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作者： Sudarshan, Vidya K. Koh, Joel E. W. Tan, Jen Hong Hagiwara, Yuki Chua, Kuang Chua Ng, Eddie Y. K. Tong, Louis Department of Biomedical Engineering School of Science and Technology Singapore University of Social Science Singapore599491 Singapore School of Electrical and Computer Engineering University of Newcastle Singapore038986 Australia Department of Electronics and Computer Engineering Ngee Ann Polytechnic Singapore599489 Singapore School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore639798 Singapore Singapore Eye Research Institute Singapore168751 Singapore Singapore National Eye Center Singapore168751 Singapore Duke-NUS Graduate Medical School Singapore169857 Singapore Yong Loo Lin School of Medicine National University of Singapore Singapore117597 Singapore

The enhanced tear film evaporation and diminished tear production causes a dry eye (DE) condition. A non-invasive infrared (IR) thermography is most commonly used as a diagnostic tool for diagnosis of DE. However, the availability of high-quality IR thermal camera at low cost is difficult. Hence, an efficient DE detection system which can perform efficiently by using low-cost and low-quality images instead of conventional IR images would be a significant contribution. Therefore, in this work, we have evaluated the performance of automated non-invasive DE detection system using low-quality images obtained by adding different levels of noise to high-quality IR images. In this work, the performances of two non-linear higher-order spectra (HOS) cumulants and bispectrum features are compared. These features are extracted from the IR images with different levels of Gaussian noise. Principal component analysis (PCA) is performed on these extracted features and they are ranked using t-value and later fed to different classifiers. We have achieved the accuracies, sensitivities and specificities of: (i) 86.90%, 85.71% and 88.10%, with noise level 0 using 24 bispectrum features, and (ii) 80.95%, 85.71% and 76.19%, with noise level 10 using 15 bispectrum features for right eye IR images. This study exhibits that even in the presence of high levels of noise, the detection of DE is possible and our proposed method performs efficiently using HOS bispectrum features. Thus, our proposed method can be used to detect DE using low-quality and inexpensive cameras instead of high-cost IR camera. © 2017 World Scientific Publishing Company.

关键词： Principal component analysis

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Antimicrobial photodynamic of blue LED for activation of curcumin extract (curcuma longa) on staphylococcus aureus bacteria, an in vitro study

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Journal of Physics: Conference Series 2018年第1期1120卷

作者： S D Astuti A F Mahmud Pudjiyanto Y Mukhammad N Fitriyah Department of Physics Faculty of Science and Technology Airlangga University Surabaya Indonesia 60115 Department of Biomedical Engineering Post Graduate School Airlangga University Surabaya Indonesia 60115

Staphylococcus aureus (***) is a normal skin flora. In abnormal conditions, these bacteria can cause mild skin infections such as acne vulgaris and cellulitis folliculitis that attack the respiratory system causing severe infections such as pneumonia and empyema occur. Systemic treatment with antibiotics for a long time can cause resistance. Antimicrobial photodynamic therapy (aPDT) is a therapy that uses light sources, photosensitizer (PS) agents and oxygen. This study aims to determine the effectiveness of blue LED (400-450) nm to activate exogenous PS of curcumin extract in *** in vitro. To determine the antibacterial effect of curcumin extract (Curcuma longa) on *** bacteria with LED radiation, the distribution of samples was divided into four treatment groups, Group (S − K −) control group without any treatment, group (S− K +) control group with curcumin extract, group (S + K−) group with LED irradiation without curcumin extract, group (S + K +) laser irradiation group with curcumin extract. Bacterial growth is measured using Elisa Reader and Total Plate Count Method. The results showed that the LED energy density 16.19 J/cm2 was able to increase the percentage of bacterial mortality by (91.49 ± 0.01) % with curcumin extract and (44.88 ± 0.18) % without curcumin extract. So LED irradiation is able to activate curcumin extract to increase the percentage of *** bacterial death.

