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Molecular Carcinogenesis 2020年第7期59卷

作者： Elizabeth Mitchell Sonali Jindal Tiffany Chan Jayasri Narasimhan Shamilene Sivagnanam Elliot Gray Young Hwan Chang Sheila Weinmann Pepper Schedin Department of Cell Developmental and Cancer Biology Oregon Health and Science University Portland Oregon Cancer Prevention and Control Knight Cancer Institute Oregon Health and Science University Portland Oregon Computational Biology Program Department of Cell Developmental and Cancer Biology Oregon Health and Science University Portland Oregon Department of Biomedical Engineering Oregon Center for Spatial Systems Biomedicine Oregon Health and Science University Portland Oregon Center for Health Research Kaiser Permanente Northwest Portland Oregon

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Cognitive chimera states in human brain networks

arXiv

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arXiv 2018年

作者： Bansal, Kanika Garcia, Javier O. Tompson, Steven H. Verstynen, Timothy Vettel, Jean M. Muldoon, Sarah F. Human Sciences US Army Research Laboratory Aberdeen Proving GroundMD21005 United States Department of Biomedical Engineering Columbia University New YorkNY10027 United States Mathematics Department University at Buffalo – SUNY BuffaloNY14260 United States Department of Biomedical Engineering University of Pennsylvania PhiladelphiaPA19104 United States Department of Psychology Carnegie Mellon University PittsburghPA15213 United States Department of Psychological and Brain Sciences University of California Santa BarbaraCA93106 United States CDSE Program and Neuroscience Program University at Buffalo – SUNY BuffaloNY14260 United States

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Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

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Bone Research 2017年第1期5卷 49-62页

作者： Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen Division of Oral Biology Department of PeriodontologyTufts University School of Dental MedicineBostonMA 02111USA Department of Anatomy Research Center for Integrative MedicineGuangzheu University of Chinese MedicineGuangzhouGuangdong Province 510405China Department of Sciences Center for Sciences and Biomedical EngineeringBostonMA 02115USA Department of Periodontology and Implant Dentistry New York University College of DentistryNew YorkNY 10010USA Department of Anatomy and Cell Biology Tufts University School of Medicine and Sackler School of Graduate Biomedical SciencesBostonMA 02111USA

Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domain- containing 5 （FNDC5） protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue （WAT） and uncoupling protein I （UCP1） expression, leading to an increase in total body energy expenditure by augmented UCPl-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones, including growth plate, trabecular bone, cortical bone, articular cartilage, and bone-tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal （IP） administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-kB ligand （RANKL）- induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice.

关键词： Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism bone

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Nanofiltration of extracellular vesicles from human plasma & their on-chip qualification and quantification with a NanoBioAnalytical platform

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Meta Gene 2018年 17卷 S7-S7页

作者： Obeid Sameh Benoît Le Roy de Boiseaumarie Celine Elie-Caille Wilfrid Boireau Ming Li Chou Thierry Burnouf Pei-Shan Sung Shie-Liang Hsieh Institut FEMTO-ST Univ. Bourgogne Franche Comté CNRS France Graduate Institute of Biomedical Material and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taiwan Institute of Clinical Medicine National Yang Ming University Taipei Taiwan Genomic Research Center Academia Sinica Taiwan Department of Medical Research Taipei Veterans General Hospital Taiwan

One complication of plasma transfusion is non-immune transfusion related acute lung injury (TRALI), which is associated with the formation of neutrophil extracellular traps (NETs) resulting from polymorphonuclear neutrophil (PMN) activation. Activated platelets have recently been shown to trigger NETs formation. We hypothesized that (a) NETs could be promoted by platelet derived microparticles (PMPs) and (b) that 75 nm-nanofiltration of plasma, by removing parts of PMPs, could avoid NETs formation. To better characterize the large spectrum of size and concentration of PMPs in complex media, we combined conventional approaches (Flow Cytometry, TRPS) with an original nanobioanalytical (NBA) platform based on Surface Plasmon Resonance imaging (SPRi) and Atomic Force Microscopy (AFM) techniques. We will demonstrate that this new analytic solution allows: • a label-free follow-up of PMPs capture in real time from various complex media, • a multiplex detection of different PMPs subpopulations, • the determination of the size and morphology of captured PMPs in a range of 20 nm to 1 μm their proteomic studies. We expect that such platform will contribute to (i) a better understanding of the physiological function of Evs subpopulations, (ii) the discovery of specific biomarkers and (iii) to therapeutic follow-up.

