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Bioprinting: 3D Bioprinting: from Benches to Translational Applications (Small 23/2019)

Small 2019年第23期15卷

作者： Marcel Alexander Heinrich Wanjun Liu Andrea Jimenez Jingzhou Yang Ali Akpek Xiao Liu Qingmeng Pi Xuan Mu Ning Hu Raymond Michel Schiffelers Jai Prakash Jingwei Xie Yu Shrike Zhang Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA Department of Biomaterials Science and Technology Section Targeted Therapeutics Technical Medical Centre University of Twente Enschede 7500AE The Netherlands Key Laboratory of Textile Science and Technology College of Textiles Donghua University Shanghai 201620 P. R. China Biomedical Engineering Laboratory Instituto Tecnológico y de Estudios Superiores de Monterrey Monterrey Nuevo León 64849 Mexico Center of Biomedical Materials 3D Printing National Engineering Laboratory for Polymer Complex Structure Additive Manufacturing Baoding 071000 P. R. China Department of Bioengineering Gebze Technical University 41400 Gebze Kocaeli Turkey Sabanci University Nanotechnology Research and Application Center Sabancı University 34956 Tuzla Istanbul Turkey Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100083 China Department of Plastic and Reconstructive Surgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 P. R. China Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027 P. R. China Department of Clinical Chemistry and Hematology University Medical Center Utrecht Utrecht 3584 CX The Netherlands Holland Regenerative Medicine Program University of Nebraska Medical Center Omaha NE 68198 USA

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Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control

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Nature immunology 2023年第4期24卷 729页

作者： Maria M Steele Abhinav Jaiswal Ines Delclaux Ian D Dryg Dhaarini Murugan Julia Femel Sunny Son Haley du Bois Cameron Hill Sancy A Leachman Young H Chang Lisa M Coussens Niroshana Anandasabapathy Amanda W Lund Ronald O. Perelman Department of Dermatology NYU Grossman School of Medicine New York University Langone Health New York NY USA. Department of Cell Developmental and Cancer Biology and Knight Cancer Institute Oregon Health and Science University Portland OR USA. Department of Dermatology Microbiology and Immunology Meyer Cancer Center Englander Institute of Precision Medicine Weill Cornell Medicine New York NY USA. Applied Bioinformatics Laboratories NYU Langone Health New York NY USA. Department of Dermatology Oregon Health and Science University Portland OR USA. Department of Biomedical Engineering and Computational Biology Program Oregon Health and Science University Portland OR USA. OHSU Center for Spatial Systems Biomedicine Oregon Health and Science University Portland OR USA. Ronald O. Perelman Department of Dermatology NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***. Department of Cell Developmental and Cancer Biology and Knight Cancer Institute Oregon Health and Science University Portland OR USA. amanda.lund@***. Department of Pathology NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***. Laura and Isaac Perlmutter Cancer Center NYU Grossman School of Medicine New York University Langone Health New York NY USA. amanda.lund@***.

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Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

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Cell Reports 2025年第6期44卷 115792页

作者： Lin, Chenchu Pulliam, Thomas L. Han, Jenny J. Xu, Jiaqian Recio, Carlos Vera Wilkenfeld, Sandi R. Shi, Yan Kushwaha, Manoj Bench, Sarah Ruiz, Eduardo Senthilkumar, Sanjanaa Dileep, Jayasurya Shepherd, Peter D.A. Navone, Nora M. Klekers, Albert R. Whitley, Elizabeth M. Ittmann, Michael M. Eberlin, Livia S. Wang, Wenyi Frigo, Daniel E. Department of Cancer Systems Imaging The University of Texas MD Anderson Cancer Center Houston 77054 TX United States UTHealth Graduate School of Biomedical Sciences The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Systems Biology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Surgery Baylor College of Medicine Houston 77030 TX United States Mayo Clinic Alix School of Medicine Phoenix 85054 AZ United States McKetta Department of Chemical Engineering University of Texas at Austin Austin 78712 TX United States Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Abdominal Radiology The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Department of Veterinary Medicine and Surgery The University of Texas MD Anderson Cancer Center Houston 77030 TX United States Departments of Pathology and Immunology Baylor College of Medicine Houston 77030 TX United States Dan L. Duncan Cancer Center Houston 77030 TX United States Michael E. DeBakey Veterans Affairs Medical Center Houston 77030 TX United States Department of Chemistry The University of Texas at Austin Austin 78712 TX United States Center for Nuclear Receptors and Cell Signaling University of Houston Houston 77204 TX United States Department of Biology and Biochemistry University of Houston Houston 77004 TX United States