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Characterization of the complete mitochondrial genome of Mauritian sardinella, Sardinella jussieu (Lacepède, 1803), collected in the Banten Bay, Indonesia

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Fisheries and Aquatic Sciences 2017年第1期20卷 1-9页

作者： Sektiana, Sinar Pagi Andriyono, Sapto Kim, Hyun-Woo Pukyong National University Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Busan 48513 South Korea Pukyong National University Department of Marine Biology Busan 48513 South Korea Jakarta Fisheries University Aquaculture Technology Study Program Jl. AUP Pasar Minggu Jakarta Selatan Jakarta 12520 Indonesia Fisheries and Marine Faculty C Campus Jl. Mulyorejo Surabaya 60115 Indonesia Universitas Airlangga Surabaya East Java Indonesia

Fishes in genus Sardinella are small pelagic species, which plays an important role in marine ecosystem as the first consumer. Those species are also commercially important, whose total catch reaches 278,600 tons in 2011 in Indonesia, but their identification has been difficult for their morphological similarity. In this study, we reported Sardinella jussieu for the first time in Indonesian coastal area (Banten Bay, Indonesia, 6° 0' 50.00" S-106° 10' 21.00" E). We were able to confirm the species by both its morphological characteristics including the black spot at dorsal fin origin, the dusky pigmentation at caudal fin, 31 total scute numbers, and DNA sequence identity in the GenBank database by the molecular analysis. Its total mitochondrial genome was determined by the combination of next-generation sequencing and typical PCR strategy. The total mitochondrial genome of Sardinella jussieu (16,695 bp) encoded 13 proteins, 2 ribosomal RNAs, 22 transfer RNAs, and the putative control region. All protein-coding genes started with ATG and typical stop codon and ended with TAA or TAG except for ND4 in which AGA is used. Phylogenetic analyses of both COI region and full mitochondrial genome showed that S. jussieu is most closely related to Sardinella albella and Sardinella gibbosa. © 2017 The Author(s).

关键词： Barcode Indonesia Mitochondrial genome Next-generation sequencing Sardinella

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Contribution of center of mass-center of pressure angle tangent to the required coefficient of friction in the sagittal plane during straight walking

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Biotribology 2016年 5卷 16-22页

作者： Yamaguchi, Takeshi Masani, Kei Graduate School of Engineering Tohoku University 6-6-01 Aramaki-Aza-Aoba Aoba-ku Sendai Miyagi 980-8579 Japan Graduate School of Biomedical Engineering Tohoku University Sendai Miyagi Japan Rehabilitation Engineering Laboratory Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto ON Canada Rehabilitation Engineering Laboratory Lyndhurst Centre Toronto Rehabilitation Institute University Health Network Toronto ON Canada

In human bipedal walking, the peak value of the traction coefficient (i.e., the ratio of the shear force component to the vertical force component exerted on the floor) produced shortly after heel contact is termed as the required coefficient of friction (RCOF). Based on a bipedal inverted pendulum model, with a whole-body center of mass (COM) and reaction forces applied at the center of pressure (COP) of standing feet, RCOF in the sagittal plane (RCOF_y) can be expressed as the sum of the tangent of the COM-COP angle and a residual term (RT), mainly comprising the moment around COM. In this study, we investigated the contribution of the tangent of the COM-COP angle to RCOF_y during straight walking. The study involved four healthy young adult males. The participants were asked to walk on a 5-m long carpeted walkway. Each participant performed nine trials, i.e., three walking speeds (1, 1.4, and 1.9 m/s) × three step lengths (0.55, 0.75, and 0.95 m). COM was estimated using motion capture. COPs for the left and right feet were measured using eight force plates embedded in the walkway. RCOF_y was calculated from the anterior-posterior and vertical ground reaction force components measured using the force plates. We found that the tangent of the COM-COP angle accounted for 91%-124% of the RCOF_y value. This percentage tended to decrease with increasing walking speed (p < 0.05). The magnitude of RT accounted for only 5.3%-24% of RCOF_y. These results suggest that the tangent of the COM-COP angle dominantly determines RCOF_y. © 2015 The Authors.

