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Author Correction: Effect of de novo transcriptome assembly on transcript quantification

Scientific reports 2019年第1期9卷 18041页

作者： Ping-Han Hsieh Yen-Jen Oyang Chien-Yu Chen Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei 10617 Taiwan. Department of Computer Science and Information Engineering National Taiwan University Taipei 10617 Taiwan. Department of Bio-Industrial Mechatronics Engineering National Taiwan University Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw. Genome and Systems Biology Program National Taiwan University and Academia sinica Taipei 10617 Taiwan. chienyuchen@ntu.edu.tw.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Near-infrared time-domain ultrasound-switchable fluorescence imaging

Near-infrared time-domain ultrasound-switchable fluorescence...

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Optical Molecular Probes, Imaging and Drug Delivery, OMP 2017

作者： Yu, Shuai Liu, Yuan Kandukuri, Jayanth Yao, Tingfeng Yuan, Baohong Ultrasound and Optical Imaging Laboratory Department of Bioengineering The University of Texas at Arlington ArlingtonTX76019 United States Joint Biomedical Engineering Program The University of Texas at Arlington and The University of Texas Southwestern Medical Center DallasTX75390 United States

High signal-to-noise ratio (SNR) in ultrasound-switchable fluorescence (USF) imaging was achieved via a new contrast agent and a new time-domain system implemented in an inverted fluorescence microscope. © 2017 OSA.

ISBN: (纸本)9781943580255

关键词： Fluorescence imaging

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Cross-sectional and longitudinal associations between sedentary behavior and behavioral problems in children with overweight/obesity

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Mental Health and Physical Activity 2025年 29卷

作者： Guan, Kaiqi Yang, Jiayi Cheval, Boris Health, Matthew Herold, Fabian Werneck, André O. Lowe, Cassandra J. Hallgren, Mats Tari, Benjamin Pindus, Dominika Falck, Ryan S. Gerber, Markus Haegele, Justin A. Kramer, Arthur F. Owen, Neville Hillman, Charles H. Guo, Tianyou Zou, Liye Body-Brain-Mind Laboratory School of Psychology Shenzhen University Shenzhen 518060 China Department of Sport Sciences and Physical Education École Normale Supérieure de Rennes Bruz France VIPS2 Laboratory University of Rennes France Canadian Centre for Activity and Aging University of Western Ontario London N6A 3K7 ON Canada Graduate Program in Neuroscience The University of Western Ontario 1151 Richmond St London N6A 3K7 ON Canada School of Kinesiology Faculty of Health Sciences The University of Western Ontario 1151 Richmond St London N6A 3K7 ON Canada Department of Physiology Faculty of Medicine HMU Health and Medical University Erfurt Erfurt Germany Center for Epidemiological Research in Nutrition and Health Department of Nutrition School of Public Health Universidade de São Paulo São Paulo Brazil Department of Psychology University of Exeter United Kingdom Department of Global Public Health Karolinska Institute Stockholm Sweden Institute of Sport Exercise and Health Division of Surgery and Interventional Sciences University College London London United Kingdom Department of Health and Kinesiology University of Illinois Urbana-Champaign Urbana IL United States Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign Urbana IL United States Neuroscience Program University of Illinois Urbana-Champaign Urbana IL United States School of Biomedical Engineering University of British Columbia Vancouver BC Canada Department of Sport Exercise and Health University of Basel Basel 4052 Switzerland Center for Movement Health & Disability Old Dominion University Norfolk VA United States Darden College of Education & Professional Studies Old Dominion University Norfolk VA United States Center for Cognitive and Brain Health Northeastern University Boston MA United States Department of Psychology Northeastern University Boston 02115 MA United States Physical Activity Laboratory Baker Heart & Diabetes I