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Self-Propelled Initiative Collision at Microelectrodes with Vertically Mobile Micromotors

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Angewandte Chemie 2022年第40期134卷

作者： Dr. Ziyi Guo Dr. Yanfang Wu Dr. Zhouzun Xie Junming Shao Dr. Jian Liu. Dr. Yin Yao Prof. Joseph Wang Prof. Yansong Shen Prof. J. Justin Gooding Dr. Kang Liang School of Chemical Engineering The University of New South Wales Sydney NSW 2052 Australia Australian Centre for NanoMedicine The University of New South Wales Sydney NSW 2052 Australia Contribution: Conceptualization (equal) Data curation (lead) Formal analysis (equal) Investigation (equal) Methodology (equal) Writing - original draft (lead) Writing - review & editing (supporting) School of Chemistry The University of New South Wales Sydney NSW 2052 Australia Contribution: Data curation (supporting) Formal analysis (equal) Investigation (supporting) Methodology (equal) Writing - review & editing (supporting) Contribution: Data curation (supporting) Formal analysis (supporting) Investigation (supporting) Methodology (equal) Writing - review & editing (supporting) School of Materials Science and Engineering Central South University Changsha 410083 China Contribution: Formal analysis (supporting) Writing - review & editing (supporting) Contribution: Formal analysis (supporting) Investigation (supporting) Writing - review & editing (supporting) Electron Microscope Unit The University of New South Wales Sydney NSW 2052 Australia Contribution: Data curation (supporting) Writing - review & editing (supporting) Department of Nanoengineering University of California San Diego La Jolla CA 92093 USA Contribution: Supervision (supporting) Writing - review & editing (supporting) Contribution: Supervision (equal) Writing - review & editing (supporting) Graduate School of Biomedical Engineering The University of New South Wales Sydney NSW 2052 Australia Contribution: Conceptualization (equal) Funding acquisition (lead) Methodology (supporting) Resources (lead) Supervision (equal) Writing - original draft (supporting) Writing - review & editing (equal)

Impact experiments enable single particle analysis for many applications. However, the effect of the trajectory of a particle to an electrode on impact signals still requires further exploration. Here, we investigate the particle impact measurements versus motion using micromotors with controllable vertical motion. With biocatalytic cascade reactions, the micromotor system utilizes buoyancy as the driving force, thus enabling more regulated interactions with the electrode. With the aid of numerical simulations, the dynamic interactions between the electrode and micromotors are categorized into four representative patterns: approaching, departing, approaching-and-departing, and departing-and-reapproaching, which correspond well with the experimentally observed impact signals. This study offers a possibility of exploring the dynamic interactions between the electrode and particles, shedding light on the design of new electrochemical sensors.

关键词： Biocatalysis Electrochemistry Metal–Organic Frameworks Micromotors Particle Impact

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Implementation of Size-Specific 3D Beam Modulation Filters On a Dedicated Breast CT Platform Using Breast Immobilization

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MEDICAL PHYSICS 2016年第6期43卷 3819-3820页

作者： Hernandez, A. Boone, J. Department of Radiology Biomedical Engineering Graduate Group University of California Davis Sacramento CA Departments of Radiology and Biomedical Engineering University of California Davis Sacramento CA