关键词： Center of mass Center of pressure Friction Gait Slip

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Defective Epstein-Barr virus in chronic active infection and haematological malignancy (vol 4, pg 404, 2019)

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NATURE MICROBIOLOGY 2019年第3期4卷 544-544页

作者： Okuno, Yusuke Murata, Takayuki Sato, Yoshitaka Muramatsu, Hideki Ito, Yoshinori Watanabe, Takahiro Okuno, Tatsuya Murakami, Norihiro Yoshida, Kenichi Sawada, Akihisa Inoue, Masami Kawa, Keisei Seto, Masao Ohshima, Koichi Shiraishi, Yuichi Chiba, Kenichi Tanaka, Hiroko Miyano, Satoru Narita, Yohei Yoshida, Masahiro Goshima, Fumi Kawada, Jun-Ichi Nishida, Tetsuya Kiyoi, Hitoshi Kato, Seiichi Nakamura, Shigeo Morishima, Satoko Yoshikawa, Tetsushi Fujiwara, Shigeyoshi Shimizu, Norio Isobe, Yasushi Noguchi, Masaaki Kikuta, Atsushi Iwatsuki, Keiji Takahashi, Yoshiyuki Kojima, Seiji Ogawa, Seishi Kimura, Hiroshi Center for Advanced Medicine and Clinical Research Nagoya University Hospital Nagoya Japan Department of Virology Nagoya University Graduate School of Medicine Nagoya Japan Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan Department of Pathology and Tumor Biology Graduate School of Medicine Kyoto University Kyoto Japan Department of Hematology/Oncology Osaka Women’s and Children’s Hospital Osaka Japan Department of Pathology Kurume University School of Medicine Kurume Japan Laboratory of DNA Information Analysis Human Genome Center Institute of Medical Science The University of Tokyo Tokyo Japan Department of Hematology and Oncology Nagoya University Graduate School of Medicine Nagoya Japan Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan Division of Endocrinology Diabetes and Metabolism Hematology Rheumatology (Second Department of Internal Medicine) Graduate School of Medicine University of the Ryukyus Nishihara Japan Department of Pediatrics Fujita Health University School of Medicine Toyoake Japan Department of Allergy and Clinical Immunology National Research Institute for Child Health and Development Tokyo Japan Center for Stem Cell and Regenerative Medicine Division of Advanced Biomedical Engineering Research Institute of Research Tokyo Medical and Dental University Tokyo Japan Division of Hematology and Oncology Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Japan Department of Hematology Juntendo University Urayasu Hospital Urayasu Japan Department of Pediatric Oncology Fukushima Medical University School of Medicine Fukushima Japan Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan

Epstein–Barr virus (EBV) infection is highly prevalent in humans and is implicated in various diseases, including cancer1,2. Chronic active EBV infection (CAEBV) is an intractable disease classified as a lymphoproliferative disorder in the 2016 World Health Organization lymphoma classification1,2. CAEBV is characterized by EBV-infected T/natural killer (NK) cells and recurrent/persistent infectious mononucleosis-like symptoms3. Here, we show that CAEBV originates from an EBV-infected lymphoid progenitor that acquiresDDX3Xand other mutations, causing clonal evolution comprising multiple cell lineages. Conspicuously, the EBV genome in CAEBV patients harboured frequent intragenic deletions (27/77) that were also common in various EBV-associated neoplastic disorders (28/61), including extranodal NK/T-cell lymphoma and EBV-positive diffuse large B-cell lymphoma, but were not detected in infectious mononucleosis or post-transplant lymphoproliferative disorders (0/47), which suggests a unique role of these mutations in neoplastic proliferation of EBV-infected cells. These deletions frequently affectedBamHI A rightward transcript microRNA clusters (31 cases) and several genes that are essential for producing viral particles (20 cases). The deletions observed in our study are thought to reactivate the lytic cycle by upregulating the expression of two immediate early genes,BZLF1andBRLF14,5,6,7, while averting viral production and subsequent cell lysis. In fact, the deletion of one of the essential genes,BALF5, resulted in upregulation of the lytic cycle and the promotion of lymphomagenesis in a xenograft model. Our findings highlight a pathogenic link between intragenic EBV deletions and EBV-associated neoplastic proliferations.

