment can be monitored. Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.

关键词： Cell culture

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Blood Transfusion and Risk of Venous Thromboembolism: A Population-Based Cohort Study

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Thrombosis and Haemostasis 2019年第1期120卷 156-167页

作者： Shih-Yi Lin Yun-Lung Chang Hung-Chieh Yeh Cheng-Li Lin Chia-Hung Kao Graduate Institute of Biomedical Sciences and School of Medicine College of Medicine China Medical University Taichung Taiwan Division of Nephrology and Kidney Institute China Medical University Hospital Taichung Taiwan Management Office for Health Data China Medical University Hospital Taichung Taiwan College of Medicine China Medical University Taichung Taiwan Department of Nuclear Medicine and PET Center China Medical University Hospital Taichung Taiwan Center of Augmented Intelligence in Healthcare China Medical University Hospital Taichung Taiwan Department of Bioinformatics and Medical Engineering Asia University Taichung Taiwan

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Gram Typing: Gram‐Typing Using Conjugated Oligoelectrolytes (Adv. Funct. Mater. 42/2020)

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Advanced Functional Materials 2020年第42期30卷

作者： Cheng Zhou James C. S. Ho Geraldine W. N. Chia Alex S. Moreland Lin Ruan Bo Liedberg Staffan Kjelleberg Jamie Hinks Guillermo C. Bazan School of Chemical and Biomedical Engineering Nanyang Technological University Singapore 639798 Singapore Singapore Centre on Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University Singapore 639798 Singapore Department of Chemistry National University of Singapore Singapore 117543 Singapore Centre for Biomimetic Sensor Science School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Interdisciplinary Graduate School Nanyang Technological University Singapore 639798 Singapore Center for Polymers and Organic Solids Departments of Chemistry and Biochemistry and Materials University of California Santa Barbara Santa Barbara CA 93106 USA

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Correction to: Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls

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Respiratory research 2020年第1期21卷 29页

作者： Kristina Krempaska Sandra Barnowski Jacopo Gavini Nina Hobi Simone Ebener Cedric Simillion Andrea Stokes Ronja Schliep Lars Knudsen Thomas K Geiser Manuela Funke-Chambour Department of Pulmonary Medicine Inselspital Bern University Hospital University of Bern CH-3010 Bern Switzerland. Department for BioMedical Research University of Bern Bern Switzerland. Graduate School for Cellular and Biomedical Sciences University of Bern Bern Switzerland. Department of Visceral Surgery and Medicine Department for BioMedical Research Inselspital Bern University Hospital and University of Bern 3010 Bern Switzerland. AlveoliX AG Murtenstrasse 50 3008 Bern Switzerland. ARTORG Center for Biomedical Engineering Research Organs-on-Chip Technologies University of Bern Bern Switzerland. Bioinformatics Unit and SIB Swiss Institute of Bioinformatics University of Bern Bern Switzerland. Institute of Functional and Applied Anatomy Hannover Medical School Hannover Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Member of the German Center for Lung Research (DZL) Hannover Germany. Department of Pulmonary Medicine Inselspital Bern University Hospital University of Bern CH-3010 Bern Switzerland. manuela.funke-chambour@insel.ch. Department for BioMedical Research University of Bern Bern Switzerland. manuela.funke-chambour@insel.ch.

After publication of our article [1], we have been notified that an extra alpha symbol (α) was mistakenly added at the beginning of the title.

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President's Welcome Message

Proceedings of the Annual International Conference of the IE...

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Proceedings of the Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBS 2017年

作者： Lovell, Nigel Graduate School of Biomedical Engineering UNSW Sydney NSW Australia

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