Purpose: To implement a 3D beam modulation filter (3D-BMF) in dedicated breast CT (bCT) and develop a method for conforming the patient's breast to a pre-defined shape, optimizing the effects of the filter. This work expands on previous work reporting the methodology for designing a 3D-BMF that can spare unnecessary dose and improve signal equalization at the detector by preferentially filtering the beam in the thinner anterior and peripheral breast regions. Methods: Effective diameter profiles were measured for 219 segmented bCT images, grouped into volume quintiles, and averaged within each group to represent the range of breast sizes found clinically. These profiles were then used to generate five size-specific computational phantoms and fabricate five size-specific UHMW phantoms. Each computational phantom was utilized for designing a size-specific 3D-BMF using previously reported methods. Glandular dose values and projection images were simulated in MCNP6 with and without the 3DBMF using the system specifications of our prototype bCT scanner “Doheny”. Lastly, thermoplastic was molded around each of the five phantom sizes and used to produce a series of breast immobilizers for use in conforming the patient's breast during bCT acquisition. Results: After incorporating the 3D-BMF, MC simulations estimated an 80% average reduction in the detector dynamic range requirements across all phantom sizes. The glandular dose was reduced on average 57% after normalizing by the number of quanta reaching the detector under the thickest region of the breast. Conclusion: A series of bCT-derived breast phantoms were used to design size-specific 3D-BMFs and breast immobilizers that can be used on the bCT platform to conform the patient's breast and therefore optimally exploit the benefits of the 3D-BMF. Current efforts are focused on fabricating several prototype 3D-BMFs and performing phantom scans on Doheny for MC simulation validation and image quality analysis. Research repor

关键词： Three dimensional sensing Image sensors Computed tomography Monte Carlo methods Three dimensional image processing Medical image segmentation Image scanners Particle beam detectors Medical image quality

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Monitoring joint blood flow with DCE TR-NIRS to assess treatment response in rheumatoid arthritis

Monitoring joint blood flow with DCE TR-NIRS to assess treat...

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Clinical and Translational Biophotonics, TRANSLATIONAL 2018

作者： Ioussoufovitch, Seva Morrison, Laura B. Desjardins, Lise Hadway, Jennifer A. Lawrence, Keith St Lee, Ting-Yim Beier, Frank Diop, Mamadou Department of Biomedical Engineering Western University LondonONN6A 5C1 Canada Imaging Program Lawson Health Research Institute 268 Grosvenor Street LondonONN6A 4V2 Canada Department of Medical Biophysics Western University LondonONN6A 5C1 Canada Imaging Program Robarts Research Institute 1151 Richmond St. North LondonONN6A 5B7 Canada Department of Physiology and Pharmacology Western University LondonONN6A 5C1 Canada

Dynamic contrast-enhanced (DCE) TR-NIRS was used to monitor joint blood flow in a rat model of rheumatoid arthritis (RA) during disease induction and treatment. Preliminary results suggest DCE TR-NIRS can monitor trea... 详细信息

ISBN: (纸本)9781943580415

关键词： Blood

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Learning-based feature extraction for active 3D scan with reducing color crosstalk of multiple pattern projections

Learning-based feature extraction for active 3D scan with re...

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2017 IEEE International Conference on Robotics and Automation, ICRA 2017

作者： Sagawa, Ryusuke Furukawa, Ryo Matsumoto, Akiko Kawasaki, Hiroshi Intelligent Systems Research Institute National Institute of Advanced Industrial Science and Technology Tsukuba Ibaraki Japan Graduate School of Information Science Hiroshima City University Hiroshima Japan Information and Biomedical Engineering Kagoshima University Kagoshima Japan

ISBN: (纸本)9781509046331

3D reconstruction methods based on active stereo technique have been widely used for many practical systems. Many of these systems are configured with a single camera and a single projector. Since such systems can only capture one side of the target object, several attempts have been conducted to enlarge the captured area, especially multi-projector systems attract many researchers. For multi-projector based systems, overlap between multiple pattern projections is a serious problem. Even if different color channels are used for each projector, complete separation is not possible because of color crosstalks. Another open problem is decoding errors of the projected patterns, which causes a failure on extracting positional information of the projected pattern form the captured image. Among several reasons for such errors, color crosstalks are crucial because their features are similar to the main signal and difficult to be decomposed. In this paper, we solve these problems by utilizing machine learning techniques where a convolutional neural network is trained to extract low dimensional pattern features for each projector. In addition, it is trained to suppress the color crosstalks from different projectors. Using this new technique, we succeeded in reconstructing 3D shapes from images where multiple patterns are overlapped. © 2017 IEEE.