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Barriers and countermeasures in developing traditional Chinese medicine in Europe

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Frontiers of Medicine 2016年第3期10卷 360-376页

作者： Yunfang Liu Zhiping Yang Jing Cheng Daiming Fan Projeet Department Consultancy Program Center Chinese Academy of Engineering Beijing 100088 China Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi 'an 710032 China

Traditional Chinese medicine （TCM） is one of the unique cultural treasures of Chinese; it represents a significant feature and prominent advantage of the healthcare cause in China. Data in this paper were from World Health Organization, Chinese Bureau of Statistics, China National Knowledge Infrastructure, and PubMed. In recent years, TCM has established a solid foundation in Europe, which made great strides in legislation, education, research, and international exchange, and has enjoyed a vast development space in the continent. Now, TCM is embracing unprecedented development opportunities in Europe. At the same time, the stiff international competition poses a grave threat to China＇s TCM industry. With multiple cultural, legal, and institutional challenges, as well as talent shortages in the way, TCM is now facing many difficulties in Europe. To fully prepare and enact active and vigorous steps to seize opportunities, we should have a clear picture about the serious challenges hampering TCM development in Europe. The TCM development at overseas markets has shifted from a spontaneous trade activity into a national strategy spearheaded by the government and participated in by multiple stakeholders. We should make a systematic, comprehensive, and sustainable push in fields such as TCM therapy, healthcare, education, research, culture, and industry development. The ultimate goal is to bring TCMs to the global market and allow them to play a role in safeguarding public health along with modern medicines.

关键词： traditional Chinese medicine Europe development

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Genomic basis for RNA alterations in cancer (vol 578, pg 129, 2020)

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NATURE 2023年第7948期614卷 E37-E37页

作者： Calabrese, Claudia Davidson, Natalie R. Demircioglu, Deniz Fonseca, Nuno A. He, Yao Lehmann, Kjong-Van Liu, Fenglin Shiraishi, Yuichi Soulette, Cameron M. Urban, Lara Greger, Liliana Li, Siliang Liu, Dongbing Perry, Marc D. Xiang, Qian Zhang, Fan Zhang, Junjun Bailey, Peter Erkek, Serap Hoadley, Katherine A. Hou, Yong Huska, Matthew R. Kilpinen, Helena Korbel, Jan O. Marin, Maximillian G. Markowski, Julia Nandi, Tannistha Pan-Hammarstrom, Qiang Pedamallu, Chandra Sekhar Siebert, Reiner Stark, Stefan G. Su, Hong Tan, Patrick Waszak, Sebastian M. Yung, Christina Zhu, Shida Awadalla, Philip Creighton, Chad J. Meyerson, Matthew Ouellette, B. F. Francis Wu, Kui Yang, Huanming Brazma, Alvis Brooks, Angela N. Goke, Jonathan Ratsch, Gunnar Schwarz, Roland F. Stegle, Oliver Zhang, Zemin European Molecular Biology Laboratory European Bioinformatics Institute Hinxton UK European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI) Cambridge UK Genome Biology Unit European Molecular Biology Laboratory (EMBL) Heidelberg Germany CIBIO/InBIO - Research Center in Biodiversity and Genetic Resources Universidade do Porto Vairão Portugal Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) partner site Berlin Germany German Cancer Research Center (DKFZ) Heidelberg Germany Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine Berlin Germany German Cancer Consortium (DKTK) Partner site Berlin Berlin Germany European Molecular Biology Laboratory Genome Biology Unit Heidelberg Germany Division of Computational Genomics and Systems Genetics German Cancer Research Center (DKFZ) Heidelberg Germany ETH Zurich Zurich Switzerland Memorial Sloan Kettering Cancer Center New York NY USA Weill Cornell Medical College New York NY USA SIB Swiss Institute of Bioinformatics Lausanne Switzerland University Hospital Zurich Zurich Switzerland Computational Biology Center Memorial Sloan Kettering Cancer Center New York NY USA Department of Biology ETH Zurich Zürich Switzerland Department of Computer Science ETH Zurich Zurich Switzerland Korea University Seoul South Korea Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine New York NY USA National University of Singapore Singapore Singapore Genome Institute of Singapore Singapore Singapore Computational and Systems Biology Genome Institute of Singap

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Measurement of blood glucose level by using mid-infrared hollow-optical fiber probe with ATR multi-reflection prism

Measurement of blood glucose level by using mid-infrared hol...