Background: Sedentary behaviors (ST) are linked to children's mental health, including internalizing and externalizing problems. Research on these associations in children with overweight/obesity is limited. To this end, we examined cross-sectional and longitudinal associations between sedentary time (ST) and behavioral problems in children with overweight/obesity, followed by an investigation of potential sex-related differences. Methods: We included 2273 children with overweight/obesity (49.9 % boys) from the UK Millennium Cohort Study. Accelerometer-measured sedentary time (ST) and MVPA were collected at age 7, and behavioral problems were assessed at ages 7 and 11 via the Strengths and Difficulties Questionnaire (SDQ). General linear models were used to examine how ST at 7 years of age was cross-sectionally and longitudinally associated with externalizing and internalizing, while ethnicity, SDQ scores, parental psychological distress, highest parental education, household poverty, and moderate-to-vigorous physical activity (MVPA) were statistically controlled. These analyses are followed by an analysis investigating sex-related differences. Results: In the cross-sectional analyses, more ST was associated with fewer externalizing problems at 7 years among boys (β: −0.008, 95 % CI: −0.013, −0.003) and girls (β: −0.006, 95 % CI: −0.011, −0.001) without controlling for MVPA. More ST at 7 years was associated with fewer externalizing problems (β: −0.010, 95 %CI: −0.015, −0.004) only among boys when adjusting for MVPA. In the longitudinal analysis, more ST at 7 years was associated with fewer externalizing problems at 11 years for boys (β: −0.006, 95 %CI: −0.010, −0.001) and girls (β: −0.007, 95 %CI: −0.012, −0.002) without controlling for MVPA. When adjusting for MVPA at 7 years, more ST at 7 years was associated with fewer externalizing problems at 11 years for girls (β: −0.006, 95 %CI: −0.013, 0.000). Conclusions: In overweight/obese children, device-measured ST at

关键词： Aggressive Behavioral problems Depression Overweight Sitting

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Cover Image, Volume 116, Number 5, May 2019

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Biotechnology and Bioengineering 2019年第5期116卷

作者： Seep Arora Adele Jing Ying Lam Christine Cheung Evelyn K. F. Yim Yi‐Chin Toh Department of Biomedical Engineering National University of Singapore Singapore Singapore Singapore Institute for Neurotechnology (SINAPSE) National University of Singapore Singapore Singapore Department of Bioengineering Imperial College London London UK Lee Kong Chian School of Medicine Nanyang Technical University Singapore Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research Singapore Singapore Department of Chemical Engineering University of Waterloo Waterloo ON Canada Biomedical Institute for Global Health Research and Technology (BIGHEART) National University of Singapore Singapore Singapore NUS Tissue Engineering Program National University of Singapore Singapore Singapore

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Paper‐Based Ratiometric Fluorescence Analytical Devices towards Point‐of‐Care Testing of Human Serum Albumin

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Angewandte Chemie 2019年第8期132卷

作者： Zijie Luo Taoyuze Lv Kangning Zhu Yi Li Lei Wang J. Justin Gooding Guozhen Liu Bin Liu Shenzhen Key Laboratory of Polymer Science and Technology College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China Graduate School of Biomedical Engineering Faculty of Engineering Australian Centre for NanoMedicine University of New South Wales (UNSW) Sydney 2052 Australia School of Chemistry Australian Centre for NanoMedicine and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology University of New South Wales Sydney 2052 Australia

Monitoring of human serum albumin (HSA) in a point‐of‐care fashion is urgently needed in particular for elderly or chronically ill patients. Herein, a dual‐state emissive chalcone probe having the feature of aggregation‐induced emission was designed and synthesized. The concentration of HSA can be evaluated by the ratios of emission from probes in aggregated and monomeric state, which gives a visually discernible red‐to‐green color change. A simple, portable paper‐based analytical device have been fabricated by integration of the recognition probe in the detection pad and employed for HSA test using the whole blood samples. This paper‐based assay shows the analytical capability comparable to the standard testing methods but is in a point‐of‐care fashion, providing a promising tool for at‐home HSA detection and HSA‐related disease diagnosis.

关键词： Aggregationsinduzierte Emission Humanalbumin Papierbasierte analytische Instrumente Point-of-Care Ratiometrische Detektion

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Low-intensity electrical stimulation and stem cells in a dog with acute spinal cord injury

Low-intensity electrical stimulation and stem cells in a dog...