Castration-resistant prostate cancer (CRPC) remains an incurable disease in need of improved treatments. CAMKK2 is an emerging therapeutic target whose oncogenic effects in prostate cancer have, to date, been largely attributed to its activation of AMP-activated protein kinase (AMPK). Here, we demonstrate that CAMKK2 promotes prostate cancer growth through an alternative downstream pathway involving CAMKI and CREB. Unbiased transcriptomics identify CREB-mediated transcription as a CAMKK2-regulated process, findings that we validate using diverse molecular, genetic, and pharmacological approaches in vitro and in vivo. CAMKK2 promotes CREB phosphorylation/activation through CAMKIα independently of AMPK, CAMKIV, or other CAMKI isoforms. Functionally, the CREB family members CREB1 and ATF1 exhibit close redundancy, necessitating co-targeting for optimal anti-tumor efficacy. An inhibitor of CREB1/ATF1 blocks CRPC with minimal side effects. Mechanistically, CAMKK2 and CREB increase CRPC growth through augmenting cholesterol metabolism. Together, these findings identify an oncogenic pathway that could be exploited for the treatment of CRPC. © 2025 The Author(s)

关键词： AMPK androgen receptor CAMKI CAMKK2 cholesterol CP: Cancer CP: Metabolism CREB metabolism prostate cancer

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Biodegradable Polymers: A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy (Adv. Funct. Mater. 23/2020)

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Advanced Functional Materials 2020年第23期30卷

作者： KangJu Lee Yumeng Xue Junmin Lee Han‐Jun Kim Yaowen Liu Peyton Tebon Einollah Sarikhani Wujin Sun Shiming Zhang Reihaneh Haghniaz Betül Çelebi‐Saltik Xingwu Zhou Serge Ostrovidov Samad Ahadian Nureddin Ashammakhi Mehmet R. Dokmeci Ali Khademhosseini Department of Bioengineering and Center for Minimally Invasive Therapeutics University of California Los Angeles CA 90095 USA College of Food Science Sichuan Agricultural University Yaan 625014 China Department of Stem Cell Sciences Graduate School of Health Sciences Hacettepe University Sihhiye Ankara 06100 Turkey Department of Radiological Sciences David Geffen School of Medicine University of California Los Angeles CA 90095 USA Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA

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Modeling brain connectivity with graphical models on frequency domain

arXiv

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arXiv 2018年

作者： Gao, Xu Shen, Weining Ting, Chee-Ming Cramer, Steven C. Srinivasan, Ramesh Ombao, Hernando Department of Statistics University of California IrvineCA United States School of Biomedical Engineering and Health Sciences Universiti Teknologi Malaysia Malaysia Department of Anatomy and Neurobiology University of California IrvineCA United States Department of Cognitive Sciences University of California IrvineCA United States Statistics Program King Abdullah University of Science and Technology Thuwal Saudi Arabia

Multichannel electroencephalograms (EEGs) have been widely used to study cortical connectivity during acquisition of motor skills. In this paper, we introduce copula Gaussian graphical models on spectral domain to characterize dependence in oscillatory activity between channels. To obtain a simple and robust representation of brain connectivity that can explain the most variation in the observed signals, we propose a framework based on maximizing penalized likelihood with Lasso regularization to search for the sparse precision matrix. To address the optimization problem, graphical Lasso, Ledoit-Wolf and sparse estimation of a covariance matrix (SPCOV) algorithms were modified and implemented. Simulations show the benefit of using the proposed algorithms in terms of robustness and small estimation errors. Furthermore, analysis of the EEG data in a motor skill task conducted using algorithms of modified graphical LASSO and Ledoit-Wolf, reveal a sparse pattern of brain connectivity among cortices which is consistent with the results from other work in the literature. Copyright © 2018, The Authors. All rights reserved.