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Asia-Pacific Optical Sensors Conference, APOS 2016

作者： Kino, Saiko Matsuura, Yuji Graduate School of Biomedical Engineering Tohoku University 6-6-05 Aoba Sendai980-8579 Japan

Mid-infrared ATR spectroscopy system comprising hollow optical fibers and a multireflection prism are developed for blood-glucose measurement. Absorption spectra of lip mucosa revealed clear signatures of glucose and ... 详细信息

ISBN: (纸本)9780960038053

关键词： Prisms

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An end-to-end triple cascade CNN for automatic segmentation of parotid glands in radiation therapy

An end-to-end triple cascade CNN for automatic segmentation ...

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2017 IEEE 国际医学影像物理和工程大会暨第八届中国医学影像物理学术年会

作者： Xinlong Sun Deqi Cui Mengqiao Li Zhengzhong Yi Shuo Zhang Pei Wang Kehong Yuan Department of Biomedical Engineering Tsinghua University Graduate School at Shenzhen Tsinghua University Linking Medical Technology Co. Ltd. Harbin Institute of Technology Shenzhen Graduate School Sichuan Cancer Hospital and Institute

Objective: Accurate and fast automatic segmentation of organs-at-risks(OARs) is a key step for efficient planning of radiation therapy in head and neck cancer treatment. In this paper, we propose an end-to-end triple cascade convolutional neural network, which is for accurate and fast automatic segmentation of parotid glands in 3 D CT image of head and neck. Methods: The proposed network is cascaded by three convolutional neural networks. The first CNN is a simple classification network to find the slice from brow bone to neck. It can accelerate the next step by reducing the search space. The second network is a 3 DCNN for locating the region of interest(ROI) of the parotid glands. At the same time, it can be used to distinguish the left parotid gland and right parotid gland. The third network is a full convolution network(FCN) based on U-Net. This is a pixel-wise detailed segmented network to classify voxels in a region of interest and generate segmentation results. We collected 3 D CT images of 90 patients from the Sichuan Cancer Hospital, 78 of which were used for training and 12 for prediction. Results: The Dice coefficient(DSC) of the segmentation results is 81.1 ± 2.6% for left parotid gland and 80.7 ±2.2% for right parotid gland, which is above the state-of-theart deep learning based method. Because parotid glands may be challenging to annotate even for a human, the dice coefficient is affected by some terrible manual depicted labels. But in terms of anatomic structure, our segmentation results even surpassed doctors. Conclusion: The proposed end-to-end triple cascade convolutional neural network can be used to accurate and fast automatic segmentation of parotid glands. The average segmentation time for one patient is 18.69 s, which indicates proposed method having practical value. It can assist doctors in outlining the parotid glands during OARs depiction.

关键词： image segmentation 3D CT image convolutional neural network radiation therapy parotid glands

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Quantifying prosthetic gait deviation using simple outcome measures

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World Journal of Orthopedics 2016年第6期7卷 383-391页

作者： Lauren Kark Ross Odell Andrew S McIntosh Anne Simmons Graduate School of Biomedical Engineering University of New South Wales Australian Centre for Research into Injuryin Sport and its Prevention Federation University

AIM:To develop a subset of simple outcome measures to quantify prosthetic gait deviation without needing three-dimensional gait analysis(3DGA).METHODS:Eight unilateral,transfemoral amputees and 12 unilateral,transtibial amputees were ***-eight able-bodied controls were *** participants underwent 3DGA,the timed-up-and-go test and the six-minute walk test(6MWT).The lowerlimb amputees also completed the Prosthesis Evaluation *** from 3DGA were summarised using the gait deviation index(GDI),which was subsequently regressed,using stepwise regression,against the other ***:Step-length(SL),self-selected walking speed(SSWS) and the distance walked during the 6MWT(6MWD) were significantly correlated with *** 6MWD was the strongest,single predictor of the GDI,followed by SL and *** predictive ability of the regression equations were improved following inclusion of self-report data related to mobility and prosthetic ***:This study offers a practicable alternative to quantifying kinematic deviation without the need to conduct complete 3DGA.

关键词： Gait deviation Prosthesis Amputation Functional outcomes Regression Receiver operating characteristic curve

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