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International Conference on biomedical engineering (IBIOMED)

作者： Eddy Krueger Lidiane M. S. Magri Agatha S. Botelho Fernando S. Bach Carmen L. K. Rebellato Letícia Fracaro Felipe Y. I. Fragoso José A. Villanova Paulo R. S. Brofman Lana Popović-Maneski Graduate Program in Biomedical Engineering Technological Federal University Curitiba Paraná Brazil Master and Doctoral Program in Rehabilitation Sciences UEL-I TNOPAR State University of Londrina Londrina Brazil Graduate Program in Biomedical Engineering Technological Federal University - Paraná Curitiba Brazil Federal University of Paraná Curitiba Brazil Pontificial Catholical University of Paraná Curitiba Brazil Institute of Technical Sciences of the Serbian Academy of Sciences and Arts Belgrade Serbia

Spinal cord injury (SCI) is classified as neurological disorder that affects motor and sensory function below the injury level. Studies show that application of low-intensity electrical stimulation (LIES) to neural tissue increases neurochemical factors responsible for regeneration as nerve growth factor. Stem cell (SC) therapy for patients with SCI can result in the replacement of injured neurons after trauma. The electromechanical delay (EMD) is defined as time elapsed between the onset of muscle electrical activation and onset of force production. A dog diagnosed with incomplete thoracolumbar SCI followed by disc hernia between the vertebral segments LI and L2, was evaluated by electromyography and mechanomyography after surgical decompression procedure, one SC transplantation and LIES. We observed motor response and decrease in the EMD from 8.25ms to 5.75ms after the procedures. The wavelet decomposition of EMG signals showed reestablishment of vastus lateralis muscle activity 30 days after the procedure. In addition, the EMG RMS increased from 3.3 µV RMS to 157 µV RMS . The preliminary results of this case report indicate positive effects of the hybrid therapy involving stem cells and low-intensity electrical stimulation after surgical decompression.

关键词： Dogs Injuries Stem cells Surgery

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Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors

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Procedia Technology 2017年 27卷 208-209页

作者： Sanjiv Sharma Eri Takagi Tony Cass Wakako Tsugawa Koji Sode Department of Chemistry & Institute of Biomedical Engineering Imperial College London (U.K) Department of Biotechnology and Life Science Graduate School of Engineering Tokyo University of Agriculture & Technology Tokyo Japan

Closed loop systems hinge on the accuracy and precision of the continuous glucose monitoring sensors. Most of the commercially available continuous glucose monitoring sensors is implanted subcutaneously for a period of 7-14 days. The subsequent biofouling effects have implications on the performance of the sensors over time especially at low glucose concentrations. In addition, the commercially available sensors are sensitive to the presence of interfering species such as acetaminophen in the skin compartment. We report here on the marriage of minimally invasive, continuous glucose sensors and a direct electron transfer type glucose dehydrogenase enzymatic system. Whilst the microneedles here are designed to sit in the dermal interstitial fluid over a 24-48 hour period to minimize the biofouling effect, the direct electron transfer enzyme allows operation of the electrochemical sensor at lower potentials to minimize the effect of interference. The microneedle structure design also enables the use of compensation electrodes for background subtraction to further nullify the effects of interference.

关键词： continuous glucose monitoring minimally invasive sensors direct electron transfer microneedles

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Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance

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Journal of experimental & clinical cancer research : CR 2023年第1期42卷 171页

作者： Ting-Wan Kao Geng-Hao Bai Tian-Li Wang Ie-Ming Shih Chi-Mu Chuang Chun-Liang Lo Meng-Chen Tsai Li-Yun Chiu Chu-Chien Lin Yao-An Shen Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. Department of Internal Medicine National Taiwan University Hospital College of Medicine National Taiwan University Taipei City 100225 Taiwan. Departments of Pathology Oncology and Gynecology and Obstetrics Johns Hopkins Medical Institutions 1550 Orleans StreetRoom 306 Baltimore MD CRB221231 USA. Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA. Faculty of Medicine School of Medicine National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Department of Obstetrics and Gynecology Taipei Veterans General Hospital Taipei 112201 Taiwan. Department of Midwifery and Women Health Care National Taipei University of Nursing and Health Sciences Taipei 112303 Taiwan. Department of Biomedical Engineering National Yang-Ming Chiao Tung University Taipei 112304 Taiwan. Medical Device Innovation and Translation Center National Yang Ming Chiao Tung University Taipei 112304 Taiwan. Department of General Medicine Taipei Medical University Hospital Taipei 110301 Taiwan. Department of General Medicine Mackay Memorial Hospital Taipei 104217 Taiwan. School of Medicine College of Medicine Taipei Medical University Taipei City 110301 Taiwan. Department of Pathology School of Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw. International Master/Ph.D. Program in Medicine College of Medicine Taipei Medical University Taipei 110301 Taiwan. shen1202@tmu.edu.tw.