关键词： Electroencephalography

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Cover Picture: Proteomic Atomics Reveals a Distinctive Uracil-5-Methyltransferase (Mol. Inf. 5/2020)

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Molecular Informatics 2020年第5期39卷

作者： Subrata Pramanik Manisha Thaker Ananda Gopu Perumal Rajasekaran Ekambaram Naresh Poondla Markus Schmidt Pok-Son Kim Arne Kutzner Klaus Heese Graduate School of Biomedical Science and Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul 1 33-791 Republic of Korea Institute of Biotechnology RWTH Aachen University Worringerweg 3 Aachen 52074 Germany Department of Medicine Harvard Medical School 3 Blackfan Circle Boston MA 02115 USA Technology Business Incubator Periyar Maniammai Institute of Science and Technology Vallam Thanjavur 613403 Tamil Nadu India Department of Chemistry V.S.B. Engineering College 67 Covai Road Karudayampalayam Post Karur 639111 Tamil Nadu India Department of Information Systems College of Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul 133-791 Republic of Korea Department of Mathematics Kookmin University 77 Jeongneung-ro Seongbuk-gu Seoul 1 36-702 Republic of Korea

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Background-free dual-mode optical and 13C magnetic resonance imaging in diamond particles

arXiv

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arXiv 2019年

作者： Lv, X. Walton, J.H. Druga, E. Wang, F. Aguilar, A. McKnelly, T. Nazaryan, R. Wu, L. Shenderova, O. Vigneron, D.B. Meriles, C.A. Reimer, J.A. Pines, A. Ajoy, Ashok Department of Chemistry University of California BerkeleyCA94720 United States Nuclear Magnetic Resonance Facility University of California Davis DavisCA95616 United States Adámas Nanotechnologies Inc. 8100 Brownleigh Dr Suite 120 RaleighNC27617 United States Department of Radiology and Biomedical Imaging University of California-San Francisco San FranciscoCA94158 United States Department of Physics CUNY-Graduate Center CUNY-City College of New York New YorkNY10031 United States Department of Chemical and Biomolecular Engineering Materials Science Division Lawrence Berkeley National Laboratory University of California BerkeleyCA94720 United States

Multimodal imaging - the ability to acquire images of an object through more than one imaging mode simultaneously - has opened new perspectives in areas ranging from astronomy to medicine. In this paper, we report progress towards combining optical and magnetic resonance (MR) imaging in such a "dual" imaging mode. They are attractive in combination because they offer complementary advantages of resolution and speed, especially in the context of imaging in scattering environments. Our approach relies on a specific material platform, microdiamond particles hosting nitrogen vacancy (NV) defect centers that fluoresce brightly under optical excitation and simultaneously "hyperpolarize" lattice 13C nuclei, making them bright under MR imaging. We highlight advantages of dual-mode optical and MR imaging in allowing background-free particle imaging, and describe regimes in which either mode can enhance the other. Leveraging the fact that the two imaging modes proceed in Fourier-reciprocal domains (real and k-space), we propose a sampling protocol that accelerates image reconstruction in sparse-imaging scenarios. Our work suggests interesting possibilities for the simultaneous optical and low-field MR imaging of targeted diamond nanoparticles. Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

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Nature communications 2025年第1期16卷 1366页

作者： Anand Ramani Giovanni Pasquini Niklas J Gerkau Vaibhav Jadhav Omkar Suhas Vinchure Nazlican Altinisik Hannes Windoffer Sarah Muller Ina Rothenaigner Sean Lin Aruljothi Mariappan Dhanasekaran Rathinam Ali Mirsaidi Olivier Goureau Lucia Ricci-Vitiani Quintino Giorgio D'Alessandris Bernd Wollnik Alysson Muotri Limor Freifeld Nathalie Jurisch-Yaksi Roberto Pallini Christine R Rose Volker Busskamp Elke Gabriel Kamyar Hadian Jay Gopalakrishnan Institute of Human Genetics University Hospital Friedrich-Schiller-Universität Jena 07740 Jena Germany. Department of Ophthalmology University Hospital Bonn Medical Faculty Bonn Germany. Institute of Neurobiology Faculty of Mathematics and Natural Sciences Heinrich-Heine-Universität 40225 Düsseldorf Germany. Research Unit Signaling and Translation Helmholtz Zentrum München 85764 Neuherberg Germany. Kugelmeiers Ltd Erlenbach Switzerland. Institut de la Vision Sorbonne Université INSERM CNRS F-75012 Paris France. Department of Oncology and Molecular Medicine Istituto Superiore di Sanità Viale Regina Elena 299 00161 Rome Italy. Department of Neuroscience Neurosurgery Section Università Cattolica del Sacro Cuore Rome Italy. Institute of Human Genetics University Medical Center Göttingen Göttingen Germany. University of California San Diego School of Medicine Department of Pediatrics/Rady Children's Hospital-San Diego San Diego USA. Department of Cellular & Molecular Medicine Stem Cell Program La Jolla CA 92093 MC 0695 USA. Department of Biomedical Engineering Technion-Israel Institute of Technology Haifa Israel. Department of Clinical and Molecular Medicine Faculty of Medicine and Health Sciences Norwegian University of Science and Technology Trondheim Norway. Institute of Human Genetics University Hospital Heinrich-Heine-Universität 40225 Düsseldorf Germany. Institute of Human Genetics University Hospital Friedrich-Schiller-Universität Jena 07740 Jena Germany. jay.gopalakrishnan@uni-jena.de.