关键词： Neural networks

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Marked point identification for interventional operation navigation of digital subtraction angiography image based on triangle topology

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Journal of engineering Science and Technology Review 2016年第6期9卷 142-148页

作者： Wang, Boyang Chen, Bin Wu, Jian Research Center of Biomedical Engineering Graduate School at Shenzhen Tsinghua University Shenzhen518055 China Department of Biomedical Engineering Tsinghua University Beijing100084 China Chinese Medicine Hospital Shenzhen518033 China

Identifying the coordinates of marked points in digital subtraction angiography (DSA) is one of the key problems in DSA image-guided navigation systems for interventional radiological procedures. DSA images directly affect the precision and speed of navigation. In this work, a novel method for marked point identification was proposed on the basis of the geographical concept of triangle topology to identify the coordinates of the marked points in a DSA image rapidly and accurately. First, a calibration model with special and distributed marked points was designed. The identifiable marked points from the pretreated image were then selected and the image coordinate of the fourth marked point was verified for calibration. Subsequently, the structure of the triangle topology and proportional relation were used to confirm the uniformized coordinates of the four points. These four points were used to calculate the homography from the coordinates of the uniformized coordinate system to the coordinates of the image coordinate system. Finally, the image coordinates of all the marked points were derived through the values of the uniformized coordinates and homography. Results show that through the marked point identification method proposed in this study, the locations of the marked points can be determined accurately and quickly in the image coordinate system and uniformized coordinate system based on the triangle topology structure, which was formed by the identifiable marked points. The image coordinates of all the marked points can be recalculated without identifying the special marked points. The average error in the algorithm is smaller than 1 mm, and the running time is shorter than 1 s. These values satisfy the requirements of actual surgery in terms of the precision and speed. Thus, the proposed method can provide practical reference for future navigation system based on DSA images for interventional operation. © 2016 Eastern Macedonia and Thrace Institute of Technolo

关键词： Navigation systems

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Author Correction: Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration

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Nature communications 2021年第1期12卷 415页

作者： Yeon Sik Choi Yuan-Yu Hsueh Jahyun Koo Quansan Yang Raudel Avila Buwei Hu Zhaoqian Xie Geumbee Lee Zheng Ning Claire Liu Yameng Xu Young Joong Lee Weikang Zhao Jun Fang Yujun Deng Seung Min Lee Abraham Vázquez-Guardado Iwona Stepien Ying Yan Joseph W Song Chad Haney Yong Suk Oh Wentai Liu Hong-Joon Yoon Anthony Banks Matthew R MacEwan Guillermo A Ameer Wilson Z Ray Yonggang Huang Tao Xie Colin K Franz Song Li John A Rogers Center for Bio-Integrated Electronics Northwestern University Evanston IL 60208 USA. Querrey Simpson Institute for Biotechnology Northwestern University Evanston IL 60208 USA. Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA. Department of Bioengineering University of California Los Angeles Los Angeles CA 90095 USA. Division of Plastic and Reconstructive Surgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70456 Taiwan. International Research Center for Wound Repair and Regeneration National Cheng Kung University Tainan 70456 Taiwan. School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea. Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea. Department of Mechanical Engineering Northwestern University Evanston IL 60208 USA. Department of Medicine University of California Los Angeles Los Angeles CA 90095 USA. State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology 116024 Dalian China. Department of Engineering Mechanics Dalian University of Technology 116024 Dalian China. International Research Center for Computational Mechanics Dalian University of Technology 116024 Dalian China. State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University 310027 Hangzhou China. Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA. State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University 200240 Shanghai China. Center for Developmental Therapeutics Chemistry Life Processes Institute Northwestern University Evanston IL 60208 USA. Department of Neurological Surgery Washington University School of Medicine St. Louis MO 63110 USA. Center for Advanced Molecular Imaging Northwestern University Evanston IL

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