Chemotherapy, radiotherapy, targeted therapy, and immunotherapy are established cancer treatment modalities that are widely used due to their demonstrated efficacy against tumors and favorable safety profiles or tolerability. Nevertheless, treatment resistance continues to be one of the most pressing unsolved conundrums in cancer treatment. Hypoxia-inducible factors (HIFs) are a family of transcription factors that regulate cellular responses to hypoxia by activating genes involved in various adaptations, including erythropoiesis, glucose metabolism, angiogenesis, cell proliferation, and apoptosis. Despite this critical function, overexpression of HIFs has been observed in numerous cancers, leading to resistance to therapy and disease progression. In recent years, much effort has been poured into developing innovative cancer treatments that target the HIF pathway. Combining HIF inhibitors with current cancer therapies to increase anti-tumor activity and diminish treatment resistance is one strategy for combating therapeutic resistance. This review focuses on how HIF inhibitors could be applied in conjunction with current cancer treatments, including those now being evaluated in clinical trials, to usher in a new era of cancer therapy.

关键词： Chemotherapy Combination therapy HIF-1 HIF-2 Hypoxia Immunotherapy Metabolic therapy Radiotherapy Target therapy Therapeutic resistance

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Author Correction: Water molecular structure underpins extreme desiccation tolerance of the resurrection plant Haberlea rhodopensis

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Scientific reports 2020年第1期10卷 9061页

作者： Shinichiro Kuroki Roumiana Tsenkova Daniela Moyankova Jelena Muncan Hiroyuki Morita Stefka Atanassova Dimitar Djilianov Laboratory for Information Engineering of Bioproduction Graduate School of Agricultural Science Kobe University 1-1 Rokkodai Nada Kobe 657-8501 Japan. Biomeasurement Technology Laboratory Graduate School of Agricultural Science Kobe University 1-1 Rokkodai Nada Kobe 657-8501 Japan. rtsen@kobe-u.ac.jp. Abiotic Stress AgroBioinstitute Agricultural Academy 8 Dragan Tzankov Blvd. 1164 Sofia Bulgaria. Nanolab Biomedical Engineering Faculty of Mechanical Engineering University of Belgrade Kraljice Marije 16 Belgrade 11120 Serbia. Nireco Corporation 2951-4 Ishikawa Machi Hachioji Tokyo Japan. Department of Biochemistry Microbiology and Physics Faculty of Agriculture Trakia University Stara Zagora Bulgaria. Abiotic Stress AgroBioinstitute Agricultural Academy 8 Dragan Tzankov Blvd. 1164 Sofia Bulgaria. d_djilianov@abi.bg.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Energy storage and return prostheses: A review of mechanical models

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Critical Reviews in biomedical engineering 2016年第4期44卷 269-292页

作者： Rigney, Stacey Simmons, Anne Kark, Lauren The Graduate School of Biomedical Engineering The University of New South Wales Sydney Australia The School of Mechanical and Manufacturing Engineering The University of New South Wales Sydney Australia

Conventional lower-limb mechanical models were originally developed for gait analysis of able-bodied subjects and therefore potentially misrepresent prosthetic foot behavior when applied to modern energy storage and return (ESAR) prostheses. This review investigates the limitations of current models of prosthetic foot dynamics and kinematics. The Scopus online database was used to identify 236 articles on prosthetic foot behavior during either experiments or simulations, categorized into three main types of models: 74% (n = 175) of studies featured a rigid-link model, 17% (n = 39) a lumped-parameter model, and 10% (n = 23) finite element (FE) analysis. Notably, 64% (n = 152) of the studies used a conventional two-link segment model, yet only 8% (n = 20) featured the rigid, articulating prosthesis that satisfies this model’s underlying rigid-body mechanics assumptions. Conversely, the available preliminary studies on multi-link segment, lumped-parameter, and FE models present viable and more mechanically relevant alternatives to conventional techniques, particularly for ESAR prostheses. Expanding these alternative models to include inertial behavior, multiple degrees of freedom and standardization of boundary conditions will lead to both accurate and standardized prosthetic foot analysis. © 2016 by Begell House, Inc.

关键词： Gait analysis

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