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Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer

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Nature communications 2023年第1期14卷 6692页

作者： Chi-Ling Chiang Yifan Ma Ya-Chin Hou Junjie Pan Sin-Yu Chen Ming-Hsien Chien Zhi-Xuan Zhang Wei-Hsiang Hsu Xinyu Wang Jingjing Zhang Hong Li Lili Sun Shannon Fallen Inyoul Lee Xing-Yu Chen Yeh-Shiu Chu Chi Zhang Tai-Shan Cheng Wen Jiang Betty Y S Kim Eduardo Reategui Robert Lee Yuan Yuan Hsiao-Chun Liu Kai Wang Michael Hsiao Chi-Ying F Huang Yan-Shen Shan Andrew S Lee L James Lee Department of Chemical and Biomolecular Engineering The Ohio State University Columbus OH 43210 USA. Comprehensive Cancer Center College of Medicine The Ohio State University Columbus OH 43210 USA. Department of Biomedical Engineering The Ohio State University Columbus OH 43210 USA. Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan 70101 Taiwan. Division of General Surgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70101 Taiwan. Institute of Biopharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan. Genomics Research Center Academia Sinica Taipei 11529 Taiwan. Key Laboratory for Ultrafine Materials of Ministry of Education and School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 PR China. Institute of Systems Biology Seattle WA 98109 USA. Brain Research Center National Yang Ming Chiao Tung University Taipei 11221 Taiwan. College of Pharmacy The Ohio State University Columbus OH 43210 USA. Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Institute of Biopharmaceutical Sciences National Yang Ming Chiao Tung University Taipei 11221 Taiwan. cyhuang5@nycu.edu.tw. Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan 70101 Taiwan. ysshan@mail.ncku.edu.tw. Division of General Surgery Department of Surgery National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan 70101 Taiwan. ysshan@mail.ncku.edu.tw. Institute for Cancer Research Shenzhen Bay Laboratory Shenzhen 518055 China. alee@***. School of Chemical Biology and Biochemistry Peking University Shenzhen Graduate School Shenzhen 518055 China. alee@pku.edu.cn. D

Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to target high solid tumour burden like PDAC. Here, we report a dual targeted extracellular vesicle (dtEV) carrying high loads of therapeutic RNA that effectively suppresses large PDAC tumours in mice. The EV surface contains a CD64 protein that has a tissue targeting peptide and a humanized monoclonal antibody. Cells sequentially transfected with plasmid DNAs encoding for the RNA and protein of interest by Transwell®-based asymmetric cell electroporation release abundant targeted EVs with high RNA loading. Together with a low dose chemotherapy drug, Gemcitabine, dtEVs suppress large orthotopic PANC-1 and patient derived xenograft tumours and metastasis in mice and extended animal survival. Our work presents a clinically accessible and scalable way to produce abundant EVs for delivering multiple gene cargoes to large solid tumours.

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Human Organ Miniaturization: 3D Miniaturization of Human Organs for Drug Discovery (Adv. Healthcare Mater. 2/2018)

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Advanced Healthcare Materials 2018年第2期7卷

作者： Joseph Park Isaac Wetzel Didier Dréau Hansang Cho Department of Mechanical Engineering and Engineering Science Department of Biological Sciences The Nanoscale Science Program Center for Biomedical Engineering and Science UNC Charlotte 9201 University City Blvd Charlotte NC 28223 USA

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